Abstract:
:Adherence of human prostate carcinoma (PC 3, DU 145), bladder (647 V, J 82) carcinoma and melanoma (RPMI-8252) cell lines to plastic and bovine endothelial monolayers (BEM) was tested in the presence of 0.5, 1, 5, 10, 20 IU of low-molecular-weight heparin (LMWH), unfractionated heparin (UFH) or saline as a control. Culture medium was supplemented either with 5% fetal calf serum or with human plasma. Floating tumor cells were counted after 2, 4, 24 h of culture in microtiter plates without BEM and after 1.5, 3 and 24 h of culture on BEM. Twenty IU of LMWH increased the numbers of bladder carcinoma cells adhering to BEM as did 20 IU of UFH in cultures of DU 145 prostate carcinoma and RPMI-8252 melanoma cells. LMWH obviously does not prevent human prostate and bladder carcinoma and melanoma cells from adhering to BEM more effectively than UFH. The in vivo effect of UFH and perhaps also LMWH that hinders intravenous tumor cell colonization in blood vessels obviously does not depend on the interaction with endothelial cells alone.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Lersch C,Gericke D,Classen Mdoi
10.1159/000282848subject
Has Abstractpub_date
1996-01-01 00:00:00pages
230-3issue
4eissn
0042-1138issn
1423-0399journal_volume
56pub_type
杂志文章abstract::Paraneoplastic syndromes are rare entities in patients with excessive HCG production. This has been attributed to the thyroid-stimulating hormone-like activity of HCG. In most cases hyperthyroidism remains subclinical. We report on a patient with diffuse metastasized malignant teratoma and thyrotoxicosis due to excess...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030466
更新日期:1999-01-01 00:00:00
abstract::We report a case of clitoral hypertrophy of unknown origin. A 3-year-old girl showed clitoral hypertrophy at birth. Biochemical analysis of peripheral blood and endocrinological examinations were normal. Other virilizing symptoms were not recognized. Clitoroplasty was carried out, and the clitoris has not enlarged 20 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030385
更新日期:1999-01-01 00:00:00
abstract::Electrostimulation was used to study the neuroanatomy and physiology of penile erection in dogs and monkeys. The canine spinal nuclei responsible for penile erection, identified by the retrograde horseradish peroxidase transport technique after verification of the cavernous nerves with neurostimulation, were mediolate...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281034
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVES:Since little investigation has been undertaken to determine if alpha1-blockers should be given continuously to sustain their efficacy, we conducted a pilot study to determine symptom change following discontinuation of tamsulosin after an initial improvement in symptoms in men with lower urinary tract sympto...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000092052
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:We reviewed our experiences in performing cytoreductive metastatectomy before initiating systemic immunochemotherapy and tried to investigate potential prognostic factors for such an approach. PATIENTS AND METHODS:A retrospective analysis of 57 patients who received interleukin-2, interferon-alpha, and 5-...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000091630
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Cystic renal tumors are a diagnostic and therapeutic challenge. Cystic nephroma (CN), cystic partially differentiated nephroblastoma (CPDN) and cystic Wilms' tumor (CWT) are a spectrum with CN at the benign end, CWT at the malignant end and CPDN in the intermediate position. CN and stage 1 CPDN are often tre...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000176028
更新日期:2009-01-01 00:00:00
abstract::Extramedullary plasmacytomas of the testes are extremely rare tumors, especially when occurring in the absence of precocious or concurrent diagnosis of multiple myeloma. This is a case report of an 83-year-old man with a solitary plasmacytoma of the left testis. Immunoperoxidase studies, performed on histologic specim...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282791
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:Immunotherapy effectively treats advanced renal cell carcinoma in only a limited number of patients. However, the predicted prognosis for each patient in relation to immune status and response to immunotherapy remains problematic. We analyzed tumor-infiltrating lymphocyte (TIL) subsets to determine whether...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000064361
更新日期:2002-01-01 00:00:00
abstract::Bisphosphonates are a standard treatment for metastatic bone disease, although agents vary in their potential for renal toxicity. This case report describes the reversal of zoledronic acid-induced renal toxicity by switching treatment to ibandronate in a patient with hormone-refractory prostate cancer and bone metasta...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000132707
更新日期:2008-01-01 00:00:00
abstract:AIMS:To investigate the effect of sildenafil on uroflowmetry values of patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic enlargement (BPE). METHODS:Thirty-eight consecutive patients and 15 control subjects without voiding symptoms were enrolled in the study. All patients underwent uroflo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000112611
更新日期:2008-01-01 00:00:00
abstract::The present study deals with morphological changes during erection both in the penile deep artery supplying the corpus cavernosum and in veins draining it. These vessels were shown to maintain wide lumina in the flaccid state. In the erect state induced by injection of papaverine, the postcavernous venules were compre...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281341
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:This study aimed to evaluate the role of bone scan as a staging investigation in newly diagnosed untreated prostate cancers. MATERIALS AND METHODS:Bone scan results in patients with newly diagnosed prostate cancer were reviewed and correlated with clinical stage, prostate-specific antigen (PSA) and Gleason s...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000091620
更新日期:2006-01-01 00:00:00
abstract:AIMS AND OBJECTIVE:To describe the technique, results and follow-up of dynamic rectus abdominis tendon colposuspension (DRTC) in the management of female stress urinary incontinence (SUI). PATIENTS AND METHODS:Eighteen patients with SUI were studied prospectively from 1998 to 1999 who underwent DRTC. Type I and type I...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071093
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To assess the effect of neoadjuvant hormone treatment before radical prostatectomy on: tumor/prostate volume, prostate-specific antigen (PSA) and testosterone levels, surgical margin status and tumor stage, and the ease of surgery following treatment. METHODS:Patients with clinically localized prostatic car...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000077113
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the intervention effect of sacral neuromodulation (SNM) in the treatment of lower urinary tract dysfunction after spinal cord injury (SCI). METHODS:We selected relevant studies published between January 1, 1971 and November 15, 2018 by searching the PubMed, EMBASE, Cochrane databases. The outcome...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析
doi:10.1159/000501529
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Prostate biopsy (PBx) techniques have changed significantly since the original Hodge's scheme, with an increase in the number and location of cores. These improvements have been realized in part because of the introduction of different local anaesthesia techniques. We critically analysed the literature discu...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000327827
更新日期:2011-01-01 00:00:00
abstract::119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The pat...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000281439
更新日期:1989-01-01 00:00:00
abstract::Dependent drainage of a lower pole pyelocaliceal diverticulum was achieved by uretero-diverticulostomy in eight patients who already had compromised renal function due to bilateral megaureters or posterior urethral valves. This procedure preserves all functional renal parenchyma and the ureteropelvic junction is left ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280071
更新日期:1976-01-01 00:00:00
abstract:INTRODUCTION:Appropriate management of renal trauma is controversial. The purpose of this study is to present our 5-year experience in renal trauma and review the literature. MATERIALS AND METHODS:From 1999 to 2003, 28 patients were identified with renal injuries. 25 (89.3%) of the injuries were caused by blunt trauma...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000093899
更新日期:2006-01-01 00:00:00
abstract::Dissemination of tumor cells by vascular channels seems to be enhanced by certain surgical procedures, e.g. transurethral resection of the prostate, an operative procedure commonly used in the diagnosis and management of prostatic cancer, the third biggest killer of men in the United States. Circulating tumor cells ha...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281298
更新日期:1988-01-01 00:00:00
abstract::Both under physiologic conditions and after short-term ischemia (1-3 min) kallikrein and locally synthesized prostaglandins contribute to control renal blood flow. In the present experiment the antiproteases aprotinin and gabexate-mesilate were administered to rabbits in an attempt to show whether the hemodynamic chan...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280880
更新日期:1983-01-01 00:00:00
abstract:INTRODUCTION:Our purpose was to evaluate patients who underwent failed hypospadias repair. PATIENTS AND METHODS:We evaluated 4 different groups of patients who underwent failed hypospadias repair. Group 1: patients who underwent only urethral surgery; group 2: patients who underwent only corpora cavernosa surgery; gro...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000319856
更新日期:2010-01-01 00:00:00
abstract::A total of 51 consecutive female patients with genuine stress incontinence who underwent a Burch or Stamey operation were clinically and urodynamically evaluated preoperatively at least 8 months postoperatively. Our study group consisted of 27 women who underwent the Burch colposuspension and 24 who had the Stamey end...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000282803
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Radical cystectomy (RC) still poses a significant risk for mortality and morbidity. OBJECTIVES:We compared in-hospital outcomes after RC in the United States and -Germany using population-based data. METHODS:We compared data from the US Nationwide Inpatient Sample to the German hospital billing database. M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000496347
更新日期:2019-01-01 00:00:00
abstract::Among the number of urological symptoms in women complaining of incontinence more specific symptoms are often overlooked. Frequency, urge, suprapubic pain, nocturia, etc., are typical for bladder wall disorders, but also often misleading as part of the incontinence symptomatology. The final diagnosis of bladder wall d...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281652
更新日期:1990-01-01 00:00:00
abstract::Prostate cancer is one of the most common malignancies occurring in men. During the last decade, several advances have been made in decreasing the morbidity of surgical therapy. Two major advances have included an improved understanding of the physiology of erection and anatomy of pelvic parasympathetic nerves mediati...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282149
更新日期:1991-01-01 00:00:00
abstract::We report the case of a woman who presented with obstruction and urosepsis of her left kidney secondary to small cystine calculi. The calculi could not be seen on initial plain abdominal X-ray. However, following percutaneous nephrostogram the calculi became more radio-dense and visible on later X-rays. Experimental e...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030375
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:The last decade has seen the emergence of a variety of supine positions for carrying out percutaneous nephrolithotomy (PCNL). These positions all differ with regard to ease of puncture under image guidance, operative field availability, ability to make and dilate multiple tracts and ease of combining retrogr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341430
更新日期:2012-01-01 00:00:00
abstract:AIM:To analyze demographics, perioperative mortality and overall survival of radical cystectomy (RC) in patients aged 70+ years in Austria in a nation-wide registry cohort. PATIENTS AND METHODS:All patients >69 years who underwent RC in public hospitals (covering >95% of all surgical procedures) in Austria between 199...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000316100
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To describe our surgical experience and clinical outcome in laparoscopic radical nephrectomy (LRN) for renal cell carcinoma (RCC) with level 1 renal vein tumor thrombus. PATIENTS AND METHODS:11 patients with RCC level 1 renal vein tumor thrombus were treated by LRN plus thrombectomy. The mean age was 66.8 ye...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000363580
更新日期:2015-01-01 00:00:00