Predictive biomechanical analysis of ascending aortic aneurysm rupture potential.


:Aortic aneurysm is a leading cause of death in adults, often taking lives without any premonitory signs or symptoms. Adverse clinical outcomes of aortic aneurysm are preventable by elective surgical repair; however, identifying at-risk individuals is difficult. The objective of this study was to perform a predictive biomechanical analysis of ascending aortic aneurysm (AsAA) tissue to assess rupture risk on a patient-specific level. AsAA tissues, obtained intra-operatively from 50 patients, were subjected to biaxial mechanical and uniaxial failure tests to obtain their passive elastic mechanical properties. A novel analytical method was developed to predict the AsAA pressure-diameter response as well as the aortic wall yield and failure responses. Our results indicated that the mean predicted AsAA diameter at rupture was 5.6 ± 0.7 cm, and the associated blood pressure to induce rupture was 579.4 ± 214.8 mmHg. Statistical analysis showed significant positive correlation between aneurysm tissue compliance and predicted risk of rupture, where patients with a pressure-strain modulus ≥100 kPa may be nearly twice as likely to experience rupture than patients with more compliant aortic tissue. The mechanical analysis of pre-dissection patient tissue properties established in this study could predict the "future" onset of yielding and rupture in AsAA patients. The analysis results implicate decreased tissue compliance as a risk factor for AsAA rupture. The presented methods may serve as a basis for the development of a pre-operative planning tool for AsAA evaluation, a tool currently unavailable.


Acta Biomater


Acta biomaterialia


Martin C,Sun W,Pham T,Elefteriades J




Has Abstract


2013-12-01 00:00:00














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    pub_type: 杂志文章


    authors: Sáez P,García A,Peña E,Gasser TC,Martínez MA

    更新日期:2016-03-01 00:00:00

  • Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging.

    abstract::The size, shape and chemical composition of europium (Eu3+) cobalt ferrite (CFEu) nanoparticles were optimized for use as a "multimodal imaging nanoprobe" for combined fluorescence and magnetic resonance bioimaging. Doping Eu3+ ions into a CF structure imparts unique bioimaging and magnetic properties to the nanostruc...

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    authors: Kevadiya BD,Bade AN,Woldstad C,Edagwa BJ,McMillan JM,Sajja BR,Boska MD,Gendelman HE

    更新日期:2017-02-01 00:00:00

  • Development of an image Mean Square Displacement (iMSD)-based method as a novel approach to study the intracellular trafficking of nanoparticles.

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    pub_type: 杂志文章


    authors: Digiacomo L,Digman MA,Gratton E,Caracciolo G

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    authors: Kai D,Wang QL,Wang HJ,Prabhakaran MP,Zhang Y,Tan YZ,Ramakrishna S

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  • Cancellous bone-like porous Fe@Zn scaffolds with core-shell-structured skeletons for biodegradable bone implants.

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    authors: He J,Fang J,Wei P,Li Y,Guo H,Mei Q,Ren F

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    authors: Zhou J,Zhao L

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  • Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction.

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    authors: Yoshihara K,Yoshida Y,Nagaoka N,Fukegawa D,Hayakawa S,Mine A,Nakamura M,Minagi S,Osaka A,Suzuki K,Van Meerbeek B

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    authors: Entezari A,Swain MV,Gooding JJ,Roohani I,Li Q

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    authors: Wada S,Kitamura N,Nonoyama T,Kiyama R,Kurokawa T,Gong JP,Yasuda K

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    authors: Matsunaga K,Kubota T,Toyoura K,Nakamura A

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  • Bone bonding ability and handling properties of a titania-polymethylmethacrylate (PMMA) composite bioactive bone cement modified with a unique PMMA powder.

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    pub_type: 杂志文章


    authors: Fukuda C,Goto K,Imamura M,Neo M,Nakamura T

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  • Changes and quantitative characterization of hyper-viscoelastic biomechanical properties for young corneal stroma after standard corneal cross-linking treatment with different ultraviolet-A energies.

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    authors: Liu T,Shen M,Li H,Zhang Y,Mu B,Zhao X,Wang Y

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  • Improved burn wound healing by the antimicrobial peptide LLKKK18 released from conjugates with dextrin embedded in a carbopol gel.

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    pub_type: 杂志文章


    authors: Silva JP,Dhall S,Garcia M,Chan A,Costa C,Gama M,Martins-Green M

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    pub_type: 杂志文章


    authors: Kambe Y,Sutherland TD,Kameda T

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    authors: Tejero R,Gutiérrez B,López D,López-Fabal F,Gómez-Garcés JL,Fernández-García M

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    pub_type: 杂志文章


    authors: Saito E,Liu Y,Migneco F,Hollister SJ

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  • Inhibition of osteoclastogenesis by stem cell-derived extracellular matrix through modulation of intracellular reactive oxygen species.

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    pub_type: 杂志文章


    authors: Li M,Chen X,Yan J,Zhou L,Wang Y,He F,Lin J,Zhu C,Pan G,Yu J,Pei M,Yang H,Liu T

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  • Peptide-mediated shape- and size-tunable synthesis of gold nanostructures.

    abstract::While several biological processes have been shown to be useful for the production of well-designed, inorganic nanostructures, the mechanism(s) controlling the size and shape of nano and micron size particles remains elusive. Here we report on the controlled size- and shape-specific production of gold nanostructures u...

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    pub_type: 杂志文章


    authors: Kim J,Rheem Y,Yoo B,Chong Y,Bozhilov KN,Kim D,Sadowsky MJ,Hur HG,Myung NV

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  • A hydrogel platform for in vitro three dimensional assembly of human stem cell-derived islet cells and endothelial cells.

    abstract::Differentiation of stem cells into functional replacement cells and tissues is a major goal of the regenerative medicine field. However, one limitation has been organization of differentiated cells into multi-cellular, three-dimensional assemblies. The islets of Langerhans contain many endocrine and non-endocrine cell...

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    pub_type: 杂志文章


    authors: Augsornworawat P,Velazco-Cruz L,Song J,Millman JR

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  • Regulation of chitosan-mediated differentiation of human olfactory receptor neurons by insulin-like growth factor binding protein-2.

    abstract::Olfaction is normally taken for granted in our lives, not only assisting us to escape from dangers, but also increasing our quality of life. Although olfactory neuroepithelium (ON) can reconstitute its olfactory receptor neurons (ORNs) after injury, no adequate treatment for olfactory loss has yet emerged. The present...

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    pub_type: 杂志文章


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  • A multi-defense strategy: Enhancing bactericidal activity of a medical grade polymer with a nitric oxide donor and surface-immobilized quaternary ammonium compound.

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    authors: Pant J,Gao J,Goudie MJ,Hopkins SP,Locklin J,Handa H

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  • Dual-ion delivery for synergistic angiogenesis and bactericidal capacity with silica-based microsphere.

    abstract::Inhibition of bacterial growth with the simultaneous promotion of angiogenesis has been challenging in the repair and regeneration of infected tissues. Here, we aim to tackle this issue through the use of cobalt-doped silicate microspheres that can sustainably release dual ions (silicate and cobalt) at therapeutically...

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    pub_type: 杂志文章


    authors: Boldbaatar K,Dashnyam K,Knowles JC,Lee HH,Lee JH,Kim HW

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  • Electroactive porous tubular scaffolds with degradability and non-cytotoxicity for neural tissue regeneration.

    abstract::Electroactive degradable porous tubular scaffolds were fabricated from the blends of polycaprolactone and a hyperbranched degradable conducting copolymer at different feed ratios by a solution-casting/salt-leaching method. Scaning electron microscopy (SEM) and microcomputed tomography tests indicated that these scaffo...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Guo B,Sun Y,Finne-Wistrand A,Mustafa K,Albertsson AC

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  • Nanoparticles for localized delivery of hyaluronan oligomers towards regenerative repair of elastic matrix.

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    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Sylvester A,Sivaraman B,Deb P,Ramamurthi A

    更新日期:2013-12-01 00:00:00

  • Microelastic properties of lung cell-derived extracellular matrix.

    abstract::The mechanical properties of the extracellular microenvironment regulate cell behavior, including migration, proliferation and morphogenesis. Although the elastic moduli of synthetic materials have been studied, little is known about the properties of naturally produced extracellular matrix. Here we have utilized atom...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Soucy PA,Werbin J,Heinz W,Hoh JH,Romer LH

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  • Pro-angiogenic near infrared-responsive hydrogels for deliberate transgene expression.

    abstract::CuS nanoparticles (CuSNP) are degradable, readily prepared, inexpensive to produce and efficiently cleared from the body. In this work, we explored the feasibility of CuSNP to function as degradable near infrared (NIR) nanotransducers within fibrin-based cellular scaffolds. To prepare NIR-responsive CuSNP hydrogels, f...

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    authors: Martín-Saavedra F,Escudero-Duch C,Prieto M,Sánchez-Casanova S,López D,Arruebo M,Voellmy R,Santamaría J,Vilaboa N

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  • In vitro assessment of three-dimensionally plotted nagelschmidtite bioceramic scaffolds with varied macropore morphologies.

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    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Xu M,Zhai D,Chang J,Wu C

    更新日期:2014-01-01 00:00:00

  • 3D printing of hydrogel scaffolds for future application in photothermal therapy of breast cancer and tissue repair.

    abstract::Surgical removal remains the main clinical approach to treat breast cancer, although risks including high local recurrence of cancer and loss of breast tissues are the threats for the survival and quality of life of patients after surgery. In this study, bifunctional scaffold based on dopamine-modified alginate and po...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Luo Y,Wei X,Wan Y,Lin X,Wang Z,Huang P

    更新日期:2019-07-01 00:00:00

  • Corneal regeneration: A review of stromal replacements.

    abstract::Corneal blindness is traditionally treated by transplantation of a donor cornea, or in severe cases by implantation of an artificial cornea or keratoprosthesis. Due to severe donor shortages and the risks of complications that come with artificial corneas, tissue engineering in ophthalmology has become more focused on...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章,评审


    authors: Matthyssen S,Van den Bogerd B,Dhubhghaill SN,Koppen C,Zakaria N

    更新日期:2018-03-15 00:00:00

  • The effect of pore geometry on the in vitro biological behavior of human periosteum-derived cells seeded on selective laser-melted Ti6Al4V bone scaffolds.

    abstract::The specific aim of this study was to gain insight into the influence of scaffold pore size, pore shape and permeability on the in vitro proliferation and differentiation of three-dimensional (3-D) human periosteum-derived cell (hPDC) cultures. Selective laser melting (SLM) was used to produce six distinct designed ge...

    journal_title:Acta biomaterialia

    pub_type: 杂志文章


    authors: Van Bael S,Chai YC,Truscello S,Moesen M,Kerckhofs G,Van Oosterwyck H,Kruth JP,Schrooten J

    更新日期:2012-07-01 00:00:00