Abstract:
INTRODUCTION:Clear cell renal cell carcinoma (ccRCC) is the most common kidney tumor. If feasible, metastasectomy is preferably indicated in metastatic disease. OBJECTIVE:The aim of this study was to determine the outcome of patients after pulmonary metastasectomy (PM). METHODS:PM for ccRCC was performed in 35 patients in the period of January 2001-2019. Clinical characteristics, type of surgery, histopathology results, and follow-up data were recorded. Progression-free survival (PFS) after PM and overall survival (OS) were defined as outcome endpoints. RESULTS:A total of 77 PMs were performed in 35 patients after nephrectomy for ccRCC. The mean size of pulmonary metastasis was 19.0 mm (4-90). With a median follow-up after PM of 79.2 months, the 3- and 5-year OS rates were 63.5 and 44.9%, respectively. The only statistically significant prognostic factor affecting both PFS (p = 0.019) and OS (p = 0.015) was the dimension of pulmonary metastases. CONCLUSIONS:The prognosis of metastatic ccRCC is generally poor, particularly in cases of larger size of metastasis. PM might improve the individual prognosis of patients with lung metastasis even in cases with higher number of metastases, bilaterality, synchronous metastasis, or a short progression-free interval after nephrectomy.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Procházková K,Vodička J,Fichtl J,Krákorová G,Šebek J,Roušarová M,Hošek P,Brookman May SD,Hes O,Hora M,Třeška Vdoi
10.1159/000502493subject
Has Abstractpub_date
2019-01-01 00:00:00pages
297-302issue
3eissn
0042-1138issn
1423-0399pii
000502493journal_volume
103pub_type
杂志文章abstract::In 1 out of 56 patients, orchiectomized in the course of treatment for prostatic carcinoma, metastatic growth in the testis was found. This uncommon metastatic spread is a sign of advanced disease. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281859
更新日期:1987-01-01 00:00:00
abstract::Biopsies of 9 testicular tumors were examined for the presence of cytoplasmic receptor proteins for estrogens, progestins, androgens, and glucocorticoids. Using an arbitrary threshold value of 10 fmol/mg cytosol protein for a postive assay, only 1 of 9 tumors was estrogen-receptor positive. However, no receptor-specif...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281072
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:To prospectively evaluate the prognostic utility of the traditional prognostic factors and molecular markers p53 and Ki-67 in a homogeneous series of patients with non-muscle-invasive bladder cancer (NMIBC) treated with Bacillus Calmette-Guérin (BCG). PATIENTS AND METHODS:192 intermediate- and high-risk NMI...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000343431
更新日期:2013-01-01 00:00:00
abstract::35 women, referred for simple total hysterectomy, were evaluated pre- and postoperatively for bladder suspension and urodynamic changes. Although all patients denied urological problems, more than half of the patients had some degree of stress and/or urge incontinence. 40% had radiological signs of bladder suspension ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281085
更新日期:1985-01-01 00:00:00
abstract::A review of the recent literature on the surgical management of anterior urethral stricture was performed. The literature was searched via PubMed using the search terms 'urethral stricture' and 'urethroplasty' from 1996 to 2009. The management of anterior urethral strictures is changing rapidly in the sense that the r...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000319501
更新日期:2011-01-01 00:00:00
abstract::Electrostimulation was used to study the neuroanatomy and physiology of penile erection in dogs and monkeys. The canine spinal nuclei responsible for penile erection, identified by the retrograde horseradish peroxidase transport technique after verification of the cavernous nerves with neurostimulation, were mediolate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281034
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:To cultivate primary human bladder smooth muscle cells (hBSMCs) in vitro and to study the influences of different sustained hydrostatic pressures upon hBSMCs in terms of cell proliferation and expression of gap-junction connexin 43 (Cx43). METHODS:hBSMCs were exposed to 0, 20, 40, 60, 80 and 100 cm H(2)O su...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000338924
更新日期:2013-01-01 00:00:00
abstract::15 patients with urinary infection were selected and analyzed in relation to infection in the vaginal and perianal areas. After treatment, 12 patients with urinary infection were cured, but bacterial organisms persisted in their vaginal and perianal areas. In spite of the persistence of the vaginal and perianal infect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280207
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:We planned to examine the connection between serum uric acid (UA) values and prostatic calculi (PCal) presence and to evaluate the relation between PCal and other etiological factors. METHODS:Patients between 20 and 60 years of age who were referred to the clinic with any reason and had non-contrast abdomina...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000495313
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Sunitinib is standard first-line therapy for metastatic clear cell renal cancer (MCRC). It is associated with leucopenia; however, its effects on specific immune cell subsets are unclear. Alterations in immune cell subsets may contribute to tumour progression. METHODS:Lymphocyte subsets (CD3, 4, 8, 19 and 5...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000319498
更新日期:2011-01-01 00:00:00
abstract:EPIDEMIOLOGY:The annual incidence of urolithiasis in the population is at least 0.1%. In rural areas, there are remarkably less actual stone formers than in urban districts, and also vegetarians show less stone diseases. Calcium carbonate as a urinary calculus compound is not in the strict sense impossible, but often a...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280781
更新日期:1981-01-01 00:00:00
abstract:AIMS:To determine factors for treatment persistence in a real-life cohort of adult neurogenic lower urinary tract dysfunction. METHODS:We reviewed records of patients with neurogenic lower urinary tract dysfunction and mirabegron prescriptions. Exclusion criteria were indwelling urethral or suprapubic catheters and im...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000500349
更新日期:2019-01-01 00:00:00
abstract::Clinical and experimental investigations seem to underline the important role of fatty acids in the pathogenesis of hypercalciuria, a well-known risk factor for lithogenesis. To evaluate the relationships between the previously reported increase in plasma phospholipid arachidonic acid level and the factors responsible...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000087161
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Gene-modified cell vaccines are now considered to be the best way to achieve immunotherapy for a variety of cancers including prostate cancer (PCa). XAGE-1b is a member of the cancer/testis antigen family which has demonstrated strong immunogenicity. We investigated whether XAGE-1b is an ideal target for P...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363333
更新日期:2015-01-01 00:00:00
abstract::We report the first case of aspergillus mycotic aneurysm as a sequel to concomitant prostatic and renal aspergillosis. The patient had undergone left nephrectomy and transurethral resection of prostate for aspergillus infection one year ago. He again presented with LUTS and backache and clinical examination showed vis...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000056561
更新日期:2001-01-01 00:00:00
abstract::It has been well established that erectile dysfunction (ED) is a common incident in patients with benign prostate hyperplasia. Animal models have been described to investigate the relationship between bladder obstruction and ED. In this study, we aimed to investigate whether partial bladder outlet obstruction (PBOO) i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000137649
更新日期:2008-01-01 00:00:00
abstract::A 33-year-old male presented to the Chiba University Hospital with the main complaint of right flank pain. Bilateral vas deferens were not palpable. Hormonal examination revealed hypergonadotropic hypogonadism and cytogenetic studies a 47,XXY karyotype. The significance of the association of this karyotype with the ab...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281703
更新日期:1990-01-01 00:00:00
abstract:INTRODUCTION:There is a need for more exhaustive data concerning the use of prophylactic ureteral stenting for extended debulking and cytoreductive procedures in the literature. MATERIAL AND METHODS:A retrospective analysis of the CARPEPACEM study protocol database was performed. The trial protocol schedules the posit...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000339920
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:This study aimed at comparing the urinary protein levels in calcium stone formers with those of healthy individuals. PATIENTS AND METHODS:From January 2002 until June 2004, 100 calcium stone formers (mean age 38.6 +/- 10.3 years), who had at least two episodes of calcium stone formation, were compared with 1...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000090882
更新日期:2006-01-01 00:00:00
abstract::Microwave surgery as a tool for improved prostatic electroresection is introduced. Prior to electroresection the prostate was coagulated with 2,450 MHz of microwave which was emitted from the bipolar electrode of a specially designed probe. We conducted a comparative study of 35 patients with bladder neck obstruction....
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000281870
更新日期:1987-01-01 00:00:00
abstract::Metastatic renal cell carcinoma (mRCC) is a difficult to treat malignancy and currently Sunitinib is a standard of care first-line therapy. A new metastasis during the treatment is considered a sign of drug failure and alternative therapeutic methods should be tried. Here, we report 2 cases of newly diagnosed isolated...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000321908
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:We aimed at evaluating the efficacy of extracorporeal shockwave lithotripsy (SWL) for treating distal ureteral calculi performed in supine vs. prone position. MATERIALS AND METHODS:Eligible studies were identified by 2 reviewers using PubMed, Embase, and Web of Science databases. Outcomes included stone-free r...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000439140
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Etiology of serum anti-p53 antibodies in bladder cancer patients is still unknown. In this study we evaluated the relationship between serum anti-p53 antibodies and microvessel density in bladder cancer patients. MATERIALS AND METHODS:Seventy-six patients with transitional cell carcinoma of the urinary bl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000080831
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:Whereas the excellent functional outcomes after Holmium laser enucleation of the prostate (HoLEP) and its equivalency to open prostatectomy (OP) have been studied in detail in the past years, the oncological equivalency has yet to be investigated. Therefore, we conducted a matched pair analysis to evaluate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000492923
更新日期:2018-01-01 00:00:00
abstract:UNLABELLED:Polytraumatized patients often present with urological injuries. After hemodynamic stability is maintained urologists are consulted to evaluate diagnostic and therapeutic interventions. The following article describes how to handle the work-up of patients with injuries to specific urogenital organs: the impo...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000074083
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:This study aims to assess the impact of a virtual reality trainer in improving percutaneous renal access skills of urological trainees. METHODS:A total of 36 urology trainees participated in this prospective study. Initially, they were taken through the exercise of gaining access to the lower pole calyceal ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000337530
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The best technique of radical prostatectomy--open retropubic versus robot-assisted surgery--is a subject of controversy. PATIENTS AND METHODS:Between January 1st, 2007 and December 31st, 2011, 2,177 men underwent radical prostatectomy at our department. 252 (12%) cases were laparoscopic robot-assisted, the ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345320
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:We compare the absorption of irrigant fluid during gyrus plasmakinetic transurethral prostatectomy (PK-TURP) and transurethral resection of the prostate (TURP). PATIENTS AND METHODS:42 patients with clinical benign prostatic hyperplasia were randomly assigned to undergo PK-TURP or TURP. In the PK-TURP gro...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000093909
更新日期:2006-01-01 00:00:00
abstract::24 h urinary pyrophosphate excretion was studied in 20 normal healthy subjects and 75 idiopathic stone formers from north-western regions of India. The mean 24-hour urinary excretion of pyrophosphate was significantly low in stone formers (50.67 +/- 2.16 mumol/24 h) as compared to that of normal subjects (71.46 +/- 5....
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282364
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:To describe our surgical experience and clinical outcome in laparoscopic radical nephrectomy (LRN) for renal cell carcinoma (RCC) with level 1 renal vein tumor thrombus. PATIENTS AND METHODS:11 patients with RCC level 1 renal vein tumor thrombus were treated by LRN plus thrombectomy. The mean age was 66.8 ye...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363580
更新日期:2015-01-01 00:00:00