Abstract:
:Decellularized allografts offer potential as heart valve substitutes and scaffolds for cell seeding. The effects of decellularization on the quasi-static and time-dependent mechanical behavior of the pulmonary valve leaflet under biaxial loading conditions have not previously been reported in the literature. In the current study, the stress-strain, relaxation and creep behaviors of the ovine pulmonary valve leaflet were investigated under planar-biaxial loading conditions to determine the effects of decellularization and a novel post-decellularization extracellular matrix (ECM) conditioning process. As expected, decellularization resulted in increased stretch along the loading axes. A reduction in relaxation was observed following decellularization. This was accompanied by a reduction in glycosaminoglycan (GAG) content. Based on previous implant studies, these changes may be of little functional consequence in the short term; however, the long term effects of decreased relaxation and GAG content remain unknown. Some restoration of relaxation was observed following ECM conditioning, especially in the circumferential specimen direction, which may help mitigate any detrimental effects due to decellularization. Regardless of processing, creep under biaxial loading was negligible.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Converse GL,Armstrong M,Quinn RW,Buse EE,Cromwell ML,Moriarty SJ,Lofland GK,Hilbert SL,Hopkins RAdoi
10.1016/j.actbio.2012.03.047subject
Has Abstractpub_date
2012-07-01 00:00:00pages
2722-9issue
7eissn
1742-7061issn
1878-7568pii
S1742-7061(12)00142-0journal_volume
8pub_type
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