Abstract:
:The easy clinical handling and applicability of biomaterials has become a focus of materials research due to rapidly increasing time and cost pressures in the public health sector. The present study assesses the in vitro and in vivo performance of a flexible, mouldable, cottonwool-like nanocomposite based on poly(lactide-co-glycolide) and amorphous tricalcium phosphate nanoparticles (PLGA/TCP 60:40). Immersion in simulated body fluid showed exceptional in vitro bioactivity for TCP-containing fibres (mass gain: 18%, 2 days, HAp deposition). Bone regeneration was quantitatively investigated by creating four circular non-critical-size calvarial defects in New Zealand White rabbits. The defects were filled with the easy applicable cottonwool-like PLGA/TCP fibres or PLGA alone. Porous bovine-derived mineral (Bio-Oss) was used as a positive control and cavities left empty served as a negative control. The area fraction of newly formed bone (4 weeks implantation) was significantly increased for TCP-containing fibres compared to pure PLGA (histological and micro-computed tomographic analysis). A spongiosa-like structure of the newly formed bone tissue was observed for PLGA/TCP nanocomposites, whereas Bio-Oss-treated defects afforded a solid cortical bone.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Schneider OD,Weber F,Brunner TJ,Loher S,Ehrbar M,Schmidlin PR,Stark WJdoi
10.1016/j.actbio.2008.11.030subject
Has Abstractpub_date
2009-06-01 00:00:00pages
1775-84issue
5eissn
1742-7061issn
1878-7568pii
S1742-7061(08)00380-2journal_volume
5pub_type
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journal_title:Acta biomaterialia
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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doi:10.1016/j.actbio.2014.09.029
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2008.02.017
更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.actbio.2020.05.040
更新日期:2020-09-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2008.02.022
更新日期:2008-09-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 临床试验,杂志文章
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更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2016-04-15 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2008.11.003
更新日期:2009-06-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2014.02.052
更新日期:2014-07-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2008.02.025
更新日期:2008-09-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2014.08.024
更新日期:2014-12-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2016.12.023
更新日期:2017-04-01 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
doi:10.1016/j.actbio.2018.06.005
更新日期:2018-07-15 00:00:00
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journal_title:Acta biomaterialia
pub_type: 杂志文章
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