Abstract：
:The present study focuses on apatite coating on collagen films, with various different densities of carboxyl groups, using an alternate soaking process. Anionic collagen (AC), which has different densities of carboxylic groups compared to native collagen (NC), was obtained by hydrolysis of carboxyamides of asparagine and glutamine residues. From X-ray diffraction analysis, apatite was found to be coated on AC and NC films. Peaks ascribed to apatite were observed at 26 degrees and 32 degrees in the diffraction patterns of hydroxyapatite crystals. The amount of apatite coated on both AC and NC collagen films continued to increase up to 100 reaction cycles. However, there is a significant difference in apatite coating between the two films. The amount of apatite formed on the surface of AC film increased 1.24 times faster than on NC film. The scanning electron photomicrograph images of the mineralized NC and the AC film coatings formed after 100cycles show that regular porous apatite coating had formed within the collagen fibrils. These results suggest that the higher content of carboxyl groups in AC plays an effective role in the heterogeneous nucleation of apatite in the body environment.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Góes JC,Figueiró SD,Oliveira AM,Macedo AA,Silva CC,Ricardo NM,Sombra ASdoi
10.1016/j.actbio.2007.02.008subject
Has Abstractpub_date
2007-09-01 00:00:00pages
773-8issue
5eissn
1742-7061issn
1878-7568pii
S1742-7061(07)00034-7journal_volume
3pub_type
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