Prophylactic intravesical chemotherapy to prevent bladder tumors after nephroureterectomy for primary upper urinary tract urothelial carcinomas: a systematic review and meta-analysis.


INTRODUCTION:Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intravesical chemotherapy in preventing bladder tumor recurrence after surgery for UUT-UCs. METHODS:A meta-analysis of the published results of clinical trials was performed to compare radical surgery alone or surgery plus postoperative intravesical chemotherapy. The primary end point was to determine the percentage of patients with recurrence in the different groups. RESULTS:Our study includes five trials with recurrence information on 614 patients. During follow-up, 55 of 268 (20.5%) patients who received postoperative instillation had bladder recurrence compared to 127 of 346 (36.7%) patients who had no adjuvant treatment--a decrease of 41% in the odds of recurrence with chemotherapy (odds ratio 0.48, 95% confidence interval 0.33-0.69, p = 0.0001). No serious adverse events were reported. Subgroup analyses were temporarily unavailable. CONCLUSIONS:Postoperative intravesical chemotherapy significantly decreases the risk of bladder recurrence after nephroureterectomy for primary UUT-UCs. Postoperative intravesical instillation is considered the treatment of choice after nephroureterectomy.


Urol Int


Urologia internationalis


Fang D,Li XS,Xiong GY,Yao L,He ZS,Zhou LQ




Has Abstract


2013-01-01 00:00:00














  • Outcomes for Patients after Resection of Pulmonary Metastases from Clear Cell Renal Cell Carcinoma: 18 Years of Experience.

    abstract:INTRODUCTION:Clear cell renal cell carcinoma (ccRCC) is the most common kidney tumor. If feasible, metastasectomy is preferably indicated in metastatic disease. OBJECTIVE:The aim of this study was to determine the outcome of patients after pulmonary metastasectomy (PM). METHODS:PM for ccRCC was performed in 35 patien...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Procházková K,Vodička J,Fichtl J,Krákorová G,Šebek J,Roušarová M,Hošek P,Brookman May SD,Hes O,Hora M,Třeška V

    更新日期:2019-01-01 00:00:00

  • Long-term efficacy of tolterodine and patient compliance in pediatric patients with neurogenic detrusor overactivity.

    abstract:INTRODUCTION:We investigated the effects of standard oral anticholinergic treatment with tolterodine in children with neurogenic bladder over a 5-year follow-up period and focused on treatment satisfaction, patient compliance and urodynamic parameters. MATERIAL AND METHODS:The follow-up consisted of regular visits and...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Christoph F,Moschkowitsch A,Kempkensteffen C,Schostak M,Miller K,Schrader M

    更新日期:2007-01-01 00:00:00

  • Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study.

    abstract:INTRODUCTION:The German Research Activities on Natural Urologicals (GRANU) study was a randomized, partially blinded, placebo-controlled, parallel-group trial that investigated the efficacy of pumpkin seed in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH/LUTS). SUBJECTS AND METH...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Vahlensieck W,Theurer C,Pfitzer E,Patz B,Banik N,Engelmann U

    更新日期:2015-01-01 00:00:00

  • Evaluation of penile rigidity with color Doppler flow imaging in Chinese patients with erectile dysfunction.

    abstract:OBJECTIVES:To assess the role of color Doppler flow imaging (CDFI) in the evaluation of Chinese patients with erectile dysfunction (ED) and to explore the association between penile rigidity and hemodynamic parameters of CDFI. METHODS:Totally 74 ED patients with an age range of 22-69 (median age 47) were included in o...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Xuan X,Wang D,Sun P,Mei H

    更新日期:2008-01-01 00:00:00

  • Intermittent pressure-loading increases transforming growth factor-beta-1 secretion from renal tubular epithelial cells: in vitro vesicoureteral reflux model.

    abstract:BACKGROUND:To investigate the effect of hydrodynamic pressure mimicking vesicoureteral reflux on renal tubular epithelial cells in vitro, we constructed an intermittent pressure-loading (IPL) model of Madin-Darby canine kidney (MDCK) cells. MATERIALS AND METHODS:Three grades of pressure were loaded onto the MDCK cells...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Maruyama T,Hayashi Y,Nakane A,Sasaki S,Kohri K

    更新日期:2005-01-01 00:00:00

  • One shot tract dilation for percutaneous nephrolithotomy: is it safe and effective in preschool children?

    abstract:OBJECTIVE:To evaluate the safety and feasibility of percutaneous tract dilation by the one-stage method in preschool children. METHODS:Between April 2009 and February 2013, all preschool (<6 years) children who were candidates for percutaneous nephrolithotomy were enrolled in this prospective study. Patients were rand...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,随机对照试验


    authors: Hosseini SR,Mohseni MG,Alizadeh F

    更新日期:2014-01-01 00:00:00

  • Varicocele: in search of a human model.

    abstract:AIMS:To study the effects of left gonadal vein ligation on semen parameters and venous hemodynamics of the testis. SUBJECTS AND METHODS:All male voluntary kidney donors who were scheduled to have left donor nephrectomy between March 2004 and February 2005, by either open or laparoscopic technique, were considered for ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Das Adhikary S,Gopalakrishnan G

    更新日期:2010-01-01 00:00:00

  • Superficial bladder tumors in patients under 40 years of age: clinical, prognostic and cytogenetic aspects.

    abstract::Bladder carcinoma with transitional cells is the most frequent neoplasia in the urinary system, but it is quite rare in patients under 40 years of age (0.4-2%). An analysis of 21 patients under 40 and a review of other reports show that tumors in patients under 20 years old have little tendency to recur and to progres...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Iori F,De Dominicis C,Liberti M,Frioni D,Vahedi M,Leonardo C,De Nunzio C,Laurenti C

    更新日期:2001-01-01 00:00:00

  • Neuroendocrine cells in benign prostatic hyperplasia and prostatic carcinoma: effect of hormonal treatment.

    abstract::The present study was undertaken to analyze the changes in neuroendocrine cells of the human prostate induced by neoplasms and the effect of hormonal treatment. Samples of human prostate (n = 47) were obtained during surgery or removal of organs for transplantation. The cases analyzed represent normal prostates (n = 4...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Guate JL,Escaf S,Menendez CL,del Valle M,Vega JA

    更新日期:1997-01-01 00:00:00

  • Urinary tract infections in women. Current unsatisfactory situation and prospects of a new therapeutic concept.

    abstract::The prevalence, pathogenesis and clinical aspects of bacterial infections of the female urinary tract are described and the efficacy of therapies used at present is discussed. Based on a retrospective compilation of data on 142 female patients with urinary tract infections, the pathogen spectrum is defined and the the...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Rüttgers H,Grischke EM

    更新日期:1987-01-01 00:00:00

  • [Frequency of the retroaortic left renal vein in adults (author's transl)].

    abstract::In 231 adults the frequency and the pattern of the retroaortic left renal vein were studied. We observed a retroaortic left renal vein in 9.09% ("renal collar" in 5.62%, single retroaortic left renal vein in 3.46%. According to our results and to the findings in the literature a retroaortic left renal vein can be expe...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Schmidt GP,Loeweneck H

    更新日期:1975-01-01 00:00:00

  • Recurrency after optical internal urethrotomy. A comparative study of long-term and short-term catheter treatment.

    abstract::The rate of recurrence after internal urethrotomy a.m. Sachse was studied in a prospective, consecutive, randomized series of 43 patients using short-term (1 day) and long-term (14 days) postoperative catheter treatment. No significant difference was found between the two groups according to voiding interview, flowmet...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Iversen Hansen R,Reimer Jensen A

    更新日期:1984-01-01 00:00:00

  • Clinical Experience of Steroid Switch from Prednisone to Dexamethasone in Patients with Metastatic Castration-Resistant Prostate Cancer Treated with Abiraterone Acetate.

    abstract:OBJECTIVE:To evaluate the therapeutic efficacy of a steroid switch from prednisone to dexamethasone in Asians with metastatic castration-resistant prostate cancer (mCRPC) that progressed after docetaxel chemotherapy. METHODS:This study included postdocetaxel patients with mCRPC treated with abiraterone acetate combine...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Fang WY,Wang PF,Fan YC,Shih HJ

    更新日期:2020-08-13 00:00:00

  • Effects of selective alpha-1-adrenergic receptor blockers on bladder weight.

    abstract:INTRODUCTION:This study was undertaken to investigate the effects of two different alpha(1)-adrenergic blockers on bladder hypertrophy using ultrasound-estimated bladder weight (UEBW) and to assess the relation between changes in UEBW and other objective and subjective parameters of disease severity in patients with be...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Egilmez T,Pourbagher MA,Guvel S,Kilinc F,Turunc T,Ozkardes H

    更新日期:2006-01-01 00:00:00

  • The haemostatic effect of purse-string suture in transvesical prostatectomy: a controlled clinical trial.

    abstract::In a series of 64 consecutive cases of transvesical prostatectomies it is shown that the use of a purse-string suture at the bladder neck significantly reduces the postoperative blood loss. A follow-up 3 months after operation has shown that the suture did not increase the number of either bladder neck stenoses, urina...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章


    authors: Overgaard Nielsen H,Højsgaard A,Larsen A,Gravgaard E,Holm-Møller S

    更新日期:1979-01-01 00:00:00

  • Transrectal ultrasonography of the prostate and seminal vesicles with hemospermia.

    abstract::Transrectal ultrasonography was performed in 46 patients with hemospermia. Abnormal findings in the prostate and seminal vesicles, including prostatic stones, benign prostatic hyperplasia, prostatitis, and dilatation and calculi of the seminal vesicles, were observed in 34 patients (73.9%). However, no malignant lesio...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Amano T,Kunimi K,Ohkawa M

    更新日期:1994-01-01 00:00:00

  • Current Role of Multiparametric MRI and MRI Targeted Biopsies for Prostate Cancer Diagnosis in Germany: A Nationwide Survey.

    abstract:INTRODUCTION:Multiparametric MRI (mpMRI) and MRI targeted biopsies (MRtb) are a new standard in prostate cancer (PCa) screening and diagnosis. Guidelines already include this approach for patients at risk. We aimed to gather information from German urologists about their knowledge, routine use, and attitude toward mpMR...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Saar M,Linxweiler J,Borkowetz A,Fussek S,Urbanova K,Bellut L,Kristiansen G,Wullich B,German Prostate Cancer Consortium (DPKK).

    更新日期:2020-01-01 00:00:00

  • Value of current chemotherapy and surgery in advanced and metastatic bladder cancer.

    abstract::The aim of the present paper was to review findings from the most relevant studies and to evaluate the value of current chemotherapy and surgery in advanced unresectable and metastatic bladder cancer. Studies were identified by searching the MEDLINE® and PubMed® databases up to 2011 using both medical subject heading ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审


    authors: Racioppi M,D'Agostino D,Totaro A,Pinto F,Sacco E,D'Addessi A,Marangi F,Palermo G,Bassi PF

    更新日期:2012-01-01 00:00:00

  • Temporary filters and liver mobilization technique improve the safety and prognosis of radical nephrectomy and inferior vena cava thrombectomy in renal cell carcinoma with subdiaphragmatic thrombosis.

    abstract:AIMS:This study aimed to investigate the safety and efficacy of preoperative temporary inferior vena cava (IVC) filter placement and intraoperative application of a liver mobilization technique. MATERIALS AND METHODS:The experiment cohort of 42 cases and the control cohort of 36 cases of renal cell carcinoma involving...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Zhang JP,Zhu Y,Liu YJ,Zhang L,Sun LA,Guo JM,Lin ZM

    更新日期:2013-01-01 00:00:00

  • Nerve sparing and continence preservation during radical prostatectomy.

    abstract::Prostate cancer is one of the most common malignancies occurring in men. During the last decade, several advances have been made in decreasing the morbidity of surgical therapy. Two major advances have included an improved understanding of the physiology of erection and anatomy of pelvic parasympathetic nerves mediati...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审


    authors: Narayan P

    更新日期:1991-01-01 00:00:00

  • The effect of alpha-difluoromethyl-ornithine on tumor growth, acute phase reactants, beta-2-microglobulin and hydroxyproline in kidney and bladder carcinomas.

    abstract::Multiple oral doses of alpha-difluoromethyl-ornithine (alpha-DFMO), 18-24 g/day for up to 2 months, were administered to 2 patients with invasive and metastatic carcinoma of the bladder and to 3 patients with metastatic renal cancer in an open study. The moderate antigrowth effect of alpha-DFMO in these patients was c...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Dunzendorfer U

    更新日期:1981-01-01 00:00:00

  • Real-Life Data on Mirabegron in Neurogenic Bladder Dysfunction.

    abstract:AIMS:To determine factors for treatment persistence in a real-life cohort of adult neurogenic lower urinary tract dysfunction. METHODS:We reviewed records of patients with neurogenic lower urinary tract dysfunction and mirabegron prescriptions. Exclusion criteria were indwelling urethral or suprapubic catheters and im...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Soebadi MA,Hakim L,Van der Aa F,De Ridder D

    更新日期:2019-01-01 00:00:00

  • Idiopathic clitoral hypertrophy.

    abstract::We report a case of clitoral hypertrophy of unknown origin. A 3-year-old girl showed clitoral hypertrophy at birth. Biochemical analysis of peripheral blood and endocrinological examinations were normal. Other virilizing symptoms were not recognized. Clitoroplasty was carried out, and the clitoris has not enlarged 20 ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Shiraishi K,Ishizu K,Takeuchi K,Takai K,Takihara H,Koga M,Naito K

    更新日期:1999-01-01 00:00:00

  • Globalization in Urology: A Bibliographical Analysis of Cross-Continent Publication between 2002 and 2012.

    abstract:INTRODUCTION:Asian scientists have now increasingly begun to contribute to globalization; yet it is not clear whether publishing in the field of urology is paralleled by elevated cross-continental scientific publishing. MATERIALS AND METHODS:An exemplary bibliometric analysis of urologic journals from 3 different cont...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Mani J,Juengel E,Bartsch G,Filmann N,Ackermann H,Nelson K,Haferkamp A,Engl T,Blaheta RA

    更新日期:2015-01-01 00:00:00

  • Testicular microlithiasis associated with seminoma: Gray-scale and color Doppler ultrasound findings.

    abstract::Testicular microlithiasis associated with seminoma was found in a 32-year-old infertile man. Gray-scale and color Doppler ultrasound findings are discussed and a brief review of the literature is presented. ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Yagci C,Ozcan H,Aytaç S,Aydos K,Atasoy C

    更新日期:1996-01-01 00:00:00

  • Renal cysts: can percutaneous ethanol injections be considered an alternative to surgery?

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    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Gasparini D,Sponza M,Valotto C,Marzio A,Luciani LG,Zattoni F

    更新日期:2003-01-01 00:00:00

  • Laparoscopic versus Robotic-Assisted Radical Prostatectomy for the Treatment of Localised Prostate Cancer: A Systematic Review.

    abstract:BACKGROUND:Prostate cancer is a prominent form of cancer diagnosed in men living in developed countries, for which radical prostatectomy is a common frontline treatment. The aim of this systematic review was to determine whether robot-assisted laparoscopic radical prostatectomy (RALP) is more effective in the treatment...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审


    authors: Allan C,Ilic D

    更新日期:2016-01-01 00:00:00

  • [Desobstructive sodium and water diuresis: pathophysiologic and clinical aspects of bilateral obstructive nephropathy (author's transl)].

    abstract::The measurement of sodium and water loss after relieve of the obstruction shows that the obstructive nephropathy originates in three pathogenetic mechanisms. (1) Acute complete bilateral ureteric obstruction causes tubular atrophy, prevents both resorption and glomerular filtration, reduces the renal blood flow and in...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Sigel A,Chlepas S,Ernstberger W

    更新日期:1979-01-01 00:00:00

  • Imaging of infantile polycystic kidney disease with some rare association.

    abstract::Seventeen patients, age 1 day to 6 years with infantile polycystic kidney disease were evaluated with ultrasound and other imaging techniques. Most patients showed bilaterally enlarged kidneys with hyperechoic renal parenchyma, which had poor differentiation in outlines as well as between renal sinus, cortex and medul...

    journal_title:Urologia internationalis

    pub_type: 杂志文章


    authors: Patel PJ

    更新日期:1992-01-01 00:00:00

  • Transurethral needle ablation of the prostate: an alternative minimally invasive therapeutic concept in the treatment of benign prostate hyperplasia.

    abstract::Alternative minimally invasive methods treating benign prostate hyperplasia (BPH) have become more and more important. Transurethral needle ablation (TUNATM) has been demonstrated to be effective in both canine and the human prostate. The goal of our study was to prove the safety, feasibility and tolerance of this new...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章


    authors: Braun M,Zumbé J,Korte D,Solleder G,Heidenreich A,Engelmann U

    更新日期:1998-01-01 00:00:00