Abstract:
INTRODUCTION:Male infertility caused by azoospermia due to non-reconstructable obstruction or non-obstructive azoospermia can be treated by microsurgical epididymal aspiration (MESA) or testicular sperm extraction (TESE) followed by an intracytoplasmatic spermatozoa injection (ICSI). MATERIAL AND METHODS:From 9/93 to 6/01, we carried out 1,025 ICSI procedures with aspirated epididymal or testicular sperms in 684 cases. 163 ICSI cycles were performed with epididymal sperms and 862 ICSI cycles with testicular sperms or spermatids. The TESE was carried out by open biopsy, frequently in a multilocular technique. The aspirated spermatozoas were used after cryopreservation (frozen) or immediately after aspiration (fresh). RESULTS:538 patients had obstructive azoospermia or ejaculation failure. In 487 cases the underlying cause of azoospermia was an impaired spermatogenesis, following maldescensus testis, chemotherapy, radiotherapy, or caused by Sertoli-cell-only syndrome, a genetic disorder or an unknown etiology. The transfer rates, pregnancy rates and birth rates per ICSI cycle showed no statistically significant differences between testicular and epididymal sperms in the cases of seminal obstruction (28% average birth rates in both cases). However, highly significant was the difference in birth rates with regard to the underlying cause of infertility. In contrast, in treating non-obstructive azoospermia we observed a birth rate of 19% per cycle. In all patient groups the birth rate with fresh spermatozoas did not differ from those with cryopreserved spermatozoa. 40% of patients after multilocular TESE showed clinical signs of testicular lesion. CONCLUSION:The underlying cause of azoospermia is the most important factor for the outcome of ICSI using epididymal and testicular sperms. In cases of non-obstructive azoospermia, the pregnancy rate is low compared with the results in cases of obstructive azoospermia. There is no difference between fresh and cryopreserved sperms. TESE with ICSI is the most efficient treatment of azoospermia caused by hypergonadotropic hypogonadism. The morbidity of the TESE procedure is highly relevant and must be considered if this technique is indicated.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Schwarzer JU,Fiedler K,v Hertwig I,Krüsmann G,Würfel W,Schleyer M,Mühlen B,Pickl U,Löchner-Ernst Ddoi
10.1159/000068185subject
Has Abstractpub_date
2003-01-01 00:00:00pages
119-23issue
2eissn
0042-1138issn
1423-0399pii
68185journal_volume
70pub_type
杂志文章abstract:INTRODUCTION:The percentage of positive prostate biopsy cores (%PBC) has been shown to be a prognostic factor in localized prostate cancer. We hypothesized that it would predict time to hormonal independence and survival in prostate cancer patients treated with androgen deprivation therapy (ADT). PATIENTS AND METHODS:...
journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
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pub_type: 杂志文章,随机对照试验
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
pub_type: 杂志文章
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abstract::Five children with end-stage reflux nephropathy underwent kidney transplantation at our clinic. Reflux nephropathy was studied clinically and histologically. All children had proteinuria before starting hemodialysis, and hypertension was present in 2 cases. Three children underwent antireflux operations prior to trans...
journal_title:Urologia internationalis
pub_type: 杂志文章
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abstract:BACKGROUND:Prostate biopsy (PBx) techniques have changed significantly since the original Hodge's scheme, with an increase in the number and location of cores. These improvements have been realized in part because of the introduction of different local anaesthesia techniques. We critically analysed the literature discu...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
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journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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journal_title:Urologia internationalis
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doi:10.1159/000096344
更新日期:2006-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000321927
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000281071
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pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000100846
更新日期:2007-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000448691
更新日期:2017-01-01 00:00:00
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更新日期:2018-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2013-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2000-01-01 00:00:00
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