Abstract:
AIM:Since DNA damage-related apoptosis is raising concerns regarding abnormal spermatogenesis, we investigated the changes in γ-H2AX during testicular germ cell apoptotic responses in the varicocele model. MATERIALS AND METHODS:Varicocele was induced by partial ligation of the left renal vein and animals were sacrificed at 1, 3, and 4 weeks after varicocele creation. The levels of activated p53 and γ-H2AX formation were determined by Western blot analysis and immunohistochemistry. RESULTS:γ-H2AX formation was augmented after varicocele creation, while a significant increase in p53 phosphorylation was detected in a time course-dependent manner. Varicocele-dependent nuclear γ-H2AX staining in the primary spermatocytes was prominent as degenerative foci, while little differences could be detected in spermatogonia. CONCLUSIONS:These results show that experimental varicocele may induce p53-dependent apoptosis through activation of γ-H2AX in the primary spermatocytes, and suggest that γ-H2AX may be related to apoptotic signal transduction in experimental varicocele.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Chang IY,Kim JH,Park KH,Yoon SPdoi
10.1159/000316356subject
Has Abstractpub_date
2010-01-01 00:00:00pages
216-20issue
2eissn
0042-1138issn
1423-0399pii
000316356journal_volume
85pub_type
杂志文章abstract::Marfan syndrome is a genetic disease responsible for causing cardiovascular, eye and musculoskeletal damages. Urinary disorders are not common. We present 4 cases of chronic urinary tract symptoms, with 2 different pathophysiological processes. Three patients presented with spinal cord infarct following aortic dissect...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000484696
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000362903
更新日期:2015-01-01 00:00:00
abstract::Tumour markers which occur in blood or urine are of value in the management of cancer patients because they allow disease status to be monitored by non-invasive techniques at low cost. An antigen, 'B5', on erythrocytes has been shown to become enhanced when cancer develops, regardless of tumour type, and thus the B5 a...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281951
更新日期:1987-01-01 00:00:00
abstract::The intracavernosal pressure changes induced by 3 vasodilating drugs, diazoxide, glyceryltrinitrate and verapamil were investigated during autologous extracorporeal penile blood perfusion in an experimental rabbit model. In order to separate the arterial and venous components the experiments were performed with both i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282454
更新日期:1993-01-01 00:00:00
abstract::The objective of the study was to evaluate possible changes of the gene expression and localization of the enzymes, heme oxygenase and nitric oxide synthase (NOS), with reference to increase of collagen type III in response to the partial obstruction of the bladder. Following initial obstruction, whole rat bladders we...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000099351
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:To analyze positive surgical margins (PSM) after radical prostatectomy (RP) in the overall population and in patients previously treated with transurethral resection of the prostate (TURP). MATERIALS AND METHODS:2,408 patients treated with RP for clinically localized prostate cancer (PCa) were consecutively ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000346748
更新日期:2013-01-01 00:00:00
abstract::Plasma carcinoembryonic antigen (CEA) levels were performed preoperatively by radioimmunoassay in 124 patients with histologically proved bladder carcinoma. The level of CEA was used to determine its prognostic value in patients with bladder cancer. The correlation of CEA levels with the stage of the disease, histolog...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280285
更新日期:1979-01-01 00:00:00
abstract::Interstitial cystitis is a chronic benign disease of the bladder that causes bothersome and debilitating symptoms and mainly affects women. Since interstitial cystitis (IC) might result from a defective glycosaminoglycan layer of the bladder epithelium, we conducted a trial of hyaluronic acid (HA), used intravesically...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000283012
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:In spite of readily available evidence-based guidelines on urolithiasis treatment, practical applications of treatments vary from country to country, or even within countries. The choice of treatment depends not only on the evidence, but often on general non-medical decision factors such as infrastructure, ex...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000441041
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Robotic-assisted laparoscopy (RAL) is being widely accepted in the field of urology as a replacement for conventional laparoscopy (CL). Nevertheless, the process of its integration in clinical routines has been rather spontaneous. OBJECTIVE:To determine the prevalence of robotic systems (RS) in urological c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000430502
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To assess the pathophysiology of lower urinary tract symptoms (LUTS) in aged men without bladder outlet obstruction in a videourodynamic study. METHODS:In a videourodynamic study of 324 consecutive men with moderate to severe LUTS suggestive for bladder outlet obstruction, 112 were found to be urodynamically...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030497
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:The treatment approach for enuresis is controversial due to the lack of consensus as to the exact causes of nocturnal enuresis. Despite various treatment modalities, pharmacotherapy still appears to be the common choice. The aim of this prospective study was the evaluation of the efficacy of combination therapy...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000064858
更新日期:2000-01-01 00:00:00
abstract::Bacillus Calmette-Guérin (BCG) immunotherapy is the most effective treatment for carcinoma in situ and high-risk non-muscle invasive bladder cancer (NMIBC). However, it can also provoke diverse side effects. We found 1 patient with a significantly and rapidly reduced bladder volume after the instillation of BCG. Few s...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000510167
更新日期:2021-01-01 00:00:00
abstract::Alpha-fetoprotein (AFP) is recognized as a tumor marker of yolk sac tumors, liver cancer and some other cancers of the digestive organs. Renal cell carcinoma (RCC) producing AFP is a rare entity. A case of AFP-producing RCC with solitary bone metastasis, but without liver involvement, is reported. The stain specific t...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000050982
更新日期:2001-01-01 00:00:00
abstract::A dermoid cyst is a particular form of a cystic teratoma. In the testis, it is very rare, with only a few cases reported in world literature. A 19-year-old patient come to our attention with a 7-year history of an intratesticular cystic mass. Sonography showed a large hypoechoic solid mass. The tumour markers alpha-fe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000094824
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066121
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Phytate as sodium salt has been used at high doses to treat stone-former patients with idiopathic hypercalciuria. The experimental and clinical hypocalciuric effects of dietary fiber have also been assigned to the presence of phytate as calcium-magnesium salt (phytin). As a consequence of the additional inte...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000077123
更新日期:2004-01-01 00:00:00
abstract::Vesicovaginal fistula (VVF) is a quite rare complication of gynecological surgery. The first attempt to repair the fistulous tract offers the best opportunity for cure. We report the successful repair of VVF in 2 patients using a combined anterior vaginal approach and porcine dermal collagen grafting as interposition ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000176038
更新日期:2009-01-01 00:00:00
abstract::We studied the impact of antireflux surgery on bladder compliance, which was an important clinical parameter in terms of urinary incontinence and upper tract deterioration, in 20 myelodysplastics (group A). For control groups, 31 myelodysplastic children with or without reflux who were conservatively treated (group B)...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282253
更新日期:1991-01-01 00:00:00
abstract::Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280348
更新日期:1980-01-01 00:00:00
abstract::The guidelines of testicular cancer were elaborated and agreed upon interdisciplinarily. Standard therapy of stage I seminoma is infradiaphragmatic radiotherapy. Possible alternatives are adjuvant carboplatin therapy (still in test procedure) and, in case of lacking risk factors, the watch-and-wait strategy. If small ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030418
更新日期:1999-01-01 00:00:00
abstract::In order to determine an optimum mode for systemic administration of recombinant interleukin 2 (rIL2), the effects of rIL2 on lymphocyte-mediated cytotoxicity against renal carcinoma cells were studied in vitro. Augmentation of the cytotoxicity by rIL2 was dose- and time-dependent. The optimum dose of rIL2 was 100-500...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282272
更新日期:1991-01-01 00:00:00
abstract::To evaluate the fragility of Ca-oxalate monohydrate stones in terms of high energy shock wave effectivity, we measured the glycosaminoglycan (GAG) content of the organic stone matrix of 35 patients who had undergone extracorporeal shock wave lithotripsy (ESWL) treatment for renal pelvic stones. The patients were class...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282944
更新日期:1997-01-01 00:00:00
abstract::Microwave surgery as a tool for improved prostatic electroresection is introduced. Prior to electroresection the prostate was coagulated with 2,450 MHz of microwave which was emitted from the bipolar electrode of a specially designed probe. We conducted a comparative study of 35 patients with bladder neck obstruction....
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000281870
更新日期:1987-01-01 00:00:00
abstract::We present a case of bilateral renal cell carcinoma occurring simultaneously with a single lymph node metastasis clearly demonstrated by angiography. Radical nephrectomy, blunt enucleation of the cortical tumor in the controlateral kidney and removal of a large lymph node metastasis were performed simultaneously. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281904
更新日期:1987-01-01 00:00:00
abstract::This study was undertaken to investigate the endocrine function of the testis that was autotransplanted by microvascular techniques in 10 healthy dogs. After a control period of 4 weeks, hemicastration was carried out, and 4 weeks later the experimental orchidopexy was done. Finally, the transplanted testis was remove...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280918
更新日期:1983-01-01 00:00:00
abstract::This report presents a case of a 16-year-old hypertensive boy who presented to our clinic. Laboratory findings showed severe hypokalemia and markedly increased plasma renin activity. Abdominal ultrasonography and contrast-enhanced computed tomography of the abdomen revealed a well-circumscribed, solid, hypoenhancing c...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000314339
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Microchimerism (MC) is the presence of a small amount of foreign cells or DNA within a person's circulation or tissues. It has been identified also in recipients of solid organ transplants where it seems to be critical for the development and maintenance of immunological tolerance. Nevertheless, natural an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000508796
更新日期:2020-01-01 00:00:00
abstract::The bladder pressure necessary to cause vesicoureteral reflux (VUR) was measured in 16 female rats. Under general anesthesia, the ureters were exposed via an abdominal incision and a pressure catheter was placed near the ureterovesical junction. Values of bladder distension and bladder pressure increase to cause VUR w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281195
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to analyze the influence of residents' participation in flexible ureteroscopy (fURS) on intra- and postoperative outcomes. MATERIALS AND METHODS:Intra- and postoperative parameters were compared in a retrospective monocentric setting between 3 groups: "resident group" (47 cases) ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504989
更新日期:2020-01-01 00:00:00