Bone-marrow-derived mesenchymal stem cell transplantation enhances closing pressure and leak point pressure in a female urinary incontinence rat model.

Abstract:

PURPOSE:The purpose of this study was to determine whether periurethral injection of allogenic mesenchymal stem cells (MSCs) could increase the leak point pressure (LPP) in a rat model of stress urinary incontinence. MATERIALS AND METHODS:Female Sprague-Dawley rats (230-240 g, n = 30) were divided into 3 groups: sham operation (group C), saline-treated (group S) and MSC-treated (group M). Bilateral pudendal nerve dissection followed by normal saline or MSC injection on both sides of the urethra was done. LPP and closing pressure (CP) testing was performed after the treatment. The specific markers for smooth muscle cells in the transplantation sites of the urethra were determined. RESULTS:Both the LPP and CP were significantly lower in group S than controls. However, these were restored to the control values in group M (p < 0.05). The LPPs of groups C, S and M were 29.1 ± 2.1, 22.0 ± 2.2 and 43.1 ± 3.2 cm H(2)O, respectively. The CPs of groups C, S and M were 27.1 ± 3.1, 21.1 ± 3.2, and 32.1 ± 2.1 cm H(2)O, respectively. The injected MSCs stained positive for muscle-specific markers. CONCLUSION:This study suggests that MSCs might differentiate into muscle lineage cells and may contribute to the repair of damaged muscle tissue.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Kim SO,Na HS,Kwon D,Joo SY,Kim HS,Ahn Y

doi

10.1159/000317322

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

110-6

issue

1

eissn

0042-1138

issn

1423-0399

pii

000317322

journal_volume

86

pub_type

杂志文章
  • Prognostic factors for upper urinary tract urothelial carcinoma after nephroureterectomy.

    abstract:INTRODUCTION:The purpose of this study was to evaluate prognostic factors for patients with upper urinary tract urothelial carcinoma (UUT-UC) after nephroureterectomy and to seek a better way of finding more favorable clinical results for these patients. PATIENTS AND METHODS:We retrospectively reviewed the medical rec...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000335274

    authors: Kuroda K,Asakuma J,Horiguchi A,Tasaki S,Yoshii H,Sato A,Ito K,Seguchi K,Sumitomo M,Asano T

    更新日期:2012-01-01 00:00:00

  • Comparison of the xenon-133 washout curve and radioactive microsphere distribution in the normal and hypoperfused dog kidney.

    abstract::Intrarenal blood flow distribution was measured in normal and hypoperfused dog kidneys by xenon-133 washout measurement in one kidney vary slightly in contrast to those done in different kidneys. In normal kidneys the ratio of compartment I (CI) flow to whole renal flow -- i.e., the CI fraction--as measured by the xen...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280818

    authors: Huland H,Leichtweiss HP,Schröder H,Jeschkies R

    更新日期:1982-01-01 00:00:00

  • Prediction of Biochemical Recurrence Following Radiotherapy among Patients with Persistent PSA after Radical Prostatectomy: A Single-Center Experience.

    abstract::Radiotherapy (RT) is applied in prostate cancer patients with a biochemical recurrence (BcR) after radical prostatectomy (RP). However, for the patients with persistent PSA but not undergoing the process of BcR, it remains unknown whether the application of RT can exempt them from the upcoming BcR. In this study, we i...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000488536

    authors: Xiang C,Liu X,Chen S,Wang P

    更新日期:2018-01-01 00:00:00

  • A study on staging bone scans in newly diagnosed prostate cancer.

    abstract:OBJECTIVE:This study aimed to evaluate the role of bone scan as a staging investigation in newly diagnosed untreated prostate cancers. MATERIALS AND METHODS:Bone scan results in patients with newly diagnosed prostate cancer were reviewed and correlated with clinical stage, prostate-specific antigen (PSA) and Gleason s...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000091620

    authors: Ayyathurai R,Mahapatra R,Rajasundaram R,Srinivasan V,Archard NP,Toussi H

    更新日期:2006-01-01 00:00:00

  • Healthcare-Associated Infections after Lower Urinary Tract Endoscopic Surgery: Analysis of Risk Factors, Associated Microorganisms and Patterns of Antibiotic Resistance.

    abstract:OBJECTIVES:To review the incidence of healthcare-associated infections/urinary tract infection (UTI), risk factors, microorganisms isolated and antibiotic resistances in patients who underwent lower urinary tract endoscopic surgery (LUTES) in a tertiary care hospital. METHODS:A prospective observational study was carr...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000488251

    authors: Sopeña-Sutil R,Medina-Polo J,Justo-Quintas J,Gil-Moradillo J,Garcia-Gonzalez L,Benítez-Sala R,Alonso-Isa M,Lara-Isla A,Tejido-Sanchez A

    更新日期:2018-01-01 00:00:00

  • Accordance of Online Health Information on Prostate Cancer with the European Association of Urology Guidelines.

    abstract:BACKGROUND:The internet is an emerging source of information for prostate cancer (PCa) patients. Since little is known about the quality of information on PCa provided online, we investigated its accordance to the latest European Association of Urology (EAU) guidelines. METHODS:A total of 89 German web pages were incl...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000487146

    authors: Bruendl J,Rothbauer C,Ludwig B,Dotzler B,Wolff C,Reimann S,Borgmann H,Burger M,Breyer J

    更新日期:2018-01-01 00:00:00

  • Prostatic malacoplakia.

    abstract::We report here a 70-year-old man with prostatic malacoplakia which is an extremely rare disease. This diagnosis was obtained from histological examination by prostatic biopsy because the patient was suspected having prostatic cancer on digital examination. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281024

    authors: Matsumoto T,Ih H,Yamada Y,Kumazawa J,Era S

    更新日期:1985-01-01 00:00:00

  • Laparoscopic management of renal tumors with macroscopic level 1 renal vein involvement.

    abstract:OBJECTIVE:To describe our surgical experience and clinical outcome in laparoscopic radical nephrectomy (LRN) for renal cell carcinoma (RCC) with level 1 renal vein tumor thrombus. PATIENTS AND METHODS:11 patients with RCC level 1 renal vein tumor thrombus were treated by LRN plus thrombectomy. The mean age was 66.8 ye...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000363580

    authors: Castillo O,Silva A,Alemán E

    更新日期:2015-01-01 00:00:00

  • Spoilt for Choice: A Survey of Current Practices of Surgical Urinary Stone Treatment and Adherence to Evidence-Based Guidelines among Swiss Urologists.

    abstract:INTRODUCTION:Urologists have to master a variety of techniques to be able to offer the most appropriate surgical stone treatment for each individual patient. Therefore, we performed a survey among board-certified Swiss urologists to assess the availability of the different surgical methods, the current practices of sur...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000502806

    authors: Betschart P,Zumstein V,Jichlinski P,Herrmann TRW,Knoll T,Engeler DS,Müllhaupt G,Schmid HP,Abt D

    更新日期:2019-01-01 00:00:00

  • Male stress incontinence. Diagnostic work-up and therapteutic considerations.

    abstract::Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphi...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280348

    authors: Thüroff JW,Petri E,Jonas U

    更新日期:1980-01-01 00:00:00

  • Pilot Experience with ABO-Incompatible Kidney Transplantation as a Second Transplant.

    abstract:BACKGROUND:Despite advances in immunosuppressant medications, improvement in long-term survival for kidney transplant recipients has been more difficult to achieve. In fact, the number of patients with failing grafts who must either return to dialysis or undergo a second transplant is increasing. Second transplantation...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000499490

    authors: Uchida J,Kosoku A,Kabei K,Nishide S,Shimada H,Iwai T,Kuwabara N,Naganuma T,Maeda K,Yoshikawa Y,Kumada N,Takemoto Y,Nakatani T

    更新日期:2019-01-01 00:00:00

  • Embolization of a segmental renal artery pseudoaneurysm after partial nephrectomy in a solitary kidney.

    abstract::Renal pseudoaneurysms are a well-documented complication following trauma or after percutaneous biopsy. When symptomatic, patients present with hematuria and deteriorating renal function. We present the case of a 62-year-old man who, due to development of a pseudoaneurysm, presented with gross hematuria 10 days after ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000030536

    authors: Chatziioannou A,Mourikis D,Awad M,Konstantinedes P,Panourgias E,Vlachos L

    更新日期:2000-01-01 00:00:00

  • Diagnostic value of 18F-FDG positron emission tomography for detection and treatment control of malignant germ cell tumors.

    abstract:INTRODUCTION:The role of positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is currently under evaluation in urologic oncology. The aim of the present study was to investigate the use of [18F]FDG positron emission tomography ([18F]FDG-PET) in the detection and treatment control of malign...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000048442

    authors: Tsatalpas P,Beuthien-Baumann B,Kropp J,Manseck A,Tiepolt C,Hakenberg OW,Burchert W,Franke WG,Wirth MP

    更新日期:2002-01-01 00:00:00

  • Outcome of repeat supratrigonal obstetric vesicovaginal fistula repair after previous failed repair.

    abstract:INTRODUCTION:Currently, surgical repair for vesicovaginal fistula (VVF) provides excellent results, but the recurrent VVF is difficult to treat as compared to primary. PATIENTS AND METHODS:Sixty-eight patients (44 primipara and 24 multipara) with recurrent VVF repair from January 2002 to December 2007 were included in...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000331503

    authors: Gupta NP,Mishra S,Mishra A,Seth A,Anand A

    更新日期:2012-01-01 00:00:00

  • Is There a Role for Double J Stent Culture in Contemporary Urology?

    abstract:INTRODUCTION:To present the incidence of bacterial colonization on ureteral double J stents (DJS); isolate the uropathogens; define the rate of multi-resistant bacteria strains (MRBS) and present their clinical importance. MATERIALS AND METHODS: The whole body of 105 DJSs was examined for the pr...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000486798

    authors: Kozyrakis D,Perikleous S,Chatzistamou SE,Kateris D,Soukias G,Karatzas A,Dimitriadis I

    更新日期:2018-01-01 00:00:00

  • Effects of antiproteases (aprotinin and gabexate-mesilate) on the postischemic vascular response of the kidney.

    abstract::Both under physiologic conditions and after short-term ischemia (1-3 min) kallikrein and locally synthesized prostaglandins contribute to control renal blood flow. In the present experiment the antiproteases aprotinin and gabexate-mesilate were administered to rabbits in an attempt to show whether the hemodynamic chan...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280880

    authors: Pflüger H,Maier M,Binder BR

    更新日期:1983-01-01 00:00:00

  • Enuresis prevalence and accompanying factors in schoolchildren: a questionnaire study from southeast Anatolia.

    abstract:INTRODUCTION:The aims of this study were to establish the prevalence of enuresis, to determine accompanying factors, and to identify common methods in the management of enuresis in Turkish children aged between 6 and 11 years living in eastern Anatolia. METHODS:The parents of 3,527 schoolchildren aged between 6 and 11...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000079696

    authors: Ozkan KU,Garipardic M,Toktamis A,Karabiber H,Sahinkanat T

    更新日期:2004-01-01 00:00:00

  • Management of a new isolated metastasis during sunitinib treatment in renal cell carcinoma patients: a lesson from two cases.

    abstract::Metastatic renal cell carcinoma (mRCC) is a difficult to treat malignancy and currently Sunitinib is a standard of care first-line therapy. A new metastasis during the treatment is considered a sign of drug failure and alternative therapeutic methods should be tried. Here, we report 2 cases of newly diagnosed isolated...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000321908

    authors: Shablak A,O'Dwyer J,Hawkins R,Board R

    更新日期:2011-01-01 00:00:00

  • Diagnosis and treatment of bladder endometriosis: state of the art.

    abstract:BACKGROUND:The bladder is the most common affected site in urinary tract endometriosis, being diagnosed during gynecologic follow-up. The surgical urological treatment might lead to good results. STUDY OBJECTIVE:To define the state of the art in the diagnosis and treatment of bladder endometriosis. METHODS:We perform...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000339519

    authors: Maccagnano C,Pellucchi F,Rocchini L,Ghezzi M,Scattoni V,Montorsi F,Rigatti P,Colombo R

    更新日期:2012-01-01 00:00:00

  • Bladder Leiomyosarcoma 25 Years after Treatment with Cyclophosphamide in Patient with History of Retinoblastoma.

    abstract::The objective of this case report is to present a rare bladder tumour in a young patient 25 years after the treatment with cyclophosphamide because of a neuroblastoma of the right eye. The first symptom of the tumour was macroscopic haematuria with dysuria and pollakiuria. The final diagnosis was dictaminated by the p...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000437442

    authors: Ramírez Sevilla C,Admella-Salvador C,Romero-Martin JA,Llopis-Manzanera J,Barranco-Sanz MA

    更新日期:2018-01-01 00:00:00

  • Serum Levels of MicroRNA371a-3p: A Highly Sensitive Tool for Diagnosing and Staging Testicular Germ Cell Tumours: A Clinical Case Series.

    abstract:INTRODUCTION:MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven. PATIENTS, METHODS:In 312 consecutive cases with various testicular diseases, serum levels of miR371a-3p were measured. Measurement results ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000477446

    authors: Anheuser P,Radtke A,Wülfing C,Kranz J,Belge G,Dieckmann KP

    更新日期:2017-01-01 00:00:00

  • Carcinosarcoma of the spermatic cord.

    abstract::The first case of carcinosarcoma in the spermatic cord is reported in a 40-year-old man. The tumor was a 2.5 X 2 cm pseudoencapsulated formation located in the connective tissue of the spermatic cord among the blood vessels. Light microscopy examination of the neoplasm revealed two different histological patterns: epi...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281727

    authors: Nistal M,Burgos F,Paniagua R

    更新日期:1990-01-01 00:00:00

  • Copper, zinc, and Cu/Zn ratio in transitional cell carcinoma of the bladder.

    abstract:INTRODUCTION:Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, involvement of trace elements in the tumorigenesis of transitional cell carcinoma of the bladder has been poorly investigated. The aim of this study was to examine the rela...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000341976

    authors: Golabek T,Darewicz B,Borawska M,Socha K,Markiewicz R,Kudelski J

    更新日期:2012-01-01 00:00:00

  • Sex-dependent urolithiasis in the portacaval shunt rat. 2. Hormones and stone formation.

    abstract::Sex-dependent stone formation following portacaval shunt (PCS) was investigated in 82 male and 71 female Sprague-Dawley rats. 72.6% of male PCS rats and none of the female PCS rats developed urolithiasis, in 90.2%, potassium-hydrogen-urate stones formed. Hormonal analysis revealed significant alterations in steroid ho...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282544

    authors: Heidenreich A,Engelmann U

    更新日期:1993-01-01 00:00:00

  • Changing surgical approaches for laparoscopic adrenalectomy: single-surgeon data of a 6-year experience.

    abstract:AIM:To evaluate outcomes of laparoscopic adrenalectomy (LA) and laparoendoscopic single-site surgery (LESS) for adrenal masses in the light of changing laparoscopic surgical techniques. MATERIALS AND METHODS:Seventy-three patients were analyzed retrospectively. There were 2 groups; group 1 included patients who had co...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000351959

    authors: Arslan M,Akin Y,Ates M,Degirmenci T,Kozacioglu Z,Ors B,Gunlusoy B

    更新日期:2013-01-01 00:00:00

  • Influence of papaverine on rat bladder contractions in vivo.

    abstract::In an acute rat model (in vivo) spontaneous rhythmic bladder contractions were induced by ligation of the urethra. In addition single bladder contractions were recorded during neurostimulation of the pelvic nerve. Spontaneous and electrically induced bladder contractions were sensitive to papaverine and isoprenaline i...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282425

    authors: Diederichs W,Majewski H,Graff J

    更新日期:1992-01-01 00:00:00

  • Efficacy of low-molecular-weight heparin and unfractionated heparin to prevent adhesion of human prostate and bladder carcinoma and melanoma cells to bovine endothelial monolayers. An in vitro study and review of the literature.

    abstract::Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Cu...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282848

    authors: Lersch C,Gericke D,Classen M

    更新日期:1996-01-01 00:00:00

  • Outcome of Selective Renal Artery Embolization in Managing Severe Bleeding after Percutaneous Nephrolithotomy.

    abstract:OBJECTIVES:The aim of this study was to evaluate the characteristics of the renal arterial segment bleeding and assess the outcome of selective renal artery embolization (SRAE). METHODS:Data on 35 patients in whom SRAE was performed after percutaneous nephrolithotomy (PCNL) from January 2005 to December 2015 in our in...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000508797

    authors: Hong Y,Xiong L,Ye H,An L,Huang X,Xu Q

    更新日期:2020-01-01 00:00:00

  • Collagen graft interposition in vesicovaginal fistula treatment.

    abstract::Vesicovaginal fistula (VVF) is a quite rare complication of gynecological surgery. The first attempt to repair the fistulous tract offers the best opportunity for cure. We report the successful repair of VVF in 2 patients using a combined anterior vaginal approach and porcine dermal collagen grafting as interposition ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000176038

    authors: Robles JE,Saiz A,Rioja J,Brugarolas X,Berian JM

    更新日期:2009-01-01 00:00:00

  • Primary invasive versus progressive invasive transitional cell bladder cancer: multicentric study of overall survival rate.

    abstract:INTRODUCTION AND OBJECTIVE:When feasible, the treatment for all-invasive bladder cancer is radical cystectomy. The aim of the present study was to analyze the prognostic difference, disease-specific survival rate, of muscle-invasive transitional cell cancer of the bladder (TCCB) for progressive invasive TCCB. PATIENTS...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000107950

    authors: Ferreira U,Matheus WE,Nardi Pedro R,Levi D'Ancona CA,Reis LO,Stopiglia RM,Denardi F,Rodrigues Netto N Jr,de Cássio Zequi S,da Fonseca FP,Lopes A,Cardoso Guimarães G,de Carvalho Fernandes R,Cardenuto Perez MD

    更新日期:2007-01-01 00:00:00