Recombinant production and film properties of full-length hornet silk proteins.

abstract：:Diopside (CaMgSi(2)O(6)) powders and dense ceramics have been shown to be bioactive biomaterials for bone repair. The aim of this study is to prepare bioactive diopside scaffolds and examine their physicochemical and biological properties. X-ray diffraction, scanning electron microscopy (SEM), micro-computerized tomog...

journal_title：Acta biomaterialia

authors： Wu C,Ramaswamy Y,Zreiqat H

更新日期：2010-06-01 00:00:00

abstract：:Sponge-like matrices with a specific three-dimensional structural design resembling the actual extracellular matrix of a particular tissue show significant potential for the regeneration and repair of a broad range of damaged anisotropic tissues. The manipulation of the structure of collagen scaffolds using a freeze-d...

journal_title：Acta biomaterialia

authors： Davidenko N,Gibb T,Schuster C,Best SM,Campbell JJ,Watson CJ,Cameron RE

更新日期：2012-02-01 00:00:00

abstract：:Cardiac fibrosis, an important pathological feature of structural remodeling, contributes to ventricular stiffness, diastolic dysfunction, arrhythmia and may even lead to sudden death. Matrix stiffness, one of the many mechanical factors acting on cells, is increasingly appreciated as an important mediator of myocardi...

journal_title：Acta biomaterialia

authors： Xie J,Zhang Q,Zhu T,Zhang Y,Liu B,Xu J,Zhao H

更新日期：2014-06-01 00:00:00

abstract：:Bone morphogenetic protein-2 (BMP-2) involved therapy is of great potential for bone regeneration. However, its clinical application is restricted due to the undesirable bioactivity and relevant complications in vivo. Immobilization of recombinant BMP-2 (rhBMP-2) is an efficient strategy to mimic natural microenvironm...

journal_title：Acta biomaterialia

authors： Chen R,Yu Y,Zhang W,Pan Y,Wang J,Xiao Y,Liu C

更新日期：2018-10-15 00:00:00

abstract：:It is challenging for traditional hemostatic sponges to meet the clinic demand for both uncontrolled and noncompressible hemorrhage. With the aim to develop a rapid shape recovery material with both active and passive hemostatic performance, a dual-functional hemostatic sponge (TRAP-Sp) with a macroporous structure an...

journal_title：Acta biomaterialia

authors： Yang X,Liu W,Shi Y,Xi G,Wang M,Liang B,Feng Y,Ren X,Shi C

更新日期：2019-11-01 00:00:00

abstract：:Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in older populations and is expected to be the most dominant cause of disability in the world population by 2030. The progression of OA is controlled by a multi-factorial pathway that has not been completely elucidated and under...

journal_title：Acta biomaterialia

authors： Rahimi M,Charmi G,Matyjaszewski K,Banquy X,Pietrasik J

更新日期：2021-01-12 00:00:00

abstract：:Differentiation of stem and progenitor cells routinely relies on the application of soluble growth factors, an approach that enables temporal control of cell fate but enables no spatial control of the differentiation process. Angiogenic progenitor cells derived from mouse embryonic stem cells (ESCs) were differentiate...

journal_title：Acta biomaterialia

authors： Chiang CK,Chowdhury MF,Iyer RK,Stanford WL,Radisic M

更新日期：2010-06-01 00:00:00

abstract：:Patterned surfaces direct cell spatial dynamics, yielding cells oriented along the surface geometry, in a process known as contact guidance. The Rho family of GTPases controls the assembly of focal adhesions and cytoskeleton dynamics, but its role in modulating bone-cell alignment on patterned surfaces remains unknown...

journal_title：Acta biomaterialia

authors： Calzado-Martín A,Méndez-Vilas A,Multigner M,Saldaña L,González-Carrasco JL,González-Martín ML,Vilaboa N

更新日期：2011-04-01 00:00:00

abstract：:Diabetics are prone to chronic wounds that have slower healing, and methods of accelerating the wound closure and to ensure protection from infections are critically needed. MicroRNA-146a gets dysregulated in diabetic wounds and injection of this microRNA combined with reactive oxygen species-scavenging cerium oxide n...

journal_title：Acta biomaterialia

authors： Sener G,Hilton SA,Osmond MJ,Zgheib C,Newsom JP,Dewberry L,Singh S,Sakthivel TS,Seal S,Liechty KW,Krebs MD

更新日期：2020-01-01 00:00:00

abstract：UNLABELLED:The generation of tissue-engineered blood vessel substitutes remains an ongoing challenge for cardiovascular tissue engineering. Full biocompatibility and immediate availability have emerged as central issues for clinical use. To address these issues, we developed a technique that allows the generation of hi...

journal_title：Acta biomaterialia

authors： Aper T,Wilhelmi M,Gebhardt C,Hoeffler K,Benecke N,Hilfiker A,Haverich A

更新日期：2016-01-01 00:00:00

abstract：:In total hip arthroplasty, osteolysis of the acetabulum often occurs at the backside of cups in the area of screw holes, indicating a clinically relevant amount of polyethylene (PE) wear particles in this area. In order to avoid a possible migration of wear particles to the acetabulum-bone, screw hole plugs are provid...

journal_title：Acta biomaterialia

authors： Braun S,Vardag S,Mueller U,Schroeder S,Sonntag R,Bormann T,Gotterbarm T,Kretzer JP

更新日期：2019-10-01 00:00:00

abstract：:Engineered three-dimensional biomaterials are known to affect the regenerative capacity of stem cells. The extent to which these materials can modify cellular activities is still poorly understood, particularly for adipose-derived stem cells (ASCs). This study evaluates PEGylated fibrin (P-fibrin) gels as an ASC-carry...

journal_title：Acta biomaterialia

authors： Chung E,Rytlewski JA,Merchant AG,Dhada KS,Lewis EW,Suggs LJ

更新日期：2015-04-01 00:00:00

abstract：:Electrospun scaffolds provide a promising approach for tissue engineering as they mimic the physical properties of extracellular matrix. Previous studies have demonstrated that electrospun scaffolds with porous features on the surface of single fibers, enhanced cellular attachment and proliferation. Yet, little is kno...

journal_title：Acta biomaterialia

authors： Chen H,Huang X,Zhang M,Damanik F,Baker MB,Leferink A,Yuan H,Truckenmüller R,van Blitterswijk C,Moroni L

更新日期：2017-09-01 00:00:00

abstract：:Dicalcium phosphate cements (brushite and monetite) are resorbable biomaterials with osteoconductive potential for bone repair and regeneration that have yet to gain widespread commercial use. Brushite can be converted to monetite by heat treatments additionally resulting in various changes in the physico-chemical pro...

journal_title：Acta biomaterialia

authors： Sheikh Z,Zhang YL,Tamimi F,Barralet J

更新日期：2017-04-15 00:00:00

abstract：:Extracellular matrix (ECM) is crucial to many aspects of vascular morphogenesis and maintenance of vasculature function. Currently the recapitulation of angiogenic ECM microenvironment is still challenging, due mainly to its diverse components and complex organization. Here we investigate the angiogenic potential of h...

journal_title：Acta biomaterialia

authors： Du P,Suhaeri M,Ha SS,Oh SJ,Kim SH,Park K

更新日期：2017-05-01 00:00:00

abstract：:Macrophages represent a large component of the tumour microenvironment and are described to establish interactions with cancer cells, playing crucial roles in several stages of cancer progression. The functional plasticity of macrophages upon stimulation from the environment makes them susceptible to the influence of ...

journal_title：Acta biomaterialia

authors： Cardoso AP,Gonçalves RM,Antunes JC,Pinto ML,Pinto AT,Castro F,Monteiro C,Barbosa MA,Oliveira MJ

更新日期：2015-09-01 00:00:00

abstract：:Well-organized composite formations such as hierarchical nested-network (NN) structure in bone tissue and reticular connective tissue present remarkable mechanical strength and play a crucial role in achieving physical and biological functions for living organisms. Inspired by these delicate microstructures in nature,...

journal_title：Acta biomaterialia

authors： Wang Z,Zhang H,Chu AJ,Jackson J,Lin K,Lim CJ,Lange D,Chiao M

更新日期：2018-04-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) represent a promising cell source for the development of β-cells for use in therapies for type 1 diabetes. Current culture approaches provide signals to mimic a temporal control of organogenesis to drive the differentiation towards β-cells. However, spatial control may represent an...

journal_title：Acta biomaterialia

authors： Youngblood RL,Sampson JP,Lebioda KR,Shea LD

更新日期：2019-09-15 00:00:00

abstract：:Tissue-engineered temporomandibular joint (TMJ) discs offer a viable treatment option for patients with severe joint internal derangement. To date, only a handful of TMJ tissue engineering studies have been carried out and all have incorporated the use of synthetic scaffold materials. These current scaffolds have show...

journal_title：Acta biomaterialia

authors： Lumpkins SB,Pierre N,McFetridge PS

更新日期：2008-07-01 00:00:00

abstract：:A biphasic layer with a Zn-containing beta-tricalcium phosphate (ZnTCP) phase and a fluoridated hydroxyapatite (FHA) phase on titanium alloy substrate was prepared by the sol-gel technique. Scanning electron microscopy and energy-dispersive X-ray analysis results showed the ZnTCP/FHA layer to have a heterogeneous surf...

journal_title：Acta biomaterialia

authors： Miao S,Cheng K,Weng W,Du P,Shen G,Han G,Yan W,Zhang S

更新日期：2008-03-01 00:00:00

abstract：:Tracheal stent placement is a principal treatment for tracheobronchial stenosis, but complications such as mucus plugging, secondary stenosis, migration, and strong foreign body sensation remain unavoidable challenges. In this study, we designed a flexible porous chiral tracheal stent intended to reduce or overcome th...

journal_title：Acta biomaterialia

authors： Liu J,Yao X,Wang Z,Ye J,Luan C,He Y,Lin H,Fu J

更新日期：2021-01-30 00:00:00

abstract：:Polymeric ultra-thin films (nanosheets) possess unique properties that make them suitable materials for various biomedical applications. In our previous study, we assessed the use of an antibiotic (tetracycline, TC)-loaded nanosheet (or "TC-nanosheet") for the treatment of gastrointestinal tissue defects. The nanoshee...

journal_title：Acta biomaterialia

authors： Saito A,Miyazaki H,Fujie T,Ohtsubo S,Kinoshita M,Saitoh D,Takeoka S

更新日期：2012-08-01 00:00:00

abstract：:The encapsulation of cells in microscale hydrogels can provide a mimic of a three-dimensional (3D) microenvironment to support cell viability and functions and to protect cells from the environmental stress, which have been widely used in tissue regeneration and cell therapies. Here, a microfluidics-based approach is ...

journal_title：Acta biomaterialia

authors： An C,Liu W,Zhang Y,Pang B,Liu H,Zhang Y,Zhang H,Zhang L,Liao H,Ren C,Wang H

更新日期：2020-07-15 00:00:00

abstract：:Nanocrystalline hydroxyapatite (HAp) and silicon-containing hydroxyapatite (SiHAp) particles were synthesized by a wet-chemical procedure and their heterogeneous structures involving a disordered phase were analyzed in detail by X-ray diffractometry (XRD), transmission electron microscopy (TEM), Fourier transform infr...

journal_title：Acta biomaterialia

authors： Hayakawa S,Kanaya T,Tsuru K,Shirosaki Y,Osaka A,Fujii E,Kawabata K,Gasqueres G,Bonhomme C,Babonneau F,Jäger C,Kleebe HJ

更新日期：2013-01-01 00:00:00

abstract：UNLABELLED:The irritation/discomfort associated with the use of contact lenses (CLs) is often related to the eyelid-lens friction. Although the use of such devices is widespread, the information about the influence of the lacrimal fluid biomolecules on the tribological behavior of the CLs hydrogels is scarce. In this w...

journal_title：Acta biomaterialia

authors： Silva D,Fernandes AC,Nunes TG,Colaço R,Serro AP

更新日期：2015-10-01 00:00:00

abstract：:We here present the first successful report on combining nanostructured silk and poly(ε-caprolactone) (PCL) with a ceramic scaffold to produce a composite scaffold that is highly porous (porosity ∼85%, pore size ∼500 μm, ∼100% interconnectivity), strong and non-brittle with a surface that resembles extracellular matri...

journal_title：Acta biomaterialia

authors： Roohani-Esfahani SI,Lu ZF,Li JJ,Ellis-Behnke R,Kaplan DL,Zreiqat H

更新日期：2012-01-01 00:00:00

abstract：:Tubular collagen scaffolds have been used for the repair of damaged hollow organs in regenerative medicine, but they generally lack the ability to reversibly expand in radial direction, a physiological characteristic seen in many native tubular organs. In this study, tubular collagen scaffolds were prepared that displ...

journal_title：Acta biomaterialia

authors： Versteegden LR,van Kampen KA,Janke HP,Tiemessen DM,Hoogenkamp HR,Hafmans TG,Roozen EA,Lomme RM,van Goor H,Oosterwijk E,Feitz WF,van Kuppevelt TH,Daamen WF

更新日期：2017-04-01 00:00:00

abstract：:Metal-binding peptides have attracted attention for their usefulness in biomineralization processes. In this work screening of high affinity peptides against ZnO was performed using a combinatorial library approach with a peptide array and computational analysis. The computationally assisted peptide screening and desi...

journal_title：Acta biomaterialia

authors： Okochi M,Ogawa M,Kaga C,Sugita T,Tomita Y,Kato R,Honda H

更新日期：2010-06-01 00:00:00

abstract：:The present study focuses on apatite coating on collagen films, with various different densities of carboxyl groups, using an alternate soaking process. Anionic collagen (AC), which has different densities of carboxylic groups compared to native collagen (NC), was obtained by hydrolysis of carboxyamides of asparagine ...

journal_title：Acta biomaterialia

authors： Góes JC,Figueiró SD,Oliveira AM,Macedo AA,Silva CC,Ricardo NM,Sombra AS

更新日期：2007-09-01 00:00:00

abstract：:Our objective was to compare the polymerization stress (sigma(pol)) of a series of composites obtained using poly(methyl methacrylate) (PMMA) or glass as bonding substrates, and to compare the results with those from in vitro microleakage of composite restorations. The tested hypothesis was that stress values obtained...

journal_title：Acta biomaterialia

authors： Boaro LC,Gonçalves F,Braga RR

更新日期：2010-02-01 00:00:00