Abstract:
:Both under physiologic conditions and after short-term ischemia (1-3 min) kallikrein and locally synthesized prostaglandins contribute to control renal blood flow. In the present experiment the antiproteases aprotinin and gabexate-mesilate were administered to rabbits in an attempt to show whether the hemodynamic changes produced by 60 min of normothermic ischemia, i.e., postischemic hyperemia and reduction of vascular resistance, were equally mediated by kallikrein. Vascular responses were evaluated by determining renal cortical blood flow using radioactively labelled microspheres, by calculating vascular resistances, and by measuring the diameters of renal medullary vessles. Kidneys exposed to normothermic ischemia and sham-operated control organs of animals treated with aprotinin (2 X 40,000 KIU/kg body weight) and gabexate-mesilate (2 X 7 mg/kg body weight) were compared with those of rabbits which were analogously operated, but did not receive any drugs. As the antiproteases used did not significantly affect the hyperemia and the reduction of renal cortical vascular resistance seen after 60 min of normothermic ischemia, these phenomena are apparently not mediated by kallikrein. Renal medullary vasodilatation (arteriolae rectae) was significantly lower under aprotinin than in untreated ischemic kidneys, and was not longer demonstrable in gabexate-mesilate-treated animals. Thus, the effect of gabexate-mesilate was superior to that of aprotinin. Whether the antiprotease action is due to an unspecific membrane-stabilizing, to a general enzyme-inhibiting, or to a specific kallikrein-inhibiting effect, is still unclear.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Pflüger H,Maier M,Binder BRdoi
10.1159/000280880subject
Has Abstractpub_date
1983-01-01 00:00:00pages
150-7issue
3eissn
0042-1138issn
1423-0399journal_volume
38pub_type
杂志文章abstract::During the past 10 years, buccal mucosa grafting for urethroplasty has gained widespread acceptance. In general the reported success rates are 80% and higher. Typical complications are recurrent strictures, fistula, and, especially when the technique of ventral onlay urethroplasty has been used, sacculations that are ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000096344
更新日期:2006-01-01 00:00:00
abstract:AIMS:The urodynamic findings and voiding habits in patients with concomitant clinical benign prostatic hyperplasia (BPH) and detrusor overactivity (DO) presenting with or without the symptom of urgency were compared. MATERIALS AND METHODS:84 BPH patients with an urodynamic diagnosis of DO by conventional cystometry we...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000099341
更新日期:2007-01-01 00:00:00
abstract::This paper presents a case of gas-forming infection of the urinary tract in a diabetic patient. Plain film and computed tomography scans of the abdomen greatly facilitated clarification of the entire inflammatory process. The patient was cured by early nephrectomy conducted following unsuccessful treatment by percutan...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282602
更新日期:1994-01-01 00:00:00
abstract:PURPOSE:Chronic renal damage due to tubulointerstitial fibrosis is one of several complications of posterior urethral valves in a significant number of children. As activation of the renin-angiotensin system plays an important role in this injury, we conducted this study to investigate whether administration of captopr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000098078
更新日期:2007-01-01 00:00:00
abstract::Penile prosthesis was implanted for erectile impotence of mainly organic origin in 104 patients. The AMS Dynaflex penile prosthesis was inserted in 39 cases, the AMS Malleable 600 prosthesis in 61 and the AMS Ultrex Plus prosthesis in 4. In 1 patient receiving a malleable prosthesis both rods had to be removed owing t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282820
更新日期:1996-01-01 00:00:00
abstract::Myelolipomas are rare benign neoplasms of the adrenal glands, characterized by the presence of adipose tissue and elements of bone marrow in various degrees of differentiation. Usually asymptomatic, they are discovered incidentally or at autopsy; sometimes larger masses may cause local symptoms. We report clinical, ra...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282612
更新日期:1994-01-01 00:00:00
abstract::A case of primary carcinoma of the urinary bladder associated with a primary retroperitoneal leiomyosarcoma is presented. Due to the lack of early symptoms, diagnosis of the retroperitoneal leiomyosarcoma was late and therefore the prognosis was poor. Twelve months after diagnosis the patient died not of the bladder t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282996
更新日期:1997-01-01 00:00:00
abstract::The anterior nutcracker syndrome is defined by the compression of the left renal vein between the aorta and superior mesenteric artery, usually related to the occurrence of hematuria. We report the case of an uncommon complication of the nutcracker syndrome. A 75-year-old woman was referred to our institution for left...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000381270
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To report continence and urodynamic findings after radical cystectomy and urinary diversion with modified S-ileal neobladder between January 1993 and January 2013. PATIENTS AND METHODS:181 patients were enrolled. Continence status, reservoir sensation, compliance, capacity and activity were assessed. RESULT...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000356283
更新日期:2014-01-01 00:00:00
abstract::The introduction in 1982 of vasoactive agents for intracavernous injection represents a milestone in the diagnosis and treatment of erectile dysfunction. Two preparations, the single drug papaverine hydrochloride and the combination of phentolamine mesylate and papaverine hydrochloride, hold great promise. In the last...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281308
更新日期:1988-01-01 00:00:00
abstract:INTRODUCTION:This study was undertaken to investigate the effects of two different alpha(1)-adrenergic blockers on bladder hypertrophy using ultrasound-estimated bladder weight (UEBW) and to assess the relation between changes in UEBW and other objective and subjective parameters of disease severity in patients with be...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000089734
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Despite advances in immunosuppressant medications, improvement in long-term survival for kidney transplant recipients has been more difficult to achieve. In fact, the number of patients with failing grafts who must either return to dialysis or undergo a second transplant is increasing. Second transplantation...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000499490
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To present a review of the literature using evidence-based criteria for diagnosis and treatment of malignant growths in the ureteric remnant following nephrectomy for non-malignant disease. METHODS:A database search using the key search words was performed, producing a total of 16 articles published between ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000349884
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Planification of living donor nephrectomy requires exact knowledge of the renal vascular architecture because of the high prevalence of anatomical variants. After magnetic resonance angiography (MRA) challenged CT angiography for preoperative assessment over the last years, we revisit in this study the rel...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000273467
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To assess the association between the development of a urethral stricture (US) and disease-free survival for patients with localized prostate cancer treated with high-intensity focused ultrasound (HIFU). PATIENTS AND METHODS:Patients with clinical stage T1-T2N0M0 prostate cancer were eligible for treatment wit...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000330909
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND/AIMS:Periurethral cysts are a rare entity that may be confused with urethral diverticula. The protocol for diagnosis and management of these lesions is still unclear. We present our experience with six patients presenting with periurethral cysts. METHODS:From 2001 to 2005 we evaluated six patients with a pa...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000098068
更新日期:2007-01-01 00:00:00
abstract::The purpose of this study is to evaluate the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections and the related risk factors among urologic surgery patients and urologists. This cross-sectional, prospective study included 300 consecutive urologic surgery patients and 24 urologists working in ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030330
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To describe our surgical experience and clinical outcome in laparoscopic radical nephrectomy (LRN) for renal cell carcinoma (RCC) with level 1 renal vein tumor thrombus. PATIENTS AND METHODS:11 patients with RCC level 1 renal vein tumor thrombus were treated by LRN plus thrombectomy. The mean age was 66.8 ye...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363580
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Epididymitis is an inflammation or infection of the epididymis, a convoluted duct that lies on the posterior surface of the testicle. Oxidative stress due to excessive production of reactive oxygen species in epididymitis, impaired antioxidant defense mechanisms, or both, precipitates a range of pathologie...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000092063
更新日期:2006-01-01 00:00:00
abstract::In unilateral kidney disease, it has been suggested that the ipsilateral state could be estimated by measuring contralateral kidney size; thus, a contralateral increase should reflect an ipsilateral impairment and vice versa. This could easily be performed using ultrasound. In our experiments with partial obstruction ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282898
更新日期:1996-01-01 00:00:00
abstract::Dissemination of tumor cells by vascular channels seems to be enhanced by certain surgical procedures, e.g. transurethral resection of the prostate, an operative procedure commonly used in the diagnosis and management of prostatic cancer, the third biggest killer of men in the United States. Circulating tumor cells ha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281298
更新日期:1988-01-01 00:00:00
abstract::During a 2-year period, 37 patients with symptomatic metastatic prostatic cancer were included in a prospective randomized phase-III trial. Nineteen patients were randomized to subcapsular orchiectomy, and 18 to cyproterone acetate (CPA) treatment with a dose of 50 mg b.i.d. The median age of the patients was 74 years...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282125
更新日期:1991-01-01 00:00:00
abstract::The sequential expressed prostatic secretion (EPS) levels of latamoxef (LMOX) were measured in 14 patients with acute bacterial prostatitis to evaluate the diffusion of this antibiotic from the plasma into the prostatic fluid. All patients received 2 g of LMOX on the 1st, 4th, and 7th days of hospitalization. The mean...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282760
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS:We genotype...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345630
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the therapeutic efficacy of a steroid switch from prednisone to dexamethasone in Asians with metastatic castration-resistant prostate cancer (mCRPC) that progressed after docetaxel chemotherapy. METHODS:This study included postdocetaxel patients with mCRPC treated with abiraterone acetate combine...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000509882
更新日期:2020-08-13 00:00:00
abstract:INTRODUCTION AND AIM:Surgical vasectomy remains the gold standard for fertility control in men. Endoluminal occlusion of the seminal ducts, thus avoiding an external incision, may become an appealing alternative to this approach. As our group has shown, nontraumatic endoscopic inspection of the seminal ducts is feasibl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000478790
更新日期:2017-01-01 00:00:00
abstract::This is the first report of urothelial carcinoma (UC) in a hemodialysis (HD) patient treated with almost the same doses of gemcitabine and paclitaxel (GP) as those administered to patients with normal renal function. There have been some reports of UC treated with cisplatin-based chemotherapy in HD patients. However, ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000327511
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Open radical cystectomy (ORC) is the gold standard of treatment for muscle-invasive bladder cancer. Laparoscopic radical cystectomy (LRC) has emerged to provide an alternative. METHODS:Between 2006 and 2012, 155 patients who underwent LRC or ORC were compared (mean follow-up 53 months). RESULTS:The ORC gro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350237
更新日期:2013-01-01 00:00:00
abstract::Inguinoscrotal herniation of the ureter is a rare finding with the potential for serious surgical complications. Two anatomic forms are defined. In the more common paraperitoneal variant, the herniating peritoneal sac drags the ureter and sometimes other abdominal structures with it. The uncommon variant--extraperiton...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000224879
更新日期:2009-01-01 00:00:00
abstract::We present a new modified in vitro culture assay for primary human renal cell carcinoma similar to the 'soft agar clonogenic assay'. However, the carrying out and expense of metrology are more simplified, allowing tumor-specific chemotherapeutic drug sensitivity testing under easier conditions. Twelve different sample...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281178
更新日期:1986-01-01 00:00:00