Corneal reinforcement using an acellular dermal matrix for an analysis of biocompatibility, mechanical properties, and transparency.

Abstract:

:The aim of this study was to analyze the viability of using an acellular dermal matrix (ADM) as a reinforcement material for peripheral corneal thinning disease. The complete removal of cell components was confirmed by hematoxylin and eosin (H&E) and 4',6-diamidino-2-phenylindole (DAPI) staining. Transmission electron microscopy determined that the stromal structure was well preserved. Uniaxial tests revealed that the ADM had strong mechanical properties. After being implanted into rabbit cornea the ADM showed no sign of rejection and even achieved good transparency 24weeks post-surgery. H&E staining demonstrated that keratocytes grew in the ADM and the ADM-cornea interface became blurry. Picrosirius red staining revealed great changes of collagen in the ADM. Uniaxial testing of the reinforced cornea showed better mechanical strength than the normal rabbit cornea, but this did not exhibit statistical significance. These results suggest that ADM is a worthy candidate for future exploration as a reinforcement material for peripheral corneal thinning problems.

journal_name

Acta Biomater

journal_title

Acta biomaterialia

authors

Liu Z,Ji J,Zhang J,Huang C,Meng Z,Qiu W,Li X,Wang W

doi

10.1016/j.actbio.2012.05.004

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

3326-32

issue

9

eissn

1742-7061

issn

1878-7568

pii

S1742-7061(12)00208-5

journal_volume

8

pub_type

杂志文章
  • Structural and spectroscopic characterization of a series of potassium- and/or sodium-substituted β-tricalcium phosphate.

    abstract::In this paper, we report X-ray diffraction investigations as well as Raman and solid-state (31)P and (23)Na magic angle spinning nuclear magnetic resonance (NMR) characterization of three series of calcium orthophosphates. The general formulae of the studied compounds are Ca(10.5-x/2)M(x)(PO(4))(7), where M=K or Na an...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2010.12.016

    authors: Quillard S,Paris M,Deniard P,Gildenhaar R,Berger G,Obadia L,Bouler JM

    更新日期:2011-04-01 00:00:00

  • Electroactive porous tubular scaffolds with degradability and non-cytotoxicity for neural tissue regeneration.

    abstract::Electroactive degradable porous tubular scaffolds were fabricated from the blends of polycaprolactone and a hyperbranched degradable conducting copolymer at different feed ratios by a solution-casting/salt-leaching method. Scaning electron microscopy (SEM) and microcomputed tomography tests indicated that these scaffo...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.09.027

    authors: Guo B,Sun Y,Finne-Wistrand A,Mustafa K,Albertsson AC

    更新日期:2012-01-01 00:00:00

  • Antibody-mediated trapping in biological hydrogels is governed by sugar-sugar hydrogen bonds.

    abstract::N-glycans on IgG and IgM antibodies (Ab) facilitate Ab-mediated crosslinking of viruses and nanoparticles to the major structural elements of mucus and basement membranes. Nevertheless, the chemical moieties in these biological hydrogel matrices to which Ab can bind remain poorly understood. To gain insights into the ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2020.03.002

    authors: Schiller JL,Fogle MM,Bussey O,Kissner WJ,Hill DB,Lai SK

    更新日期:2020-04-15 00:00:00

  • The dependence of DNA supercoiling on solution electrostatics.

    abstract::We develop an elastic-isotropic rod model for twisted DNA in the plectonemic regime. We account for DNA elasticity, electrostatic interactions and entropic effects due to thermal fluctuations. We apply our model to single-molecule experiments on a DNA molecule attached to a substrate at one end, while subjected to a t...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2012.01.030

    authors: Argudo D,Purohit PK

    更新日期:2012-07-01 00:00:00

  • Conducting polymers on hydrogel-coated neural electrode provide sensitive neural recordings in auditory cortex.

    abstract::Recently, a significant amount of effort has been dedicated to understanding factors that influence the functionality of bio-electronic sensors and to development of novel coating technologies for modifying biosensor surfaces. Due to its well-known biocompatibility, alginate hydrogel (HG) has been used as a coating ma...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2009.07.034

    authors: Kim DH,Wiler JA,Anderson DJ,Kipke DR,Martin DC

    更新日期:2010-01-01 00:00:00

  • Microcontact printing of polydopamine on thermally expandable hydrogels for controlled cell adhesion and delivery of geometrically defined microtissues.

    abstract::Scaffold-free harvest of microtissue with a defined structure has received a great deal of interest in cell-based assay and regenerative medicine. In this study, we developed thermally expandable hydrogels with spatially controlled cell adhesive patterns for rapid harvest of geometrically controlled microtissue. We pa...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2017.07.040

    authors: Lee YB,Kim SJ,Kim EM,Byun H,Chang HK,Park J,Choi YS,Shin H

    更新日期:2017-10-01 00:00:00

  • A mechanical evaluation of three decellularization methods in the design of a xenogeneic scaffold for tissue engineering the temporomandibular joint disc.

    abstract::Tissue-engineered temporomandibular joint (TMJ) discs offer a viable treatment option for patients with severe joint internal derangement. To date, only a handful of TMJ tissue engineering studies have been carried out and all have incorporated the use of synthetic scaffold materials. These current scaffolds have show...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2008.01.016

    authors: Lumpkins SB,Pierre N,McFetridge PS

    更新日期:2008-07-01 00:00:00

  • Hafnium-doped hydroxyapatite nanoparticles with ionizing radiation for lung cancer treatment.

    abstract:UNLABELLED:Recently, photodynamic therapy (PDT) is one of the new clinical options by generating cytotoxic reactive oxygen species (ROS) to kill cancer cells. However, the optical approach of PDT is limited by tissue penetration depth of visible light. In this study, we propose that a ROS-enhanced nanoparticle, hafnium...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.04.004

    authors: Chen MH,Hanagata N,Ikoma T,Huang JY,Li KY,Lin CP,Lin FH

    更新日期:2016-06-01 00:00:00

  • Supramolecular organization of protein-releasing functional amyloids solved in bacterial inclusion bodies.

    abstract::Slow protein release from amyloidal materials is a molecular platform used by nature to control protein hormone secretion in the endocrine system. The molecular mechanics of the sustained protein release from amyloids remains essentially unexplored. Inclusion bodies (IBs) are natural amyloids that occur as discrete pr...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2012.11.033

    authors: Cano-Garrido O,Rodríguez-Carmona E,Díez-Gil C,Vázquez E,Elizondo E,Cubarsi R,Seras-Franzoso J,Corchero JL,Rinas U,Ratera I,Ventosa N,Veciana J,Villaverde A,García-Fruitós E

    更新日期:2013-04-01 00:00:00

  • Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model.

    abstract::This work investigated the delivery of marrow mesenchymal stem cells (MSCs), with or without the growth factor transforming growth factor-beta1 (TGF-beta1), from biodegradable hydrogel composites on the repair of osteochondral defects in a rabbit model. Three formulations of oligo(poly(ethylene glycol) fumarate) (OPF)...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2009.07.041

    authors: Guo X,Park H,Young S,Kretlow JD,van den Beucken JJ,Baggett LS,Tabata Y,Kasper FK,Mikos AG,Jansen JA

    更新日期:2010-01-01 00:00:00

  • Janus nanocarrier-based co-delivery of doxorubicin and berberine weakens chemotherapy-exacerbated hepatocellular carcinoma recurrence.

    abstract::Despite the rapid progress which has been made in hepatocellular carcinoma (HCC) chemotherapeutics, recurrence of liver cancer still remains a barrier to achieve satisfying prognosis. Herein, we aimed to decipher the role of berberine (BER) in chemotherapy-exacerbated HCC repopulation via developing a nanocarrier co-d...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2019.09.034

    authors: Zhang F,Jia Y,Zheng X,Shao D,Zhao Y,Wang Z,Dawulieti J,Liu W,Sun M,Sun W,Pan Y,Cui L,Wang Y,He K,Zhang M,Li J,Dong WF,Chen L

    更新日期:2019-12-01 00:00:00

  • A multi-functional polymeric carrier for simultaneous positron emission tomography imaging and combination therapy.

    abstract::Multifunctional nanoplatforms offering simultaneous imaging and therapeutic functions have been recognized as a highly promising strategy for personalized nanomedicine. In this work, we synthesized a farnesylthiosalicylate (FTS, a nontoxic Ras antagonist) based triblock copolymer POEG-b-PVBA-b-PFTS (POVF) composed of ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.06.010

    authors: Sun J,Sun L,Li J,Xu J,Wan Z,Ouyang Z,Liang L,Li S,Zeng D

    更新日期:2018-07-15 00:00:00

  • Can human mesenchymal stem cells survive on a NiTi implant material subjected to cyclic loading?

    abstract::Nickel-titanium shape memory alloys (NiTi-SMAs) exhibit mechanical and chemical properties which make them attractive candidate materials for various types of biomedical applications. However, the high nickel content of NiTi-SMAs may result in adverse tissue reactions, especially when they are considered for load-bear...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.02.022

    authors: Habijan T,Glogowski T,Kühn S,Pohl M,Wittsiepe J,Greulich C,Eggeler G,Schildhauer TA,Köller M

    更新日期:2011-06-01 00:00:00

  • A tailored positively-charged hydrophobic surface reduces the risk of implant associated infections.

    abstract::Implant-associated infections is one of the most challenging post-operative complications in bone-related implantations. To tackle this clinical issue, we developed a low-cost and durable surface coating for medical grade titanium implants that uses positively charged silane molecules. The in vitro antimicrobial tests...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2020.07.040

    authors: Shen J,Gao P,Han S,Kao RYT,Wu S,Liu X,Qian S,Chu PK,Cheung KMC,Yeung KWK

    更新日期:2020-09-15 00:00:00

  • The effects of pulsed electromagnetic field on the functions of osteoblasts on implant surfaces with different topographies.

    abstract::The use of pulsed electromagnetic fields (PEMFs) is a promising approach to promote osteogenesis. However, few studies have reported the effects of this technique on the osseointegration of endosseous implants, especially with regard to different implant topographies. We focused on how the initial interaction between ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2013.10.008

    authors: Wang J,An Y,Li F,Li D,Jing D,Guo T,Luo E,Ma C

    更新日期:2014-02-01 00:00:00

  • Characterization of water in hydrated Bombyx mori silk fibroin fiber and films by 2H NMR relaxation and 13C solid state NMR.

    abstract::The mechanical properties of Bombyx mori silk fibroin (SF), such as elasticity and tensile strength, change remarkably upon hydration. However, the microscopic interaction with water is not currently well understood on a molecular level. In this work, the dynamics of water molecules interacting with SF was studied by ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.12.052

    authors: Asakura T,Isobe K,Kametani S,Ukpebor OT,Silverstein MC,Boutis GS

    更新日期:2017-03-01 00:00:00

  • Comparison of PEG chain length and density on amphiphilic macromolecular nanocarriers: self-assembled and unimolecular micelles.

    abstract::Two classes of amphiphilic macromolecules were evaluated for drug delivery applications: those that exist as unimolecular micelles and those that self-assemble in aqueous solution to form micelles. This study compares the poly(ethylene glycol) (PEG) chain length and density that constitute the corona of both classes. ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2008.10.019

    authors: Wang J,del Rosario LS,Demirdirek B,Bae A,Uhrich KE

    更新日期:2009-03-01 00:00:00

  • Recombinant production and film properties of full-length hornet silk proteins.

    abstract::Full-length versions of the four main components of silk cocoons of Vespa simillima hornets, Vssilk1-4, were produced as recombinant proteins in Escherichia coli. In shake flasks, the recombinant Vssilk proteins yielded 160-330mg recombinant proteinl(-1). Films generated from solutions of single Vssilk proteins had a ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2014.05.013

    authors: Kambe Y,Sutherland TD,Kameda T

    更新日期:2014-08-01 00:00:00

  • In vitro evaluation of Pt-coated electrospun nanofibers for endovascular coil embolization.

    abstract::Recently, endovascular coil embolization has been introduced to treat intracranial aneurysms because it has lower morbidity and mortality than surgical clipping. The endovascular coils prevent the extravasation of blood by decreasing the permeability of an aneurysm flow governed by Darcy's law. Here, we developed and ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2019.10.015

    authors: Kim MW,An S,Seok H,Jung H,Park DH,Yarin AL,Yoon SS

    更新日期:2020-01-01 00:00:00

  • Bioengineering of the silica-polymerizing enzyme silicatein-alpha for a targeted application to hydroxyapatite.

    abstract::Since its discovery, numerous biotechnological approaches have aimed to explore the silica-polymerizing catalytic activity of the enzyme silicatein. In vivo, silicatein catalyzes polymerization of amorphous silica nanospheres from soluble precursors. In vitro, it directs the formation of nanostructured biosilica. This...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2010.03.010

    authors: Natalio F,Link T,Müller WE,Schröder HC,Cui FZ,Wang X,Wiens M

    更新日期:2010-09-01 00:00:00

  • Cell-laden hydrogel/titanium microhybrids: Site-specific cell delivery to metallic implants for improved integration.

    abstract:UNLABELLED:Porous titanium implants are widely used in dental, orthopaedic and otorhinolaryngology fields to improve implant integration to host tissue. A possible step further to improve the integration with the host is the incorporation of autologous cells in porous titanium structures via cell-laden hydrogels. Fast ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2016.01.023

    authors: Koenig G,Ozcelik H,Haesler L,Cihova M,Ciftci S,Dupret-Bories A,Debry C,Stelzle M,Lavalle P,Vrana NE

    更新日期:2016-03-01 00:00:00

  • Layer-by-layer assembly of graphene oxide on thermosensitive liposomes for photo-chemotherapy.

    abstract::Stimuli responsive polyelectrolyte nanoparticles have been developed for chemo-photothermal destruction of breast cancer cells. This novel system, called layer by layer Lipo-graph (LBL Lipo-graph), is composed of alternate layers of graphene oxide (GO) and graphene oxide conjugated poly (l-lysine) (GO-PLL) deposited o...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2017.10.040

    authors: Hashemi M,Omidi M,Muralidharan B,Tayebi L,Herpin MJ,Mohagheghi MA,Mohammadi J,Smyth HDC,Milner TE

    更新日期:2018-01-01 00:00:00

  • Effects of in vitro chondrogenic priming time of bone-marrow-derived mesenchymal stromal cells on in vivo endochondral bone formation.

    abstract::Recapitulation of endochondral ossification leads to a new concept of bone tissue engineering via a cartilage intermediate as an osteoinductive template. In this study, we aimed to investigate the influence of in vitro chondrogenic priming time for the creation of cartilage template on the in vivo endochondral bone fo...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2014.11.029

    authors: Yang W,Both SK,van Osch GJ,Wang Y,Jansen JA,Yang F

    更新日期:2015-02-01 00:00:00

  • Stable modification of poly(lactic acid) surface with neurite outgrowth-promoting peptides via hydrophobic collagen-like sequence.

    abstract::Surface modification of poly(dl-lactic acid) (PLA) scaffolds has been performed using a biofunctional small peptide composed of collagen-like repetitive sequence and laminin-derived sequence (AG73-G(3)-(PPG)(5)) via hydrophobic interaction. The results of surface analysis suggest that AG73-G(3)-(PPG)(5) can be stably ...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2009.12.001

    authors: Kakinoki S,Yamaoka T

    更新日期:2010-06-01 00:00:00

  • Bootstrap analysis of the relation between initial adhesive events and long-term cellular functions of human osteoblasts cultured on biocompatible metallic substrates.

    abstract::Classically, the evaluation of cellular adhesion of cells on substrates is limited to the evaluation of cell attachment after some hours. We have claimed for several years that this evaluation is incomplete concerning the evaluation of cell adhesion and more precisely of the quality of the in vitro cell/biomaterial in...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2005.06.001

    authors: Bigerelle M,Anselme K

    更新日期:2005-09-01 00:00:00

  • Modelling the role of surface stress on the kinetics of tissue growth in confined geometries.

    abstract::In a previous paper we presented a theoretical framework to describe tissue growth in confined geometries based on the work of Ambrosi and Guillou [Ambrosi D, Guillou A. Growth and dissipation in biological tissues. Cont Mech Thermodyn 2007;19:245-51]. A thermodynamically consistent eigenstrain rate for growth was der...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2012.10.020

    authors: Gamsjäger E,Bidan CM,Fischer FD,Fratzl P,Dunlop JW

    更新日期:2013-03-01 00:00:00

  • In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization.

    abstract::Degradation characteristics in response to electron beam sterilization of designed and biodegradable aliphatic polyester scaffolds are relevant for clinically successful synthetic graft tissue regeneration. Scaffold degradation in vitro and in vivo were documented and correlated to the macroscopic structure and chemic...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2011.02.011

    authors: Dånmark S,Finne-Wistrand A,Schander K,Hakkarainen M,Arvidson K,Mustafa K,Albertsson AC

    更新日期:2011-05-01 00:00:00

  • Fibrin glue mesh fixation combined with mesenchymal stem cells or exosomes modulates the inflammatory reaction in a murine model of incisional hernia.

    abstract::Surgical meshes are effective and frequently used to reinforce soft tissues. Fibrin glue (FG) has been widely used for mesh fixation and is also considered an optimal vehicle for stem cell delivery. The aim of this preclinical study was to evaluate the therapeutic effect of MSCs and their exosomes combined with FG for...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2018.02.014

    authors: Blázquez R,Sánchez-Margallo FM,Álvarez V,Usón A,Marinaro F,Casado JG

    更新日期:2018-04-15 00:00:00

  • Nano-scale modification of titanium implant surfaces to enhance osseointegration.

    abstract::The main aim of this review study was to report the state of art on the nano-scale technological advancements of titanium implant surfaces to enhance the osseointegration process. Several methods of surface modification are chronologically described bridging ordinary methods (e.g. grit blasting and etching) and advanc...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审

    doi:10.1016/j.actbio.2019.05.045

    authors: Souza JCM,Sordi MB,Kanazawa M,Ravindran S,Henriques B,Silva FS,Aparicio C,Cooper LF

    更新日期:2019-08-01 00:00:00

  • Avidin-conjugated calcium phosphate nanoparticles as a modular targeting system for the attachment of biotinylated molecules in vitro and in vivo.

    abstract::Avidin was covalently conjugated to the surface of calcium phosphate nanoparticles, coated with a thin silica shell and terminated by sulfhydryl groups (diameter of the solid core about 50nm), with a bifunctional crosslinker connecting the amino groups of avidin to the sulfhydryl group on the nanoparticle surface. Thi...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章

    doi:10.1016/j.actbio.2017.05.049

    authors: van der Meer SB,Knuschke T,Frede A,Schulze N,Westendorf AM,Epple M

    更新日期:2017-07-15 00:00:00