Location and characterization of GAPDS in male reproduction.

Abstract:

:Sperm-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) originates from spermatogenic cells of the human testis. A strong staining of GAPDS was detected in epididymal epithelium, especially in principal cells and basal cells of the epithelium. GAPDS also bound to the fibrous sheet of the sperm tail and inhibited the motility and penetration ability of sperms. The rat model showed that at postnatal day 28 the spermatogenic cells began to express GAPDS protein. By day 60 its expression decreased in spermatogenic cells while it increased in Sertoli cells. After sexual maturation (120 days) GAPDS protein was expressed in both Sertoli cells and elongated sperms. The expression of GAPDS gradually increased with age in the epididymis.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Liu J,Sun CM,Zhang CL,Wang X,Li JY

doi

10.1159/000345629

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

449-54

issue

4

eissn

0042-1138

issn

1423-0399

pii

000345629

journal_volume

90

pub_type

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