Abstract:
OBJECTIVES:To prospectively evaluate the prognostic utility of the traditional prognostic factors and molecular markers p53 and Ki-67 in a homogeneous series of patients with non-muscle-invasive bladder cancer (NMIBC) treated with Bacillus Calmette-Guérin (BCG). PATIENTS AND METHODS:192 intermediate- and high-risk NMIBC cases were enrolled. The variables in study were age, stage, grade, focality, tumour size, presence of associated carcinoma in situ, recurrence rate before BCG, maintenance for BCG, Ki-67 and p53. The endpoints considered were recurrence-free survival, progression-free survival, cancer-specific survival (CSS) and overall survival (OS). RESULTS:T stage resulted in being associated with CSS, whereas age with OS. BCG maintenance was a significantly favourable independent predictor of OS, CSS, recurrence and progression. In univariate analysis, the labelling index of Ki-67 was significantly associated with OS, CSS and progression. Multivariate analysis, however, confirmed this association only for OS. On the contrary, the labelling index of p53 was a significant predictor of recurrence, both in uni- and multivariate analyses, but with a HR inferior to 1. CONCLUSIONS:Ki-67 was an independent predictor of survival. p53 overexpression showed a significant yet inverse correlation with recurrence, thus showing little clinical utility. Age, stage and maintenance were confirmed as independent predictors of BCG response.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Oderda M,Ricceri F,Pisano F,Fiorito C,Gurioli A,Casetta G,Zitella A,Pacchioni D,Gontero Pdoi
10.1159/000343431subject
Has Abstractpub_date
2013-01-01 00:00:00pages
184-90issue
2eissn
0042-1138issn
1423-0399pii
000343431journal_volume
90pub_type
杂志文章abstract:INTRODUCTION:We aimed to evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile function in patients who had no cavernosal or urethral injury by using International Index of Erectile Function (IIEF) questionnaire. MATERIALS AND METHODS:The male patients who were treated by HBOT for several diseases betwe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000490356
更新日期:2018-01-01 00:00:00
abstract::A case of malignant peripheral nerve sheath tumor of the bladder in a 57-year-old man with multiple neurofibromatosis type 1 is presented. The patient had a recent history of a transurethrally resected bladder ganglioneuroma. A probable histogenetic association between these two extremely rare neoplasms is proposed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000065568
更新日期:2002-01-01 00:00:00
abstract::Bisphosphonates are a standard treatment for metastatic bone disease, although agents vary in their potential for renal toxicity. This case report describes the reversal of zoledronic acid-induced renal toxicity by switching treatment to ibandronate in a patient with hormone-refractory prostate cancer and bone metasta...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000132707
更新日期:2008-01-01 00:00:00
abstract::We examined a 46-year-old male patient with idiopathic myelofibrosis diagnosed 28 months earlier. After chemotherapy and irradiation, CT showed nonnodular, soft tissue masses in the renal hilum, pelvicaliceal system, perirenal and periureteral spaces. Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000087809
更新日期:2005-01-01 00:00:00
abstract::We performed sonography in 7 males with membranous and posterior urethral calculi. Sonography demonstrated the urethral calculi in all 7 patients. These findings suggest that sonography is useful as a noninvasive screening technique for urethral calculi. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282484
更新日期:1993-01-01 00:00:00
abstract::Marfan syndrome is a genetic disease responsible for causing cardiovascular, eye and musculoskeletal damages. Urinary disorders are not common. We present 4 cases of chronic urinary tract symptoms, with 2 different pathophysiological processes. Three patients presented with spinal cord infarct following aortic dissect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000484696
更新日期:2018-01-01 00:00:00
abstract::The purpose of this study was to make a model of renal vasoconstriction induced by mechanical manipulation of the renal artery and to investigate the influence of endothelin (ET) in renal vasoconstriction. Renal arteries of anesthetized rats were stretched with a 30-gram weight for 5 min, and released. Renal blood flo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030510
更新日期:2000-01-01 00:00:00
abstract::We present a 17-year-old patient with a right testicular dislocation. In this case, dislocated testis had been considered as hematoma and therefore remained untreated for 4 months. The patient underwent right orchiopexy 4 months after the injury. Intraoperative testicular biopsy revealed impaired spermatogenesis and e...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282830
更新日期:1996-01-01 00:00:00
abstract::The intracavernosal pressure changes induced by 3 vasodilating drugs, diazoxide, glyceryltrinitrate and verapamil were investigated during autologous extracorporeal penile blood perfusion in an experimental rabbit model. In order to separate the arterial and venous components the experiments were performed with both i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282454
更新日期:1993-01-01 00:00:00
abstract::The present study was undertaken to analyze the changes in neuroendocrine cells of the human prostate induced by neoplasms and the effect of hormonal treatment. Samples of human prostate (n = 47) were obtained during surgery or removal of organs for transplantation. The cases analyzed represent normal prostates (n = 4...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000283051
更新日期:1997-01-01 00:00:00
abstract::From July 1992 to April 1994, 70 patients with prostatic cancer underwent laparoscopic pelvic lymph-node dissection (LPLD) before retropubic radical prostatectomy or afterloading therapy in our clinic. After an initial learning phase, the accuracy of LPLD was excellent, with only 3.0% residual nodes and no false-negat...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282756
更新日期:1995-01-01 00:00:00
abstract::Prazosin HCl was administered to 20 patients with urinary obstructions associated with prostatic hypertrophy. Significant reductions were recorded in the nighttime and the mean 24-hour urination frequencies. Patient-assessed symptoms diminished significantly, and uroflowmetry revealed significant increases in average ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282023
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the management of urolithiasis in children since the development of extracorporeal shock-wave lithotripsy (ESWL). METHODS:Between 1988 and 1994, 37 children, aged from 2 to 15 years (mean 10), with upper tract urolithiasis were evaluated and treated. Lithogenic metabolic disorders or anomalies of...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282882
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:This study aims to assess the impact of a virtual reality trainer in improving percutaneous renal access skills of urological trainees. METHODS:A total of 36 urology trainees participated in this prospective study. Initially, they were taken through the exercise of gaining access to the lower pole calyceal ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000337530
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:Polytraumatized patients often present with urological injuries. After hemodynamic stability is maintained urologists are consulted to evaluate diagnostic and therapeutic interventions. The following article describes how to handle the work-up of patients with injuries to specific urogenital organs: the impo...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000074083
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:We aimed at evaluating the efficacy of extracorporeal shockwave lithotripsy (SWL) for treating distal ureteral calculi performed in supine vs. prone position. MATERIALS AND METHODS:Eligible studies were identified by 2 reviewers using PubMed, Embase, and Web of Science databases. Outcomes included stone-free r...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000439140
更新日期:2016-01-01 00:00:00
abstract::The first case of carcinosarcoma in the spermatic cord is reported in a 40-year-old man. The tumor was a 2.5 X 2 cm pseudoencapsulated formation located in the connective tissue of the spermatic cord among the blood vessels. Light microscopy examination of the neoplasm revealed two different histological patterns: epi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281727
更新日期:1990-01-01 00:00:00
abstract:AIM:Since DNA damage-related apoptosis is raising concerns regarding abnormal spermatogenesis, we investigated the changes in γ-H2AX during testicular germ cell apoptotic responses in the varicocele model. MATERIALS AND METHODS:Varicocele was induced by partial ligation of the left renal vein and animals were sacrific...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000316356
更新日期:2010-01-01 00:00:00
abstract::Intestinal ischemia is reported to be the most common gastrointestinal complication of renal transplantation and a potential cause of morbidity and mortality. The recent use of more potent immunosuppressive drug regimens has reduced the incidence of acute rejection, increasing the incidence of potentially fatal infect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000106334
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Afferents from the urinary tract transmit bladder sensations to the central nervous system. Spinal cord injury (SCI) may affect both efferent motor and afferent sensory pathways. Presence/absence of bladder sensations in patients with complete spinal cord, conus or cauda equina lesions was compared with neur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000342815
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Prostate biopsy (PBx) techniques have changed significantly since the original Hodge's scheme, with an increase in the number and location of cores. These improvements have been realized in part because of the introduction of different local anaesthesia techniques. We critically analysed the literature discu...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000327827
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Increased pneumoperitoneum pressure during laparoscopic surgery can result in acute kidney injury. We aimed to clarify whether intraabdominal pressure tolerance is modified in various degrees of unilateral kidney hydronephrosis in rabbits. METHODS:A total 90 rabbits were randomly allocated to three groups (g...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000362845
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:To evaluate the antifibrotic role of captopril during ureteral scarring in a New Zealand rabbit model. MATERIALS AND METHODS:The tissue expression and the fluctuation of EGF, TGF-β, FN, Col Ia1, Col Ia2 and Col III of the impaired ureter and the contralateral normal ureter were investigated by RT-PCR. The h...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341790
更新日期:2012-01-01 00:00:00
abstract::Serum-ionized calcium (Ca++) was measured in 65 patients with idiopathic calcium urolithiasis. The patients were then divided into hypercalciuric and normocalciuric groups based on the mean + SD of the control group, with greater than 180 mg/24 h in males and greater than 176 mg/24 h in females defined as hypercalciur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280303
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. MATERIALS AND METHODS:The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000084434
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of transobturator tape (TOT) in the management of stress urinary incontinence at a medium term follow-up. METHODS:TOT is a polypropylene tape positioned through the obturator foramen. 70 patients with type II urinary stress incontinence were treated with TOT between June 2003 and May 2...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000127340
更新日期:2008-01-01 00:00:00
abstract::A small group of patients with nephrolithiasis who forms mixed (calcium oxalate and uric acid) calculi presents particular problems in their clinical management. In 3,158 stones analyzed in our laboratory, we found 158 mixed calculi in 86 of the patients. In this work, the clinical and biochemical results obtained fro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
abstract:AIM:To evaluate the efficacy of a new sclerotization technique with pure ethanol in the treatment of symptomatic renal cysts. PATIENTS AND METHODS:Fourteen patients having renal cysts with a meant diameter of 10 (range 5-15) cm were treated. Our technique includes: ultrasound-guided percutaneous puncture with an 18-ga...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071846
更新日期:2003-01-01 00:00:00
abstract::Primary penile carcinoma is one of the rarest male genital tract tumors. We rarely encounter this malignancy in Turkey because circumcision is routinely performed as a part of the Islamic tradition. Despite the medical paradox that the penis is rarely affected by metastases, approximately 300 cases have been reported ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000090872
更新日期:2006-01-01 00:00:00
abstract::The introduction in 1982 of vasoactive agents for intracavernous injection represents a milestone in the diagnosis and treatment of erectile dysfunction. Two preparations, the single drug papaverine hydrochloride and the combination of phentolamine mesylate and papaverine hydrochloride, hold great promise. In the last...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281308
更新日期:1988-01-01 00:00:00