Understanding the composition-structure-bioactivity relationships in diopside (CaO·MgO·2SiO₂)-tricalcium phosphate (3CaO·P₂O₅) glass system.

abstract：:Predictive in vitro models are valuable alternatives to animal experiments for evaluating the transport of molecules and (nano)particles across biological barriers. In this work, an improved triple co-culture of air-blood barrier was set-up, being exclusively constituted by human cell lines that allowed to perform exp...

journal_title：Acta biomaterialia

authors： Costa A,de Souza Carvalho-Wodarz C,Seabra V,Sarmento B,Lehr CM

更新日期：2019-06-01 00:00:00

abstract：:The easy clinical handling and applicability of biomaterials has become a focus of materials research due to rapidly increasing time and cost pressures in the public health sector. The present study assesses the in vitro and in vivo performance of a flexible, mouldable, cottonwool-like nanocomposite based on poly(lact...

journal_title：Acta biomaterialia

authors： Schneider OD,Weber F,Brunner TJ,Loher S,Ehrbar M,Schmidlin PR,Stark WJ

更新日期：2009-06-01 00:00:00

abstract：:A major problem with transcutaneous osseointegrated implants is infection, mainly due to improper closure of the implant-skin interface. Therefore, the design of transcutaneous osseointegrated devices that better promote skin growth around these exit sites needs to be examined and, if successful, would clearly limit i...

journal_title：Acta biomaterialia

authors： Puckett SD,Lee PP,Ciombor DM,Aaron RK,Webster TJ

更新日期：2010-06-01 00:00:00

abstract：:Diopside (CaMgSi(2)O(6)) powders and dense ceramics have been shown to be bioactive biomaterials for bone repair. The aim of this study is to prepare bioactive diopside scaffolds and examine their physicochemical and biological properties. X-ray diffraction, scanning electron microscopy (SEM), micro-computerized tomog...

journal_title：Acta biomaterialia

authors： Wu C,Ramaswamy Y,Zreiqat H

更新日期：2010-06-01 00:00:00

abstract：:Bacteria have inherent properties of self-propelled navigation and specific infiltration into solid tumors. In the current study, we investigate a novel type of bacterial microbots for delivery of hybrid micelles to promote the synergistic antitumor efficacy. Escherichia coli Nissle 1917 (EcN) is used as a bacterial c...

journal_title：Acta biomaterialia

authors： Xie S,Chen M,Song X,Zhang Z,Zhang Z,Chen Z,Li X

更新日期：2018-09-15 00:00:00

abstract：:Vitamin D3 modulates immune response, induces endogenous antimicrobial peptide production, and enhances innate immunity to defend against infections. These findings suggest that incorporating vitamin D3 into medical devices or scaffolds could positively modulate host immune response and prevent infections. In the curr...

journal_title：Acta biomaterialia

authors： Chen S,Ge L,Wang H,Cheng Y,Gorantla S,Poluektova LY,Gombart AF,Xie J

更新日期：2019-10-01 00:00:00

abstract：UNLABELLED:We have developed a novel hydroxyapatite (HAp)-coated double-network (DN) hydrogel (HAp/DN gel). The purpose of this study was to determine details of the cell and tissue responses around the implanted HAp/DN gel and to determine how quickly and strongly the HAp/DN gel bonds to the bone in a rabbit osteochon...

journal_title：Acta biomaterialia

authors： Wada S,Kitamura N,Nonoyama T,Kiyama R,Kurokawa T,Gong JP,Yasuda K

更新日期：2016-10-15 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) have tremendous potential as a cell source for regenerative medicine due to their capacity for differentiation into a wide range of connective tissue cell types. Although significant progress has been made in the identification of defined growth factor conditions to induce lineage ...

journal_title：Acta biomaterialia

authors： Phillips JE,Petrie TA,Creighton FP,García AJ

更新日期：2010-01-01 00:00:00

abstract：:First-principles calculations were carried out to reveal local atomic arrangements and thermodynamic stability of substitutional divalent cations of Mg(2+), Zn(2+), Sr(2+) and Ba(2+) in tricalcium phosphates (TCPs). There are two modifications of α-TCP and β-TCP, and a number of inequivalent Ca sites are present in th...

journal_title：Acta biomaterialia

authors： Matsunaga K,Kubota T,Toyoura K,Nakamura A

更新日期：2015-09-01 00:00:00

abstract：:The proliferation epidermal growth factor (EGF) is known to acquire contradictory apoptotic activities upon conjugation with gold nanoparticles (GNPs) through hitherto unknown mechanisms. Here, we identified an essential role of membrane rafts in the drastic activity switching of EGF-GNPs through the following intrace...

journal_title：Acta biomaterialia

authors： Yamamoto S,Iwamaru Y,Shimizu Y,Ueda Y,Sato M,Yamaguchi K,Nakanishi J

更新日期：2019-04-01 00:00:00

abstract：UNLABELLED:Medical device-associated infections are a multi-billion dollar burden for the worldwide healthcare systems. The modification of medical devices with non-leaching coatings capable of killing microorganisms on contact is one of the strategies being investigated to prevent microorganism colonization. Here we d...

journal_title：Acta biomaterialia

authors： Rai A,Pinto S,Evangelista MB,Gil H,Kallip S,Ferreira MG,Ferreira L

更新日期：2016-03-01 00:00:00

abstract：:Metal-binding peptides have attracted attention for their usefulness in biomineralization processes. In this work screening of high affinity peptides against ZnO was performed using a combinatorial library approach with a peptide array and computational analysis. The computationally assisted peptide screening and desi...

journal_title：Acta biomaterialia

authors： Okochi M,Ogawa M,Kaga C,Sugita T,Tomita Y,Kato R,Honda H

更新日期：2010-06-01 00:00:00

abstract：:Corneal collagen cross-linking (CXL) treatment can restore vision in patients suffering from keratoconus and corneal injury, by improving the mechanical properties of the cornea. The correlation between ultraviolet-A (UVA) irradiant energies of standard CXL (SCXL) and corneal visco-hyperelastic mechanical behavior rem...

journal_title：Acta biomaterialia

authors： Liu T,Shen M,Li H,Zhang Y,Mu B,Zhao X,Wang Y

更新日期：2020-09-01 00:00:00

abstract：:The goal of this study was to explore the effects of osteoporosis-related therapeutics on bone remodeling in vitro. A previously established bone-tissue mimetic system consisting of silk protein biomaterials in combination with hydroxyapatite and human cells was used for the study. Silk-hydroxyapatite films were pre-c...

journal_title：Acta biomaterialia

authors： Hayden RS,Vollrath M,Kaplan DL

更新日期：2014-01-01 00:00:00

abstract：:Molecular traps can control activity and abundance of many biological factors. Here, we report the development of a generic opto-trap to reversibly bind and release biomolecules with high spatiotemporal control by illumination with non-invasive and cell-compatible red and far-red light. We use the Arapidopsis thaliana...

journal_title：Acta biomaterialia

authors： Beyer HM,Thomas OS,Riegel N,Zurbriggen MD,Weber W,Hörner M

更新日期：2018-10-01 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) represent a promising cell source for the development of β-cells for use in therapies for type 1 diabetes. Current culture approaches provide signals to mimic a temporal control of organogenesis to drive the differentiation towards β-cells. However, spatial control may represent an...

journal_title：Acta biomaterialia

authors： Youngblood RL,Sampson JP,Lebioda KR,Shea LD

更新日期：2019-09-15 00:00:00

abstract：:This study concerns the preparation and in vitro characterization of an apatite-wollastonite-2M bioactive glass ceramic which is intended to be used for the regeneration of hard tissue (i.e. in dental and craniomaxillofacial surgery). This bioglass ceramic has been obtained by appropriate thermal treatment through the...

journal_title：Acta biomaterialia

authors： Magallanes-Perdomo M,De Aza AH,Mateus AY,Teixeira S,Monteiro FJ,De Aza S,Pena P

更新日期：2010-06-01 00:00:00

abstract：:The brown pelican (Pelecanus occidentalis) wields one of the largest bills of any bird and is distinguished by the deployable throat pouch of extensible tissue used to capture prey. Here we report on mechanical properties and microstructure of the pouch skin. It exhibits significant anisotropy, with the transverse dir...

journal_title：Acta biomaterialia

authors： Dike S,Yang W,Pissarenko A,Quan H,Garcia Filho FC,Ritchie RO,Meyers MA

更新日期：2020-12-01 00:00:00

abstract：:A series of six copolymeric families, P(AN-co-MTAs) with various molar fractions of acrylonitrile (fAN) and methacrylates (fMTA) based on 1,3-thiazole and 1,2,3-triazole pendant groups with several spacers of different length and nature (alkyl or succinic), have been synthesized by conventional radical polymerization....

journal_title：Acta biomaterialia

authors： Tejero R,Gutiérrez B,López D,López-Fabal F,Gómez-Garcés JL,Fernández-García M

更新日期：2015-10-01 00:00:00

abstract：:Strombus gigas (conch) shells and Tridacna gigas (Giant clam) shells have dense, tailored structures that impart excellent mechanical properties to these shells. In this investigation, conch and clam seashells were converted to hydroxyapatite (HAP) by a hydrothermal method at different temperatures and for different c...

journal_title：Acta biomaterialia

authors： Vecchio KS,Zhang X,Massie JB,Wang M,Kim CW

更新日期：2007-11-01 00:00:00

abstract：UNLABELLED:A novel kind of monodisperse mesoporous manganese silicate coated silica nanoparticle (MMSSN) as a highly efficient T1-weighted MRI contrast agent (CA) and drug carrier for cancer diagnosis and chemotherapy has been constructed by a modified "SiO2 sacrifice and in situ silicate growth" approach under a relat...

journal_title：Acta biomaterialia

authors： Li X,Zhao W,Liu X,Chen K,Zhu S,Shi P,Chen Y,Shi J

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:The novel concept of modifying and enhancing the properties of existing functional micelles through self-complementary interactions has significant potential. In this study, a practical approach to living polymerization of functionalized thermoresponsive monomers enabled the incorporation of self-constituted...

journal_title：Acta biomaterialia

authors： Cheng CC,Chang FC,Kao WY,Hwang SM,Liao LC,Chang YJ,Liang MC,Chen JK,Lee DJ

更新日期：2016-03-01 00:00:00

abstract：:Sponge-like matrices with a specific three-dimensional structural design resembling the actual extracellular matrix of a particular tissue show significant potential for the regeneration and repair of a broad range of damaged anisotropic tissues. The manipulation of the structure of collagen scaffolds using a freeze-d...

journal_title：Acta biomaterialia

authors： Davidenko N,Gibb T,Schuster C,Best SM,Campbell JJ,Watson CJ,Cameron RE

更新日期：2012-02-01 00:00:00

abstract：:Functional and perfusable vascular network formation is critical to ensure the long-term survival and functionality of engineered tissues after their transplantation. Although several vascularization strategies have been reviewed in past, the significance of microvessel organization in three-dimensional (3D) scaffolds...

journal_title：Acta biomaterialia

authors： Sharma D,Ross D,Wang G,Jia W,Kirkpatrick SJ,Zhao F

更新日期：2019-09-01 00:00:00

abstract：:Implantation of biomaterials into the body elicits a material-dependent inflammatory response called the foreign body reaction (FBR). Macrophages play a pivotal role in the FBR by orchestrating the pro-inflammatory microenvironment around the biomaterials by secreting cytokines, chemokines and growth factors. When the...

journal_title：Acta biomaterialia

authors： van Putten SM,Ploeger DT,Popa ER,Bank RA

更新日期：2013-05-01 00:00:00

abstract：:Decellularized nerve, or acellular nerve allografts (ANAs), are an increasingly used alternative to nerve autografts to repair nerve gaps to facilitate regeneration. The adaptive immune system, specifically T cells, plays a role in promoting regeneration upon these ANA scaffolds. However, how T cells promote regenerat...

journal_title：Acta biomaterialia

authors： Pan D,Hunter DA,Schellhardt L,Fuchs A,Halevi AE,Snyder-Warwick AK,Mackinnon SE,Wood MD

更新日期：2020-08-01 00:00:00

abstract：:Bioactive ions released from bioceramics play important roles in bone regeneration; however, it is unclear how each ionic composition in complex bioceramics exerts its specific effect on bone regeneration. The aim of this study is to elucidate the functional effects of Sr and Si ions in bioceramics on the regeneration...

journal_title：Acta biomaterialia

authors： Mao L,Xia L,Chang J,Liu J,Jiang L,Wu C,Fang B

更新日期：2017-10-01 00:00:00

abstract：:It is of high clinical relevance in bone tissue engineering that scaffolds promote a high seeding efficiency of cells capable of osteogenic differentiation, such as human bone marrow-derived mesenchymal stem cells (hMSCs). We evaluated the effects of a novel polycaprolactone (PCL) scaffold on hMSC seeding efficiency, ...

journal_title：Acta biomaterialia

authors： Chen M,Le DQ,Baatrup A,Nygaard JV,Hein S,Bjerre L,Kassem M,Zou X,Bünger C

更新日期：2011-05-01 00:00:00

abstract：:It is important to understand the effects of mechanical stimulation on cell behaviors for homeostasis. Many studies have been performed on cell responses to mechanical stimuli, but the mechanosensing mechanism is still under debate. In the present study, experiments employing molecular dynamics (MD) simulations concer...

journal_title：Acta biomaterialia

authors： Deguchi S,Kato A,Wu P,Hakamada M,Mabuchi M

更新日期：2021-02-01 00:00:00

abstract：:Implant-derived material from metal-on-metal (MOM) hip arthroplasties may be responsible for an unexplained tissue inflammatory response. The chemical form of the metal species in the tissues is predominantly chromium (Cr), but the currently used techniques have not been able to determine whether this is Cr(III) phosp...

journal_title：Acta biomaterialia

authors： Hart AJ,Quinn PD,Sampson B,Sandison A,Atkinson KD,Skinner JA,Powell JJ,Mosselmans JF

更新日期：2010-11-01 00:00:00