Abstract:
OBJECTIVE:To assess perioperative complications and 90-day mortality of radical cystectomy (RC) in elderly patients with muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS:This is a retrospective, multicentre (n = 11) study of a consecutive series of patients ≥75 years who underwent RC for MIBC between 2006 and 2010. Medical, surgical and wound complications were graded according to the modified Clavien-Dindo classification. RESULTS:A total of 256 patients with a mean age of 79.6 years (range 75.0-86.6) were analysed. Urinary diversion with the use of bowel was performed in 79.5% and ureterocutaneostomy in 20.5%, with a higher proportion in the ≥80 cohort (32.2 vs. 14%; p = 0.001). 41.4% of patients had an uneventful postoperative course (Clavien grade 0) and 26.6% developed severe complications (Clavien grade III-V). In a multivariable regression analysis, the Charlson comorbidity index (odds ratio 1.5 per unit increase; p < 0.001) and the body mass index (odds ratio 1.13 per kg/m(2) increase; p = 0.015) were predictors for the development of complications. The 90-day mortality rate was 9% and the independent correlates thereof were the development of severe medical complications (p = 0.004), the American Society of Anesthesiologists (ASA) score (p = 0.03) and age (p = 0.005). CONCLUSIONS:Morbidity and 90-day mortality of RC in the elderly remain substantial. The interrelation between comorbidity, complication rate and 90-day mortality underlines the need for a comprehensive geriatric assessment of elderly patients with MIBC in whom RC is indicated.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Berger I,Martini T,Wehrberger C,Comploj E,Ponholzer A,Wolfgang M,Breinl E,Dunzinger M,Hofbauer J,Höltl W,Jeschke K,Krause S,Kugler W,Pauer W,Rauchenwald M,Pycha A,Madersbacher Sdoi
10.1159/000357127subject
Has Abstractpub_date
2014-01-01 00:00:00pages
296-302issue
3eissn
0042-1138issn
1423-0399pii
000357127journal_volume
93pub_type
杂志文章,多中心研究abstract::The effects of ammonium chloride, methenamine hippurate and ascorbic acid on urinary pH was studied in 14 normal subjects. A statistically significant reduction of urinary pH was recorded with ammonium chloride in daily doses of 1.5 and 3 g, but not with 2 g of methenamine hippurate or 1.8 g of ascorbic acid. Long-ter...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281732
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Sunitinib is standard first-line therapy for metastatic clear cell renal cancer (MCRC). It is associated with leucopenia; however, its effects on specific immune cell subsets are unclear. Alterations in immune cell subsets may contribute to tumour progression. METHODS:Lymphocyte subsets (CD3, 4, 8, 19 and 5...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000319498
更新日期:2011-01-01 00:00:00
abstract:AIMS:To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). METHODS:Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000112611
更新日期:2008-01-01 00:00:00
abstract::Serum-ionized calcium (Ca++) was measured in 65 patients with idiopathic calcium urolithiasis. The patients were then divided into hypercalciuric and normocalciuric groups based on the mean + SD of the control group, with greater than 180 mg/24 h in males and greater than 176 mg/24 h in females defined as hypercalciur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280303
更新日期:1980-01-01 00:00:00
abstract:INTRODUCTION:Microchimerism (MC) is the presence of a small amount of foreign cells or DNA within a person's circulation or tissues. It has been identified also in recipients of solid organ transplants where it seems to be critical for the development and maintenance of immunological tolerance. Nevertheless, natural an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000508796
更新日期:2020-01-01 00:00:00
abstract::Adenosine triphosphate (ATP) and adenosine diphosphate (ADP) have been correlated with traditional semen parameters such as forward motility and sperm count. ATP and ADP were determined by a bioluminescence assay using the luciferin-luciferase reaction. Short boiling of the ejaculate was performed to inactivate phosph...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282361
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Prostate cancer is a prominent form of cancer diagnosed in men living in developed countries, for which radical prostatectomy is a common frontline treatment. The aim of this systematic review was to determine whether robot-assisted laparoscopic radical prostatectomy (RALP) is more effective in the treatment...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000435861
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:To assess the influence of music therapy on perceived anxiety and pain during outpatient urodynamic study (UDS) in a prospective, randomized fashion. METHODS:Between January and December 2018, a total of 70 patients were randomized to either have music therapy (study) or not have (control) in a 1:1 ratio....
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000502298
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000362903
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To evaluate the association between dyslipidemia and nephrolithiasis risk in a Chinese population. MATERIALS AND METHODS:Fasting plasma lipid profiles were measured in a case-control study of 540 nephrolithiasis cases and 656 kidney stone-free controls. RESULTS:Triglycerides (TG) levels were significantly hig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496208
更新日期:2019-01-01 00:00:00
abstract::We investigated the baseline levels of urine nuclear matrix protein 22 (U-NMP22) and survivin in urine after radical cystectomy for primary invasive bladder cancer. We measured U-NMP22 and survivin values in 72 patients with four types of urinary diversion (Indiana bladder, Bricker bladder, Mainz bladder and orthotopi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000330911
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:The short-term effects of intravesical chemoimmunotherapy with epirubicin and bacillus Calmette-Guérin (BCG) administered repeatedly for prophylaxis of recurrence of superficial bladder cancer (pTa, pT1) were investigated in 24 patients aged a median of 70 years between March 1996 and February 1999, and were co...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000051005
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Meatal stenosis usually presents in adults with a history of urethral trauma or inflammation or as a complication after hypospadias repair. The objective of this study is to present the correction of meatal stenosis using a preputial island flap, created on the dorsal surface of the penis. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000102905
更新日期:2007-01-01 00:00:00
abstract::Intestinal ischemia is reported to be the most common gastrointestinal complication of renal transplantation and a potential cause of morbidity and mortality. The recent use of more potent immunosuppressive drug regimens has reduced the incidence of acute rejection, increasing the incidence of potentially fatal infect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000106334
更新日期:2007-01-01 00:00:00
abstract::Stereology was shown in several studies to be a relevant method to study the quantitative amount of tissue and cell compartments of normal and pathological altered prostatic tissue. A morphological comparison of the rat (ventral lobe), dog and human prostate was performed by quantitative morphology. In comparing the l...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280309
更新日期:1980-01-01 00:00:00
abstract:AIM:To determine efficacy and clinical predictors of stone fragmentation when using slow-rate shock wave lithotripsy (SWL). PATIENTS AND METHODS:In total, 116 patients with radiopaque urinary tract stones were randomized into two groups: 57 patients were treated with SWL at 90 shocks/min, and 59 patients were treated ...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000106324
更新日期:2007-01-01 00:00:00
abstract::The objective of this case report is to present a rare bladder tumour in a young patient 25 years after the treatment with cyclophosphamide because of a neuroblastoma of the right eye. The first symptom of the tumour was macroscopic haematuria with dysuria and pollakiuria. The final diagnosis was dictaminated by the p...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000437442
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in syner...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000288243
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:To describe a case of cystic dysplasia of the testis (CDT), an uncommon cause of scrotal swelling in the pediatric patient. Clinic, therapy, fertility, and radiographic and pathologic findings are discussed and the 30 previously reported cases are reviewed. METHODS:A 9-year-old boy presented with asymptomat...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000064351
更新日期:2002-01-01 00:00:00
abstract::Injuries of the penis are uncommon but represent urological emergencies. We report 3 cases of penile trauma illustrating the diversity of penile injury presentation. Radiological investigations are only mandatory if there is any suspicion of a urethral injury. Primary surgical approach is recommended in cases of penil...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000151421
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. MATERIALS AND METHODS:The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000084434
更新日期:2005-01-01 00:00:00
abstract::The purpose of this study was to make a model of renal vasoconstriction induced by mechanical manipulation of the renal artery and to investigate the influence of endothelin (ET) in renal vasoconstriction. Renal arteries of anesthetized rats were stretched with a 30-gram weight for 5 min, and released. Renal blood flo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030510
更新日期:2000-01-01 00:00:00
abstract::At the Institute of Urology, University of Padova, 125 patients with multifocal superficial bladder cancer underwent treatment with intravesical Mitomycin C (MMC; 1 weekly instillation of 40 mg for 8 consecutive weeks) between January 1982 and December 1988. Eighty-four patients had multifocal papillary tumors (stages...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282320
更新日期:1992-01-01 00:00:00
abstract::A case of spontaneous, partial, unilateral thrombosis of the corpus cavernosum is described. A 35-year-old white male presented with a painful mass in the perineum without priapism. Diagnostic evaluation with sonography and magnetic resonance imaging revealed a thrombosis in the left posterior corporal body. Treatment...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030246
更新日期:1998-01-01 00:00:00
abstract::119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The pat...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000281439
更新日期:1989-01-01 00:00:00
abstract:PURPOSE:With a median age at diagnosis of 73 years, bladder cancer has the highest median age of all cancers. Age alone seems to be an independent risk factor for developing the disease with peak age advancing into the range of 85 years. As demographic changes will lead to an ever more aging population in western count...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000510137
更新日期:2020-01-01 00:00:00
abstract::The identification and diagnosis of thyroid metastases from renal adenocarcinoma are rare in living patients, though more frequent during autopsy. A case is reported in which the identification of thyroid metastases indicated a clear-cell renal carcinoma in a kidney treated 12 years earlier for emptying of multiple cy...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281389
更新日期:1988-01-01 00:00:00
abstract:AIMS:To determine factors for treatment persistence in a real-life cohort of adult neurogenic lower urinary tract dysfunction. METHODS:We reviewed records of patients with neurogenic lower urinary tract dysfunction and mirabegron prescriptions. Exclusion criteria were indwelling urethral or suprapubic catheters and im...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000500349
更新日期:2019-01-01 00:00:00
abstract::The alpha-adrenergic innervation of the functional urethra is a well-known fact, while beta-adrenergic influence is rather unknown until now. We studied the influence of beta-stimulating and beta-blocking agents on the human urethra by the urethral pressure profile (UPP). A decrease of the UPP under orciprenaline sulf...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280224
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVES:To assess the effect of neoadjuvant hormone treatment before radical prostatectomy on: tumor/prostate volume, prostate-specific antigen (PSA) and testosterone levels, surgical margin status and tumor stage, and the ease of surgery following treatment. METHODS:Patients with clinically localized prostatic car...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000077113
更新日期:2004-01-01 00:00:00