Abstract：
:Titanium oxide (TiO₂) scaffolds have previously been reported to exhibit very low mechanical strength. However, we have been able to produce a scaffold that features a high interconnectivity, a porosity of 91% and a compressive strength above 1.2 MPa. This study analyzed the in vivo performance of the porous TiO₂ scaffolds in a peri-implant cortical defect model in the rabbit. After 8 weeks of healing, morphological microcomputed tomography analyses of the defects treated with the TiO₂ scaffolds had significantly higher bone volume, bone surface and bone surface-to-volume ratio when compared to sham, both in the cortical and bone marrow compartment. No adverse effects, i.e. tissue necrosis or inflammation as measured by lactate dehydrogenase activity and real-time reverse transcription polymerase chain reaction analysis, were observed. Moreover, the scaffold did not hinder bone growth onto the adjacent cortical titanium implant. Histology clearly demonstrated new bone formation in the cortical sections of the defects and the presence of newly formed bone in close proximity to the scaffold surface and the surface of the adjacent Ti implant. Bone-to-material contact between the newly formed bone and the scaffold was observed in the histological sections. Islets of new bone were also present in the marrow compartment albeit in small amounts. In conclusion, the present investigation demonstrates that TiO₂ scaffolds osseointegrate well and are a suitable scaffold for peri-implant bone healing and growth.
journal_name
Acta Biomaterjournal_title
Acta biomaterialiaauthors
Haugen HJ,Monjo M,Rubert M,Verket A,Lyngstadaas SP,Ellingsen JE,Rønold HJ,Wohlfahrt JCdoi
10.1016/j.actbio.2012.09.009subject
Has Abstractpub_date
2013-02-01 00:00:00pages
5390-9issue
2eissn
1742-7061issn
1878-7568pii
S1742-7061(12)00437-0journal_volume
9pub_type
杂志文章abstract：:In vitro cell culture models representing the physiological and pathological features of the outer retina are urgently needed. Artificial tissue replacements for patients suffering from degenerative retinal diseases are similarly in great demand. Here, we developed a co-culture system based solely on the use of human ...
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更新日期：2020-01-01 00:00:00
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journal_title：Acta biomaterialia
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2015-10-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2013-05-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2014.02.041
更新日期：2014-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2016.09.014
更新日期：2016-12-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2020.05.037
更新日期：2020-08-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2010.02.023
更新日期：2010-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
doi：10.1016/j.actbio.2009.01.025
更新日期：2009-06-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章,评审
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更新日期：2021-01-25 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2015-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-06-01 00:00:00
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更新日期：2018-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-01-15 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2019-12-01 00:00:00
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更新日期：2019-03-15 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章,评审
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更新日期：2020-12-19 00:00:00
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journal_title：Acta biomaterialia
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更新日期：2019-09-15 00:00:00
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更新日期：2018-03-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Acta biomaterialia
pub_type： 杂志文章
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更新日期：2019-10-01 00:00:00
