Abstract:
INTRODUCTION:Immunotherapy effectively treats advanced renal cell carcinoma in only a limited number of patients. However, the predicted prognosis for each patient in relation to immune status and response to immunotherapy remains problematic. We analyzed tumor-infiltrating lymphocyte (TIL) subsets to determine whether these correlated with the prognoses for the patients and the response to alpha-interferon therapy. MATERIALS AND METHODS:TIL subsets from resected specimens of 79 patients were analyzed by two-color flow cytometry and then compared with the patients' long-term clinical courses and responses to interferon therapy. RESULTS:In patients with stages III and IV, an increased infiltration of CD4+ cells and decreased CD8+ cells constituted a fair prognostic factor. In 17 patients with metastatic lesions, 8 of 10 patients who had disease progression after interferon therapy showed an increase in CD8+ cells above 25%, whereas 2 responders and 5 patients who had stable disease showed infiltration of CD8+ cells below 25%. CONCLUSIONS:The TIL subset is a prognostic factor for advanced renal cell carcinoma, and its analysis provides a method to predict the susceptibility to interferon therapy.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Igarashi T,Takahashi H,Tobe T,Suzuki H,Mizoguchi K,Nakatsu HO,Ito Hdoi
10.1159/000064361subject
Has Abstractpub_date
2002-01-01 00:00:00pages
51-6issue
1eissn
0042-1138issn
1423-0399pii
64361journal_volume
69pub_type
杂志文章abstract:INTRODUCTION:We aimed to perform a multi-institutional study using a national database led by the Japanese Society of Endourology to investigate the effect of surgeon or hospital volume on the safety of robot-assisted radical prostatectomy (RARP). MATERIALS AND METHODS:Clinical data of 3,214 patients who underwent RAR...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000460304
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Our aim was to determine the safety and feasibility of catheter removal on the first morning after transurethral prostatectomy. METHODS:Fifty-four patients who underwent transurethral prostatectomy were included in a prospective study. The decision to remove the catheters on the first morning after surgery w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000048428
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to examine clinical/pathological characteristics, prognosis and tendency to metastasis of mixed germ cell tumours (MGCTs) that contain a seminoma component. METHODS:A total of 111 MGCT cases between 2008 and 2018 were retrospectively enrolled. The patients were divided into 2 group...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000506780
更新日期:2020-01-01 00:00:00
abstract::Emphysematous cystitis is a rare disorder most commonly seen in patients with urinary tract infection and diabetes mellitus. We present a nondiabetic case of a 46-year-old woman with this entity following brain contusion. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030520
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study is to compare vesical and renal calcium oxalate crystalluria in an attempt to correlate crystal formation with chemical composition and calcium oxalate saturation of renal urine. MATERIAL AND METHODS:Urine specimens were directly collected from the bladder and the kidney, of 11 stone fo...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000030201
更新日期:1998-01-01 00:00:00
abstract::Behçet's disease is a multiple disorder in which urogenital involvement mainly consists of genital aphthous ulcers, epididymitis, urethritis and recurrent cystitis. We report 2 cases of neurogenic bladder due to Behçet's disease. Both cases showed detrusor hyperreflexia and detrusor-sphincter dyssynergia. One case has...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000064832
更新日期:2000-01-01 00:00:00
abstract::Sacrocolpopexy, a surgical technique with a low morbidity rate, is a valid procedure for repairing vaginal vault prolapse. To our knowledge, only 1 case of rectum erosion after open sacrocolpopexy has been reported in the literature, and there is no record of any such incident after laparoscopic sacrocolpopexy. We rep...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000353421
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:This study sought to investigate whether ischemia-induced prostate damage during cardiac surgery involving cardiopulmonary bypass causes bladder outlet obstruction. MATERIALS AND METHODS:The study involved 37 men who underwent elective cardiac surgery involving cardiopulmonary bypass. Prostate-specific antig...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000084434
更新日期:2005-01-01 00:00:00
abstract::Two patients with entire urethral stricture were treated with balloon dilatation of the whole urethra using a torpedo-type dilatation balloon with satisfactory results. Postdilatation urethrograms revealed that the lumen of the urethra was of satisfactory width in both cases, and the patients are now voiding normally....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282141
更新日期:1991-01-01 00:00:00
abstract::Aneurysmectomy and renal angioplasty were performed on a 14-year-old Japanese male and the blood pressure was within normal values 3 years after this surgery. Measurement of renal blood flow was facilitated by using 133Xe washout technique. This incidence is the eighth such case to be reported from Japan. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280073
更新日期:1976-01-01 00:00:00
abstract::Nuclear Magnetic Resonance (NMR), a recently developed diagnostic method, has proved to be useful in the study of patients with prostatic disease. The authors report their experience with this technique in 10 cases of advanced prostate cancer (stage D) treated with LH-RH agonists (HOE 766-Buserelin). NMR provided info...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281218
更新日期:1986-01-01 00:00:00
abstract::The effectiveness of parasympathicolytic drugs in the treatment of ureteric colics is doubtful. Bencyclane is a new myotropic substance. Its spasmolytic effect on smooth muscle is five times stronger than that of papaverine. The results of the clinical use of Bencyclane in cases of ureteric colic are described and dis...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280208
更新日期:1978-01-01 00:00:00
abstract:INTRODUCTION:Virtual reality (VR) simulation has been known to shorten learning curves. The aim of this research was to determine whether VR transurethral bladder tumor resection (TURBT) with and without photodynamic diagnostic (PDD) can improve endourological skills in novice and trained endoscopists. MATERIALS AND M...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328218
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The last decade has seen the emergence of a variety of supine positions for carrying out percutaneous nephrolithotomy (PCNL). These positions all differ with regard to ease of puncture under image guidance, operative field availability, ability to make and dilate multiple tracts and ease of combining retrogr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000341430
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to analyze the influence of residents' participation in flexible ureteroscopy (fURS) on intra- and postoperative outcomes. MATERIALS AND METHODS:Intra- and postoperative parameters were compared in a retrospective monocentric setting between 3 groups: "resident group" (47 cases) ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504989
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:We report our experience with the use of povidone iodine instillation into the renal pelvis for the treatment of chyluria. MATERIALS AND METHODS:From August 2006 to November 2008, 26 patients with chyluria were treated. There were 18 males and 8 females ranging from 24-55 years of age. Cystoscopic localization...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000288233
更新日期:2010-01-01 00:00:00
abstract::Varicocele is one of the causes of male infertility. Treatment aims to improve the chance of conception despite lasting controversies about benefits of varicocele repair on fertility. Many techniques have been described for varicocele management including the antegrade scrotal sclerotherapy (ASS). Interestingly, ASS i...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000481831
更新日期:2018-01-01 00:00:00
abstract::Nephrotic syndrome developed in a patient with autosomal-dominant polycystic kidney disease. Renal biopsy revealed minor glomerular abnormalities. This type of nephrotic syndrome complication in an autosomal-dominant polycystic kidney disease has only rarely been reported. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281782
更新日期:1991-01-01 00:00:00
abstract::We report on a unique-sized large leiomyoma of the bladder wall in a male patient. After open surgical intervention all symptoms resolved spontaneously and no relapse occurred within a 3-year follow-up period. In conclusion, for symptomatic leiomyoma of the bladder surgical intervention should be considered as an earl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030317
更新日期:1998-01-01 00:00:00
abstract::In 231 adults the frequency and the pattern of the retroaortic left renal vein were studied. We observed a retroaortic left renal vein in 9.09% ("renal collar" in 5.62%, single retroaortic left renal vein in 3.46%. According to our results and to the findings in the literature a retroaortic left renal vein can be expe...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000279997
更新日期:1975-01-01 00:00:00
abstract::A case of malignant peripheral nerve sheath tumor of the bladder in a 57-year-old man with multiple neurofibromatosis type 1 is presented. The patient had a recent history of a transurethrally resected bladder ganglioneuroma. A probable histogenetic association between these two extremely rare neoplasms is proposed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000065568
更新日期:2002-01-01 00:00:00
abstract::Cystinuria is a rare cause of renal calculi, whose management presents a complex problem mainly due to the hardness and high recurrence rate of cystine stones. During the period 1987-1991, 28 established cases of cystine calculi were treated by extracorporeal shock wave lithotripsy (ESWL) and percutaneous nephrolithot...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282836
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:To assess the pathophysiology of lower urinary tract symptoms (LUTS) in aged men without bladder outlet obstruction in a videourodynamic study. METHODS:In a videourodynamic study of 324 consecutive men with moderate to severe LUTS suggestive for bladder outlet obstruction, 112 were found to be urodynamically...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030497
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVES:Improvements in quality of life (QoL) and disease-related symptoms are key goals in the treatment of hormone refractory prostate cancer (HRPC). Our aim was to evaluate the impact of gefitinib on QoL of patients with HRPC. METHODS:Patients with HRPC received gefitinib 250 mg daily in addition to antiandrogen...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000200800
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Currently no consensus exists about the role of the foreskin or the effect circumcision has on penile sensitivity and overall sexual satisfaction. Our study assesses the effect of circumcision on sexually active men and the relative impact this may have on informed consent prior to surgery. MATERIALS AND ME...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000085930
更新日期:2005-01-01 00:00:00
abstract::Idiopathic scrotal calcinosis is a rare, benign condition characterized by progressive calcification of the scrotal skin. A 29-year-old man who had undergone primary surgical excision of idiopathic scrotal calcinosis 7 years previously presented with recurrence that he had first noticed 3 years after surgery. Multiple...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350240
更新日期:2014-01-01 00:00:00
abstract::We performed four living related kidney transplantations from donors with double inferior vena cava (D-IVC), in which the left kidney was selected in two cases and the right in two cases. By dissecting the right internal iliac vein and isolating the right external iliac vein, the surgical procedure of the recipient si...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000077695
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:We compared the applicability and reproducibility of the condom catheter method for noninvasive urodynamics in two Dutch studies. MATERIALS AND METHODS:A longitudinal study of changes in bladder contractility secondary to benign prostatic enlargement is taking place at the Erasmus MC in Rotterdam. Volunteer...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000144051
更新日期:2008-01-01 00:00:00
abstract::Myelolipomas of the adrenal gland were first described in 1905. They are rare cortical, nonfunctioning, benign neoplasms, generally unilateral, usually discovered by accident or at autopsy. Thus they are often classified as 'incidentaloma'. These tumors are more frequent in males 40-60 years old. Most adrenal myelolip...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030353
更新日期:1999-01-01 00:00:00
abstract::The bladder pressure necessary to cause vesicoureteral reflux (VUR) was measured in 16 female rats. Under general anesthesia, the ureters were exposed via an abdominal incision and a pressure catheter was placed near the ureterovesical junction. Values of bladder distension and bladder pressure increase to cause VUR w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281195
更新日期:1986-01-01 00:00:00