The beneficial effects of tadalafil on renal ischemia-reperfusion injury in rats.

Abstract:

:Acute renal failure due to ischemia-reperfusion (I/R) injury is a common complication in cardiovascular surgery. We determined the influence of tadalafil on renal injury in a renal I/R model in rats. For this purpose, 21 male Wistar albino rats were separated into 3 groups: sham, placebo and tadalafil. A right nephrectomy was performed, and the left renal pedicles were occluded for 60 min and reperfused for 60 min in the placebo and tadalafil groups. A single dose of tadalafil (10 mg/kg) through an orogastric tube was administered to the tadalafil group. Tubular atrophy with acute inflammation in renal histology, total oxidant status (TOS) and total antioxidant status (TAS) were determined in tissue homogenates. Compared to the tadalafil group, tubular atrophy and acute inflammation was significant in the placebo group. TAS levels were significantly higher in the tadalafil group compared to the placebo (p = 0.01) and sham groups (p = 0.04). While TOS levels were significantly higher in the placebo group (p = 0.03), tadalafil did not significantly alter the TOS levels. The beneficial effects of tadalafil can be attributed to its protective effects on renal tubular cells and inhibition of leukocyte infiltration in renal tissue. We think that tadalafil treatment has an important role in reducing renal injury resulting from renal I/R.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Guzeloglu M,Yalcinkaya F,Atmaca S,Bagriyanik A,Oktar S,Yuksel O,Fansa I,Hazan E

doi

10.1159/000321927

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

197-203

issue

2

eissn

0042-1138

issn

1423-0399

pii

000321927

journal_volume

86

pub_type

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