Prognostic factors including Ki-67 and p53 in Bacillus Calmette-Guérin-treated non-muscle-invasive bladder cancer: a prospective study.

Abstract:

OBJECTIVES:To prospectively evaluate the prognostic utility of the traditional prognostic factors and molecular markers p53 and Ki-67 in a homogeneous series of patients with non-muscle-invasive bladder cancer (NMIBC) treated with Bacillus Calmette-Guérin (BCG). PATIENTS AND METHODS:192 intermediate- and high-risk NMIBC cases were enrolled. The variables in study were age, stage, grade, focality, tumour size, presence of associated carcinoma in situ, recurrence rate before BCG, maintenance for BCG, Ki-67 and p53. The endpoints considered were recurrence-free survival, progression-free survival, cancer-specific survival (CSS) and overall survival (OS). RESULTS:T stage resulted in being associated with CSS, whereas age with OS. BCG maintenance was a significantly favourable independent predictor of OS, CSS, recurrence and progression. In univariate analysis, the labelling index of Ki-67 was significantly associated with OS, CSS and progression. Multivariate analysis, however, confirmed this association only for OS. On the contrary, the labelling index of p53 was a significant predictor of recurrence, both in uni- and multivariate analyses, but with a HR inferior to 1. CONCLUSIONS:Ki-67 was an independent predictor of survival. p53 overexpression showed a significant yet inverse correlation with recurrence, thus showing little clinical utility. Age, stage and maintenance were confirmed as independent predictors of BCG response.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Oderda M,Ricceri F,Pisano F,Fiorito C,Gurioli A,Casetta G,Zitella A,Pacchioni D,Gontero P

doi

10.1159/000343431

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

184-90

issue

2

eissn

0042-1138

issn

1423-0399

pii

000343431

journal_volume

90

pub_type

杂志文章
  • The Effect of Hyperbaric Oxygen Therapy on Erectile Functions: A Prospective Clinical Study.

    abstract:INTRODUCTION:We aimed to evaluate the effects of hyperbaric oxygen therapy (HBOT) on erectile function in patients who had no cavernosal or urethral injury by using International Index of Erectile Function (IIEF) questionnaire. MATERIALS AND METHODS:The male patients who were treated by HBOT for several diseases betwe...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000490356

    authors: Sahin MO,Sen V,Eser E,Koc E,Gumus U,Karakuzu C,Ucer O

    更新日期:2018-01-01 00:00:00

  • Malignant peripheral nerve sheath tumor of the urinary bladder in von Recklinghausen disease.

    abstract::A case of malignant peripheral nerve sheath tumor of the bladder in a 57-year-old man with multiple neurofibromatosis type 1 is presented. The patient had a recent history of a transurethrally resected bladder ganglioneuroma. A probable histogenetic association between these two extremely rare neoplasms is proposed. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000065568

    authors: Kalafatis P,Kavantzas N,Pavlopoulos PM,Agapitos E,Politou M,Kranides A

    更新日期:2002-01-01 00:00:00

  • Renal toxicity following zoledronic acid reversed with ibandronate in a prostate cancer patient with bone metastases.

    abstract::Bisphosphonates are a standard treatment for metastatic bone disease, although agents vary in their potential for renal toxicity. This case report describes the reversal of zoledronic acid-induced renal toxicity by switching treatment to ibandronate in a patient with hormone-refractory prostate cancer and bone metasta...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000132707

    authors: Joensuu TK

    更新日期:2008-01-01 00:00:00

  • Extramedullary hematopoiesis in chronic myelofibrosis encasing the pelvicaliceal system and perirenal spaces: CT findings.

    abstract::We examined a 46-year-old male patient with idiopathic myelofibrosis diagnosed 28 months earlier. After chemotherapy and irradiation, CT showed nonnodular, soft tissue masses in the renal hilum, pelvicaliceal system, perirenal and periureteral spaces. Ultrasound-guided biopsy showed extramedullary hematopoiesis (EMH)....

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000087809

    authors: La Fianza A,Torretta L,Spinazzola A

    更新日期:2005-01-01 00:00:00

  • Sonography of urethral calculi.

    abstract::We performed sonography in 7 males with membranous and posterior urethral calculi. Sonography demonstrated the urethral calculi in all 7 patients. These findings suggest that sonography is useful as a noninvasive screening technique for urethral calculi. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282484

    authors: Koga S,Shiraishi K,Saito Y,Arakaki Y,Matsuoka M

    更新日期:1993-01-01 00:00:00

  • Urinary Disorders and Marfan Syndrome: A Series of 4 Cases.

    abstract::Marfan syndrome is a genetic disease responsible for causing cardiovascular, eye and musculoskeletal damages. Urinary disorders are not common. We present 4 cases of chronic urinary tract symptoms, with 2 different pathophysiological processes. Three patients presented with spinal cord infarct following aortic dissect...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000484696

    authors: Hentzen C,Turmel N,Chesnel C,Le Breton F,Sheikh Ismael S,Amarenco G

    更新日期:2018-01-01 00:00:00

  • Endothelin A receptor antagonist reduces renal vasoconstriction induced by mechanical manipulation of renal artery.

    abstract::The purpose of this study was to make a model of renal vasoconstriction induced by mechanical manipulation of the renal artery and to investigate the influence of endothelin (ET) in renal vasoconstriction. Renal arteries of anesthetized rats were stretched with a 30-gram weight for 5 min, and released. Renal blood flo...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000030510

    authors: Watarai Y,Yoshioka M,Tanda K,Seki T,Saito H,Koyanagi T

    更新日期:2000-01-01 00:00:00

  • Pathological changes of traumatic dislocated testis.

    abstract::We present a 17-year-old patient with a right testicular dislocation. In this case, dislocated testis had been considered as hematoma and therefore remained untreated for 4 months. The patient underwent right orchiopexy 4 months after the injury. Intraoperative testicular biopsy revealed impaired spermatogenesis and e...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282830

    authors: Hayami S,Ishigooka M,Suzuki Y,Sasagawa I,Nakada T,Mitobe K

    更新日期:1996-01-01 00:00:00

  • A hydrodynamic model of rabbit corpus cavernosum pressure responses to vasodilators.

    abstract::The intracavernosal pressure changes induced by 3 vasodilating drugs, diazoxide, glyceryltrinitrate and verapamil were investigated during autologous extracorporeal penile blood perfusion in an experimental rabbit model. In order to separate the arterial and venous components the experiments were performed with both i...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282454

    authors: Lundbech PE,Kirkeby HJ,Djurhuus JC

    更新日期:1993-01-01 00:00:00

  • Neuroendocrine cells in benign prostatic hyperplasia and prostatic carcinoma: effect of hormonal treatment.

    abstract::The present study was undertaken to analyze the changes in neuroendocrine cells of the human prostate induced by neoplasms and the effect of hormonal treatment. Samples of human prostate (n = 47) were obtained during surgery or removal of organs for transplantation. The cases analyzed represent normal prostates (n = 4...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000283051

    authors: Guate JL,Escaf S,Menendez CL,del Valle M,Vega JA

    更新日期:1997-01-01 00:00:00

  • Laparoscopic pelvic lymphadenectomy in prostatic cancer: an analysis of seventy consecutive cases.

    abstract::From July 1992 to April 1994, 70 patients with prostatic cancer underwent laparoscopic pelvic lymph-node dissection (LPLD) before retropubic radical prostatectomy or afterloading therapy in our clinic. After an initial learning phase, the accuracy of LPLD was excellent, with only 3.0% residual nodes and no false-negat...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282756

    authors: Klän R,Meier T,Knispel HH,Wegner HE,Miller K

    更新日期:1995-01-01 00:00:00

  • The efficacy of prazosin HCl in the treatment of urinary flow obstruction due to prostatic hypertrophy.

    abstract::Prazosin HCl was administered to 20 patients with urinary obstructions associated with prostatic hypertrophy. Significant reductions were recorded in the nighttime and the mean 24-hour urination frequencies. Patient-assessed symptoms diminished significantly, and uroflowmetry revealed significant increases in average ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282023

    authors: Kondo A,Gotoh M,Saito M,Takita T,Kobayashi M,Otani T,Ito K

    更新日期:1990-01-01 00:00:00

  • Childhood urolithiasis: urological management of upper tract calculi in the era of extracorporeal shock-wave lithotripsy.

    abstract:OBJECTIVE:To evaluate the management of urolithiasis in children since the development of extracorporeal shock-wave lithotripsy (ESWL). METHODS:Between 1988 and 1994, 37 children, aged from 2 to 15 years (mean 10), with upper tract urolithiasis were evaluated and treated. Lithogenic metabolic disorders or anomalies of...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282882

    authors: Robert M,Drianno N,Guiter J,Averous M,Grasset D

    更新日期:1996-01-01 00:00:00

  • Use of a virtual reality simulator to improve percutaneous renal access skills: a prospective study in urology trainees.

    abstract:OBJECTIVES:This study aims to assess the impact of a virtual reality trainer in improving percutaneous renal access skills of urological trainees. METHODS:A total of 36 urology trainees participated in this prospective study. Initially, they were taken through the exercise of gaining access to the lower pole calyceal ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000337530

    authors: Papatsoris AG,Shaikh T,Patel D,Bourdoumis A,Bach C,Buchholz N,Masood J,Junaid I

    更新日期:2012-01-01 00:00:00

  • Imaging studies in the diagnosis of urogenital trauma.

    abstract:UNLABELLED:Polytraumatized patients often present with urological injuries. After hemodynamic stability is maintained urologists are consulted to evaluate diagnostic and therapeutic interventions. The following article describes how to handle the work-up of patients with injuries to specific urogenital organs: the impo...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000074083

    authors: Herbst A,Schmelz HU,Sparwasser C

    更新日期:2003-01-01 00:00:00

  • Supine versus Prone Position during Extracorporeal Shockwave Lithotripsy for Treating Distal Ureteral Calculi: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:We aimed at evaluating the efficacy of extracorporeal shockwave lithotripsy (SWL) for treating distal ureteral calculi performed in supine vs. prone position. MATERIALS AND METHODS:Eligible studies were identified by 2 reviewers using PubMed, Embase, and Web of Science databases. Outcomes included stone-free r...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000439140

    authors: Li T,Gao L,Chen P,Bu S,Cao D,Yang L,Wei Q

    更新日期:2016-01-01 00:00:00

  • Carcinosarcoma of the spermatic cord.

    abstract::The first case of carcinosarcoma in the spermatic cord is reported in a 40-year-old man. The tumor was a 2.5 X 2 cm pseudoencapsulated formation located in the connective tissue of the spermatic cord among the blood vessels. Light microscopy examination of the neoplasm revealed two different histological patterns: epi...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281727

    authors: Nistal M,Burgos F,Paniagua R

    更新日期:1990-01-01 00:00:00

  • Experimental varicocele induces p53-dependent germ cell apoptosis through activation of γ-H2AX.

    abstract:AIM:Since DNA damage-related apoptosis is raising concerns regarding abnormal spermatogenesis, we investigated the changes in γ-H2AX during testicular germ cell apoptotic responses in the varicocele model. MATERIALS AND METHODS:Varicocele was induced by partial ligation of the left renal vein and animals were sacrific...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000316356

    authors: Chang IY,Kim JH,Park KH,Yoon SP

    更新日期:2010-01-01 00:00:00

  • Cytomegalovirus and Clostridium difficile ischemic colitis in a renal transplant recipient: a lethal complication of anti-rejection therapy?

    abstract::Intestinal ischemia is reported to be the most common gastrointestinal complication of renal transplantation and a potential cause of morbidity and mortality. The recent use of more potent immunosuppressive drug regimens has reduced the incidence of acute rejection, increasing the incidence of potentially fatal infect...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000106334

    authors: Veroux M,Puzzo L,Corona D,Buffone A,Tallarita T,Murabito P,Veroux P

    更新日期:2007-01-01 00:00:00

  • Afferent pathways arising from the lower urinary tract after complete spinal cord injury or cauda equina lesion: clinical observations with neurophysiological implications.

    abstract:BACKGROUND:Afferents from the urinary tract transmit bladder sensations to the central nervous system. Spinal cord injury (SCI) may affect both efferent motor and afferent sensory pathways. Presence/absence of bladder sensations in patients with complete spinal cord, conus or cauda equina lesions was compared with neur...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000342815

    authors: Reitz A

    更新日期:2012-01-01 00:00:00

  • Anaesthesia in transrectal prostate biopsy: which is the most effective technique?

    abstract:BACKGROUND:Prostate biopsy (PBx) techniques have changed significantly since the original Hodge's scheme, with an increase in the number and location of cores. These improvements have been realized in part because of the introduction of different local anaesthesia techniques. We critically analysed the literature discu...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000327827

    authors: Maccagnano C,Scattoni V,Roscigno M,Raber M,Angiolilli D,Montorsi F,Rigatti P

    更新日期:2011-01-01 00:00:00

  • Acute kidney injury induced by various pneumoperitoneum pressures in a rabbit model of mild and severe hydronephrosis.

    abstract:OBJECTIVE:Increased pneumoperitoneum pressure during laparoscopic surgery can result in acute kidney injury. We aimed to clarify whether intraabdominal pressure tolerance is modified in various degrees of unilateral kidney hydronephrosis in rabbits. METHODS:A total 90 rabbits were randomly allocated to three groups (g...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000362845

    authors: Li W,Cao Z,Xia Z,Meng Q,Yu WM,Yao X,Cheng F

    更新日期:2015-01-01 00:00:00

  • Antifibrotic role of captopril after ureteral injury.

    abstract:OBJECTIVES:To evaluate the antifibrotic role of captopril during ureteral scarring in a New Zealand rabbit model. MATERIALS AND METHODS:The tissue expression and the fluctuation of EGF, TGF-β, FN, Col Ia1, Col Ia2 and Col III of the impaired ureter and the contralateral normal ureter were investigated by RT-PCR. The h...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000341790

    authors: Pan J,Xue W,Chen Q,Chen Y,Chen H,Huang Y

    更新日期:2012-01-01 00:00:00

  • Serum-ionized calcium as a diagnostic tool in hypercalciuria.

    abstract::Serum-ionized calcium (Ca++) was measured in 65 patients with idiopathic calcium urolithiasis. The patients were then divided into hypercalciuric and normocalciuric groups based on the mean + SD of the control group, with greater than 180 mg/24 h in males and greater than 176 mg/24 h in females defined as hypercalciur...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280303

    authors: Iguchi M,Kohri K,Akiyama T,Yachiku S,Kurita T

    更新日期:1980-01-01 00:00:00

  • Does ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass cause bladder outlet obstruction?

    abstract:OBJECTIVE:This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. MATERIALS AND METHODS:The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antig...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000084434

    authors: Guvel S,Turkoz R,Egilmez T,Kilinc F,Yaycioglu O,Atalay H,Ozkardes H

    更新日期:2005-01-01 00:00:00

  • Transobturator tape in the management of female stress incontinence: clinical outcomes at medium term follow-up.

    abstract:OBJECTIVE:To assess the efficacy of transobturator tape (TOT) in the management of stress urinary incontinence at a medium term follow-up. METHODS:TOT is a polypropylene tape positioned through the obturator foramen. 70 patients with type II urinary stress incontinence were treated with TOT between June 2003 and May 2...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000127340

    authors: Kocjancic E,Crivellaro S,Oyama IA,Singla A,Ranzoni S,Carone R,Manassero A,Gontero P,Frea B

    更新日期:2008-01-01 00:00:00

  • Hypocitraturia as a pathogenic risk factor in the mixed (calcium oxalate/uric acid) renal stones.

    abstract::A small group of patients with nephrolithiasis who forms mixed (calcium oxalate and uric acid) calculi presents particular problems in their clinical management. In 3,158 stones analyzed in our laboratory, we found 158 mixed calculi in 86 of the patients. In this work, the clinical and biochemical results obtained fro...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:

    authors: Alvarez Arroyo MV,Traba ML,Rapado A

    更新日期:1992-01-01 00:00:00

  • Renal cysts: can percutaneous ethanol injections be considered an alternative to surgery?

    abstract:AIM:To evaluate the efficacy of a new sclerotization technique with pure ethanol in the treatment of symptomatic renal cysts. PATIENTS AND METHODS:Fourteen patients having renal cysts with a meant diameter of 10 (range 5-15) cm were treated. Our technique includes: ultrasound-guided percutaneous puncture with an 18-ga...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000071846

    authors: Gasparini D,Sponza M,Valotto C,Marzio A,Luciani LG,Zattoni F

    更新日期:2003-01-01 00:00:00

  • Penile metastasis from other malignancies. A study of ten cases and review of the literature.

    abstract::Primary penile carcinoma is one of the rarest male genital tract tumors. We rarely encounter this malignancy in Turkey because circumcision is routinely performed as a part of the Islamic tradition. Despite the medical paradox that the penis is rarely affected by metastases, approximately 300 cases have been reported ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000090872

    authors: Hizli F,Berkmen F

    更新日期:2006-01-01 00:00:00

  • Diagnosis and therapy of erectile dysfunction using papaverine and phentolamine.

    abstract::The introduction in 1982 of vasoactive agents for intracavernous injection represents a milestone in the diagnosis and treatment of erectile dysfunction. Two preparations, the single drug papaverine hydrochloride and the combination of phentolamine mesylate and papaverine hydrochloride, hold great promise. In the last...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000281308

    authors: Zentgraf M,Baccouche M,Jünemann KP

    更新日期:1988-01-01 00:00:00