Abstract:
OBJECTIVE:To evaluate the therapeutic efficacy of a steroid switch from prednisone to dexamethasone in Asians with metastatic castration-resistant prostate cancer (mCRPC) that progressed after docetaxel chemotherapy. METHODS:This study included postdocetaxel patients with mCRPC treated with abiraterone acetate combined with prednisone (AA + P) who had experienced prostate-specific antigen (PSA) progression. All patients underwent a steroid switch from prednisone (10 mg/day) to dexamethasone (1 mg/day). The PSA level and clinical symptoms were recorded. Moreover, follow-up was conducted until patients were either lost to follow-up or death. RESULTS:This study included 11 patients from a single center in Taiwan. The median follow-up time starting from AA + P treatment was 19.47 months. Seven patients (63.64%) had >30% PSA decline, and 6 patients (54.55%) had >50% PSA decline. The median percentage of PSA decline was 83.6%. The median time until PSA progression after the steroid switch was 11.38 months. No adverse events greater than grade 3 were noted. CONCLUSIONS:Steroid switching is a feasible and effective therapy in docetaxel-treated Asian patients with mCRPC.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Fang WY,Wang PF,Fan YC,Shih HJdoi
10.1159/000509882subject
Has Abstractpub_date
2020-08-13 00:00:00pages
1-6eissn
0042-1138issn
1423-0399pii
000509882pub_type
杂志文章abstract::Characteristics of placental-like alkaline phosphatase (PLAP-like enzyme) in seminoma was studied. By use of lectin affinity chromatography, PLAP-like enzyme in seminoma revealed extra sugar chains compared to placental alkaline phosphatase (PLAP), indicating heterogeneity of the carbohydrate moiety. However, the glyc...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282263
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The internet is an emerging source of information for prostate cancer (PCa) patients. Since little is known about the quality of information on PCa provided online, we investigated its accordance to the latest European Association of Urology (EAU) guidelines. METHODS:A total of 89 German web pages were incl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000487146
更新日期:2018-01-01 00:00:00
abstract::We report a rare case of massive bilateral staghorn calculi in a spinal cord injury patient with significant renal compromise. The patient was successfully treated with percutaneous nephrolithotomy to achieve a stone-free status. The various options of treatment are discussed with special attention to the technical as...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030340
更新日期:1998-01-01 00:00:00
abstract::The introduction in 1982 of vasoactive agents for intracavernous injection represents a milestone in the diagnosis and treatment of erectile dysfunction. Two preparations, the single drug papaverine hydrochloride and the combination of phentolamine mesylate and papaverine hydrochloride, hold great promise. In the last...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281308
更新日期:1988-01-01 00:00:00
abstract::119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The pat...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000281439
更新日期:1989-01-01 00:00:00
abstract:INTRODUCTION:This study aimed to determine the safety and efficacy of a modified technique for performing transurethral resection of the prostate (TURP) combined with percutaneous cystolithotripsy (PCCL). METHODS:Clinical data from 24 patients with benign prostate hyperplasia (BPH) and aggregate stone sizes ≥3 cm were...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000437213
更新日期:2015-01-01 00:00:00
abstract::In 1 out of 56 patients, orchiectomized in the course of treatment for prostatic carcinoma, metastatic growth in the testis was found. This uncommon metastatic spread is a sign of advanced disease. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281859
更新日期:1987-01-01 00:00:00
abstract::The effects of ammonium chloride, methenamine hippurate and ascorbic acid on urinary pH was studied in 14 normal subjects. A statistically significant reduction of urinary pH was recorded with ammonium chloride in daily doses of 1.5 and 3 g, but not with 2 g of methenamine hippurate or 1.8 g of ascorbic acid. Long-ter...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281732
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:We investigated the effects of standard oral anticholinergic treatment with tolterodine in children with neurogenic bladder over a 5-year follow-up period and focused on treatment satisfaction, patient compliance and urodynamic parameters. MATERIAL AND METHODS:The follow-up consisted of regular visits and...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000102915
更新日期:2007-01-01 00:00:00
abstract::Two patients treated with chronic dialysis and renal transplantation developed acute hemorrhage from a native kidney. Bilateral native nephrectomy demonstrated acquired cystic disease and adenocarcinoma in each of the four kidneys. The etiology of acquired cystic kidney disease (ACKD) is unclear and its incidence incr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030222
更新日期:1998-01-01 00:00:00
abstract::We report the case of a 70-year-old man who received sunitinib treatment for brain metastatic clear cell renal cell carcinoma. After 6 months of treatment, brain MRI showed complete disappearance of two brain metastases. To the best of our knowledge, this is the first reported case of multifocal brain metastases in re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000251193
更新日期:2009-01-01 00:00:00
abstract::Two patients with entire urethral stricture were treated with balloon dilatation of the whole urethra using a torpedo-type dilatation balloon with satisfactory results. Postdilatation urethrograms revealed that the lumen of the urethra was of satisfactory width in both cases, and the patients are now voiding normally....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282141
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:The urinary bladder is commonly involved in pelvic malignancy. The incidence of apparent extension into adjacent organs in locally advanced colorectal malignancy is 5-12%. It is not known with other pelvic malignancy. No guidelines are available for its management. Often a dilemma exists between cystectomy...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000092929
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Robot-assisted bladder diverticulectomy (RABD) through a technique for easier identification of diverticulum along with concomitant management of bladder outlet obstruction (BOO) utilizing a combination of transurethral prostatectomy (TUR-P) and photoselective vaporization of prostate (PVP) is presented. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000443799
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:Improvements in quality of life (QoL) and disease-related symptoms are key goals in the treatment of hormone refractory prostate cancer (HRPC). Our aim was to evaluate the impact of gefitinib on QoL of patients with HRPC. METHODS:Patients with HRPC received gefitinib 250 mg daily in addition to antiandrogen...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000200800
更新日期:2009-01-01 00:00:00
abstract::Clinical and experimental investigations seem to underline the important role of fatty acids in the pathogenesis of hypercalciuria, a well-known risk factor for lithogenesis. To evaluate the relationships between the previously reported increase in plasma phospholipid arachidonic acid level and the factors responsible...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000087161
更新日期:2005-01-01 00:00:00
abstract::We report 2 patients with epididymo-orchitis, caused by Brucella melitensis, accompanied by severe delay of diagnosis. In 1 patient the correct diagnosis was only suspected after his wife had been diagnosed with brucellosis. Our cases illustrate that diagnosing brucellosis can be difficult in nonendemic areas, especia...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000218542
更新日期:2009-01-01 00:00:00
abstract:AIM:To compare the efficacy and safety of silodosin versus tamsulosin as medical expulsive therapy for stones of lower-third ureter in children. PATIENTS AND METHODS:This prospective single-blind placebo-controlled randomized study included 167 pediatric patients who presented with distal ureteric stone (DUS) less tha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000513074
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:Genetic variants of vitamin D receptor (VDR) were implicated in urolithiasis susceptibility in several case-control studies. However, these studies so far have provided conflicting results. In order to investigate the potential relationship, a meta-analysis was conducted. METHODS:Eligible studies were retrie...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000323949
更新日期:2011-01-01 00:00:00
abstract:AIMS:To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). METHODS:Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000112611
更新日期:2008-01-01 00:00:00
abstract::To clarify the relative importance of clinicopathological factors affecting survival in patients with renal cell carcinoma, univariate and multivariate analyses by Cox's proportional hazards model were performed for 121 patients undergoing nephrectomy between 1980 and 1991. The 5-year survival rate was 67% for all 121...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282439
更新日期:1993-01-01 00:00:00
abstract::A 33-year-old male presented to the Chiba University Hospital with the main complaint of right flank pain. Bilateral vas deferens were not palpable. Hormonal examination revealed hypergonadotropic hypogonadism and cytogenetic studies a 47,XXY karyotype. The significance of the association of this karyotype with the ab...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281703
更新日期:1990-01-01 00:00:00
abstract::The cross-antigenicity between streptococcus, Su strain (OK-432), and rat bladder cancer BC-47 was studied by the immunocytochemistry. Both anti-Su (OK-432) and anti-BC-47 reacted with both homo- and heterogenous antigens. The specificity of the PAP reactions using these sera was confirmed by absorption study of the f...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281504
更新日期:1989-01-01 00:00:00
abstract:AIM:To clarify the factors affecting the success rate of endoscopic subureteral injection (ESI) treatment of vesicoureteral reflux (VUR). METHOD:All patients who had ESI treatment for VUR at our unit between 1999 and 2002 were retrospectively reviewed with regard to age, gender, causes of VUR, reflux grade, type of in...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000137639
更新日期:2008-01-01 00:00:00
abstract::The intracavernosal pressure changes induced by 3 vasodilating drugs, diazoxide, glyceryltrinitrate and verapamil were investigated during autologous extracorporeal penile blood perfusion in an experimental rabbit model. In order to separate the arterial and venous components the experiments were performed with both i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282454
更新日期:1993-01-01 00:00:00
abstract::We report on the familial occurrence of congenital bulbar urethral stricture in 2 brothers. Embryological mechanisms are briefly discussed and the literature reviewed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281795
更新日期:1991-01-01 00:00:00
abstract:AIM:Papillary renal cell carcinoma type 1 (pRCC1) represents the second most common type of malignant renal epithelial tumour. The origin of its characteristic appearance, its growth mechanism, and the long-term efficiency of its surgical treatment remain uncertain. Our aim was to determine typical characteristics of s...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000448434
更新日期:2017-01-01 00:00:00
abstract::A total of 51 consecutive female patients with genuine stress incontinence who underwent a Burch or Stamey operation were clinically and urodynamically evaluated preoperatively at least 8 months postoperatively. Our study group consisted of 27 women who underwent the Burch colposuspension and 24 who had the Stamey end...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282803
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Intravesical epirubicin is a widely used agent for the treatment of superficial bladder cancer. A direct relationship between dose and activity has been reported: unfortunately the dose increase also increased the frequency and the intensity of treatment-related side effects. MATERIALS AND METHODS:A phase...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000058438
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS:We genotype...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345630
更新日期:2013-01-01 00:00:00