Abstract:
INTRODUCTION:Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with those obtained by ORC. PATIENTS AND METHODS:We retrospectively analyzed the data of 50 patients with MIBC treated by trimodal chemoradiotherapy with cisplatin (CDDP-radiation [CDDP-R]). Transurethral resection of the bladder tumor (TURBT) was performed before treatment to confirm pathological stage ≥T2. Extensive TURBT was performed after chemoradiotherapy to evaluate the pathological response to treatment. We compared the survival outcomes of our CDDP-R with those of ORC (retrospective cohort, n = 205) by propensity score matching analysis. RESULTS:The 2- and 5-year progression-free survival, bladder-intact survival, cancer-specific survival, and overall survival (OS) rates after treatment were 70.8 and 63.9%, 64.0 and 49.8%, 86.7 and 71.8%, and 84.3 and 64.8%, respectively. The 2- and 5-year OS rates after CDDP-R were 90.5 and 74.3%, respectively, and those after ORC were 71.8 and 59.9%, respectively, indicating a significant survival advantage conferred by CDDP-R over ORC (p < 0.05, HR 0.45, 95% CI 0.21-0.94). CONCLUSIONS:In selected patients, CDDP-R for MIBC may provide comparative oncological outcomes as ORC.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Nagao K,Hara T,Nishijima J,Shimizu K,Fujii N,Kobayashi K,Kawai Y,Inoue R,Yamamoto Y,Matsumoto H,Matsuyama Hdoi
10.1159/000477912subject
Has Abstractpub_date
2017-01-01 00:00:00pages
446-452issue
4eissn
0042-1138issn
1423-0399pii
000477912journal_volume
99pub_type
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000051005
更新日期:2001-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,多中心研究
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journal_title:Urologia internationalis
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Urologia internationalis
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-01-01 00:00:00
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更新日期:2015-01-01 00:00:00
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更新日期:2003-01-01 00:00:00
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更新日期:2008-01-01 00:00:00