Reverse freeze casting: a new method for fabricating highly porous titanium scaffolds with aligned large pores.

Abstract:

:Highly porous titanium with aligned large pores up to 500 μm in size, which is suitable for scaffold applications, was successfully fabricated using the reverse freeze casting method. In this process we have newly developed, the Ti powders migrated spontaneously along the pre-aligned camphene boundaries at a temperature of 45.5°C and formed a titanium-camphene mixture with an aligned structure; this was followed by freeze drying and sintering. As the casting time increased from 24 to 48 h, the initial columnar structures turned into lamellar structures, with the porosity decreasing from 69 to 51%. This reduction in porosity caused the compressive yield strength to increase from 121 to 302 MPa, with an elastic modulus of the samples being in the range of 2-5 GPa. In addition, it was demonstrated that reverse freeze casting can also be successfully applied to various other raw powders, suggesting that the method developed in this work opens up new avenues for the production of a range of porous metallic and ceramic scaffolds with highly aligned pores.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Yook SW,Jung HD,Park CH,Shin KH,Koh YH,Estrin Y,Kim HE

doi

10.1016/j.actbio.2012.03.020

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

2401-10

issue

6

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(12)00106-7

journal_volume

8

pub_type

杂志文章
  • Tailoring surface nanoroughness of electrospun scaffolds for skeletal tissue engineering.

    abstract::Electrospun scaffolds provide a promising approach for tissue engineering as they mimic the physical properties of extracellular matrix. Previous studies have demonstrated that electrospun scaffolds with porous features on the surface of single fibers, enhanced cellular attachment and proliferation. Yet, little is kno...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2017.07.003

    authors: Chen H,Huang X,Zhang M,Damanik F,Baker MB,Leferink A,Yuan H,Truckenmüller R,van Blitterswijk C,Moroni L

    更新日期:2017-09-01 00:00:00

  • An interferon-γ-delivery system based on chitosan/poly(γ-glutamic acid) polyelectrolyte complexes modulates macrophage-derived stimulation of cancer cell invasion in vitro.

    abstract::Macrophages represent a large component of the tumour microenvironment and are described to establish interactions with cancer cells, playing crucial roles in several stages of cancer progression. The functional plasticity of macrophages upon stimulation from the environment makes them susceptible to the influence of ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2015.05.022

    authors: Cardoso AP,Gonçalves RM,Antunes JC,Pinto ML,Pinto AT,Castro F,Monteiro C,Barbosa MA,Oliveira MJ

    更新日期:2015-09-01 00:00:00

  • Crystallographic relationships in the crossed lamellar microstructure of the shell of the gastropod Conus marmoreus.

    abstract::The crossed lamellar microstructure of mollusk shells shows a very complex hierarchical architecture constituted of long rod-shaped aragonite crystals stacked parallel to each other inside each first order lamella, which are almost perpendicular to the ones contained in parallel neighboring lamellae. To better underst...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.11.001

    authors: Rodriguez-Navarro AB,Checa A,Willinger MG,Bolmaro R,Bonarski J

    更新日期:2012-02-01 00:00:00

  • Multifunctional properties of organic-inorganic hybrid nanocomposites based on chitosan derivatives and layered double hydroxides for ocular drug delivery.

    abstract:UNLABELLED:To improve the ocular bioavailability of the model drug of pirenoxine sodium (PRN), organic-inorganic hybrid nanocomposites including layered double hydroxides (LDH) and chitosan derivatives (chitosan-glutathione (CG), chitosan-glutathione-valine (CG-V) and chitosan-glutathione-valine-valine (CG-VV)) were de...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.02.041

    authors: Xu T,Zhang J,Chi H,Cao F

    更新日期:2016-05-01 00:00:00

  • Optimized in vitro procedure for assessing the cytocompatibility of magnesium-based biomaterials.

    abstract::Magnesium (Mg) is a promising biomaterial for degradable implant applications that has been extensively studied in vitro and in vivo in recent years. In this study, we developed a procedure that allows an optimized and uniform in vitro assessment of the cytocompatibility of Mg-based materials while respecting the stan...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2015.06.005

    authors: Jung O,Smeets R,Porchetta D,Kopp A,Ptock C,Müller U,Heiland M,Schwade M,Behr B,Kröger N,Kluwe L,Hanken H,Hartjen P

    更新日期:2015-09-01 00:00:00

  • Multi-armed poly(aspartate-g-OEI) copolymers as versatile carriers of pDNA/siRNA.

    abstract::To search for potential non-viral nucleic acids carriers, a series of novel cationic polymers, multi-armed poly(aspartate-graft-oligoethylenimine) (MP-g-OEI) copolymers were designed and synthesized by grafting different types of oligoethylenimine (OEI) to a multi-armed poly(l-aspartic acid) backbone. The as-synthesiz...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2013.02.007

    authors: Dong X,Lin L,Chen J,Tian H,Xiao C,Guo Z,Li Y,Wei Y,Chen X

    更新日期:2013-06-01 00:00:00

  • Adaptable poly(ethylene glycol) microspheres capable of mixed-mode degradation.

    abstract::A simple, degradable poly(ethylene glycol) (PEG) microsphere system formed from a water-in-water emulsion process is presented. Microsphere network degradation and erosion were controlled by adjusting the number of hydrolytically labile sites, by varying the PEG molecular weight, and by adjusting the emulsion conditio...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2013.08.011

    authors: Parlato M,Johnson A,Hudalla GA,Murphy WL

    更新日期:2013-12-01 00:00:00

  • Fabrication of a nanoparticle-containing 3D porous bone scaffold with proangiogenic and antibacterial properties.

    abstract::3D porous scaffolds based on agarose and nanocrystalline apatite, two structural components that act as a temporary mineralized extracellular matrix, were prepared by the GELPOR3D method. This shaping technology allows the introduction of thermally-labile molecules within the scaffolds during the fabrication procedure...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2019.01.013

    authors: Paris JL,Lafuente-Gómez N,Cabañas MV,Román J,Peña J,Vallet-Regí M

    更新日期:2019-03-01 00:00:00

  • Apatite coating on anionic and native collagen films by an alternate soaking process.

    abstract::The present study focuses on apatite coating on collagen films, with various different densities of carboxyl groups, using an alternate soaking process. Anionic collagen (AC), which has different densities of carboxylic groups compared to native collagen (NC), was obtained by hydrolysis of carboxyamides of asparagine ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2007.02.008

    authors: Góes JC,Figueiró SD,Oliveira AM,Macedo AA,Silva CC,Ricardo NM,Sombra AS

    更新日期:2007-09-01 00:00:00

  • Inflammatory response against different carbon fiber-reinforced PEEK wear particles compared with UHMWPE in vivo.

    abstract::Poly(ether ether ketone) (PEEK) and its composites are recognized as alternative bearing materials for use in arthroplasty because of their mechanical properties. The objective of this project was to evaluate the biological response of two different kinds of carbon fiber-reinforced (CFR) PEEK compared with ultra-high ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2010.06.002

    authors: Utzschneider S,Becker F,Grupp TM,Sievers B,Paulus A,Gottschalk O,Jansson V

    更新日期:2010-11-01 00:00:00

  • Biomechanical properties of female dolphin reproductive tissue.

    abstract::Whales, dolphins, and porpoises have unusual vaginal folds of unknown function(s) that are hypothesized to play an important role in sexual selection. The potential function of vaginal folds was assessed by testing the mechanical properties of common bottlenose dolphin (Tursiops truncatus) reproductive tract tissues i...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2019.01.012

    authors: Orbach DN,Rattan S,Hogan M,Crosby AJ,Brennan PLR

    更新日期:2019-03-01 00:00:00

  • Tubular collagen scaffolds with radial elasticity for hollow organ regeneration.

    abstract::Tubular collagen scaffolds have been used for the repair of damaged hollow organs in regenerative medicine, but they generally lack the ability to reversibly expand in radial direction, a physiological characteristic seen in many native tubular organs. In this study, tubular collagen scaffolds were prepared that displ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2017.02.005

    authors: Versteegden LR,van Kampen KA,Janke HP,Tiemessen DM,Hoogenkamp HR,Hafmans TG,Roozen EA,Lomme RM,van Goor H,Oosterwijk E,Feitz WF,van Kuppevelt TH,Daamen WF

    更新日期:2017-04-01 00:00:00

  • Predicting and understanding collagen remodeling in human native heart valves during early development.

    abstract::The hemodynamic functionality of heart valves strongly depends on the distribution of collagen fibers, which are their main load-bearing constituents. It is known that collagen networks remodel in response to mechanical stimuli. Yet, the complex interplay between external load and collagen remodeling is poorly underst...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.08.040

    authors: Ristori T,Bouten CVC,Baaijens FPT,Loerakker S

    更新日期:2018-10-15 00:00:00

  • Degradation and hemostatic properties of polyphosphate coacervates.

    abstract:UNLABELLED:Sodium polyphosphate is a linear polymer formed from phosphate units linked together by sharing oxygen atoms. Addition of calcium to a solution of sodium polyphosphate results in phase separation and formation of a polyphosphate coacervate best described as a polymeric rich viscoelastic material. Polyphospha...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.06.002

    authors: Momeni A,Filiaggi MJ

    更新日期:2016-09-01 00:00:00

  • Flexural characterization of cell encapsulated PEGDA hydrogels with applications for tissue engineered heart valves.

    abstract::The limitations of the current clinical options for valve replacements have inspired the development of enabling technologies to create a tissue engineered heart valve (TEHV). Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds permit greater biological and biomechanical customization than do non-woven mesh sc...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.02.018

    authors: Durst CA,Cuchiara MP,Mansfield EG,West JL,Grande-Allen KJ

    更新日期:2011-06-01 00:00:00

  • Unveiling the fate of adhering bacteria to antimicrobial surfaces: expression of resistance-associated genes and macrophage-mediated phagocytosis.

    abstract::Since most antibacterial coatings reported to fight biomaterial-associated infections (BAI) fail in completely preventing bacterial colonization, it is crucial to know the impact of that small fraction of adhered bacteria in BAI recrudescence. This study aims to understand the fate of Staphylococcus aureus able to adh...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.07.052

    authors: Alves DF,Magalhães AP,Neubauer D,Bauer M,Kamysz W,Pereira MO

    更新日期:2018-09-15 00:00:00

  • Enzyme-accelerated and structure-guided crystallization of calcium carbonate: role of the carbonic anhydrase in the homologous system.

    abstract::The calcareous spicules from sponges, e.g. from Sycon raphanus, are composed of almost pure calcium carbonate. In order to elucidate the formation of those structural skeletal elements, the function of the enzyme carbonic anhydrase (CA), isolated from this species, during the in vitro calcium carbonate-based spicule f...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2013.08.025

    authors: Müller WE,Schlossmacher U,Schröder HC,Lieberwirth I,Glasser G,Korzhev M,Neufurth M,Wang X

    更新日期:2014-01-01 00:00:00

  • A bilayered elastomeric scaffold for tissue engineering of small diameter vascular grafts.

    abstract::A major barrier to the development of a clinically useful small diameter tissue engineered vascular graft (TEVG) is the scaffold component. Scaffold requirements include matching the mechanical and structural properties with those of native vessels and optimizing the microenvironment to foster cell integration, adhesi...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2009.06.026

    authors: Soletti L,Hong Y,Guan J,Stankus JJ,El-Kurdi MS,Wagner WR,Vorp DA

    更新日期:2010-01-01 00:00:00

  • Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds.

    abstract::N-glycans on IgG and IgM antibodies (Ab) facilitate Ab-mediated crosslinking of viruses and nanoparticles to the major structural elements of mucus and basement membranes. Nevertheless, the chemical moieties in these biological hydrogel matrices to which Ab can bind remain poorly understood. To gain insights into the ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2020.03.002

    authors: Schiller JL,Fogle MM,Bussey O,Kissner WJ,Hill DB,Lai SK

    更新日期:2020-04-15 00:00:00

  • Biomimetic remineralization as a progressive dehydration mechanism of collagen matrices--implications in the aging of resin-dentin bonds.

    abstract::Biomineralization is a dehydration process in which water from the intrafibrillar compartments of collagen fibrils are progressively replaced by apatites. As water is an important element that induces a lack of durability of resin-dentin bonds, this study has examined the use of a biomimetic remineralization strategy ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2010.03.021

    authors: Kim YK,Mai S,Mazzoni A,Liu Y,Tezvergil-Mutluay A,Takahashi K,Zhang K,Pashley DH,Tay FR

    更新日期:2010-09-01 00:00:00

  • Therapeutic enhancement of a cytotoxic agent using photochemical internalisation in 3D compressed collagen constructs of ovarian cancer.

    abstract::Photochemical internalisation (PCI) is a method for enhancing delivery of drugs to their intracellular target sites of action. In this study we investigated the efficacy of PCI using a porphyrin photosensitiser and a cytotoxic agent on spheroid and non-spheroid compressed collagen 3D constructs of ovarian cancer versu...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.09.041

    authors: Hadi LM,Yaghini E,Stamati K,Loizidou M,MacRobert AJ

    更新日期:2018-11-01 00:00:00

  • Surface modifications by gas plasma control osteogenic differentiation of MC3T3-E1 cells.

    abstract::Numerous studies have shown that the physicochemical properties of biomaterials can control cell activity. Cell adhesion, proliferation, differentiation as well as tissue formation in vivo can be tuned by properties such as the porosity, surface micro- and nanoscale topography and chemical composition of biomaterials....

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2012.04.021

    authors: Barradas AM,Lachmann K,Hlawacek G,Frielink C,Truckenmoller R,Boerman OC,van Gastel R,Garritsen H,Thomas M,Moroni L,van Blitterswijk C,de Boer J

    更新日期:2012-08-01 00:00:00

  • Investigation of adhesive interactions in the specific targeting of Triptorelin-conjugated PEG-coated magnetite nanoparticles to breast cancer cells.

    abstract::The understanding of adhesive interaction at the nanoscale between functionalized nanoparticles and biological cells is of great importance to develop effective theranostic nanocarriers for targeted cancer therapy. Here, we report a combination of experimental and computational approaches to evaluate the adhesion betw...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.02.011

    authors: Hu J,Youssefian S,Obayemi J,Malatesta K,Rahbar N,Soboyejo W

    更新日期:2018-04-15 00:00:00

  • An in vitro evaluation of the Ca/P ratio for the cytocompatibility of nano-to-micron particulate calcium phosphates for bone regeneration.

    abstract::Calcium phosphate based bioceramics have been widely used for orthopedic applications due to their chemical similarity to natural bone. The Ca/P stoichiometry of calcium phosphates strongly influences their performance under biological conditions, which have not yet been fully elucidated to date. For this reason, the ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2008.02.025

    authors: Liu H,Yazici H,Ergun C,Webster TJ,Bermek H

    更新日期:2008-09-01 00:00:00

  • A versatile strategy to create an active tumor-targeted chemo-photothermal therapy nanoplatform: A case of an IR-780 derivative co-assembled with camptothecin prodrug.

    abstract::Self-assembled nanovehicles of chemotherapy drug with photothermal agent are regarded as intriguing chemo-photothermal therapy nanoplatform. However, most of the drugs and photothermal agents have poor water solubility and poor interactions to drive the formation of self-assembled nanovehicles, which is a bottleneck o...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.11.049

    authors: He W,Jiang Y,Li Q,Zhang D,Li Z,Luan Y

    更新日期:2019-01-15 00:00:00

  • Quantum dots in biomedical applications.

    abstract::Semiconducting nanoparticles, more commonly known as quantum dots, possess unique size and shape dependent optoelectronic properties. In recent years, these unique properties have attracted much attention in the biomedical field to enable real-time tissue imaging (bioimaging), diagnostics, single molecule probes, and ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审

    doi:10.1016/j.actbio.2019.05.022

    authors: Wagner AM,Knipe JM,Orive G,Peppas NA

    更新日期:2019-08-01 00:00:00

  • Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid.

    abstract::β-Cyclodextrin can form inclusion complex with a series of guest molecules including phenyl moieties, and has gained considerable popularity in the study of supramolecular nanostructure. In this study, a biodegradable nanocomplex (HA(CD)-4Phe4 nanocomplex) was developed from β-cyclodextrin grafted hyaluronic acid (HA)...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2017.08.036

    authors: Ji Y,Shan S,He M,Chu CC

    更新日期:2017-10-15 00:00:00

  • Eradication of Pseudomonas aeruginosa cells by cathodic electrochemical currents delivered with graphite electrodes.

    abstract::Antibiotic resistance is a major challenge to the treatment of bacterial infections associated with medical devices and biomaterials. One important intrinsic mechanism of such resistance is the formation of persister cells that are phenotypic variants of microorganisms and highly tolerant to antibiotics. Recently, we ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.12.053

    authors: Niepa THR,Wang H,Gilbert JL,Ren D

    更新日期:2017-03-01 00:00:00

  • Functional biopolymer-based matrices for modulation of chronic wound enzyme activities.

    abstract::Collagen, collagen/hyaluronic acid (HA) and collagen/HA/chitosan (CS) sponges loaded with epigallocatechin gallate (EGCG), catechin (CAT) and gallic acid (GA) were developed and evaluated as active chronic wound dressings. Their physico-mechanical properties, biostability, biocompatibility and ability to inhibit in vi...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2012.10.014

    authors: Francesko A,Soares da Costa D,Reis RL,Pashkuleva I,Tzanov T

    更新日期:2013-02-01 00:00:00

  • Osteoblast response and osseointegration of a Ti-6Al-4V alloy implant incorporating strontium.

    abstract::This study investigated the surface characteristics, in vitro and in vivo biocompatibility of Ti-6Al-4V alloy implants incorporating strontium ions (Sr), produced by hydrothermal treatment using a Sr-containing solution, for future biomedical applications. The surface characteristics were evaluated by scanning electro...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2010.01.017

    authors: Park JW,Kim HK,Kim YJ,Jang JH,Song H,Hanawa T

    更新日期:2010-07-01 00:00:00