Fatty acids and idiopathic calcium nephrolithiasis.

Abstract:

:Clinical and experimental investigations seem to underline the important role of fatty acids in the pathogenesis of hypercalciuria, a well-known risk factor for lithogenesis. To evaluate the relationships between the previously reported increase in plasma phospholipid arachidonic acid level and the factors responsible for calcium metabolism in idiopathic calcium nephrolithiasis, a best-fit model was constructed. This new statistical application shows a causal relationship between plasma phospholipid arachidonic acid content, intestinal calcium absorption, biochemical markers of bone turnover, urinary calcium excretion and bone mineral density at the lumbar spine. This model suggests that a defect in the phospholipid fatty acid composition could represent the primary event responsible for the mosaic of metabolic and clinical alterations that are distinctive features of renal stone formers, such as kidney, intestine, and bone calcium metabolism, and several forms of idiopathic hypercalciuria.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Baggio B,Budakovic A

doi

10.1159/000087161

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

97-101

issue

2

eissn

0042-1138

issn

1423-0399

pii

87161

journal_volume

75

pub_type

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