Abstract：
OBJECTIVES:The aim of this study is to modify and validate a novel screening tool to determine the necessity of bone scans in Chinese PCa patients at the time of diagnosis. METHODS:Five-hundred-and-one patients diagnosed with PCa between 2010 and 2013 at Zhongshan Hospital, Fudan University, were included in the study. All received bone scans using technetium 99m methylene diphosphonate (99mTc-MDP) at the initial staging. Age, prostate-specific antigen (PSA) and alkaline phosphatase (ALP) at diagnosis, disease stage, and biopsy Gleason score were collected from all patients. Multivariate logistic regression analysis and discrimination analysis were performed. A validation analysis of this screening tool was performed by Shanghai Cancer Center, Fudan University. RESULTS:Among the 501 patients, 84 (16.7%) of them had BM. The area under the ROC curve was 0.9006 (95% CI, 0.87-0.93). The sensitivity of the cut-off point was 94.1%, and the specificity was 58.3%. The validation analysis demonstrated an area under the ROC curve of 0.846 (95% CI, 0.805-0.887). CONCLUSIONS:Study results demonstrated that a baseline bone scan can be safely omitted for cT1-T3 PCa patients who have a PSA ≤39 ng/ml and an ALP ≤88 IU/l. This novel screening tool may help determine the necessity of including a bone scan at the time of initial diagnosis of PCa.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Wang Y,Wan F,Xu L,Zhao N,Xu Z,Wang H,Wang G,Ye D,Guo Jdoi
10.1159/000368912subject
Has Abstractpub_date
2015-01-01 00:00:00pages
342-6issue
3eissn
0042-1138issn
1423-0399pii
000368912journal_volume
94pub_type
杂志文章abstract：:Controversies abound in relation to the treatment of every stage of prostate cancer and its natural history. We critically evaluate the controversies and information that exist. An ongoing autopsy project at Wayne State University aims to: define the prevalence of incidental cancer in subjects between 20 and 70 years ...
journal_title：Urologia internationalis
pub_type： 杂志文章,评审
doi：10.1159/000282860
更新日期：1996-01-01 00:00:00
abstract：:A 50-year-old man with hemophilia A presented with recurrent hematuria due to renal stone disease. He was receiving approximately 50,000 units of recombinant factor (rF) VIII concentrate every year due to hematuria. Between 1996 and 2002, his serum creatinine level increased from 0.7 to 1.2 ng/ml. In an effort to reso...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000100846
更新日期：2007-01-01 00:00:00
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journal_title：Urologia internationalis
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doi：10.1159/000437213
更新日期：2015-01-01 00:00:00
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journal_title：Urologia internationalis
pub_type： 杂志文章,多中心研究
doi：10.1159/000343993
更新日期：2013-01-01 00:00:00
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journal_title：Urologia internationalis
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doi：10.1159/000288233
更新日期：2010-01-01 00:00:00
abstract：:Between March 1983 and March 1988 we registered and treated 49 patients with bladder cancer less than 40 years of age (7 patients less than 30 years of age). Hematuria was present in 40 cases (81.6%). 33 of the patients had a pTA tumor (67.3%). 47 patients had transitional carcinoma of the bladder, of which 21 (44.7%)...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000281475
更新日期：1989-01-01 00:00:00
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journal_title：Urologia internationalis
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doi：10.1159/000064868
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abstract：:Aneurysmectomy and renal angioplasty were performed on a 14-year-old Japanese male and the blood pressure was within normal values 3 years after this surgery. Measurement of renal blood flow was facilitated by using 133Xe washout technique. This incidence is the eighth such case to be reported from Japan. ...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000280073
更新日期：1976-01-01 00:00:00
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journal_title：Urologia internationalis
pub_type： 杂志文章,评审
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journal_title：Urologia internationalis
pub_type： 杂志文章,评审
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更新日期：2010-01-01 00:00:00
abstract：:Prostate volume in multiparametric MRI (mpMRI) is of clinical importance. For 3-Tesla mpMRI without endorectal coil, there is no distinctive standard for volume calculation. We tested the accuracy of the ellipsoid formula with planimetric volume measurements as reference and investigated the correlation of gland volum...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000448593
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Phytate as sodium salt has been used at high doses to treat stone-former patients with idiopathic hypercalciuria. The experimental and clinical hypocalciuric effects of dietary fiber have also been assigned to the presence of phytate as calcium-magnesium salt (phytin). As a consequence of the additional inte...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000077123
更新日期：2004-01-01 00:00:00
abstract：:From April 1978 to September 1993, the Department of Urology of Giessen Medical School used laser urethrotomy as standard endoscopic treatment in benign urethral strictures. In this period, 900 urethrotomies were performed in 450 patients. The majority of strictures treated were iatrogenic (65%), located in the poster...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000282774
更新日期：1995-01-01 00:00:00
abstract：INTRODUCTION:Obesity is usually considered a risk factor for postoperative complications; however, previous studies conclude contradictory results in retroperitoneal laparoscopic adrenalectomy (LA). We aim to evaluate the impact of obesity on the perioperative outcomes of LA. METHODS:A retrospective cohort study from ...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000431183
更新日期：2015-01-01 00:00:00
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journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000282206
更新日期：1991-01-01 00:00:00
abstract：:A small group of patients with nephrolithiasis who forms mixed (calcium oxalate and uric acid) calculi presents particular problems in their clinical management. In 3,158 stones analyzed in our laboratory, we found 158 mixed calculi in 86 of the patients. In this work, the clinical and biochemical results obtained fro...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:Chronic renal damage due to tubulointerstitial fibrosis is one of several complications of posterior urethral valves in a significant number of children. As activation of the renin-angiotensin system plays an important role in this injury, we conducted this study to investigate whether administration of captopr...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000098078
更新日期：2007-01-01 00:00:00
abstract：:In an acute rat model (in vivo) spontaneous rhythmic bladder contractions were induced by ligation of the urethra. In addition single bladder contractions were recorded during neurostimulation of the pelvic nerve. Spontaneous and electrically induced bladder contractions were sensitive to papaverine and isoprenaline i...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000282425
更新日期：1992-01-01 00:00:00
abstract：:Acute renal failure due to ischemia-reperfusion (I/R) injury is a common complication in cardiovascular surgery. We determined the influence of tadalafil on renal injury in a renal I/R model in rats. For this purpose, 21 male Wistar albino rats were separated into 3 groups: sham, placebo and tadalafil. A right nephrec...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000321927
更新日期：2011-01-01 00:00:00
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journal_title：Urologia internationalis
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Urologia internationalis
pub_type：
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journal_title：Urologia internationalis
pub_type： 杂志文章,多中心研究
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更新日期：2013-01-01 00:00:00
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更新日期：2016-01-01 00:00:00
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journal_title：Urologia internationalis
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doi：10.1159/000342643
更新日期：2013-01-01 00:00:00
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doi：10.1159/000330909
更新日期：2011-01-01 00:00:00
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journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000281782
更新日期：1991-01-01 00:00:00
abstract：:We report a rare case of Budd-Chiari syndrome (BCS) as a postoperative complication after bilateral nephrectomy in a kidney transplant recipient with polycystic liver and kidneys. Contrast-enhanced computed tomography of the abdomen showed a narrowed inferior vena cava, compressed by the polycystic liver that moved do...
journal_title：Urologia internationalis
pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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更新日期：2019-01-01 00:00:00
abstract：:Carcinoma of the bladder following augmentation cystoplasty is rare. Only 15 cases have been reported worldwide. We report a further 2 cases, 1 of which, a squamous cell carcinoma, has not previously been described in this context. ...
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pub_type： 杂志文章,评审
doi：10.1159/000030479
更新日期：2000-01-01 00:00:00
abstract：INTRODUCTION:Urethrocutaneous fistulas (UCF) and flap dehiscence (FD) are the most common postoperative complications after hypospadias (HS) surgical repair. The aim of this study was to evaluate whether the application of fibrin sealant over the site of surgery and suture lines reduces these complications. MATERIALS ...
journal_title：Urologia internationalis
pub_type： 杂志文章
doi：10.1159/000096932
更新日期：2007-01-01 00:00:00
