Abstract:
OBJECTIVES:Improvements in quality of life (QoL) and disease-related symptoms are key goals in the treatment of hormone refractory prostate cancer (HRPC). Our aim was to evaluate the impact of gefitinib on QoL of patients with HRPC. METHODS:Patients with HRPC received gefitinib 250 mg daily in addition to antiandrogen plus luteinizing hormone-releasing hormone (LHRH) analogue for at least 2 months or until disease progression. QoL was evaluated monthly by the European Organisation for Research on the Treatment of Cancer (EORTC) QLQ-C30 questionnaire. Pain was assessed daily by patients and scored by visual analogue scale and analgesic consumption in a diary. Monthly pain intensity was estimated using the McGill-Melzack questionnaire. RESULTS:Analysis of global health status according to EORTC QLQ-C30 showed an improvement of the status in only 6 patients (26%). The greatest benefit in the patients was in the subscale representing prostate-specific concerns (including appetite, pain, physical comfort, and genitourinary function). Improvement of symptoms was correlated with antiandrogen withdrawal. Global health status and QoL decreased during treatment according to tumor progression. CONCLUSIONS:Among HRPC patients treated with gefitinib, improvement of symptoms preceded evidence of biochemical response of prostate-specific antigen following antiandrogen withdrawal. These findings suggest no beneficial effect of gefitinib in QoL improvement.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Curigliano G,Spitaleri G,De Cobelli O,Scardino E,Sbanotto A,de Braud Fdoi
10.1159/000200800subject
Has Abstractpub_date
2009-01-01 00:00:00pages
196-202issue
2eissn
0042-1138issn
1423-0399pii
000200800journal_volume
82pub_type
杂志文章abstract:OBJECTIVES:In spite of a great amount of data, the hormonal treatment of advanced prostatic carcinoma (CaP) still remains controversial. As a relevant amount of dihydrotestosterone is present within the prostate tissue after castration, complete androgen blockade (CAB), with inhibition of the activity of both testicula...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000056541
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:The aim of this prospective study was to examine the ability of the Snap-Gauge band to differentiate organic from psychogenic erectile dysfunction (ED). PATIENTS AND METHODS:Nocturnal penile tumescence testing was performed on 12 patients using a Snap-Gauge band and RigiScan Plus. A total of 29 nightly exami...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071103
更新日期:2003-01-01 00:00:00
abstract::Characteristics of placental-like alkaline phosphatase (PLAP-like enzyme) in seminoma was studied. By use of lectin affinity chromatography, PLAP-like enzyme in seminoma revealed extra sugar chains compared to placental alkaline phosphatase (PLAP), indicating heterogeneity of the carbohydrate moiety. However, the glyc...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282263
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. PATIENTS AND METHODS:A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000443185
更新日期:2016-01-01 00:00:00
abstract::We report a symptomatic multicystic seminal vesicle with ipsilateral renal agenesis in a 37-year-old man. Preoperatively the diagnosis could be suggested by different imaging modalities, including endorectal surface coil magnetic resonance imaging. To our knowledge, we present the 1st case of seminal vesicle cyst to b...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282892
更新日期:1996-01-01 00:00:00
abstract::Concomitance of different primary malignant neoplasms in the same individual has been observed and explained by several possible mechanisms. For urogenital malignancies in concomitance with lymphoid or with intestinal malignancies some data indicate that common etiologic factor(s) with pleiotropic effects may be invol...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281069
更新日期:1985-01-01 00:00:00
abstract::A review of the recent literature on the surgical management of anterior urethral stricture was performed. The literature was searched via PubMed using the search terms 'urethral stricture' and 'urethroplasty' from 1996 to 2009. The management of anterior urethral strictures is changing rapidly in the sense that the r...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000319501
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The objective of this study is to describe and analyze the experience over a period of 10 years at our center through a retrospective study of a series of diagnosed and treated cases of penile fracture. MATERIAL AND METHODS:From 2005 to 2009 the Urology Department of the Hospital Clínico San Carlos of Madri...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324249
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study is to modify and validate a novel screening tool to determine the necessity of bone scans in Chinese PCa patients at the time of diagnosis. METHODS:Five-hundred-and-one patients diagnosed with PCa between 2010 and 2013 at Zhongshan Hospital, Fudan University, were included in the study...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000368912
更新日期:2015-01-01 00:00:00
abstract::Cyclic dysmenorrhea, unilateral abdominopelvic mass, acute urinary retention and renal agenesis ipsilateral to the pelvic mass in a young woman suggest uterus didelphys with unilaterally imperforate vagina. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282018
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVES:This meta-analysis was to assess solifenacin and tolterodine in patients with overactive bladder. METHODS:We searched PubMed, the Cochrane Library, EMBASE, CNKI, Wanfang, and ClinicalTrials.gov databases for randomized controlled trials (RCTs). The efficacy endpoint was daily micturition frequency, daily ur...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析
doi:10.1159/000497311
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:Meatal stenosis usually presents in adults with a history of urethral trauma or inflammation or as a complication after hypospadias repair. The objective of this study is to present the correction of meatal stenosis using a preputial island flap, created on the dorsal surface of the penis. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000102905
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Cyclooxygenase-2 (COX-2) is a key enzyme involved in the production of prostaglandins and its inhibitors have been shown to induce apoptosis in a variety of cancer cells. We reasoned that combination treatment of renal cell carcinoma (RCC) cells with COX-2 inhibitors and anticancer agents may result in syner...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000288243
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intr...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000350508
更新日期:2013-01-01 00:00:00
abstract::We report the case of a 70-year-old man who received sunitinib treatment for brain metastatic clear cell renal cell carcinoma. After 6 months of treatment, brain MRI showed complete disappearance of two brain metastases. To the best of our knowledge, this is the first reported case of multifocal brain metastases in re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000251193
更新日期:2009-01-01 00:00:00
abstract:AIMS AND OBJECTIVE:To describe the technique, results and follow-up of dynamic rectus abdominis tendon colposuspension (DRTC) in the management of female stress urinary incontinence (SUI). PATIENTS AND METHODS:Eighteen patients with SUI were studied prospectively from 1998 to 1999 who underwent DRTC. Type I and type I...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071093
更新日期:2003-01-01 00:00:00
abstract::It is well known that diabetes mellitus is accompanied by complications of sexual dysfunction and it is believed that diabetic neuropathy may cause impotence. In our study, we found that not all the patients who visited our center with the chief complaint of diabetic impotence were suffering from organic impotence, an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282978
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To assess the pathophysiology of lower urinary tract symptoms (LUTS) in aged men without bladder outlet obstruction in a videourodynamic study. METHODS:In a videourodynamic study of 324 consecutive men with moderate to severe LUTS suggestive for bladder outlet obstruction, 112 were found to be urodynamically...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030497
更新日期:2000-01-01 00:00:00
abstract::The authors improved the Nélaton catheter with a pair of carbon fiber electrodes as previously published and also improved the Foley catheter with a pair of carbon fiber electrodes which are less painful and easier to use. We also have made efforts how to record the vesical electromyogram (EMG) simultaneously with cys...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280979
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVE:To investigate the impact of socioeconomic status-related parameters on competing (non-bladder cancer) mortality after radical cystectomy. PATIENTS AND METHODS:A total of 1,268 consecutive patients who underwent radical cystectomy for urothelial or undifferentiated bladder cancer at our institution between 1...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000502781
更新日期:2020-01-01 00:00:00
abstract::A technical evaluation of the Exeter recording nappy has been carried out with particular reference to (a) linearity, (b) reproducibility of calibration, (c) the effect of variation in the position of moistened zones produced by consecutive leakages and (d) the effect of variation in the electrical conductivity of the...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280034
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:We present a large series of eosinophilic cystitis including 8 cases; 3 of them had tumor-like lesions. MATERIALS AND METHODS:The archives of pathology clinic of Inonu University Medical Faculty were reviewed from 1988 to 2002. The characteristics of patients and their diseases were recorded. Data obtained fro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000072680
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:We compared the applicability and reproducibility of the condom catheter method for noninvasive urodynamics in two Dutch studies. MATERIALS AND METHODS:A longitudinal study of changes in bladder contractility secondary to benign prostatic enlargement is taking place at the Erasmus MC in Rotterdam. Volunteer...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000144051
更新日期:2008-01-01 00:00:00
abstract:UNLABELLED:BACKGROUND/AIMS/OBJECTIVES: To describe the depth of the laser coagulation zone in vivo based on histological examinations and the functional outcome of a 1,318-nm diode laser for enucleation in benign prostatic enlargement (BPE). METHODS:A total of 20 patients with BPE were treated by laser Eraser® enuclea...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000353554
更新日期:2013-01-01 00:00:00
abstract::Clinical and experimental investigations seem to underline the important role of fatty acids in the pathogenesis of hypercalciuria, a well-known risk factor for lithogenesis. To evaluate the relationships between the previously reported increase in plasma phospholipid arachidonic acid level and the factors responsible...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000087161
更新日期:2005-01-01 00:00:00
abstract::The pathophysiological considerations for regaining continence are discussed first. Our operation method for postprostatectomy incontinence is described and the results enumerated. The success rate is approximatively 80%. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281155
更新日期:1986-01-01 00:00:00
abstract::Bacillus Calmette-Guérin (BCG) immunotherapy is the most effective treatment for carcinoma in situ and high-risk non-muscle invasive bladder cancer (NMIBC). However, it can also provoke diverse side effects. We found 1 patient with a significantly and rapidly reduced bladder volume after the instillation of BCG. Few s...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000510167
更新日期:2021-01-01 00:00:00
abstract:AIM:To clarify the factors affecting the success rate of endoscopic subureteral injection (ESI) treatment of vesicoureteral reflux (VUR). METHOD:All patients who had ESI treatment for VUR at our unit between 1999 and 2002 were retrospectively reviewed with regard to age, gender, causes of VUR, reflux grade, type of in...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000137639
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Urethral valves can be of enormous clinical importance. Both the prognosis for an affected fetus and the indication for a prenatal therapeutic intervention depend to a high degree on the accuracy of the prenatal diagnosis. PATIENTS AND METHODS:The sonographic findings and the results of the postnatal diag...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000081586
更新日期:2004-01-01 00:00:00
abstract:UNLABELLED:Polytraumatized patients often present with urological injuries. After hemodynamic stability is maintained urologists are consulted to evaluate diagnostic and therapeutic interventions. The following article describes how to handle the work-up of patients with injuries to specific urogenital organs: the impo...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000074083
更新日期:2003-01-01 00:00:00