Abstract:
AIMS:To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). METHODS:Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflowmetry testing thrice on different occasions. The highest maximum urinary flow rate (Q(max)) values with a sufficient voided volume (> or =150 ml) were evaluated. The patients and controls were seen the day after the initial uroflowmetry measurements and were given 100 mg sildenafil. Afterwards uroflowmetry was repeated. The uroflowmetry values of both groups before and after sildenafil were compared. RESULTS:Of the 38 patients, 29 (76%) showed improvement in flow rates. The mean Q(max) was 11.4 +/- 0.39 and 15.7 +/- 0.74 ml/s before and after sildenafil, respectively (p < 0.0001). The mean percentage difference in Q(max) was +38% higher after sildenafil. The mean average flow rate (Q(ave)) and the mean voiding time values were also significantly improved. The mean voided volumes of the patients before and after sildenafil were 241 +/- 78 and 264 +/- 72 ml, respectively (p = 0.07). There were no significant differences in the Q(max), Q(ave) and voided volumes of the control group. CONCLUSIONS:Sildenafil exhibits a significant improvement in Q(max) and Q(ave) rates in men with LUTS.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Güler C,Tüzel E,Doğantekin E,Kiziltepe Gdoi
10.1159/000112611subject
Has Abstractpub_date
2008-01-01 00:00:00pages
181-5issue
2eissn
0042-1138issn
1423-0399pii
000112611journal_volume
80pub_type
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journal_title:Urologia internationalis
pub_type: 杂志文章
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:Urologia internationalis
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1978-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282440
更新日期:1993-01-01 00:00:00
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doi:10.1159/000345630
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000357127
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000316100
更新日期:2010-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1159/000502298
更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-01-01 00:00:00