A functional insertion/deletion polymorphism (-94 ins/del ATTG) in the promoter region of the NFKB1 gene is related to the risk of renal cell carcinoma.

Abstract:

OBJECTIVE:Activated nuclear factor-ĸB is associated with the pathogenesis of numerous malignancies, including renal cell carcinoma (RCC). This study aimed to clarify the influence of a common insertion/deletion polymorphism (-94 ins/del ATTG, rs28362491) in the NFKB1 promoter on RCC susceptibility. METHODS:We genotyped the NFKB1 -94 ins/del ATTG promoter polymorphism by the TaqMan method and assessed the association with RCC risk, clinicopathological parameters in a case-control study of 1,027 cases and 1,094 controls. RESULTS:The genotype frequencies were significantly different between RCC cases and controls (p = 0.046). Compared with individuals carrying the ins/del + del/del genotypes, those with the ins/ins genotype had an increased RCC risk [p = 0.036, adjusted odds ratio (OR) = 1.23, 95% confidence interval (CI) = 1.02-1.48], particularly in the subgroup of younger age (p = 0.005, adjusted OR = 1.42, 95% CI = 1.11-1.83) and never smokers (p = 0.013, adjusted OR = 1.34, 95% CI = 1.07-1.69). Furthermore, the polymorphism was significantly associated with the risk of developing localized stage RCC (p = 0.020, OR = 1.26, 95% CI = 1.04-1.53). CONCLUSIONS:The functional NFKB1 promoter polymorphism is associated with an increased risk of RCC.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Cai H,Sun L,Cui L,Cao Q,Qin C,Zhang G,Mao X,Wang M,Zhang Z,Shao P,Yin C

doi

10.1159/000345630

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

206-12

issue

2

eissn

0042-1138

issn

1423-0399

pii

000345630

journal_volume

91

pub_type

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