Downregulation of Checkpoint Protein Kinase 2 in the Urothelium of Healthy Male Tobacco Smokers.

Abstract:

:With this letter to the editor we present for the first time a study on CHEK2 expression in normal urothelium of healthy male smokers, former smokers and non-smokers. We could show a statistically significant downregulation of this DNA repair gene in current smokers compared to non-smokers, suggesting that smoking downregulates CHEK2 in normal urothelium, probably associated with an early step in carcinogenesis of urothelial bladder carcinoma.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Breyer J,Denzinger S,Hartmann A,Otto W

doi

10.1159/000446827

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

480-481

issue

4

eissn

0042-1138

issn

1423-0399

pii

000446827

journal_volume

97

pub_type

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