An Open-Label Pilot Study of Metformin as a Concomitant Therapy on Patients with Prostate Cancer Undergoing Androgen Deprivation Treatment.

Abstract:

PURPOSE:The study aimed to evaluate the effects of metformin on insulin, C-peptide and body weight in Chinese men undergoing androgen deprivation therapy (ADT). METHODS:Between March 2013 and June 2014, 62 newly diagnosed patients of prostate cancer (PCa) due to receive ADT were recruited from 7 hospitals in Shanghai. Patients were randomized to respectively receive ADT (n = 31) and ADT + metformin (n = 31) for 6 months. Fasting and postprandial serum levels of insulin and C-peptide, blood glucose, prostate specific antigen, body mass index (BMI) and waist circumference (WC) were measured at the beginning and end of 6-month treatment. RESULTS:Baseline characteristics were comparable between the 2 groups. Controlling for baseline levels, the ADT group had significantly higher levels of fasting glucose (p = 0.01) and higher WC (p = 0.04) than the ADT + metformin group. The levels of insulin, C-peptide and BMI did not differ significantly. CONCLUSIONS:Metformin may be potentially efficient as a concomitant therapy on patients with PCa undergoing androgen deprivation treatment.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Zhu W,Xu H,Ma J,Guo J,Xue W,Gu B,Sheng L,Yao X,Sun F,Gong J,Qiu W,Ding Q,Jiang H

doi

10.1159/000448691

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

79-84

issue

1

eissn

0042-1138

issn

1423-0399

pii

000448691

journal_volume

98

pub_type

杂志文章,随机对照试验
  • Percutaneous-based management of Staghorn calculi in solitary kidney: combined mini percutaneous nephrolithotomy versus retrograde intrarenal surgery.

    abstract:INTRODUCTION:Mini percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS) are well-established techniques with little morbidity. The combined use of standard PCNL and the mini-PCNL or the RIRS technique was evaluated and compared to investigate their own role in the management of staghorn calc...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000360708

    authors: Zhong W,Zhao Z,Wang L,Swami S,Zeng G

    更新日期:2015-01-01 00:00:00

  • Prostatic malacoplakia.

    abstract::We report here a 70-year-old man with prostatic malacoplakia which is an extremely rare disease. This diagnosis was obtained from histological examination by prostatic biopsy because the patient was suspected having prostatic cancer on digital examination. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281024

    authors: Matsumoto T,Ih H,Yamada Y,Kumazawa J,Era S

    更新日期:1985-01-01 00:00:00

  • Long-term follow-up after clam ileocystoplasty. Complications and results including some quality-of-life parameters for 32 patients treated for neuropathic and nonneuropathic bladder disease.

    abstract::The results of clam ileocystoplasty in 32 patients were evaluated. Nineteen patients had a neuropathic (group N) and 13 a nonneuropathic disease (group NN). Mean follow-up was 75 months; 62 months for group N and 95 months for group NN. Mean age was 38 years. Postoperative complications and some quality-of-life parame...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282577

    authors: Geertsen U,Mommsen S

    更新日期:1994-01-01 00:00:00

  • Serum Levels of MicroRNA371a-3p: A Highly Sensitive Tool for Diagnosing and Staging Testicular Germ Cell Tumours: A Clinical Case Series.

    abstract:INTRODUCTION:MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven. PATIENTS, METHODS:In 312 consecutive cases with various testicular diseases, serum levels of miR371a-3p were measured. Measurement results ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000477446

    authors: Anheuser P,Radtke A,Wülfing C,Kranz J,Belge G,Dieckmann KP

    更新日期:2017-01-01 00:00:00

  • Idiopathic partial thrombosis of the corpus cavernosum.

    abstract::A case of spontaneous, partial, unilateral thrombosis of the corpus cavernosum is described. A 35-year-old white male presented with a painful mass in the perineum without priapism. Diagnostic evaluation with sonography and magnetic resonance imaging revealed a thrombosis in the left posterior corporal body. Treatment...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000030246

    authors: Thiel R,Kahn T,Vögeli TA

    更新日期:1998-01-01 00:00:00

  • Renal Autotransplantation at Three Academic Institutions in Turkey.

    abstract:OBJECTIVE:The objective of this study is to present the experience of 3 institutions performing renal autotransplantation (RAT) and to discuss surgical techniques employed and the results in the light of the medical literature. MATERIALS AND METHODS:A total of 14 patients (11 male and 3 female) with a mean age of 47 ±...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000448482

    authors: Yakupoglu YK,Aki FT,Kordan Y,Ozden E,Tonyali S,Bostanci Y,Vuruskan H,Bilen CY,Sarikaya S

    更新日期:2016-01-01 00:00:00

  • Duplication of the renal pelvis and blind-ending bifid ureter in twins.

    abstract::Blind-ending bifid ureter in a woman with urinary tract infection and a duplicated renal pelvis in her twin sister are reported. The blind-ending bifid ureter terminated as a fibrous cord with a terminal mass of immature renal tissue. This type of ureter may be a transitional form between histologically blind-ending b...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280110

    authors: Bergman B,Hansson G,Nilson AE

    更新日期:1977-01-01 00:00:00

  • Acceptance, Prevalence and Indications for Robot-Assisted Laparoscopy - Results of a Survey Among Urologists in Germany, Austria and Switzerland.

    abstract:BACKGROUND:Robotic-assisted laparoscopy (RAL) is being widely accepted in the field of urology as a replacement for conventional laparoscopy (CL). Nevertheless, the process of its integration in clinical routines has been rather spontaneous. OBJECTIVE:To determine the prevalence of robotic systems (RS) in urological c...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000430502

    authors: Imkamp F,Herrmann TR,Tolkach Y,Dziuba S,Stolzenburg JU,Rassweiler J,Sulser T,Zimmermann U,Merseburger AS,Kuczyk MA,Burchardt M

    更新日期:2015-01-01 00:00:00

  • Comparison of fluid absorption between transurethral enucleation and transurethral resection for benign prostate hyperplasia.

    abstract:INTRODUCTION:Although transurethral resection of prostate (TURP) remains the reference standard for benign prostate hyperplasia (BPH), the concern about complications promotes researchers to develop alternative surgical methods with fewer complications. In this study, we compared the safety and efficacy between the tra...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000348793

    authors: Ran L,He W,Zhu X,Zhou Q,Gou X

    更新日期:2013-01-01 00:00:00

  • Association of congenital left renal vein anomalies and unexplained hematuria: multidetector computed tomography findings.

    abstract:OBJECTIVES:To investigate whether congenital renal vein anomalies are involved in the etiology of hematuria by analyzing abdominal multidetector computed tomography (MDCT) results. METHODS:Six hundred and eighty patients undergoing MDCT for various abdominal pathologies in whom possible causes of hematuria were exclud...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000365664

    authors: Resorlu M,Sariyildirim A,Resorlu B,Sancak EB,Uysal F,Adam G,Akbas A,Aylanc N,Gulpinar MT,Karatag O,Ozdemir H

    更新日期:2015-01-01 00:00:00

  • Cystic dysplasia of the testis: a very rare paediatric tumor of the testis.

    abstract:OBJECTIVES:To describe a case of cystic dysplasia of the testis (CDT), an uncommon cause of scrotal swelling in the pediatric patient. Clinic, therapy, fertility, and radiographic and pathologic findings are discussed and the 30 previously reported cases are reviewed. METHODS:A 9-year-old boy presented with asymptomat...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000064351

    authors: Eberli D,Gretener H,Dommann-Scherrer C,Pestalozzi D,Fehr JL

    更新日期:2002-01-01 00:00:00

  • Extramedullary hematopoiesis in chronic myelofibrosis encasing the pelvicaliceal system and perirenal spaces: CT findings.

    abstract::We examined a 46-year-old male patient with idiopathic myelofibrosis diagnosed 28 months earlier. After chemotherapy and irradiation, CT showed nonnodular, soft tissue masses in the renal hilum, pelvicaliceal system, perirenal and periureteral spaces. Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)....

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000087809

    authors: La Fianza A,Torretta L,Spinazzola A

    更新日期:2005-01-01 00:00:00

  • An unusual cause of urinary retention in a young female: a case report.

    abstract::Inflammatory myofibroblastic tumors are commonly seen in young adults and adolescents and commonly present with painless hematuria. We report a case of a 38-year-old woman who presented to us with urinary retention due to a prolapsing tumor mass from the urethra, which was discovered to be an inflammatory myofibroblas...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000350516

    authors: Regmi SK,Walia R,Kumar R

    更新日期:2014-01-01 00:00:00

  • Inflammatory malignant fibrous histiocytoma of the spermatic cord.

    abstract::A 74-year-old man with a right inguinal hernia since 15 years was admitted because of inguinal pain and enlarged ipsilateral testis. Surgical exploration revealed a hernia with an empty hernial sac and three tumoral masses in the spermatic cord. Tumoral masses, spermatic cord, and testis were removed. Histological exa...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281335

    authors: Nistal M,Regadera J,Jareño E,Paniagua R

    更新日期:1988-01-01 00:00:00

  • Testicular metastasis of cerebral malignant lymphoma.

    abstract::Cerebral metastases of testicular malignant lymphomas have been reported. In this case a testicular metastasis secondary to a primary cerebral malignant lymphoma is presented. This unusual case does not correspond to the known metastatic pattern of malignant lymphoma. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282688

    authors: Buchholz NP,Huber-Buchholz MM,Stähelin J

    更新日期:1995-01-01 00:00:00

  • Pubovaginal cutaneous fascial sling procedure for stress urinary incontinence: 10 years' experience.

    abstract:OBJECTIVES:There is a considerable lack of consensus regarding indications and long-term efficacy of the many techniques for treating urinary stress incontinence. We report the long-term results of a modified pubovaginal sling procedure. METHODS:From 1989 to 1998, 129 consecutive patients underwent a pubovaginal sling...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000077685

    authors: Reichelt O,Weirich T,Wunderlich H,Schubert J

    更新日期:2004-01-01 00:00:00

  • Endoscopic treatment of vesicoureteral reflux in children: our experience and analysis of factors affecting success rate.

    abstract:AIM:To clarify the factors affecting the success rate of endoscopic subureteral injection (ESI) treatment of vesicoureteral reflux (VUR). METHOD:All patients who had ESI treatment for VUR at our unit between 1999 and 2002 were retrospectively reviewed with regard to age, gender, causes of VUR, reflux grade, type of in...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000137639

    authors: Alkan M,Ciftci AO,Senocak ME,Tanyel FC,Buyukpamukcu N

    更新日期:2008-01-01 00:00:00

  • Efficacy of low-molecular-weight heparin and unfractionated heparin to prevent adhesion of human prostate and bladder carcinoma and melanoma cells to bovine endothelial monolayers. An in vitro study and review of the literature.

    abstract::Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Cu...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282848

    authors: Lersch C,Gericke D,Classen M

    更新日期:1996-01-01 00:00:00

  • Perioperative complications and 90-day mortality of radical cystectomy in the elderly (75+): a retrospective, multicentre study.

    abstract:OBJECTIVE:To assess perioperative complications and 90-day mortality of radical cystectomy (RC) in elderly patients with muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS:This is a retrospective, multicentre (n = 11) study of a consecutive series of patients ≥75 years who underwent RC for MIBC between 2006 ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000357127

    authors: Berger I,Martini T,Wehrberger C,Comploj E,Ponholzer A,Wolfgang M,Breinl E,Dunzinger M,Hofbauer J,Höltl W,Jeschke K,Krause S,Kugler W,Pauer W,Rauchenwald M,Pycha A,Madersbacher S

    更新日期:2014-01-01 00:00:00

  • Intracavernous injection of prostaglandin E1: the application to cavernosography and penile blood flow measurement for the diagnosis of venogenic impotence.

    abstract::We injected 20 micrograms of prostaglandin E1 (PGE1) intracavernously in 32 patients with impotence, we then examined penile blood flow using a Xe-133 washout technique. In addition, we also performed a cavernosography. After PGE1 injection, 18 patients (56%) showed complete erection, 10 (31%) tumescence, and 4 (13%) ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282131

    authors: Ishigooka M,Irisawa C,Watanabe H,Adachi M,Ishii N,Nakada T

    更新日期:1991-01-01 00:00:00

  • Long-term efficacy of tolterodine and patient compliance in pediatric patients with neurogenic detrusor overactivity.

    abstract:INTRODUCTION:We investigated the effects of standard oral anticholinergic treatment with tolterodine in children with neurogenic bladder over a 5-year follow-up period and focused on treatment satisfaction, patient compliance and urodynamic parameters. MATERIAL AND METHODS:The follow-up consisted of regular visits and...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000102915

    authors: Christoph F,Moschkowitsch A,Kempkensteffen C,Schostak M,Miller K,Schrader M

    更新日期:2007-01-01 00:00:00

  • In-Hospital Outcomes after Radical Cystectomy for Bladder Cancer: Comparing National Trends in the United States and Germany from 2006 to 2014.

    abstract:BACKGROUND:Radical cystectomy (RC) still poses a significant risk for mortality and morbidity. OBJECTIVES:We compared in-hospital outcomes after RC in the United States and -Germany using population-based data. METHODS:We compared data from the US Nationwide Inpatient Sample to the German hospital billing database. M...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000496347

    authors: Groeben C,Koch R,Baunacke M,Borkowetz A,Wirth MP,Huber J

    更新日期:2019-01-01 00:00:00

  • Sequential changes in the prostatic fluid level of latamoxef in patients with acute bacterial prostatitis.

    abstract::The sequential expressed prostatic secretion (EPS) levels of latamoxef (LMOX) were measured in 14 patients with acute bacterial prostatitis to evaluate the diffusion of this antibiotic from the plasma into the prostatic fluid. All patients received 2 g of LMOX on the 1st, 4th, and 7th days of hospitalization. The mean...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282760

    authors: Itoh M,Katoh N,Ono Y,Ohshima S,Miyake K

    更新日期:1995-01-01 00:00:00

  • Steroid receptor status of human testicular tumors.

    abstract::Biopsies of 9 testicular tumors were examined for the presence of cytoplasmic receptor proteins for estrogens, progestins, androgens, and glucocorticoids. Using an arbitrary threshold value of 10 fmol/mg cytosol protein for a postive assay, only 1 of 9 tumors was estrogen-receptor positive. However, no receptor-specif...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281072

    authors: Bojar H,Weissbach L,Petzinna D,Maar K,Staib W

    更新日期:1985-01-01 00:00:00

  • Impact of E-Cadherin and β-Catenin as Prognostic Factor in Renal Cell Carcinoma with Tumor Thrombus of the Vena Cava.

    abstract:PURPOSE:Renal cell carcinoma (RCC) forming tumor thrombus (TT) of vena cava (VC) is characterized by poor prognosis. Nevertheless, the outcome of patients after radical surgery varies. To date only limited data concerning prognostic biomarkers in this RCC subgroup are available. METHODS:Out of 159 patients with pT3b/c...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000497279

    authors: Spachmann PJ,Breyer J,Kalogirou C,Lausenmeyer EM,Weber F,Prohaska S,Denzinger S,Burger M,Kübler H,Otto W,Vergho D

    更新日期:2019-01-01 00:00:00

  • Follow-up of testicular microlithiasis for subsequent testicular cancer development.

    abstract:INTRODUCTION:To demonstrate the relationship between testicular microlithiasis and testicular tumor development. PATIENTS AND METHODS:Between January 1996 and March 2004, bilateral testicular microlithiasis was found in 40 of the 5,263 patients who underwent scrotal ultrasonography yielding a prevalence of 0.76%. Of t...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000083279

    authors: Pourbagher MA,Kilinc F,Guvel S,Pourbagher A,Egilmez T,Ozkardes H

    更新日期:2005-01-01 00:00:00

  • Holmium Laser Enucleation of the Prostate Provides Similar Incidental Prostate Cancer Detection Rates as Open Prostatectomy: A Matched Pair Analysis.

    abstract:INTRODUCTION:Whereas the excellent functional outcomes after Holmium laser enucleation of the prostate (HoLEP) and its equivalency to open prostatectomy (OP) have been studied in detail in the past years, the oncological equivalency has yet to be investigated. Therefore, we conducted a matched pair analysis to evaluate...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000492923

    authors: Rosenhammer B,Lausenmeyer EM,Mayr R,Burger M,Eichelberg C

    更新日期:2018-01-01 00:00:00

  • [Progress in urolithiasis research. Report and comments on the Urolithiasis Symposium 1981, Bonn (author's transl)].

    abstract:EPIDEMIOLOGY:The annual incidence of urolithiasis in the population is at least 0.1%. In rural areas, there are remarkably less actual stone formers than in urban districts, and also vegetarians show less stone diseases. Calcium carbonate as a urinary calculus compound is not in the strict sense impossible, but often a...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280781

    authors: Asper R

    更新日期:1981-01-01 00:00:00

  • Diagnosis and treatment of bladder endometriosis: state of the art.

    abstract:BACKGROUND:The bladder is the most common affected site in urinary tract endometriosis, being diagnosed during gynecologic follow-up. The surgical urological treatment might lead to good results. STUDY OBJECTIVE:To define the state of the art in the diagnosis and treatment of bladder endometriosis. METHODS:We perform...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000339519

    authors: Maccagnano C,Pellucchi F,Rocchini L,Ghezzi M,Scattoni V,Montorsi F,Rigatti P,Colombo R

    更新日期:2012-01-01 00:00:00

  • Bilateral Renal Autotransplantation May Be an Effective and Definitive Treatment in Case of Loin Pain Haematuria Syndrome.

    abstract::Loin pain haematuria (LPHS) is a rare and difficult-to-diagnose syndrome. Different therapeutic approaches have been used historically with little or no success. We report a case of LPHS in which bilateral renal autotransplantation led to pain relief, cessation of all medication and no recurrence beyond two years of f...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000430503

    authors: Rohrer F,Déglise S,Bettschart V,Schmidtko J

    更新日期:2017-01-01 00:00:00