Outcomes of radical prostatectomy in clinically locally advanced N0M0 prostate cancer.

Abstract:

INTRODUCTION:Radical prostatectomy (RP) in patients with locally advanced (cT3) prostate cancer (PCa) is considered an optional therapy. AIM:To evaluate outcomes of surgery for cT3 disease and to compare results with those of patients treated for cT1-T2 PCa. PATIENTS AND METHODS:Data of 74 consecutive patients with cT3 N0M0 PCa who underwent RP were compared to those of 425 consecutive unselected patients who underwent surgery for cT1-T2 N0M0 disease. RESULTS:cT3: The pathological report showed a pathological downstaging in 16.3% of cases. Continence rate was 65.5%, potency rate was 38.8%, 5-year PSA-free survival was 61.9%, 5-year cancer-specific survival was 95.2%. cT1-T2: The pathological report showed a clinical downstaging in 39.1%. Continence rate was 70.8%, potency rate was 56.2%, 5-year PSA-free survival was 67.4%, 5-year cancer-specific survival was 96.0%. CONCLUSIONS:cT3 PCa presents challenges for the uro-oncologist since standard treatment is still under debate. RP in well-informed patients is a procedure with acceptable morbidity and should be at least a first part of a multimodality approach.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Mearini L,Zucchi A,Costantini E,Bini V,Nunzi E,Porena M

doi

10.1159/000316944

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

166-72

issue

2

eissn

0042-1138

issn

1423-0399

pii

000316944

journal_volume

85

pub_type

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