Abstract:
INTRODUCTION:Etiology of serum anti-p53 antibodies in bladder cancer patients is still unknown. In this study we evaluated the relationship between serum anti-p53 antibodies and microvessel density in bladder cancer patients. MATERIALS AND METHODS:Seventy-six patients with transitional cell carcinoma of the urinary bladder were assessed prospectively (18 Ta, 30 T1, 28 T2>or =). Serum anti-p53 antibodies were detected by enzyme-linked immunosorbent assay. Tumor p53 overexpression was assessed by immunohistochemical staining. Vessels were stained immunohistochemically using an antibody against platelet endothelial cell-adhesion molecule CD31. Spearman correlation test and t test were used for statistical analysis. RESULTS:Serum anti-p53 antibodies were positive in 25 (60%) of 41 tumor p53-positive patients. While the mean (SD, range) microvessel density was found to be 43 (7.59, 8-99) in patients who had positive serum anti-p53 antibodies, it was found to be 23 (4.53, 6-98) in patients who had negative serum anti-p53 antibodies. There was a good correlation between serum anti-p53 antibodies and microvessel density (p<0.05). No correlation was found between tumor p53 expression and microvessel density (p>0.05). CONCLUSIONS:We found that there is a significant correlation between the microvessel density and serum anti-p53 antibodies. This result may show the role of angiogenesis in the etiology of serum anti-p53 antibodies in bladder cancer patients.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Gumus E,Erdamar S,Demirel G,Horasanli K,Ozmen G,Miroglu Cdoi
10.1159/000080831subject
Has Abstractpub_date
2004-01-01 00:00:00pages
219-25issue
3eissn
0042-1138issn
1423-0399pii
80831journal_volume
73pub_type
杂志文章abstract:BACKGROUND/AIMS:In this study we wanted to examine the effects that transurethral needle ablation (TUNA) might have on the urodynamic characteristics of bladder outlet obstruction and to evaluate the clinical changes and the safety profile in patients undergoing the TUNA procedure, including the effects on erectile and...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000056577
更新日期:2001-01-01 00:00:00
abstract::A total of 51 consecutive female patients with genuine stress incontinence who underwent a Burch or Stamey operation were clinically and urodynamically evaluated preoperatively at least 8 months postoperatively. Our study group consisted of 27 women who underwent the Burch colposuspension and 24 who had the Stamey end...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282803
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:Wnt-1 is capable of inducing metanephric mesenchyme to undergo tubulogenesis. A relationship between the degree of cystogenesis and reduced E-cadherin (E-cad) expression was described. Syndecan-1 (Sdc-1) has a critical role in kidney development. MATERIALS AND METHODS:Ten multicystic dysplastic kidneys (M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000296285
更新日期:2010-01-01 00:00:00
abstract::Nephrotic syndrome developed in a patient with autosomal-dominant polycystic kidney disease. Renal biopsy revealed minor glomerular abnormalities. This type of nephrotic syndrome complication in an autosomal-dominant polycystic kidney disease has only rarely been reported. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281782
更新日期:1991-01-01 00:00:00
abstract:OBJECTIVE:This article systematically analyses comparative studies to evaluate the efficacy and safety of tubeless percutaneous nephrolithotomy (PCNL) versus standard PCNL. METHODS:The Medline, EMBASE, PsycINFO, Cochrane and DARE databases were searched from 1997 to February 2011. Comparative studies evaluating outcom...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000336145
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To assess the association between the development of a urethral stricture (US) and disease-free survival for patients with localized prostate cancer treated with high-intensity focused ultrasound (HIFU). PATIENTS AND METHODS:Patients with clinical stage T1-T2N0M0 prostate cancer were eligible for treatment wit...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000330909
更新日期:2011-01-01 00:00:00
abstract::The ability of three compounds, all similar in chemical structure to citric acid, to decrease calcium crystalluria has been measured. The measurements were made in normal human urine at 37 degrees C and compared with the crystal-decreasing power of citric acid when measured in the same way and in the same urine sample...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282875
更新日期:1996-01-01 00:00:00
abstract::The concept of resection of a solitary metastatic lesion is quite foreign in prostate cancer, as metastases to regional lymph nodes or to other distant sites are most likely suggestive of disseminated disease. The current report demonstrates a very unique case, in whom excision of a solitary pulmonary metastasis has r...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000109727
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Despite advances in immunosuppressant medications, improvement in long-term survival for kidney transplant recipients has been more difficult to achieve. In fact, the number of patients with failing grafts who must either return to dialysis or undergo a second transplant is increasing. Second transplantation...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000499490
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Micropapillary carcinoma (MPC) of the bladder is a rare and aggressive histologic variant of urothelial carcinoma (UC). At the time of presentation, most MPC are muscle invasive with frequent vascular invasion (VI). Our series explores protein expression of markers known to be indicators of poor clinical o...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000209364
更新日期:2009-01-01 00:00:00
abstract::Vesicovaginal fistula (VVF) is a quite rare complication of gynecological surgery. The first attempt to repair the fistulous tract offers the best opportunity for cure. We report the successful repair of VVF in 2 patients using a combined anterior vaginal approach and porcine dermal collagen grafting as interposition ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000176038
更新日期:2009-01-01 00:00:00
abstract::To help bolster penile tension mechanically, we have tried implantation of silicone penile prostheses varying in type. Our simple and apparently successful procedures for organic impotence with the implantation of intrapenile silicone prostheses may well deserve recommendation in view of spinal impairment therapeutica...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000279981
更新日期:1975-01-01 00:00:00
abstract::We performed four living related kidney transplantations from donors with double inferior vena cava (D-IVC), in which the left kidney was selected in two cases and the right in two cases. By dissecting the right internal iliac vein and isolating the right external iliac vein, the surgical procedure of the recipient si...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000077695
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:We investigated the hypothesis that testicles and scrotal skin undergo morphologic changes that would serve the mechanism of erection and ejaculation. MATERIALS AND METHODS:Testicular and scrotal skin changes during erection and ejaculation were studied in 9 dogs. Testicular volume was measured by ultrasound, ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000107960
更新日期:2007-01-01 00:00:00
abstract::We report a case of Klinefelter's syndrome associated with unilateral cryptorchidism and chordee without hypospadia. The literature is reviewed, and hormonal conditions of Klinefelter's syndrome during childhood are discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282369
更新日期:1992-01-01 00:00:00
abstract::In unilateral kidney disease, it has been suggested that the ipsilateral state could be estimated by measuring contralateral kidney size; thus, a contralateral increase should reflect an ipsilateral impairment and vice versa. This could easily be performed using ultrasound. In our experiments with partial obstruction ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282898
更新日期:1996-01-01 00:00:00
abstract::Extramedullary plasmacytomas of the testes are extremely rare tumors, especially when occurring in the absence of precocious or concurrent diagnosis of multiple myeloma. This is a case report of an 83-year-old man with a solitary plasmacytoma of the left testis. Immunoperoxidase studies, performed on histologic specim...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282791
更新日期:1995-01-01 00:00:00
abstract::Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Cu...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282848
更新日期:1996-01-01 00:00:00
abstract::The effect of vinblastine sulfate on the acceptance and growth of a very malignant, human adenocarcinoma of the kidney (RCCI) on nude mice was investigated. Without any treatment, this tumor has an acceptance rate of 100%. Subcutaneously transplanted pieces of tumor, measuring 3 X 3 X 1 mm, commence to grow rapidly 1 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280404
更新日期:1981-01-01 00:00:00
abstract:AIM:To examine the hypothesis that the risk of high-grade bladder cancer can be predicted using noninvasively obtained data. PATIENTS AND METHODS:We retrospectively analyzed the database of 431 patients that had transurethral resection of first-time bladder tumors between June 1998 and December 2009. Pre-operative par...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328635
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:To evaluate the safety and efficacy of the TiLOOP® male sling (pfm medical, Cologne, Germany) used in the treatment for male stress urinary incontinence (SUI). MATERIAL AND METHODS:We retrospectively evaluated a total of 34 patients with a TiLOOP® male sling. Perioperative complication rates were assessed...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000477765
更新日期:2018-01-01 00:00:00
abstract::Serum concentrations of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were determined before and after orchidectomy performed at different intervals (2-29 months) after withdrawal of estrogen therapy in patients with prostatic carcinoma. Patients previously treated with estrogen for mor...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282012
更新日期:1987-01-01 00:00:00
abstract::To evaluate the possible effect of urinary tract infection (UTI) on the fragility of calcium-containing stones (calcium-oxalate, calcium-phosphate), the results of extracorporeal shock wave lithotripsy (ESWL) therapy in 81 patients with UTI and 30 patients with no sign of UTI were comparatively evaluated. ESWL paramet...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282908
更新日期:1996-01-01 00:00:00
abstract::Electrostimulation was used to study the neuroanatomy and physiology of penile erection in dogs and monkeys. The canine spinal nuclei responsible for penile erection, identified by the retrograde horseradish peroxidase transport technique after verification of the cavernous nerves with neurostimulation, were mediolate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281034
更新日期:1985-01-01 00:00:00
abstract::From April 1978 to September 1993, the Department of Urology of Giessen Medical School used laser urethrotomy as standard endoscopic treatment in benign urethral strictures. In this period, 900 urethrotomies were performed in 450 patients. The majority of strictures treated were iatrogenic (65%), located in the poster...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282774
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and feasibility of percutaneous tract dilation by the one-stage method in preschool children. METHODS:Between April 2009 and February 2013, all preschool (<6 years) children who were candidates for percutaneous nephrolithotomy were enrolled in this prospective study. Patients were rand...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000356327
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with thos...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000477912
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:Adherence to international guidelines is viewed as a prerequisite for optimal medical care delivery. Previously reported surveys for non-muscle-invasive bladder cancer (NMIBC) employed mailed questionnaires to urologists or patients resulting in conflicting degrees of agreement with existing guidelines. In...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000321926
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:To investigate the diagnostic value of the nuclear matrix protein 22 (NMP22) test in comparison to urine cytology for the detection of upper tract urothelial carcinoma. PATIENTS AND METHODS:Patients with transitional cell carcinoma of the upper urinary tract (n = 34) and patients with renal calculosis (n = 2...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000330246
更新日期:2011-01-01 00:00:00
abstract::We report a case of clitoral hypertrophy of unknown origin. A 3-year-old girl showed clitoral hypertrophy at birth. Biochemical analysis of peripheral blood and endocrinological examinations were normal. Other virilizing symptoms were not recognized. Clitoroplasty was carried out, and the clitoris has not enlarged 20 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030385
更新日期:1999-01-01 00:00:00