Abstract:
:Radiotherapy (RT) is applied in prostate cancer patients with a biochemical recurrence (BcR) after radical prostatectomy (RP). However, for the patients with persistent PSA but not undergoing the process of BcR, it remains unknown whether the application of RT can exempt them from the upcoming BcR. In this study, we identified 104 patients treated with RP who had persistent PSA level >0.1 but ≤0.2 ng/mL at 6-8 weeks after RP, of which 52 were treated with postoperative RT. Overall, 51 patients experienced BcR, among which 20 patients were treated with postoperative RT. The 5-year BCR-free survival rate of patients treated with or without postoperative RT was 96.2 and 50.0% respectively. Subgroup analysis showed that statistical differences in BcR-free survival were observed regarding to applying RT on patients with Gleason score ≤7 (p = 0.0365), with pathological tumor stage T2 or T3 (p = 0.0210 and p = 0.0073, respectively), without or with lymph node invasion (p = 0.0118 and p = 0.0303, respectively), with positive surgical margins (p < 0.0001), and with Pre-RT PSA ≤0.5 ng/mL (p < 0.0001). In multivariate analyses, PSA after surgery, Gleason score, pathological tumor stage, immediate androgen deprivation therapy after RP, and postoperative RT were significant predictors of BcR for patients with persistently elevated PSA (all p < 0.05). Finally, a coefficient-based nomogram was constructed with an excellent C-index for 5-year BCR prediction (0.76, 95% CI 0.73-0.79). These findings suggested that postoperative RT affords excellent control in BcR for patients with persistent PSA after surgery.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Xiang C,Liu X,Chen S,Wang Pdoi
10.1159/000488536subject
Has Abstractpub_date
2018-01-01 00:00:00pages
47-55issue
1eissn
0042-1138issn
1423-0399pii
000488536journal_volume
101pub_type
杂志文章abstract:PURPOSE:To evaluate the association between dyslipidemia and nephrolithiasis risk in a Chinese population. MATERIALS AND METHODS:Fasting plasma lipid profiles were measured in a case-control study of 540 nephrolithiasis cases and 656 kidney stone-free controls. RESULTS:Triglycerides (TG) levels were significantly hig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496208
更新日期:2019-01-01 00:00:00
abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000209374
更新日期:2009-01-01 00:00:00
abstract::The introduction in 1982 of vasoactive agents for intracavernous injection represents a milestone in the diagnosis and treatment of erectile dysfunction. Two preparations, the single drug papaverine hydrochloride and the combination of phentolamine mesylate and papaverine hydrochloride, hold great promise. In the last...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281308
更新日期:1988-01-01 00:00:00
abstract::We report on a 32-year-old man with a history of chronic lower abdominal pain and urogenital symptoms, leading to the diagnosis of coloseminal fistula complicating diverticular disease. We reviewed the literature on this rare clinical entity and would like to stress the role of pelvic imaging with rectal contrast to i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000353351
更新日期:2014-01-01 00:00:00
abstract:AIM:To determine efficacy and clinical predictors of stone fragmentation when using slow-rate shock wave lithotripsy (SWL). PATIENTS AND METHODS:In total, 116 patients with radiopaque urinary tract stones were randomized into two groups: 57 patients were treated with SWL at 90 shocks/min, and 59 patients were treated ...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000106324
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:The role of positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is currently under evaluation in urologic oncology. The aim of the present study was to investigate the use of [18F]FDG positron emission tomography ([18F]FDG-PET) in the detection and treatment control of malign...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000048442
更新日期:2002-01-01 00:00:00
abstract::Urethral diverticula are pouches opening into the urethral canal that may be either acquired or congenital. Diverticula of the female urethra are fairly common. However, diverticula of the male urethra are relatively uncommon abnormalities. Clinical manifestation is frequently described with irritative and/or obstruct...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000346321
更新日期:2013-01-01 00:00:00
abstract::The adreno-renal-ureteral sheath is described, showing the continuity of the anterior and posterior leaves of the sheath along the entire length of the retroperitoneum of each side. The study is based on anatomical dissections and on surgical observations. Anatomical and pathological considerations are discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280049
更新日期:1976-01-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective study was to examine the ability of the Snap-Gauge band to differentiate organic from psychogenic erectile dysfunction (ED). PATIENTS AND METHODS:Nocturnal penile tumescence testing was performed on 12 patients using a Snap-Gauge band and RigiScan Plus. A total of 29 nightly exami...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071103
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To conduct a meta-analysis examining p53 expression as a potential risk factor in upper urinary tract urothelial carcinoma (UUT-UC) and to systematically review the available data. METHODS:A comprehensive literature review was performed from January 1991 to August 2012, using search engines such as PubMed, E...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000360227
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to describe a novel negative-pressure laser lithotripsy device to overcome the deficiencies of the conventional procedure. PATIENTS AND METHODS:Between August 2018 and March 2019, 78 patients with a single ureteral stone underwent retrograde ureteroscopy with a Wolf 8F/9.8F rigid u...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000507266
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:This study was undertaken to investigate the effects of two different alpha(1)-adrenergic blockers on bladder hypertrophy using ultrasound-estimated bladder weight (UEBW) and to assess the relation between changes in UEBW and other objective and subjective parameters of disease severity in patients with be...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000089734
更新日期:2006-01-01 00:00:00
abstract::The major difficulties encountered in the surgical correction of pediatric communicating hydroceles are separating the hernial sac from the spermatic vessels and vas, and identifying the anatomical location of the internal inguinal ring. The passage of a pediatric Foley catheter through the hernial sac via a high scro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281250
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:IL-6 has been reported to be a significant prognostic factor for prostate cancer and induces synthesis of C-reactive protein (CRP) by hepatocytes. The present study was undertaken to evaluate the clinical value of serum CRP in prostate cancer patients with metastases. METHODS:The prognostic significance of ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000112601
更新日期:2008-01-01 00:00:00
abstract::During infancy, the renal parenchyma and pelvicalyceal system are relatively fragile. Therefore, percutaneous nephrolithotomy for the management of renal stones in this age group is a challenging procedure for urologists. Herein, we present the uneventful management of bilateral renal stones using micropercutaneous ne...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000360645
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Multi-parametric magnetic resonance imaging (mpMRI)-directed biopsy for prostate cancer (PC) diagnosis improves the detection of clinically significant prostate cancer (CSPC) and decreases the rate of over-diagnosis of insignificant disease. The aim of this study was to investigate the value of mpMRI combine...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000500350
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to analyze the influence of residents' participation in flexible ureteroscopy (fURS) on intra- and postoperative outcomes. MATERIALS AND METHODS:Intra- and postoperative parameters were compared in a retrospective monocentric setting between 3 groups: "resident group" (47 cases) ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504989
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of fesoterodine extended-release (ER) plus tamsulosin in men with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:Men aged ≥50 years, with LUTS, prostate volume ≤60 ml and International Prostate Symptom Score (IP...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000345050
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:This study aimed at comparing the urinary protein levels in calcium stone formers with those of healthy individuals. PATIENTS AND METHODS:From January 2002 until June 2004, 100 calcium stone formers (mean age 38.6 +/- 10.3 years), who had at least two episodes of calcium stone formation, were compared with 1...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000090882
更新日期:2006-01-01 00:00:00
abstract::During a 2-year period, 37 patients with symptomatic metastatic prostatic cancer were included in a prospective randomized phase-III trial. Nineteen patients were randomized to subcapsular orchiectomy, and 18 to cyproterone acetate (CPA) treatment with a dose of 50 mg b.i.d. The median age of the patients was 74 years...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282125
更新日期:1991-01-01 00:00:00
abstract::The overactive bladder syndrome (OAB) negatively affects the daily life of many people. Conservative treatments, such as antimuscarinics, do not always lead to sufficient improvement of the complaints and/or are often associated with considerable side effects resulting in treatment failure. In the case of failure or i...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000288223
更新日期:2010-01-01 00:00:00
abstract::Prostate volume in multiparametric MRI (mpMRI) is of clinical importance. For 3-Tesla mpMRI without endorectal coil, there is no distinctive standard for volume calculation. We tested the accuracy of the ellipsoid formula with planimetric volume measurements as reference and investigated the correlation of gland volum...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000448593
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:To analyze positive surgical margins (PSM) after radical prostatectomy (RP) in the overall population and in patients previously treated with transurethral resection of the prostate (TURP). MATERIALS AND METHODS:2,408 patients treated with RP for clinically localized prostate cancer (PCa) were consecutively ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000346748
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the feasibility and safety of bilateral single-session ureteroscopy in the treatment of bilateral stones with different localizations. MATERIALS AND METHODS:Between February 2001 and October 2006, a total of 1,296 patients underwent ureteroscopy with pneumatic lithotripsy. Of these, 38 patient...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000144061
更新日期:2008-01-01 00:00:00
abstract::Penile prosthesis was implanted for erectile impotence of mainly organic origin in 104 patients. The AMS Dynaflex penile prosthesis was inserted in 39 cases, the AMS Malleable 600 prosthesis in 61 and the AMS Ultrex Plus prosthesis in 4. In 1 patient receiving a malleable prosthesis both rods had to be removed owing t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282820
更新日期:1996-01-01 00:00:00
abstract::Of 15 patients with primary aldosteronism, 7 had idiopathic adrenal hyperplasia (IHA) and 8 had aldosterone-producing adenoma (APA). In order to determine any renal problems involved in the treatment, the renal clearance of these patients was analyzed and the results compared with those obtained from 12 patients with ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281962
更新日期:1987-01-01 00:00:00
abstract::In a 3-year study, silicone rubber prostheses were implanted in 6 minipigs as ureteric replacement. A Dacron velour cuff was applied for the proximal anastomosis and a disc of the same material implanted into the bladder wall to anchor the prosthesis distally. The silicone tube incorporated a metal spiral to prevent k...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280953
更新日期:1984-01-01 00:00:00
abstract::Twenty-five patients with transitional cell carcinoma of the bladder have been treated with combined therapy consisting of microwave regional coagulation and intracavitary irradiation. A remote-controlled after-loading system was utilized for the radiation therapy. The follow-up period ranged from 6 to 19 months with ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281330
更新日期:1988-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000209354
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in syner...
journal_title:Urologia internationalis
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00