Abstract:
:119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The patients' follow-up periods run from 6 to 66 months averaging in 38.5 months. 6 complete remissions, 4 partial responses and 29 stable diseases were seen, whereas 54 patients had progressive disease. Patients with a T1 primary tumor all survived the follow-up period irrespective of whether lymph node metastases (n = 2), venous invasion (n = 12) or distant metastases (n = 6) were present at the time of operation. Follow-up periods run from 12 to 48 months (averaging 23 months). Patients with T2 tumors showed survival up to 50 months postoperatively, of these only 3 died. Follow-up averages 30 months. The 3 patients died within the first year after operation. Patients with very large primary tumors showed the poor prognosis normally expected. 23 of these 40 patients died after a mean follow-up of 15 months. These results may indicate that immunotherapy can slow down tumor progression and induce objective responses. Those patients with small primary lesions apparently benefit from the treatment even though metastases are present at the time of diagnosis.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Schärfe T,Müller S,Riedmiller H,Jacobi GH,Hohenfellner Rdoi
10.1159/000281439subject
Has Abstractpub_date
1989-01-01 00:00:00pages
1-4issue
1eissn
0042-1138issn
1423-0399journal_volume
44pub_type
临床试验,杂志文章,多中心研究abstract::Recent interest has focused on natural killer T (NKT) cells as effector cells in a possible new form of immunotherapy. NKT cells express T cell and natural killer cell receptors. They are CD1d-dependent and can be stimulated by alpha-galactosylceramide. We have studied peripheral blood levels of NKT cells simultaneous...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000071836
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:No relevant data have been published on the impact of retroperitoneal lymph node dissection (LND) on clinical outcome in patients with castration-resistant prostate cancer. METHODS:We retrospectively studied the records of 6 patients with lymph node metastases from castration-resistant prostate cancer who u...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000335206
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066121
更新日期:2002-01-01 00:00:00
abstract:INTRODUCTION:Intravesical epirubicin is a widely used agent for the treatment of superficial bladder cancer. A direct relationship between dose and activity has been reported: unfortunately the dose increase also increased the frequency and the intensity of treatment-related side effects. MATERIALS AND METHODS:A phase...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000058438
更新日期:2002-01-01 00:00:00
abstract::We present a 17-year-old patient with a right testicular dislocation. In this case, dislocated testis had been considered as hematoma and therefore remained untreated for 4 months. The patient underwent right orchiopexy 4 months after the injury. Intraoperative testicular biopsy revealed impaired spermatogenesis and e...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282830
更新日期:1996-01-01 00:00:00
abstract::Chromosomal anomalies may be a reason for male infertility. To find out whether this is true mitotic chromosome studies were performed on 41 males with azoospermia and 61 males with oligozoospermia. A constitutional chromosomal abnormality was diagnosed in 14 (34.1%) azoospermic patients and in 2 (3.3%) oligozoospermi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030280
更新日期:1998-10-01 00:00:00
abstract::Fifty consecutive female patients with genuine urinary stress incontinence were randomized either to surgery or to a pelvic floor training program. The operative procedure was chosen according to the type of bladder suspension defect on micturition cystourethrography. The training program was given 5 times in weekly l...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000281181
更新日期:1986-01-01 00:00:00
abstract::The guidelines of testicular cancer were elaborated and agreed upon interdisciplinarily. Standard therapy of stage I seminoma is infradiaphragmatic radiotherapy. Possible alternatives are adjuvant carboplatin therapy (still in test procedure) and, in case of lacking risk factors, the watch-and-wait strategy. If small ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000030418
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:We aimed to evaluate the predictive factors in a holistic manner for ureterorenoscopy (URS) outcomes in proximal ureteral stones by a multicenter study. MATERIALS AND METHODS:The data of patients who underwent URS for proximal ureteral stones between the years 2015 and 2018 in eight centers were recorded ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000504790
更新日期:2020-01-01 00:00:00
abstract:PURPOSE:We aimed at evaluating the efficacy of extracorporeal shockwave lithotripsy (SWL) for treating distal ureteral calculi performed in supine vs. prone position. MATERIALS AND METHODS:Eligible studies were identified by 2 reviewers using PubMed, Embase, and Web of Science databases. Outcomes included stone-free r...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000439140
更新日期:2016-01-01 00:00:00
abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000209374
更新日期:2009-01-01 00:00:00
abstract::We present a new modified in vitro culture assay for primary human renal cell carcinoma similar to the 'soft agar clonogenic assay'. However, the carrying out and expense of metrology are more simplified, allowing tumor-specific chemotherapeutic drug sensitivity testing under easier conditions. Twelve different sample...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281178
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Routine follow-up after cystectomy for bladder cancer detect patients with local recurrence late in the course of disease. We set out to determine the value of transrectal ultrasound (TRUS) as diagnostic tool to diagnose local failure. PATIENTS AND METHODS:Between 1986 and 2003, radical cystectomy for bladde...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000176018
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION AND AIM:Surgical vasectomy remains the gold standard for fertility control in men. Endoluminal occlusion of the seminal ducts, thus avoiding an external incision, may become an appealing alternative to this approach. As our group has shown, nontraumatic endoscopic inspection of the seminal ducts is feasibl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000478790
更新日期:2017-01-01 00:00:00
abstract::Carcinoembryonic antigen (CEA) is elevated in urine and/or serum of patients with transitional cell carcinoma (TCC) of the urinary bladder. A group of 26 patients with TCC of the urinary bladder were evaluated with regard to urine/serum CEA levels and CEA tissue content. CEA could be detected in normal, metaplastic an...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280875
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVE:To analyze positive surgical margins (PSM) after radical prostatectomy (RP) in the overall population and in patients previously treated with transurethral resection of the prostate (TURP). MATERIALS AND METHODS:2,408 patients treated with RP for clinically localized prostate cancer (PCa) were consecutively ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000346748
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with thos...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000477912
更新日期:2017-01-01 00:00:00
abstract::The effectiveness of parasympathicolytic drugs in the treatment of ureteric colics is doubtful. Bencyclane is a new myotropic substance. Its spasmolytic effect on smooth muscle is five times stronger than that of papaverine. The results of the clinical use of Bencyclane in cases of ureteric colic are described and dis...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280208
更新日期:1978-01-01 00:00:00
abstract:OBJECTIVE:Increased pneumoperitoneum pressure during laparoscopic surgery can result in acute kidney injury. We aimed to clarify whether intraabdominal pressure tolerance is modified in various degrees of unilateral kidney hydronephrosis in rabbits. METHODS:A total 90 rabbits were randomly allocated to three groups (g...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000362845
更新日期:2015-01-01 00:00:00
abstract:AIMS:To determine factors for treatment persistence in a real-life cohort of adult neurogenic lower urinary tract dysfunction. METHODS:We reviewed records of patients with neurogenic lower urinary tract dysfunction and mirabegron prescriptions. Exclusion criteria were indwelling urethral or suprapubic catheters and im...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000500349
更新日期:2019-01-01 00:00:00
abstract::The ability of three compounds, all similar in chemical structure to citric acid, to decrease calcium crystalluria has been measured. The measurements were made in normal human urine at 37 degrees C and compared with the crystal-decreasing power of citric acid when measured in the same way and in the same urine sample...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282875
更新日期:1996-01-01 00:00:00
abstract::Between March 1983 and March 1988 we registered and treated 49 patients with bladder cancer less than 40 years of age (7 patients less than 30 years of age). Hematuria was present in 40 cases (81.6%). 33 of the patients had a pTA tumor (67.3%). 47 patients had transitional carcinoma of the bladder, of which 21 (44.7%)...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281475
更新日期:1989-01-01 00:00:00
abstract::We present a case of an appendicular mass mimicking symptoms of a bladder tumour in a 27-year-old female. The patient initially presented with a 5-month history of intermittent lower abdominal pain associated with dysuria, anorexia and weight loss. Cystoscopy revealed an erythematous urothelium with the appearance of ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000089178
更新日期:2005-01-01 00:00:00
abstract::Bisphosphonates are a standard treatment for metastatic bone disease, although agents vary in their potential for renal toxicity. This case report describes the reversal of zoledronic acid-induced renal toxicity by switching treatment to ibandronate in a patient with hormone-refractory prostate cancer and bone metasta...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000132707
更新日期:2008-01-01 00:00:00
abstract::In order to investigate the influence of the endorphins on lower urinary tract function we antagonized the endogenous opiates with naloxone. We performed urodynamic examination in 17 incontinent women, administered intravenously 0.4 mg naloxone, and repeated the urodynamic examination. Bladder volume and pressure were...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280969
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to describe a novel negative-pressure laser lithotripsy device to overcome the deficiencies of the conventional procedure. PATIENTS AND METHODS:Between August 2018 and March 2019, 78 patients with a single ureteral stone underwent retrograde ureteroscopy with a Wolf 8F/9.8F rigid u...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000507266
更新日期:2020-01-01 00:00:00
abstract::The identification and diagnosis of thyroid metastases from renal adenocarcinoma are rare in living patients, though more frequent during autopsy. A case is reported in which the identification of thyroid metastases indicated a clear-cell renal carcinoma in a kidney treated 12 years earlier for emptying of multiple cy...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281389
更新日期:1988-01-01 00:00:00
abstract::Proteus syndrome is a rare hamartomatous disorder comprising a broad spectrum of congenital malformations and overgrowth of multiple tissues. Some rare urogenital malformations have been reported before. This case is unique for the presence of multiple genitourinary anomalies including retroperitoneal cystic mass, int...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000089744
更新日期:2006-01-01 00:00:00
abstract::We present an unusual case of condylomata acuminata arising in the transplanted skin of a neovagina in a male-to-female transsexual. The neovagina had been constructed using a penile and a scrotal skin flap. Resection of the larger condylomata was performed; then all visible lesions were ablated by electrovaporization...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000078811
更新日期:2004-01-01 00:00:00
abstract::Multiple oral doses of alpha-difluoromethyl-ornithine (alpha-DFMO), 18-24 g/day for up to 2 months, were administered to 2 patients with invasive and metastatic carcinoma of the bladder and to 3 patients with metastatic renal cancer in an open study. The moderate antigrowth effect of alpha-DFMO in these patients was c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280403
更新日期:1981-01-01 00:00:00