Effects of prolactin and dihydrotestosterone upon the rat prostate gland.

Abstract:

:The simultaneous subcutaneous injections of dihydrotestosterone (0.5 mg/kg) and/or ovine prolactin (5 or 50 IU/kg) to mature castrate rats for periods of 5-10 days led to an augmentation of prostate gland levels of RNA, DNA and protein. Of the various lobes of the prostate gland, the dorsal portion seemed to be particularly sensitive to the effects of the combined hormone treatment. In general, the highest dose of prolactin (50 IU/kg) and the longer duration of administration (10 days) produced the most consistent augmentation responses between dihydrotestosterone and prolactin as compared to those rats receiving only androgen. These findings reveal that certain lobes of the prostate are more responsive to hormonal interactions, but do not clarify the mechanisms involved in causing such enhancements of prostate cell growth and proliferation.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Thomas JA,Manandhar MS,Keenan EJ,Edwards WD,Klase PA

doi

10.1159/000280062

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

265-71

issue

4

eissn

0042-1138

issn

1423-0399

journal_volume

31

pub_type

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