Abstract:
INTRODUCTION:We investigated the effects of standard oral anticholinergic treatment with tolterodine in children with neurogenic bladder over a 5-year follow-up period and focused on treatment satisfaction, patient compliance and urodynamic parameters. MATERIAL AND METHODS:The follow-up consisted of regular visits and urodynamic evaluation at least once a year. The patients or their parents were interviewed to evaluate voiding behavior, as well as factors leading to lower patient compliance and deterioration in urodynamic parameters. RESULTS:Of the 43 patients evaluated, 30 (70%) took their anticholinergic medication consistently and 13 (30%) sporadically. The mean bladder capacity was 354.7 ml in the first group but only 214.7 ml in the noncompliant group (p < 0.001). The mean maximal detrusor pressure decreased from 42.2 to 33.6 cm H(2)O in the compliant group (p < 0.001) and from 49.7 to 46.4 cm H(2)O in the noncompliant group (p = 0.21). The mean detrusor compliance increased from 18.9 to 19.3 ml/cm H(2)O in the compliant group (p = 0.63) and from 11.8 to 12.3 ml/cm H(2)O in the noncompliant group (p = 0.87). Side effects such as dry mouth (11/13) and dizziness (7/13) were common in the noncompliant group, whereas only 5/30 reported dry mouth in the compliant group. CONCLUSIONS:These data demonstrate the efficacy and tolerability of tolterodine over a long follow-up period. The results are promising in view of the fact that the patients will probably require life-long medication. Nevertheless, anticholinergic side effects still cause some patients to refuse regular medication, which results in a poorer urodynamic outcome.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Christoph F,Moschkowitsch A,Kempkensteffen C,Schostak M,Miller K,Schrader Mdoi
10.1159/000102915subject
Has Abstractpub_date
2007-01-01 00:00:00pages
55-9issue
1eissn
0042-1138issn
1423-0399pii
000102915journal_volume
79pub_type
杂志文章abstract::Between March 1983 and March 1988 we registered and treated 49 patients with bladder cancer less than 40 years of age (7 patients less than 30 years of age). Hematuria was present in 40 cases (81.6%). 33 of the patients had a pTA tumor (67.3%). 47 patients had transitional carcinoma of the bladder, of which 21 (44.7%)...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281475
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abstract::Extramedullary plasmacytomas of the testes are extremely rare tumors, especially when occurring in the absence of precocious or concurrent diagnosis of multiple myeloma. This is a case report of an 83-year-old man with a solitary plasmacytoma of the left testis. Immunoperoxidase studies, performed on histologic specim...
journal_title:Urologia internationalis
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
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abstract::During 1986 and 1987, 47 patients with renal cell carcinoma were evaluated preoperatively with CT, angiography and MRI. The preoperative tumor stage (T), lymph node metastases and venous involvement determined with the three methods were compared to the operative and histopathological findings. For T stage, angiograph...
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Urologia internationalis
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abstract:INTRODUCTION:We aimed to assess the outcome of free tube graft urethroplasty for single-stage repair of hypospadias with chordee in children. MATERIALS AND METHODS:We retrospectively evaluated a series of 56 patients (16 months to 9 years old, median 24 months) who underwent free graft urethroplasty for repair of hypo...
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