Sequential changes in the prostatic fluid level of latamoxef in patients with acute bacterial prostatitis.

Abstract:

:The sequential expressed prostatic secretion (EPS) levels of latamoxef (LMOX) were measured in 14 patients with acute bacterial prostatitis to evaluate the diffusion of this antibiotic from the plasma into the prostatic fluid. All patients received 2 g of LMOX on the 1st, 4th, and 7th days of hospitalization. The mean LMOX level in EPS and the EPS/serum ratio were 16.4 micrograms/ml and 0.24 on the 1st day, 5.5 micrograms/ml and 0.08 on the 4th day, and 3.5 micrograms/ml and 0.04 on the 7th day, respectively. The mean value of prostatic fluid was 7.7, 7.8, and 7.8, respectively. Thus, both the EPS level of LMOX and the EPS/serum ratio decreased along with the recovery from acute bacterial prostatitis and did not correlate with the pH gradient between prostatic fluid and plasma.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Itoh M,Katoh N,Ono Y,Ohshima S,Miyake K

doi

10.1159/000282760

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

101-4

issue

2

eissn

0042-1138

issn

1423-0399

journal_volume

55

pub_type

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