Abstract:
INTRODUCTION:MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven. PATIENTS, METHODS:In 312 consecutive cases with various testicular diseases, serum levels of miR371a-3p were measured. Measurement results became available only after completion of treatment. Five patients with testicular seminoma were selected for review because of unanticipated clinical courses. RESULTS:In each two patients, elevated miR levels heralded undetected primary testicular GCT and metastases despite inconclusive radiological findings. In one case, a normal miR371a-3p level correctly pointed to the absence of metastases contrary to clinical assessment. In all cases, knowledge about the miR371a-3p levels would have altered the clinical management. CONCLUSIONS:These cases highlight the exceptional usefulness of the new GCT biomarker. In contrast to classical markers, miR371a-3p can identify primary testicular GCT. The marker can aid in clinical decision making in cases with ambiguous clinical findings.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Anheuser P,Radtke A,Wülfing C,Kranz J,Belge G,Dieckmann KPdoi
10.1159/000477446subject
Has Abstractpub_date
2017-01-01 00:00:00pages
98-103issue
1eissn
0042-1138issn
1423-0399pii
000477446journal_volume
99pub_type
杂志文章abstract::Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280348
更新日期:1980-01-01 00:00:00
abstract:INTRODUCTION:Immunotherapy effectively treats advanced renal cell carcinoma in only a limited number of patients. However, the predicted prognosis for each patient in relation to immune status and response to immunotherapy remains problematic. We analyzed tumor-infiltrating lymphocyte (TIL) subsets to determine whether...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000064361
更新日期:2002-01-01 00:00:00
abstract::Clear cell adenocarcinoma arising in the lower urinary tract is unusual. We report a case of clear cell adenocarcinoma of the bladder in a 54-year-old male. Cystoscopic examination revealed a tumour arising from the dome of the urinary bladder. Histologically, the tumour was chiefly composed of tubulocystic and papill...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000071856
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:We aimed to assess the diagnostic accuracy of radiolabeled prostate-specific membrane antigen positron emission tomography (PSMA PET) or positron emission tomography/computed tomography (PET/CT) for primary lymph node (LN) staging in newly diagnosed intermediate to high-risk prostate cancer (PCa) patients....
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析
doi:10.1159/000493169
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:β-HCG has been the only tumor marker evaluated in testicular vein (VT) blood until now. OBJECTIVE:To evaluate the correlation between the tumor markers β-HCG, AFP, PLAP, and LDH from the VT and peripheral blood as well as their significance in predicting tumor recurrence and tumor stage. METHODS:Patients...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000511649
更新日期:2020-12-17 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000497279
更新日期:2019-01-01 00:00:00
abstract::An unusual case of metastatic carcinoma of prostate, which presented as a huge abdominal mass and responded extremely well to endocrine therapy, is presented. The literature is reviewed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281205
更新日期:1986-01-01 00:00:00
abstract::The spontaneous contractile force of muscle strips isolated from male rabbit urinary bladder dome [detrusor) and base (trigonal muscle) was dose dependently inhibited by isoproterenol, a non-specific beta-adrenoceptor agonist. The relaxant response to 10(-6) M isoproterenol in the detrusor muscle was completely blocke...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281650
更新日期:1990-01-01 00:00:00
abstract:PURPOSE:With a median age at diagnosis of 73 years, bladder cancer has the highest median age of all cancers. Age alone seems to be an independent risk factor for developing the disease with peak age advancing into the range of 85 years. As demographic changes will lead to an ever more aging population in western count...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000510137
更新日期:2020-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000072680
更新日期:2003-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282986
更新日期:1997-01-01 00:00:00
abstract::We examined the effects of recombinant human tumor necrosis factor (rTNF) on highly metastatic rat prostatic cancer, Dunning R3327 MAT-LyLu, in vivo. It seemed that the inhibition of tumor growth needed more than 5 x 10(5) units of rTNF and this dose was near the lethal dose. Concerning the effect of rTNF on metastasi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282519
更新日期:1993-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000090882
更新日期:2006-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000357627
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Nearly 80% of the patients suffering from advanced stages of prostate cancer in Germany are treated currently with luteinizing hormone-releasing hormone (LH-RH) analogs alone or in combination with androgen receptor antagonists. The aim of this study was to assess whether the prescription practice for LH-R...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000096334
更新日期:2006-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282577
更新日期:1994-01-01 00:00:00
abstract::Of 15 patients with primary aldosteronism, 7 had idiopathic adrenal hyperplasia (IHA) and 8 had aldosterone-producing adenoma (APA). In order to determine any renal problems involved in the treatment, the renal clearance of these patients was analyzed and the results compared with those obtained from 12 patients with ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281962
更新日期:1987-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000075267
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To present a review of the literature using evidence-based criteria for diagnosis and treatment of malignant growths in the ureteric remnant following nephrectomy for non-malignant disease. METHODS:A database search using the key search words was performed, producing a total of 16 articles published between ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000349884
更新日期:2013-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000448482
更新日期:2016-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000338808
更新日期:2012-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281516
更新日期:1989-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000077113
更新日期:2004-01-01 00:00:00
abstract::Blind-ending bifid ureter in a woman with urinary tract infection and a duplicated renal pelvis in her twin sister are reported. The blind-ending bifid ureter terminated as a fibrous cord with a terminal mass of immature renal tissue. This type of ureter may be a transitional form between histologically blind-ending b...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280110
更新日期:1977-01-01 00:00:00
abstract::Non-clear cell renal cell carcinoma accounts for about 20% of all kidney cancers. Tubulocystic carcinoma of the kidney (TCK) is a newly described entity with distinct molecular, genetic and clinical features. In 2013, it was one of five new renal tumors to be recognized by the International Society of Urological Patho...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000366287
更新日期:2015-01-01 00:00:00
abstract::A case of malignant peripheral nerve sheath tumor of the bladder in a 57-year-old man with multiple neurofibromatosis type 1 is presented. The patient had a recent history of a transurethrally resected bladder ganglioneuroma. A probable histogenetic association between these two extremely rare neoplasms is proposed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000065568
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. MATERIALS AND METHODS:Experiments were performed on male C57BL/6 mice (8 weeks old, 20-25 g). The animals were divided into 3 groups including 6 mice in each group: control (sham), tor...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000318890
更新日期:2010-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000490356
更新日期:2018-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000048442
更新日期:2002-01-01 00:00:00