Endothelin A receptor antagonist reduces renal vasoconstriction induced by mechanical manipulation of renal artery.

Abstract:

:The purpose of this study was to make a model of renal vasoconstriction induced by mechanical manipulation of the renal artery and to investigate the influence of endothelin (ET) in renal vasoconstriction. Renal arteries of anesthetized rats were stretched with a 30-gram weight for 5 min, and released. Renal blood flow (RBF) was monitored with a laser flowmeter. To determine the role of ET, a selective ET(A) receptor antagonist, BQ-123 (0.1 and 1 mg/kg) was administered into the aorta. The manipulation was invariably followed by a flow reduction of about 57% after temporary hyperemia. RBF returned to the basal level 5 min after the release. BQ-123 partially, but significantly, inhibited the mechanical manipulation-induced reduction of RBF in a dose-dependent manner. These results suggest that endogeneous ET may play an important role in renal vasoconstriction induced by mechanical manipulation of the renal artery.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Watarai Y,Yoshioka M,Tanda K,Seki T,Saito H,Koyanagi T

doi

10.1159/000030510

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

121-5

issue

3

eissn

0042-1138

issn

1423-0399

pii

30510

journal_volume

64

pub_type

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