Natural killer T cells in patients with prostatic carcinoma.

Abstract:

:Recent interest has focused on natural killer T (NKT) cells as effector cells in a possible new form of immunotherapy. NKT cells express T cell and natural killer cell receptors. They are CD1d-dependent and can be stimulated by alpha-galactosylceramide. We have studied peripheral blood levels of NKT cells simultaneously with CD8+ cells and natural killer cells in 54 patients with prostatic carcinoma. Levels of NKT cells in patients with androgen withdrawal and stable PSA levels were 211.8 +/- 138.4 cells/microl and in patients with rising PSA levels were 27.0 +/- 22.1 cells/microl. A similar but less pronounced difference in CD8+ cells between these groups was found (656.4 vs. 212.0 cells/microl). Comparing all 54 patients studied, a positive correlation was found between the levels of NKT cells and CD8+ cells (r = 0.83). Our results suggest an important and regulatory role of NKT cells in patients with prostatic carcinoma.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Schwemmer B

doi

10.1159/000071836

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

146-9

issue

2

eissn

0042-1138

issn

1423-0399

pii

71836

journal_volume

71

pub_type

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