Abstract:
INTRODUCTION AND AIM:Surgical vasectomy remains the gold standard for fertility control in men. Endoluminal occlusion of the seminal ducts, thus avoiding an external incision, may become an appealing alternative to this approach. As our group has shown, nontraumatic endoscopic inspection of the seminal ducts is feasible in the human cadaver. We investigated the feasibility and reliability of occlusion using several commercially available medical sealing agents in the porcine vas deferens (VD). METHODS AND MAIN OUTCOME MEASURES:Tests were conducted using 25 porcine spermatic ducts (10 cm length) ex vivo. The explanted specimens were fixed and cannulated using the Seldinger technique. We administered 5 different agents (n-butyle-2-cyanoacrylate, n-butyle-2-cyanoacrylate in combination with a platinum vascular coil, Tissucol Duo S®, Gelita Spon® and AFP Plug®) endoluminally. Tightness was evaluated after 5, 15, 60, 360, 720, and 1,440 min for each of the five grades, respectively, using a solution of methylene blue and saline injected under controlled pressure of 300 mm Hg followed by histological examination. RESULTS:All agents were administered into the porcine seminal ducts (4 out of 5 via a ureteric catheter). Gelita Spon® and Tissucol Duo S® did not occlude the lumen sufficiently, whereas n-butyle-2-cyanoacrylate, n-butyle-2-cyanoacrylate in combination with coil, Tissucol Duo and AFP Plug® performed satisfactorily. In particular, cyanoacrylate combined with a coil was able to close the seminal duct tightly and for a long time. Histological findings confirmed this sealant's gapless adhesion. AFP Plug® application revealed similarly good results. However, its form needs to be optimized to ensure its suitability for endoscopic use. CONCLUSION:Various developments regarding minimally invasive fertility control methods have been underway for decades. Further miniaturization of endoscopy and novel materials may pave the way for endoscopic fertility control in males in the future. We demonstrated the potential of commercially available medical sealing agents to reliably occlude the porcine VD.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Schlager D,Maas M,Hein S,Adams F,Schoenthaler M,Spittau B,Wetterauer U,Miernik Adoi
10.1159/000478790subject
Has Abstractpub_date
2017-01-01 00:00:00pages
467-475issue
4eissn
0042-1138issn
1423-0399pii
000478790journal_volume
99pub_type
杂志文章abstract:INTRODUCTION:We compare the absorption of irrigant fluid during gyrus plasmakinetic transurethral prostatectomy (PK-TURP) and transurethral resection of the prostate (TURP). PATIENTS AND METHODS:42 patients with clinical benign prostatic hyperplasia were randomly assigned to undergo PK-TURP or TURP. In the PK-TURP gro...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000093909
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:This randomized controlled study compared a novel transparent urinary tract simulator with the traditional opaque urinary tract simulator as an aid for efficiently teaching urological surgical procedures. METHODS:Senior medical students were tested on their understanding of urological theory before and after...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000375129
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. PATIENTS AND METHODS:A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000443185
更新日期:2016-01-01 00:00:00
abstract::Chromosomal anomalies may be a reason for male infertility. To find out whether this is true mitotic chromosome studies were performed on 41 males with azoospermia and 61 males with oligozoospermia. A constitutional chromosomal abnormality was diagnosed in 14 (34.1%) azoospermic patients and in 2 (3.3%) oligozoospermi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030280
更新日期:1998-10-01 00:00:00
abstract::A total of 51 consecutive female patients with genuine stress incontinence who underwent a Burch or Stamey operation were clinically and urodynamically evaluated preoperatively at least 8 months postoperatively. Our study group consisted of 27 women who underwent the Burch colposuspension and 24 who had the Stamey end...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282803
更新日期:1996-01-01 00:00:00
abstract::In an acute rat model (in vivo) spontaneous rhythmic bladder contractions were induced by ligation of the urethra. In addition single bladder contractions were recorded during neurostimulation of the pelvic nerve. Spontaneous and electrically induced bladder contractions were sensitive to papaverine and isoprenaline i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282425
更新日期:1992-01-01 00:00:00
abstract::Primary penile carcinoma is one of the rarest male genital tract tumors. We rarely encounter this malignancy in Turkey because circumcision is routinely performed as a part of the Islamic tradition. Despite the medical paradox that the penis is rarely affected by metastases, approximately 300 cases have been reported ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000090872
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:There is a need for more exhaustive data concerning the use of prophylactic ureteral stenting for extended debulking and cytoreductive procedures in the literature. MATERIAL AND METHODS:A retrospective analysis of the CARPEPACEM study protocol database was performed. The trial protocol schedules the posit...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000339920
更新日期:2012-01-01 00:00:00
abstract::Recent interest has focused on natural killer T (NKT) cells as effector cells in a possible new form of immunotherapy. NKT cells express T cell and natural killer cell receptors. They are CD1d-dependent and can be stimulated by alpha-galactosylceramide. We have studied peripheral blood levels of NKT cells simultaneous...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071836
更新日期:2003-01-01 00:00:00
abstract::Extrarenal calyces are an extremely rare entity and only a few cases have been reported worldwide. We report a case with extrarenal calyces and give a brief review of the literature. Awareness of this rare entity can prevent inadvertent injury to the pelvicalyceal system during surgery. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000072690
更新日期:2003-01-01 00:00:00
abstract:INTRODUCTION:We reviewed our experiences in performing cytoreductive metastatectomy before initiating systemic immunochemotherapy and tried to investigate potential prognostic factors for such an approach. PATIENTS AND METHODS:A retrospective analysis of 57 patients who received interleukin-2, interferon-alpha, and 5-...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000091630
更新日期:2006-01-01 00:00:00
abstract::Intestinal ischemia is reported to be the most common gastrointestinal complication of renal transplantation and a potential cause of morbidity and mortality. The recent use of more potent immunosuppressive drug regimens has reduced the incidence of acute rejection, increasing the incidence of potentially fatal infect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000106334
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:We aimed to evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile function in patients who had no cavernosal or urethral injury by using International Index of Erectile Function (IIEF) questionnaire. MATERIALS AND METHODS:The male patients who were treated by HBOT for several diseases betwe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000490356
更新日期:2018-01-01 00:00:00
abstract:AIM:To compare the efficacy and safety of silodosin versus tamsulosin as medical expulsive therapy for stones of lower-third ureter in children. PATIENTS AND METHODS:This prospective single-blind placebo-controlled randomized study included 167 pediatric patients who presented with distal ureteric stone (DUS) less tha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000513074
更新日期:2021-02-01 00:00:00
abstract::Nephrotic syndrome developed in a patient with autosomal-dominant polycystic kidney disease. Renal biopsy revealed minor glomerular abnormalities. This type of nephrotic syndrome complication in an autosomal-dominant polycystic kidney disease has only rarely been reported. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281782
更新日期:1991-01-01 00:00:00
abstract::Idiopathic scrotal calcinosis is a rare, benign condition characterized by progressive calcification of the scrotal skin. A 29-year-old man who had undergone primary surgical excision of idiopathic scrotal calcinosis 7 years previously presented with recurrence that he had first noticed 3 years after surgery. Multiple...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350240
更新日期:2014-01-01 00:00:00
abstract::Paraneoplastic syndromes are rare entities in patients with excessive HCG production. This has been attributed to the thyroid-stimulating hormone-like activity of HCG. In most cases hyperthyroidism remains subclinical. We report on a patient with diffuse metastasized malignant teratoma and thyrotoxicosis due to excess...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030466
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To investigate the reliability of the physician-assisted International Index of Erectile Function (IIEF). PATIENTS AND METHODS:374 patients who applied to our clinic with erectile dysfunction problems were asked to complete the IIEF questionnaire; 225 patients who visited the clinic again within 1-3 days com...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000335432
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the management of urolithiasis in children since the development of extracorporeal shock-wave lithotripsy (ESWL). METHODS:Between 1988 and 1994, 37 children, aged from 2 to 15 years (mean 10), with upper tract urolithiasis were evaluated and treated. Lithogenic metabolic disorders or anomalies of...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282882
更新日期:1996-01-01 00:00:00
abstract::The major difficulties encountered in the surgical correction of pediatric communicating hydroceles are separating the hernial sac from the spermatic vessels and vas, and identifying the anatomical location of the internal inguinal ring. The passage of a pediatric Foley catheter through the hernial sac via a high scro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281250
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVES:Improvements in quality of life (QoL) and disease-related symptoms are key goals in the treatment of hormone refractory prostate cancer (HRPC). Our aim was to evaluate the impact of gefitinib on QoL of patients with HRPC. METHODS:Patients with HRPC received gefitinib 250 mg daily in addition to antiandrogen...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000200800
更新日期:2009-01-01 00:00:00
abstract::We studied the impact of antireflux surgery on bladder compliance, which was an important clinical parameter in terms of urinary incontinence and upper tract deterioration, in 20 myelodysplastics (group A). For control groups, 31 myelodysplastic children with or without reflux who were conservatively treated (group B)...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282253
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:We aimed to evaluate the predictive factors in a holistic manner for ureterorenoscopy (URS) outcomes in proximal ureteral stones by a multicenter study. MATERIALS AND METHODS:The data of patients who underwent URS for proximal ureteral stones between the years 2015 and 2018 in eight centers were recorded ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504790
更新日期:2020-01-01 00:00:00
abstract::We report a rare case of massive bilateral staghorn calculi in a spinal cord injury patient with significant renal compromise. The patient was successfully treated with percutaneous nephrolithotomy to achieve a stone-free status. The various options of treatment are discussed with special attention to the technical as...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030340
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:The study aimed to document the types of meatal occlusive disease (MOD) in adult males in terms of its clinical presentation, management and prognosis. MATERIAL AND METHODS:Eighty-six adult males with MOD were assessed during the study period. The patients were divided into Group 1, having meatal opening tha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000446221
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:This present study was undertaken to determine the levels of malondialdehyde (MDA), nitric oxide (NO) and total antioxidant status (TAS) in testes of adolescent rats with experimental bilateral varicocele and to determine the effects of oxidative stress on testis produced by varicocele. METHODS:6-week-old, m...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000081596
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Partial unilateral ureteral obstruction (PUUO) is the type of obstruction that is most often encountered in pediatric clinical practice. The majority of our knowledge on PUUO has been derived from experimental studies and the effects of PUUO on the kidney have still been a source of continual investigation...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000111736
更新日期:2008-01-01 00:00:00
abstract::Blind-ending bifid ureter in a woman with urinary tract infection and a duplicated renal pelvis in her twin sister are reported. The blind-ending bifid ureter terminated as a fibrous cord with a terminal mass of immature renal tissue. This type of ureter may be a transitional form between histologically blind-ending b...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280110
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Limited data are available for the use of agents in metastatic castration-resistant prostate cancer (mCRPC) beyond the third-line. We provide data during treatment with cabazitaxel (CAB), helping to improve the informed-consent process. PATIENTS AND METHODS:We retrospectively reviewed patients treated with ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,评审
doi:10.1159/000477943
更新日期:2017-01-01 00:00:00
abstract::We performed sonography in 7 males with membranous and posterior urethral calculi. Sonography demonstrated the urethral calculi in all 7 patients. These findings suggest that sonography is useful as a noninvasive screening technique for urethral calculi. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282484
更新日期:1993-01-01 00:00:00