Restriction fragment length polymorphism of the L-myc gene and susceptibility to metastasis in genitourinary cancers.

Abstract:

:We examined Southern blot analysis of genomic DNAs from 70 patients with sporadic renal cell carcinoma, using the human L-myc oncogene fragment as a hybridization probe. Our purpose was to study the relationship between the restriction fragment length polymorphism (RFLP) of the L-myc and the frequencies of metastasis. The patients were classified into 3 genotypes according to the polymorphic patterns defined by two alleles (L-L:17, L-S:31, S-S:22). The relative ratios of the 3 genotypes in the renal cancer patients were similar to those seen in healthy Japanese. However, of 20 patients who exhibited distant metastases at diagnosis, only 2 belonged to the L-L type. The incidence of distant metastasis in L-L type patients was significantly lower than that in L-S and S-S patients (p = 0.068, by Fisher's exact probability test). These results basically correspond to the previous findings in the lung cancer patients [Kawashima et al.: Proc. natn. Acad. Sci. USA 85: 2353-2356, 1988]. On the other hand, L-myc RFLP analysis in 50 prostatic cancer patients revealed that the incidence of metastasis at diagnosis did not correlate with L-myc genotypes. L-myc RFLP seems to be less promising in prostatic cancer than in lung or kidney cancer.

journal_name

Urol Int

journal_title

Urologia internationalis

authors

Kakehi Y,Taki Y,Yoshida O

doi

10.1159/000282261

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

86-9

eissn

0042-1138

issn

1423-0399

journal_volume

47 Suppl 1

pub_type

杂志文章
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    doi:10.1159/000280270

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  • Current information on sacral neuromodulation and botulinum toxin treatment for refractory idiopathic overactive bladder syndrome: a review.

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    journal_title:Urologia internationalis

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    doi:10.1159/000288223

    authors: Leong RK,De Wachter SG,van Kerrebroeck PE

    更新日期:2010-01-01 00:00:00

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  • Aurora-A/STK-15 is differentially expressed in the micropapillary variant of bladder cancer.

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

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    更新日期:2008-01-01 00:00:00

  • DNA methylation analysis in immature testicular sperm cells at different developmental stages.

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    更新日期:2001-01-01 00:00:00

  • Diagnostic value of 18F-FDG positron emission tomography for detection and treatment control of malignant germ cell tumors.

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    journal_title:Urologia internationalis

    pub_type: 杂志文章

    doi:10.1159/000048442

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  • Postoperative Quality of Life in Patients with Ileal Neobladder at Short-, Intermediate- and Long-Term Follow-Up.

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    pub_type: 杂志文章,多中心研究

    doi:10.1159/000443185

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  • The adreno-renal-ureteral sheath: surgical-anatomical study.

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    pub_type: 杂志文章,多中心研究

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    更新日期:2004-01-01 00:00:00

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  • The Feasibility, Technique, and Medium-Term Follow-Up of Laparoscopic Transvesical Diverticulectomy.

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    pub_type: 杂志文章

    doi:10.1159/000283051

    authors: Guate JL,Escaf S,Menendez CL,del Valle M,Vega JA

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