Abstract:
BACKGROUND:No relevant data have been published on the impact of retroperitoneal lymph node dissection (LND) on clinical outcome in patients with castration-resistant prostate cancer. METHODS:We retrospectively studied the records of 6 patients with lymph node metastases from castration-resistant prostate cancer who underwent a retroperitoneal LND between 2005 and 2010. Complication rate and clinical outcome were examined. RESULTS:Mean patient age was 69.2 (63-81) years. Primary therapy was radical prostatectomy, radiation therapy, or pelvic LND and androgen deprivation in 3, 2 and 1 cases, respectively. Mean prostate-specific antigen (PSA) at LND was 37.6 (20.3-139) ng/dl. LND was performed as a modified unilateral (n = 3), bilateral (n = 1) and bilateral extended (n = 2) approach with a median lymph node density of 0.739 (0.111-1). Preoperative Charlson index was 0 (n = 3) or 1 (n = 3). No intra- or postoperative complications occurred. The average postoperative decline of PSA was 39.3% (-99.4 to +31.3). Differences between mean pre- and postoperative PSA velocities and densities were 23.9 ng/ml/year and 11.2 months, respectively (p = 0.24 and p = 0.40). Four patients (67%) developed bone metastases after a mean period of 23.5 (5-58) months. Median bone metastases-free survival was 15.5 months and median overall survival after LND was 31.7 months on Kaplan-Meier analysis. CONCLUSIONS:A selective LND in castration-resistant prostate cancer patients could be safely performed. A positive effect on the PSA and PSA kinetics was accomplished for the majority of patients. This new surgical approach represents an alternative treatment option in the palliative setting of prostate cancer patients and could delay toxic systemic therapy up to 12 months.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Busch J,Hinz S,Kempkensteffen C,Erber B,Klopf C,Weikert S,Miller K,Magheli Adoi
10.1159/000335206subject
Has Abstractpub_date
2012-01-01 00:00:00pages
441-6issue
4eissn
0042-1138issn
1423-0399pii
000335206journal_volume
88pub_type
杂志文章abstract::A 63-year-old man underwent inguinal orchiectomy for painless enlargement of the left testis. The diagnosis of malignant gonadal stromal tumor was made on the basis of morphology and immunohistochemical studies. At computed tomography there was bulky retroperitoneal metastasis. The patient then underwent retroperitone...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000283061
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abstract:INTRODUCTION:Epididymitis is an inflammation or infection of the epididymis, a convoluted duct that lies on the posterior surface of the testicle. Oxidative stress due to excessive production of reactive oxygen species in epididymitis, impaired antioxidant defense mechanisms, or both, precipitates a range of pathologie...
journal_title:Urologia internationalis
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
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abstract::In 1 out of 56 patients, orchiectomized in the course of treatment for prostatic carcinoma, metastatic growth in the testis was found. This uncommon metastatic spread is a sign of advanced disease. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281859
更新日期:1987-01-01 00:00:00
abstract::The alpha-adrenergic innervation of the functional urethra is a well-known fact, while beta-adrenergic influence is rather unknown until now. We studied the influence of beta-stimulating and beta-blocking agents on the human urethra by the urethral pressure profile (UPP). A decrease of the UPP under orciprenaline sulf...
journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
pub_type: 杂志文章
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abstract:BACKGROUND:The principle of treating male infertility in those with chromosomal aberrations should change according to progress in treatment modalities. METHODS:In this study, ten patients with Robertsonian translocation were assessed for their cytogenetic and clinical characteristics to establish guidelines for treat...
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journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282018
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更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1986-01-01 00:00:00
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更新日期:1997-01-01 00:00:00
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journal_title:Urologia internationalis
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更新日期:1996-01-01 00:00:00