Immunotherapy of metastasizing renal cell carcinoma. Results of a multicentered trial.

Abstract:

:119 patients with stage-IV renal cell carcinoma were treated using immunotherapy with autologous tumor vaccine. The immunization was carried out at monthly intervals, the patients were restaged every 3 months using X-ray, ultrasound scanning or computed tomography as well as bone scintigraphy in the follow-up. The patients' follow-up periods run from 6 to 66 months averaging in 38.5 months. 6 complete remissions, 4 partial responses and 29 stable diseases were seen, whereas 54 patients had progressive disease. Patients with a T1 primary tumor all survived the follow-up period irrespective of whether lymph node metastases (n = 2), venous invasion (n = 12) or distant metastases (n = 6) were present at the time of operation. Follow-up periods run from 12 to 48 months (averaging 23 months). Patients with T2 tumors showed survival up to 50 months postoperatively, of these only 3 died. Follow-up averages 30 months. The 3 patients died within the first year after operation. Patients with very large primary tumors showed the poor prognosis normally expected. 23 of these 40 patients died after a mean follow-up of 15 months. These results may indicate that immunotherapy can slow down tumor progression and induce objective responses. Those patients with small primary lesions apparently benefit from the treatment even though metastases are present at the time of diagnosis.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Schärfe T,Müller S,Riedmiller H,Jacobi GH,Hohenfellner R

doi

10.1159/000281439

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

1-4

issue

1

eissn

0042-1138

issn

1423-0399

journal_volume

44

pub_type

临床试验,杂志文章,多中心研究
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    pub_type: 杂志文章

    doi:10.1159/000071836

    authors: Schwemmer B

    更新日期:2003-01-01 00:00:00

  • Selective lymph node dissection for castration-resistant prostate cancer.

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000335206

    authors: Busch J,Hinz S,Kempkensteffen C,Erber B,Klopf C,Weikert S,Miller K,Magheli A

    更新日期:2012-01-01 00:00:00

  • The management of T1G3 bladder cancer.

    abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000066121

    authors: Bogdanović J,Marusić G,Djozić J,Sekulić V,Budakov P,Dejanović N,Stojkov J

    更新日期:2002-01-01 00:00:00

  • Delayed high-dose intravesical epirubicin therapy of superficial bladder cancer. A way to reduce the side effects and increase the efficacy--a phase 2 trial.

    abstract:INTRODUCTION:Intravesical epirubicin is a widely used agent for the treatment of superficial bladder cancer. A direct relationship between dose and activity has been reported: unfortunately the dose increase also increased the frequency and the intensity of treatment-related side effects. MATERIALS AND METHODS:A phase...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章

    doi:10.1159/000058438

    authors: Bassi P,Spinadin R,Longo F,Saraeb S,Pappagallo GL,Zattoni F,Pagano F

    更新日期:2002-01-01 00:00:00

  • Pathological changes of traumatic dislocated testis.

    abstract::We present a 17-year-old patient with a right testicular dislocation. In this case, dislocated testis had been considered as hematoma and therefore remained untreated for 4 months. The patient underwent right orchiopexy 4 months after the injury. Intraoperative testicular biopsy revealed impaired spermatogenesis and e...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282830

    authors: Hayami S,Ishigooka M,Suzuki Y,Sasagawa I,Nakada T,Mitobe K

    更新日期:1996-01-01 00:00:00

  • Cytogenetic study in 102 infertile men.

    abstract::Chromosomal anomalies may be a reason for male infertility. To find out whether this is true mitotic chromosome studies were performed on 41 males with azoospermia and 61 males with oligozoospermia. A constitutional chromosomal abnormality was diagnosed in 14 (34.1%) azoospermic patients and in 2 (3.3%) oligozoospermi...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000030280

    authors: Gündüz G,Lüleci G,Baykara M

    更新日期:1998-10-01 00:00:00

  • Pelvic floor exercise versus surgery for female urinary stress incontinence.

    abstract::Fifty consecutive female patients with genuine urinary stress incontinence were randomized either to surgery or to a pelvic floor training program. The operative procedure was chosen according to the type of bladder suspension defect on micturition cystourethrography. The training program was given 5 times in weekly l...

    journal_title:Urologia internationalis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000281181

    authors: Klarskov P,Belving D,Bischoff N,Dorph S,Gerstenberg T,Okholm B,Pedersen PH,Tikjøb G,Wormslev M,Hald T

    更新日期:1986-01-01 00:00:00

  • Guidelines for the diagnosis and therapy of testicular cancer and new developments.

    abstract::The guidelines of testicular cancer were elaborated and agreed upon interdisciplinarily. Standard therapy of stage I seminoma is infradiaphragmatic radiotherapy. Possible alternatives are adjuvant carboplatin therapy (still in test procedure) and, in case of lacking risk factors, the watch-and-wait strategy. If small ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,评审

    doi:10.1159/000030418

    authors: Weissbach L

    更新日期:1999-01-01 00:00:00

  • Predictive Factors of Ureterorenoscopy Outcomes in Proximal Ureteral Stones: A Multicenter Study of Aegean Study Group of the Society of Urological Surgery.

    abstract:INTRODUCTION:We aimed to evaluate the predictive factors in a holistic manner for ureterorenoscopy (URS) outcomes in proximal ureteral stones by a multicenter study. MATERIALS AND METHODS:The data of patients who underwent URS for proximal ureteral stones between the years 2015 and 2018 in eight centers were recorded ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000504790

    authors: Sen V,Irer B,Erbatu O,Yildiz A,Ongun Ş,Cinar O,Cihan A,Sahin M,Sahin MO,Ucer O,Kizilay F,Bozkurt O,Aegean Study Group of the Society of Urological Surgery.

    更新日期:2020-01-01 00:00:00

  • Supine versus Prone Position during Extracorporeal Shockwave Lithotripsy for Treating Distal Ureteral Calculi: A Systematic Review and Meta-Analysis.

    abstract:PURPOSE:We aimed at evaluating the efficacy of extracorporeal shockwave lithotripsy (SWL) for treating distal ureteral calculi performed in supine vs. prone position. MATERIALS AND METHODS:Eligible studies were identified by 2 reviewers using PubMed, Embase, and Web of Science databases. Outcomes included stone-free r...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000439140

    authors: Li T,Gao L,Chen P,Bu S,Cao D,Yang L,Wei Q

    更新日期:2016-01-01 00:00:00

  • Rectourethral fistula following LDR brachytherapy.

    abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000209374

    authors: Borchers H,Pinkawa M,Donner A,Wolter TP,Pallua N,Eble MJ,Jakse G

    更新日期:2009-01-01 00:00:00

  • [In vitro sensitivity testing of human kidney tumors to cytostatic drugs with a rapid in vitro test].

    abstract::We present a new modified in vitro culture assay for primary human renal cell carcinoma similar to the 'soft agar clonogenic assay'. However, the carrying out and expense of metrology are more simplified, allowing tumor-specific chemotherapeutic drug sensitivity testing under easier conditions. Twelve different sample...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281178

    authors: de Riese W,Aeikens B,Lenis G,Schindler E

    更新日期:1986-01-01 00:00:00

  • Transrectal ultrasound as diagnostic tool for the detection of local recurrence following cystectomy and urinary diversion.

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000176018

    authors: Simon J,Bartsch G Jr,Rinnab L,Hautmann RE,Volkmer BG

    更新日期:2009-01-01 00:00:00

  • Is Endoscopic Vasectomy Just a Dream: An ex vivo Study on Feasibility and Reliability of Endoluminal Occlusion of Porcine Vas Deferens.

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000478790

    authors: Schlager D,Maas M,Hein S,Adams F,Schoenthaler M,Spittau B,Wetterauer U,Miernik A

    更新日期:2017-01-01 00:00:00

  • Determination of carcinoembryonic antigen in tissue, serum and urine in patients with transitional cell carcinoma of the urinary bladder.

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280875

    authors: Jakse G,Rauschmeier H,Rosmanith P,Hofstädter F

    更新日期:1983-01-01 00:00:00

  • The impact of prior TURP on radical prostatectomy surgical margins: a multicenter analysis.

    abstract:OBJECTIVE:To analyze positive surgical margins (PSM) after radical prostatectomy (RP) in the overall population and in patients previously treated with transurethral resection of the prostate (TURP). MATERIALS AND METHODS:2,408 patients treated with RP for clinically localized prostate cancer (PCa) were consecutively ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章,多中心研究

    doi:10.1159/000346748

    authors: Gacci M,Simonato A,Lanciotti M,Ennas M,Varca V,Maffezzini M,Imbimbo C,Gontero P,Schiavina R,Carini M,Martorana G,Nicita G,Mirone V,Carmignani G

    更新日期:2013-01-01 00:00:00

  • The Efficacy of Trimodal Chemoradiotherapy with Cisplatin as a Bladder-Preserving Strategy for the Treatment of Muscle-Invasive Bladder Cancer.

    abstract:INTRODUCTION:Open radical cystectomy (ORC) is currently the standard treatment for muscle-invasive bladder cancer (MIBC) without metastasis, while many patients with MIBC are not always appropriate candidates due to multiple comorbidities. To evaluate the bladder-preservation strategy, we compared the results with thos...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000477912

    authors: Nagao K,Hara T,Nishijima J,Shimizu K,Fujii N,Kobayashi K,Kawai Y,Inoue R,Yamamoto Y,Matsumoto H,Matsuyama H

    更新日期:2017-01-01 00:00:00

  • [Myotropic spasmolysis in the treatment of ureteric colics (author's transl)].

    abstract::The effectiveness of parasympathicolytic drugs in the treatment of ureteric colics is doubtful. Bencyclane is a new myotropic substance. Its spasmolytic effect on smooth muscle is five times stronger than that of papaverine. The results of the clinical use of Bencyclane in cases of ureteric colic are described and dis...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280208

    authors: Patel VJ

    更新日期:1978-01-01 00:00:00

  • Acute kidney injury induced by various pneumoperitoneum pressures in a rabbit model of mild and severe hydronephrosis.

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000362845

    authors: Li W,Cao Z,Xia Z,Meng Q,Yu WM,Yao X,Cheng F

    更新日期:2015-01-01 00:00:00

  • Real-Life Data on Mirabegron in Neurogenic Bladder Dysfunction.

    abstract:AIMS:To determine factors for treatment persistence in a real-life cohort of adult neurogenic lower urinary tract dysfunction. METHODS:We reviewed records of patients with neurogenic lower urinary tract dysfunction and mirabegron prescriptions. Exclusion criteria were indwelling urethral or suprapubic catheters and im...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000500349

    authors: Soebadi MA,Hakim L,Van der Aa F,De Ridder D

    更新日期:2019-01-01 00:00:00

  • The inhibitory activity of some citrate analogues upon calcium crystalluria: observations using an improved urine evaporation technique.

    abstract::The ability of three compounds, all similar in chemical structure to citric acid, to decrease calcium crystalluria has been measured. The measurements were made in normal human urine at 37 degrees C and compared with the crystal-decreasing power of citric acid when measured in the same way and in the same urine sample...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000282875

    authors: Hallson PC,Kasidas GP,Samuell CT

    更新日期:1996-01-01 00:00:00

  • Bladder carcinoma in patients less than 40 years of age.

    abstract::Between March 1983 and March 1988 we registered and treated 49 patients with bladder cancer less than 40 years of age (7 patients less than 30 years of age). Hematuria was present in 40 cases (81.6%). 33 of the patients had a pTA tumor (67.3%). 47 patients had transitional carcinoma of the bladder, of which 21 (44.7%)...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281475

    authors: Witjes JA,Debruyne FM

    更新日期:1989-01-01 00:00:00

  • An appendicular mass mimicking a bladder tumour.

    abstract::We present a case of an appendicular mass mimicking symptoms of a bladder tumour in a 27-year-old female. The patient initially presented with a 5-month history of intermittent lower abdominal pain associated with dysuria, anorexia and weight loss. Cystoscopy revealed an erythematous urothelium with the appearance of ...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000089178

    authors: Johal NS,Kouriefs C,Apthorp L,Plail RO

    更新日期:2005-01-01 00:00:00

  • Renal toxicity following zoledronic acid reversed with ibandronate in a prostate cancer patient with bone metastases.

    abstract::Bisphosphonates are a standard treatment for metastatic bone disease, although agents vary in their potential for renal toxicity. This case report describes the reversal of zoledronic acid-induced renal toxicity by switching treatment to ibandronate in a patient with hormone-refractory prostate cancer and bone metasta...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000132707

    authors: Joensuu TK

    更新日期:2008-01-01 00:00:00

  • [Role of endorphins in the function of the lower urinary tract].

    abstract::In order to investigate the influence of the endorphins on lower urinary tract function we antagonized the endogenous opiates with naloxone. We performed urodynamic examination in 17 incontinent women, administered intravenously 0.4 mg naloxone, and repeated the urodynamic examination. Bladder volume and pressure were...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280969

    authors: Riss P,Spernol R,Pfersmann C

    更新日期:1984-01-01 00:00:00

  • Negative-Pressure Ureteroscopic Holmium-YAG Laser Lithotripsy for Ureteral Stones.

    abstract:OBJECTIVES:The aim of this study was to describe a novel negative-pressure laser lithotripsy device to overcome the deficiencies of the conventional procedure. PATIENTS AND METHODS:Between August 2018 and March 2019, 78 patients with a single ureteral stone underwent retrograde ureteroscopy with a Wolf 8F/9.8F rigid u...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000507266

    authors: Wu ZH,Liu TZ,Wang XH,Wang YZ,Zheng H,Zhang YG,Zhang XH

    更新日期:2020-01-01 00:00:00

  • Thyroid metastases from renal carcinoma.

    abstract::The identification and diagnosis of thyroid metastases from renal adenocarcinoma are rare in living patients, though more frequent during autopsy. A case is reported in which the identification of thyroid metastases indicated a clear-cell renal carcinoma in a kidney treated 12 years earlier for emptying of multiple cy...

    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000281389

    authors: Prati GF,Muolo A,Dean P,Ghimenton C

    更新日期:1988-01-01 00:00:00

  • Proteus syndrome with multiple genitourinary abnormalities.

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    pub_type: 杂志文章

    doi:10.1159/000089744

    authors: Karabulut A,Karabulut AA,Sunay M,Emir L,Erol D

    更新日期:2006-01-01 00:00:00

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000078811

    authors: Liguori G,Trombetta C,Bucci S,De Seta F,De Santo D,Siracusano S,Belgrano E

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000280403

    authors: Dunzendorfer U

    更新日期:1981-01-01 00:00:00