Abstract:
INTRODUCTION:Microchimerism (MC) is the presence of a small amount of foreign cells or DNA within a person's circulation or tissues. It has been identified also in recipients of solid organ transplants where it seems to be critical for the development and maintenance of immunological tolerance. Nevertheless, natural and/or iatrogenic MC can be acquired prior to transplantation, through pregnancy and/or blood transfusion. OBJECTIVE:The aim of this study was to detect the presence of MC in women after renal transplantation from male cadaveric donors and its relationship with graft outcomes. METHODS:We studied by qPCR the presence of the DYS14 gene sequence of the Y chromosome in 12 females who received a kidney graft from a male donor before transplantation (T0), after 15 days (T1) and 1 year of transplantation (T2). We found the sequence in all recipients after renal transplantation. RESULTS:All the women were negative for this sequence prior to transplantation (T0). Mean (SD) Y-related DNA quantity was 0.80 (0.69) ng/mL plasma and 0.15 (0.26) ng/mL plasma at T1 and T2, respectively. No acute rejection was observed, and mean (SD) estimated Cr clearance was 68.8 (16.9) mL/min within 1 year from transplantation. CONCLUSIONS:Presence of MC was associated with good kidney graft outcomes after 1 year of transplantation, but further studies will be needed to investigate the relationship between clinical outcomes and the development of MC in renal transplant recipient.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Villari D,Salvianti F,Zanazzi M,Martini A,Spatafora P,Caroassai Grisanti S,Sebastianelli A,Nicita G,Serni S,Pinzani Pdoi
10.1159/000508796subject
Has Abstractpub_date
2020-01-01 00:00:00pages
865-870issue
11-12eissn
0042-1138issn
1423-0399pii
000508796journal_volume
104pub_type
杂志文章abstract::By transforming uroflowmetrograms from curves of flow rate versus time into curves of flow rate versus instantaneous bladder volume, additional information about the variation of the flow rate during voiding is obtained. These curves show that, within a certain volume range, the maximum flow rate is more or less indep...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280157
更新日期:1977-01-01 00:00:00
abstract::Urachal adenocarcinoma is a rare bladder tumor, occasionally associated with calcification. We report a case of urachal adenocarcinoma with remarkable stromal osseous metaplasia and review the literature on this rare condition. This is the first complete case report in English of this uncommon entity. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282554
更新日期:1993-01-01 00:00:00
abstract::Ninety-five patients with erectile dysfunction underwent standardized cavernosometry and cavernosography. In a first stage, the investigation was performed in each patient without and in a second stage with 60 mg papaverine injected intracavernously. A pathological maintenance flow rate between 20 and 120 ml/min decre...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282389
更新日期:1992-01-01 00:00:00
abstract::We report a symptomatic multicystic seminal vesicle with ipsilateral renal agenesis in a 37-year-old man. Preoperatively the diagnosis could be suggested by different imaging modalities, including endorectal surface coil magnetic resonance imaging. To our knowledge, we present the 1st case of seminal vesicle cyst to b...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282892
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:To provide a systematic review and meta-analysis of studies comparing ureterolithotripsy (URS) with percutaneous nephrolithotripsy (PCNL) or laparoscopic ureterolithotomy (LU) techniques for the management of large proximal ureteral stones (diameter greater than 10 mm). METHODS:A literature search was perfo...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000471773
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The aims of this study were to establish the prevalence of enuresis, to determine accompanying factors, and to identify common methods in the management of enuresis in Turkish children aged between 6 and 11 years living in eastern Anatolia. METHODS:The parents of 3,527 schoolchildren aged between 6 and 11...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000079696
更新日期:2004-01-01 00:00:00
abstract:AIMS:To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). METHODS:Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000112611
更新日期:2008-01-01 00:00:00
abstract::Seventeen patients, age 1 day to 6 years with infantile polycystic kidney disease were evaluated with ultrasound and other imaging techniques. Most patients showed bilaterally enlarged kidneys with hyperechoic renal parenchyma, which had poor differentiation in outlines as well as between renal sinus, cortex and medul...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282303
更新日期:1992-01-01 00:00:00
abstract::A 25-year-old male with an incisional hernia following suprapubic trocar cystostomy for a failed traumatic perurethral catheterization is presented. This is only the 2nd case reported in the literature. Pathophysiology and management of this rare complication are discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000068764
更新日期:2003-01-01 00:00:00
abstract::The influence of unilateral ureteral ligation in the rat nephron has been morphometrically analysed. The glomeruli show no significant differences compared with the control groups. The lumen of the tubulus rectus I increases significantly, but irregularly, after the 6th day of ureter ligation. The brush border is most...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280329
更新日期:1980-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000502493
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION AND AIM:Surgical vasectomy remains the gold standard for fertility control in men. Endoluminal occlusion of the seminal ducts, thus avoiding an external incision, may become an appealing alternative to this approach. As our group has shown, nontraumatic endoscopic inspection of the seminal ducts is feasibl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000478790
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Our aim was to determine the safety and feasibility of catheter removal on the first morning after transurethral prostatectomy. METHODS:Fifty-four patients who underwent transurethral prostatectomy were included in a prospective study. The decision to remove the catheters on the first morning after surgery w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000048428
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:The study aimed to evaluate the predictive value of ureteral wall thickness (UWT) and stone-related parameters for medical expulsive therapy (MET) success with an alpha blocker in pediatric upper ureteral stones. PATIENTS AND METHODS:A total of 35 children receiving MET ureteral stones (<10 mm) were evaluate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000453668
更新日期:2017-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000330246
更新日期:2011-01-01 00:00:00
abstract::Five children with end-stage reflux nephropathy underwent kidney transplantation at our clinic. Reflux nephropathy was studied clinically and histologically. All children had proteinuria before starting hemodialysis, and hypertension was present in 2 cases. Three children underwent antireflux operations prior to trans...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281672
更新日期:1990-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000089744
更新日期:2006-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345630
更新日期:2013-01-01 00:00:00
abstract::To help bolster penile tension mechanically, we have tried implantation of silicone penile prostheses varying in type. Our simple and apparently successful procedures for organic impotence with the implantation of intrapenile silicone prostheses may well deserve recommendation in view of spinal impairment therapeutica...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000279981
更新日期:1975-01-01 00:00:00
abstract::119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The pat...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000281439
更新日期:1989-01-01 00:00:00
abstract::Idiopathic scrotal calcinosis is a rare, benign condition characterized by progressive calcification of the scrotal skin. A 29-year-old man who had undergone primary surgical excision of idiopathic scrotal calcinosis 7 years previously presented with recurrence that he had first noticed 3 years after surgery. Multiple...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350240
更新日期:2014-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496833
更新日期:2019-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324098
更新日期:2011-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000251183
更新日期:2009-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000137639
更新日期:2008-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000083289
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Gene-modified cell vaccines are now considered to be the best way to achieve immunotherapy for a variety of cancers including prostate cancer (PCa). XAGE-1b is a member of the cancer/testis antigen family which has demonstrated strong immunogenicity. We investigated whether XAGE-1b is an ideal target for P...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363333
更新日期:2015-01-01 00:00:00
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abstract::Renal pseudoaneurysms are a well-documented complication following trauma or after percutaneous biopsy. When symptomatic, patients present with hematuria and deteriorating renal function. We present the case of a 62-year-old man who, due to development of a pseudoaneurysm, presented with gross hematuria 10 days after ...
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journal_title:Urologia internationalis
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00