Abstract：
:The limitations of the current clinical options for valve replacements have inspired the development of enabling technologies to create a tissue engineered heart valve (TEHV). Poly(ethylene glycol) diacrylate (PEGDA) hydrogel scaffolds permit greater biological and biomechanical customization than do non-woven mesh scaffold technologies. However, the material characterization of PEGDA hydrogels has been predominantly limited to compression and tension, as opposed to bending. Since large flexural deformations result in points of maximum stress in native valves as well as TEHVs, it is crucial to evaluate any potential scaffold material in this mode. The effect of formulation parameters on the bending mechanics of cell-seeded PEGDA hydrogels were investigated with a custom designed bending tester. Three molecular weights (3.4, 6, and 8 kDa) and three weight fractions (5%, 10%, and 15%, w/v) were subjected to three-point bending tests and the flexural stiffness was calculated. Manipulating the composition of the hydrogels resulted in flexural stiffnesses comparable with native tissues (15-220 kPa) with varied mesh sizes and swelling ratios. Hydrogels containing encapsulated valve cells, methacrylated heparin (Hep-MA), or both were substantially less stiff than acellular hydrogels. In conclusion, PEGDA hydrogels are an attractive potential scaffold system for TEHVs because they are not only cytocompatible and modifiable but can also withstand bending deformations. These studies are the first to explore the encapsulation of valvular interstitial cells in pure PEGDA hydrogels as well as to investigate the bending properties of PEGDA gels.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Durst CA,Cuchiara MP,Mansfield EG,West JL,Grande-Allen KJdoi
10.1016/j.actbio.2011.02.018subject
Has Abstractpub_date
2011-06-01 00:00:00pages
2467-76issue
6eissn
1742-7061issn
1878-7568pii
S1742-7061(11)00077-8journal_volume
7pub_type
杂志文章abstract：:This study investigated whether a novel alkali-based surface modification enhances in vitro mineralization as well as in vivo bone formation around titanium (Ti) implants in a femoral condyle model of 36 male Wister rats. All implant surfaces were grit-blasted and then received either acid-etching treatment, alkali-ba...
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
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pub_type： 杂志文章
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更新日期：2009-09-01 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2018-04-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2014.05.013
更新日期：2014-08-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2012.09.009
更新日期：2013-02-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2015.02.013
更新日期：2015-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2017-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2013.12.027
更新日期：2014-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
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journal_title：Acta biomaterialia
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doi：10.1016/j.actbio.2015.06.005
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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journal_title：Acta biomaterialia
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更新日期：2018-09-15 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2019-10-01 00:00:00
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2010.04.024
更新日期：2010-10-01 00:00:00
abstract：:Dentin contains 1-2μm diameter tubules extending from the pulp cavity to near the junction with enamel. Peritubular dentin (PTD) borders the tubule lumens and is surrounded by intertubular dentin (ITD). Differences in PTD and ITD composition and microstructure remain poorly understood. Here, a (∼200nm)(2), 10.1keV syn...
journal_title：Acta biomaterialia
pub_type： 杂志文章
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