Abstract:
OBJECTIVES:To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. MATERIALS AND METHODS:Experiments were performed on male C57BL/6 mice (8 weeks old, 20-25 g). The animals were divided into 3 groups including 6 mice in each group: control (sham), torsion/detorsion (TD) and TD+TQ. Mice, except the sham-operated group, were subjected to left unilateral torsion (720° rotation in the clockwise direction). The experiments were finished after sham operation time for controls, 120 min torsion and 240 min detorsion for the other groups. In the TD+TQ group 10 mg TQ was injected intraperitoneally 30 min before detorsion. RESULTS:In the TD group total oxidative stress (TOS), oxidative stress index (OSI) and malondialdehyde (MDA) levels were higher than in the controls. TQ treatment decreased MDA, TOS and OSI values, but did not affect the total antioxidant capacity and myeloperoxidase activity in the TD+TQ group. Upon histological examination, mice in the TD group displayed moderate-to-severe disruption of the seminiferous epithelium. Treatment with TQ resulted in significantly reduced histological damage associated with I/R injury. CONCLUSION:Our results suggested that TQ treatment may have a protective effect on testicular I/R injury.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Gökçe A,Oktar S,Koc A,Gonenci R,Yalcinkaya F,Yonden Z,Duru Mdoi
10.1159/000318890subject
Has Abstractpub_date
2010-01-01 00:00:00pages
461-5issue
4eissn
0042-1138issn
1423-0399pii
000318890journal_volume
85pub_type
杂志文章abstract:INTRODUCTION:To evaluate the role of serum carbohydrate antigen 19-9 (CA19-9) in the prognosis and follow-up evaluation of patients with urothelial carcinoma, the authors studied the association of the serum level and positive rate with clinical features such as infiltration and metastasis in 164 patients admitted to t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000075963
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:We aimed to evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile function in patients who had no cavernosal or urethral injury by using International Index of Erectile Function (IIEF) questionnaire. MATERIALS AND METHODS:The male patients who were treated by HBOT for several diseases betwe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000490356
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the feasibility and safety of bilateral single-session ureteroscopy in the treatment of bilateral stones with different localizations. MATERIALS AND METHODS:Between February 2001 and October 2006, a total of 1,296 patients underwent ureteroscopy with pneumatic lithotripsy. Of these, 38 patient...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000144061
更新日期:2008-01-01 00:00:00
abstract::Penile prosthesis was implanted for erectile impotence of mainly organic origin in 104 patients. The AMS Dynaflex penile prosthesis was inserted in 39 cases, the AMS Malleable 600 prosthesis in 61 and the AMS Ultrex Plus prosthesis in 4. In 1 patient receiving a malleable prosthesis both rods had to be removed owing t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282820
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Afferents from the urinary tract transmit bladder sensations to the central nervous system. Spinal cord injury (SCI) may affect both efferent motor and afferent sensory pathways. Presence/absence of bladder sensations in patients with complete spinal cord, conus or cauda equina lesions was compared with neur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000342815
更新日期:2012-01-01 00:00:00
abstract:AIM:The aim of this study was to compare the postoperative analgesic effectiveness of the 2 block types. We also aimed to evaluate the effect of these block types on the postoperative complications and parental satisfaction. MATERIALS AND METHODS:This prospective observational study was conducted between April and Jul...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000509173
更新日期:2020-01-01 00:00:00
abstract::With this letter to the editor we present for the first time a study on CHEK2 expression in normal urothelium of healthy male smokers, former smokers and non-smokers. We could show a statistically significant downregulation of this DNA repair gene in current smokers compared to non-smokers, suggesting that smoking dow...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000446827
更新日期:2016-01-01 00:00:00
abstract::A medium that had been conditioned by PC-3 cells stimulated the calcification of a human osteoblastic cell line, Tak-10, in a nonmitogenic culture. The calcification of the osteoblasts was stimulated maximally at a 25% concentration of the conditioned medium. Calcification activity was markedly enhanced by the additio...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282291
更新日期:1992-01-01 00:00:00
abstract:PURPOSE:We investigated the hypothesis that testicles and scrotal skin undergo morphologic changes that would serve the mechanism of erection and ejaculation. MATERIALS AND METHODS:Testicular and scrotal skin changes during erection and ejaculation were studied in 9 dogs. Testicular volume was measured by ultrasound, ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000107960
更新日期:2007-01-01 00:00:00
abstract::Technetium-labeled red blood cell scintigraphy using a bolus injection was used to obtain a noninvasive quantitative measurement of renal blood flow. The method used is an adaptation of the one used for calculating cerebral blood flow which involves deconvolution of the first pass of the isotope through the kidneys. T...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281863
更新日期:1987-01-01 00:00:00
abstract:PURPOSE:To assess MRI/Transrectal Ultrasound (TRUS) fusion three-dimensional model-guided targeted biopsy (3D-Tb) versus TRUS-guided systematic biopsy (Sb) in detecting overall and high-Gleason-score (≥7) prostate cancer (PCa). METHODS:Pubmed and Web of science were searched. Studies with men having a suspicious lesio...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000484144
更新日期:2018-01-01 00:00:00
abstract::The overnight (12 h) urinary excretion of glycosaminoglycans, citrate, magnesium, calcium and uric acid were measured in 82 normal subjects and 63 outpatients who had formed at least one urinary stone. No significant difference could be found between the two groups of unselected subjects with respect to any of the uri...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281493
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:To develop risk predictive models of postpartum stress urinary incontinence (SUI) for both primiparous and multiparous women. MATERIALS AND METHODS:From July 2016 to July 2017, 815 singleton pregnant women without incontinence before pregnancy who were 18 years or older and admitted to 2 hospitals in Shenzh...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000508416
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:With a median age at diagnosis of 73 years, bladder cancer has the highest median age of all cancers. Age alone seems to be an independent risk factor for developing the disease with peak age advancing into the range of 85 years. As demographic changes will lead to an ever more aging population in western count...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000510137
更新日期:2020-01-01 00:00:00
abstract:AIMS:This study aimed to investigate the safety and efficacy of preoperative temporary inferior vena cava (IVC) filter placement and intraoperative application of a liver mobilization technique. MATERIALS AND METHODS:The experiment cohort of 42 cases and the control cohort of 36 cases of renal cell carcinoma involving...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350521
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in syner...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000288243
更新日期:2010-01-01 00:00:00
abstract::The present study was undertaken to analyze the changes in neuroendocrine cells of the human prostate induced by neoplasms and the effect of hormonal treatment. Samples of human prostate (n = 47) were obtained during surgery or removal of organs for transplantation. The cases analyzed represent normal prostates (n = 4...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000283051
更新日期:1997-01-01 00:00:00
abstract::This study was undertaken to investigate the endocrine function of the testis that was autotransplanted by microvascular techniques in 10 healthy dogs. After a control period of 4 weeks, hemicastration was carried out, and 4 weeks later the experimental orchidopexy was done. Finally, the transplanted testis was remove...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280918
更新日期:1983-01-01 00:00:00
abstract::In a 3-year study, silicone rubber prostheses were implanted in 6 minipigs as ureteric replacement. A Dacron velour cuff was applied for the proximal anastomosis and a disc of the same material implanted into the bladder wall to anchor the prosthesis distally. The silicone tube incorporated a metal spiral to prevent k...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280953
更新日期:1984-01-01 00:00:00
abstract::The momentary entry of urine into the proximal urethra during coughing can be demonstrated by a new test which can be conducted using apparatus now commonly available for urodynamic investigations. If the bladder neck opens, a fluid bridge is established between points of pressure measurement in the bladder and in the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280287
更新日期:1979-01-01 00:00:00
abstract::During a 2-year period, 37 patients with symptomatic metastatic prostatic cancer were included in a prospective randomized phase-III trial. Nineteen patients were randomized to subcapsular orchiectomy, and 18 to cyproterone acetate (CPA) treatment with a dose of 50 mg b.i.d. The median age of the patients was 74 years...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282125
更新日期:1991-01-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280875
更新日期:1983-01-01 00:00:00
abstract::Ischemia, induced by atherosclerosis, is a common cause of disorders in the elderly. Bladder dysfunction in older people may be caused by detrusor ischemia. We compared blood flow to the bladder and detrusor function in vivo and in vitro in young (6-month-old) and aged (24-month-old) male Sprague-Dawley rats. In both ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030365
更新日期:1999-01-01 00:00:00
abstract::In unilateral kidney disease, it has been suggested that the ipsilateral state could be estimated by measuring contralateral kidney size; thus, a contralateral increase should reflect an ipsilateral impairment and vice versa. This could easily be performed using ultrasound. In our experiments with partial obstruction ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282898
更新日期:1996-01-01 00:00:00
abstract::Controversies abound in relation to the treatment of every stage of prostate cancer and its natural history. We critically evaluate the controversies and information that exist. An ongoing autopsy project at Wayne State University aims to: define the prevalence of incidental cancer in subjects between 20 and 70 years ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282860
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Male infertility caused by azoospermia due to non-reconstructable obstruction or non-obstructive azoospermia can be treated by microsurgical epididymal aspiration (MESA) or testicular sperm extraction (TESE) followed by an intracytoplasmatic spermatozoa injection (ICSI). MATERIAL AND METHODS:From 9/93 to ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000068185
更新日期:2003-01-01 00:00:00
abstract::Experiments were performed to explore the influence of noradrenaline and isoproterenol on the ureteral peristalsis in the canine pelviureteral system in vitro. The rhythmic changes of intrapelvic pressure no longer became manifest, and simultaneously recorded electromyograms revealed disappearance of peristalsis at si...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280908
更新日期:1983-01-01 00:00:00
abstract::A method of synchronous study for monitoring the pressure activity of the rectum, bladder and urethral sphincter was described. Intrarectal pressures were obtained using a 8 F custom made balloon catheter. Constant urethral infusion with intrasphincteric pressure recording was arranged through a specially designed 12 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280126
更新日期:1977-01-01 00:00:00
abstract:INTRODUCTION:Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intr...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000350508
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, involvement of trace elements in the tumorigenesis of transitional cell carcinoma of the bladder has been poorly investigated. The aim of this study was to examine the rela...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341976
更新日期:2012-01-01 00:00:00