Abstract:
INTRODUCTION AND OBJECTIVE:When feasible, the treatment for all-invasive bladder cancer is radical cystectomy. The aim of the present study was to analyze the prognostic difference, disease-specific survival rate, of muscle-invasive transitional cell cancer of the bladder (TCCB) for progressive invasive TCCB. PATIENTS AND METHODS:A retrospective multicentric analysis was performed studying a total of 242 patients who underwent radical cystectomy for invasive TCCB from 1993 to 2005. The patients were divided into two groups: group 1 included 57 patients with progressive invasive TCCB, and group 2 included 185 patients with primary invasive TCCB. Both groups were further divided according to the pathological findings in pT2/3 (muscle and/or perivesical fat invasion), pT4 (adjacent organs/structure invasion), N+ (positive lymphatic nodes) and M+ (distant organ metastasis). Several tests were employed for statistical analysis: chi2, Mann-Whitney, Kaplan-Meier method and Wilcoxon (Breslow) method were used to compare the possible survival curve differences of groups 1 and 2. Multivariated analysis determined by proportional risk regression excluded sex, age and disease stage interferences in the final results. RESULTS:The average time for a superficial TCCB to become muscle-invasive was 37.4 months, and the average number of transurethral resections performed in each patient was 3. The average and median global survival rates were, respectively, 96 and 88 months in group 1 and 98 and 90 months in group 2, without a statistically significant difference (p = 0.0734). The 1-year survival rate was 84.32% in group 1 and 76.54% in group 2. After 3 years of follow-up the survival rate fell to 74.50% in group 1 and to 59.05% in group 2. Finally, the 5-year survival rate was 57.94% in group 1 and 52.24% in group 2. CONCLUSION:In the present study, patients with primary invasive and progressive invasive TCCB showed a similar 5-year disease-specific survival rate. Pathological stage (pTN, N and M) and patient demography did not interfere with the results.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Ferreira U,Matheus WE,Nardi Pedro R,Levi D'Ancona CA,Reis LO,Stopiglia RM,Denardi F,Rodrigues Netto N Jr,de Cássio Zequi S,da Fonseca FP,Lopes A,Cardoso Guimarães G,de Carvalho Fernandes R,Cardenuto Perez MDdoi
10.1159/000107950subject
Has Abstractpub_date
2007-01-01 00:00:00pages
200-3issue
3eissn
0042-1138issn
1423-0399pii
000107950journal_volume
79pub_type
杂志文章,多中心研究abstract::We report here a 70-year-old man with prostatic malacoplakia which is an extremely rare disease. This diagnosis was obtained from histological examination by prostatic biopsy because the patient was suspected having prostatic cancer on digital examination. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281024
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To assess the feasibility, problems and results of Nd-YAG laser core through urethrotomy in the management of failed urethroplasty for posttraumatic bulbomembranous urethral strictures. MATERIAL AND METHODS:61 patients with obliterative posttraumatic urethral strictures were treated by Nd-YAG laser core thro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000058448
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Multi-parametric magnetic resonance imaging (mpMRI)-directed biopsy for prostate cancer (PC) diagnosis improves the detection of clinically significant prostate cancer (CSPC) and decreases the rate of over-diagnosis of insignificant disease. The aim of this study was to investigate the value of mpMRI combine...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000500350
更新日期:2019-01-01 00:00:00
abstract::We present a new modified in vitro culture assay for primary human renal cell carcinoma similar to the 'soft agar clonogenic assay'. However, the carrying out and expense of metrology are more simplified, allowing tumor-specific chemotherapeutic drug sensitivity testing under easier conditions. Twelve different sample...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281178
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:The last decade has seen the emergence of a variety of supine positions for carrying out percutaneous nephrolithotomy (PCNL). These positions all differ with regard to ease of puncture under image guidance, operative field availability, ability to make and dilate multiple tracts and ease of combining retrogr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341430
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:This study aims to assess the impact of a virtual reality trainer in improving percutaneous renal access skills of urological trainees. METHODS:A total of 36 urology trainees participated in this prospective study. Initially, they were taken through the exercise of gaining access to the lower pole calyceal ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000337530
更新日期:2012-01-01 00:00:00
abstract::The pathophysiological considerations for regaining continence are discussed first. Our operation method for postprostatectomy incontinence is described and the results enumerated. The success rate is approximatively 80%. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281155
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of transobturator tape (TOT) in the management of stress urinary incontinence at a medium term follow-up. METHODS:TOT is a polypropylene tape positioned through the obturator foramen. 70 patients with type II urinary stress incontinence were treated with TOT between June 2003 and May 2...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000127340
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:The short-term effects of intravesical chemoimmunotherapy with epirubicin and bacillus Calmette-Guérin (BCG) administered repeatedly for prophylaxis of recurrence of superficial bladder cancer (pTa, pT1) were investigated in 24 patients aged a median of 70 years between March 1996 and February 1999, and were co...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000051005
更新日期:2001-01-01 00:00:00
abstract::In order to assess the clinical implications of the cytology of voided urine we analyzed 65 patients among 147 cases of transitional cell carcinoma (TCC) in relation to the cytohistologic correlation and prognostic significance. Urinary cytology detected 42.6% of bladder tumors, 59% of renal pelvic tumors, and 35.3% o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282625
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:To conduct a meta-analysis examining p53 expression as a potential risk factor in upper urinary tract urothelial carcinoma (UUT-UC) and to systematically review the available data. METHODS:A comprehensive literature review was performed from January 1991 to August 2012, using search engines such as PubMed, E...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000360227
更新日期:2015-01-01 00:00:00
abstract::The aim of the present paper was to review findings from the most relevant studies and to evaluate the value of current chemotherapy and surgery in advanced unresectable and metastatic bladder cancer. Studies were identified by searching the MEDLINE® and PubMed® databases up to 2011 using both medical subject heading ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000335556
更新日期:2012-01-01 00:00:00
abstract::Experience with chemodissolution of uric acid stones in 30 patients is presented. Chemodissolution was achieved either with infusion of 0.16 M i.v. lactate or oral sodium bicarbonate, in addition to liberal fluid intake and allopurinol wherever indicated. In some cases direct chemodissolution by in situ irrigation wit...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282302
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:This open label, phase I clinical trial (NCT02945462) using 2 consecutive intracavernous autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) for the first time in the treatment of diabetic patients with erectile dysfunction (ED). The primary outcome is to assess the safety and tolerability of int...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000492120
更新日期:2018-01-01 00:00:00
abstract:AIM:To determine efficacy and clinical predictors of stone fragmentation when using slow-rate shock wave lithotripsy (SWL). PATIENTS AND METHODS:In total, 116 patients with radiopaque urinary tract stones were randomized into two groups: 57 patients were treated with SWL at 90 shocks/min, and 59 patients were treated ...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000106324
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:We planned to examine the connection between serum uric acid (UA) values and prostatic calculi (PCal) presence and to evaluate the relation between PCal and other etiological factors. METHODS:Patients between 20 and 60 years of age who were referred to the clinic with any reason and had non-contrast abdomina...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000495313
更新日期:2019-01-01 00:00:00
abstract::In a series of 64 consecutive cases of transvesical prostatectomies it is shown that the use of a purse-string suture at the bladder neck significantly reduces the postoperative blood loss. A follow-up 3 months after operation has shown that the suture did not increase the number of either bladder neck stenoses, urina...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000280259
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVES:Improvements in quality of life (QoL) and disease-related symptoms are key goals in the treatment of hormone refractory prostate cancer (HRPC). Our aim was to evaluate the impact of gefitinib on QoL of patients with HRPC. METHODS:Patients with HRPC received gefitinib 250 mg daily in addition to antiandrogen...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000200800
更新日期:2009-01-01 00:00:00
abstract::The simultaneous subcutaneous injections of dihydrotestosterone (0.5 mg/kg) and/or ovine prolactin (5 or 50 IU/kg) to mature castrate rats for periods of 5-10 days led to an augmentation of prostate gland levels of RNA, DNA and protein. Of the various lobes of the prostate gland, the dorsal portion seemed to be partic...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280062
更新日期:1976-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study is to clarify the relationship of erectile dysfunction (ED) and diabetes mellitus (DM) parameters (referred to with '1'), including peripheral neuropathy (referred to with '2'). METHODS:(1) The DM parameters including age, serum levels of blood sugar, hemoglobin A1c, duration of DM a...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000327991
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The flexible ureterorenoscope (URS) and associated devices have developed rapidly. However, despite its therapeutic benefits, URS may be associated with some complications. To the best of our knowledge, there are no studies discussing the complications of flexURS during the learning curve. METHODS:A retrosp...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000368617
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The treatment approach for enuresis is controversial due to the lack of consensus as to the exact causes of nocturnal enuresis. Despite various treatment modalities, pharmacotherapy still appears to be the common choice. The aim of this prospective study was the evaluation of the efficacy of combination therapy...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000064858
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS:We genotype...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345630
更新日期:2013-01-01 00:00:00
abstract::An important aspect of modern extracorporeal shock wave lithotripsy is the ability to perform the procedure without anesthesia. Between June 1987 and April 1990, a total of 7,500 treatments were performed in our Lithotripsy Unit, using the Lithostar (Siemens AG, Erlangen, FRG): moreover 80% of the treatments were carr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282191
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:The study aimed to present our experience of surgical treatment for urorectal fistulas (URF) that develop after cancer surgery. MATERIALS AND METHODS:Fourteen patients with URF who were treated at our institution from 2005 through 2015 were retrospectively analyzed. Among these, 7 patients had previous su...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000457835
更新日期:2017-01-01 00:00:00
abstract::A retrospective analysis based on Robson's tumor stage classification was performed on 56 patients with renal cell carcinoma who had undergone radical nephrectomy through a lumbar flank approach and 35 who had through a transperitoneal approach. The 5-year survival rates of patients with nephrectomy through the lumbar...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281772
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:No established technique for locating solitary carcinoma in situ (CIS) of the urinary bladder or CIS accompanying bladder cancer has been determined. Here we investigated whether the location of CIS of the urinary bladder can be macroscopically ascertained by instilling pirarubicin hydrochloride (THP) into...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000083555
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to analyze the influence of residents' participation in flexible ureteroscopy (fURS) on intra- and postoperative outcomes. MATERIALS AND METHODS:Intra- and postoperative parameters were compared in a retrospective monocentric setting between 3 groups: "resident group" (47 cases) ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504989
更新日期:2020-01-01 00:00:00
abstract:AIM:To evaluate outcomes of laparoscopic adrenalectomy (LA) and laparoendoscopic single-site surgery (LESS) for adrenal masses in the light of changing laparoscopic surgical techniques. MATERIALS AND METHODS:Seventy-three patients were analyzed retrospectively. There were 2 groups; group 1 included patients who had co...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000351959
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:The aims of this study were to establish the prevalence of enuresis, to determine accompanying factors, and to identify common methods in the management of enuresis in Turkish children aged between 6 and 11 years living in eastern Anatolia. METHODS:The parents of 3,527 schoolchildren aged between 6 and 11...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000079696
更新日期:2004-01-01 00:00:00