Abstract:
:We examined Southern blot analysis of genomic DNAs from 70 patients with sporadic renal cell carcinoma, using the human L-myc oncogene fragment as a hybridization probe. Our purpose was to study the relationship between the restriction fragment length polymorphism (RFLP) of the L-myc and the frequencies of metastasis. The patients were classified into 3 genotypes according to the polymorphic patterns defined by two alleles (L-L:17, L-S:31, S-S:22). The relative ratios of the 3 genotypes in the renal cancer patients were similar to those seen in healthy Japanese. However, of 20 patients who exhibited distant metastases at diagnosis, only 2 belonged to the L-L type. The incidence of distant metastasis in L-L type patients was significantly lower than that in L-S and S-S patients (p = 0.068, by Fisher's exact probability test). These results basically correspond to the previous findings in the lung cancer patients [Kawashima et al.: Proc. natn. Acad. Sci. USA 85: 2353-2356, 1988]. On the other hand, L-myc RFLP analysis in 50 prostatic cancer patients revealed that the incidence of metastasis at diagnosis did not correlate with L-myc genotypes. L-myc RFLP seems to be less promising in prostatic cancer than in lung or kidney cancer.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Kakehi Y,Taki Y,Yoshida Odoi
10.1159/000282261subject
Has Abstractpub_date
1991-01-01 00:00:00pages
86-9eissn
0042-1138issn
1423-0399journal_volume
47 Suppl 1pub_type
杂志文章abstract:BACKGROUND:The objective of this study is to describe and analyze the experience over a period of 10 years at our center through a retrospective study of a series of diagnosed and treated cases of penile fracture. MATERIAL AND METHODS:From 2005 to 2009 the Urology Department of the Hospital Clínico San Carlos of Madri...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324249
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Intravesical recurrence after treatment of primary upper urinary tract urothelial carcinomas (UUT-UCs) is common. While intravesical instillation is widely used to prevent recurrence after transurethral resection for primary bladder tumors, there is still no consensus on the prophylactic capability of intr...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000350508
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To investigate the reliability of the physician-assisted International Index of Erectile Function (IIEF). PATIENTS AND METHODS:374 patients who applied to our clinic with erectile dysfunction problems were asked to complete the IIEF questionnaire; 225 patients who visited the clinic again within 1-3 days com...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000335432
更新日期:2012-01-01 00:00:00
abstract::The effect of vinblastine sulfate on the acceptance and growth of a very malignant, human adenocarcinoma of the kidney (RCCI) on nude mice was investigated. Without any treatment, this tumor has an acceptance rate of 100%. Subcutaneously transplanted pieces of tumor, measuring 3 X 3 X 1 mm, commence to grow rapidly 1 ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280404
更新日期:1981-01-01 00:00:00
abstract:INTRODUCTION:Mini percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS) are well-established techniques with little morbidity. The combined use of standard PCNL and the mini-PCNL or the RIRS technique was evaluated and compared to investigate their own role in the management of staghorn calc...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000360708
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:In spite of a great amount of data, the hormonal treatment of advanced prostatic carcinoma (CaP) still remains controversial. As a relevant amount of dihydrotestosterone is present within the prostate tissue after castration, complete androgen blockade (CAB), with inhibition of the activity of both testicula...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1159/000056541
更新日期:1998-01-01 00:00:00
abstract::The measurement of sodium and water loss after relieve of the obstruction shows that the obstructive nephropathy originates in three pathogenetic mechanisms. (1) Acute complete bilateral ureteric obstruction causes tubular atrophy, prevents both resorption and glomerular filtration, reduces the renal blood flow and in...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280270
更新日期:1979-01-01 00:00:00
abstract::The overactive bladder syndrome (OAB) negatively affects the daily life of many people. Conservative treatments, such as antimuscarinics, do not always lead to sufficient improvement of the complaints and/or are often associated with considerable side effects resulting in treatment failure. In the case of failure or i...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000288223
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:To compare the safety and efficacy of standard-tract combined with mini-tract to single standard-tract in percutaneous nephrolithotomy (PCNL) for renal staghorn calculi. METHODS:The records of 216 patients with staghorn calculi (110 (50.9%) had complete and 106 (49.1%) had partial) who received PCNL were revie...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000354427
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Micropapillary carcinoma (MPC) of the bladder is a rare and aggressive histologic variant of urothelial carcinoma (UC). At the time of presentation, most MPC are muscle invasive with frequent vascular invasion (VI). Our series explores protein expression of markers known to be indicators of poor clinical o...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000209364
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:Endorectal coil MRI (endoMRI) of the prostate is useful to evaluate tumor localization. There is little evidence on patient characteristics affecting its diagnostic performance. We evaluate the influence of clinical and histological parameters on the accuracy of endoMRI. METHODS:Sixty-nine patients with pro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324098
更新日期:2011-01-01 00:00:00
abstract::Two patients treated with chronic dialysis and renal transplantation developed acute hemorrhage from a native kidney. Bilateral native nephrectomy demonstrated acquired cystic disease and adenocarcinoma in each of the four kidneys. The etiology of acquired cystic kidney disease (ACKD) is unclear and its incidence incr...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030222
更新日期:1998-01-01 00:00:00
abstract::This report presents a case of a 16-year-old hypertensive boy who presented to our clinic. Laboratory findings showed severe hypokalemia and markedly increased plasma renin activity. Abdominal ultrasonography and contrast-enhanced computed tomography of the abdomen revealed a well-circumscribed, solid, hypoenhancing c...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000314339
更新日期:2010-01-01 00:00:00
abstract::A new device for the simultaneous in vivo measurement of pressure and developed force in the ureter is introduced. The 5-French catheter was cystoscopically inserted into the ureters of 12 dogs under anesthesia. The forms of the peristaltic waves for pressure and force show considerable differences. A basal force anal...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282119
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:Clear cell renal cell carcinoma (ccRCC) is the most common kidney tumor. If feasible, metastasectomy is preferably indicated in metastatic disease. OBJECTIVE:The aim of this study was to determine the outcome of patients after pulmonary metastasectomy (PM). METHODS:PM for ccRCC was performed in 35 patien...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000502493
更新日期:2019-01-01 00:00:00
abstract::Adrenal cysts are very rare lesions, usually asymptomatic or without characteristic symptoms. They are classified as pseudocysts, endothelial cysts, epithelial cysts or parasitic cysts. Although pseudocysts are reported to be the most common clinically recognized adrenal cysts in surgical series, endothelial cysts are...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000111726
更新日期:2008-01-01 00:00:00
abstract::Testicular sperm extraction and intracytoplasmic sperm injection (TESE-ICSI) is a frequently used therapeutic option in azoospermic males. Genetic imprinting is a mechanism of gene regulation - mediated by the methylation of deoxyribonucleic acids (DNA) - by which only one of the parental copies of a gene is expressed...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000050972
更新日期:2001-01-01 00:00:00
abstract:INTRODUCTION:The role of positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is currently under evaluation in urologic oncology. The aim of the present study was to investigate the use of [18F]FDG positron emission tomography ([18F]FDG-PET) in the detection and treatment control of malign...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000048442
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:To evaluate the difference at different steps of follow-up of the postoperative quality of life (QoL) in patients who had undergone radical cystectomy and ileal orthotopic neobladder derivation. PATIENTS AND METHODS:A multicentric, cross-qualitative study was performed in 5 Italian centers of reference for ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000443185
更新日期:2016-01-01 00:00:00
abstract::The adreno-renal-ureteral sheath is described, showing the continuity of the anterior and posterior leaves of the sheath along the entire length of the retroperitoneum of each side. The study is based on anatomical dissections and on surgical observations. Anatomical and pathological considerations are discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280049
更新日期:1976-01-01 00:00:00
abstract::Urinary incontinence in 80 men was classifed by combined radiological and urodynamic techniques. 28 cases of pure stress incontinence were evaluated for grading of sphincteric loss. Clinical and sphincterometric data were correlated. Functional urethral length, urethral closure pressure at rest and with voluntary sphi...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280348
更新日期:1980-01-01 00:00:00
abstract:INTRODUCTION:The aim of our study was to determine the validity of the updated nomogram [Briganti et al.: Eur Urol 2012;61:480-487] as a prediction tool for pelvic lymph node invasion (LNI) in the current era by using a large multicentric population of men who underwent extended pelvic lymph node dissection (ePLND) at ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000343993
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:We investigated the status of erectile function and urinary continence after radical prostatectomy to investigate a possible relation between them and then determined whether the status of postoperative urinary continence affected erectile function. PATIENTS AND METHODS:Seventy-six patients who had no sym...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000078801
更新日期:2004-01-01 00:00:00
abstract::The influence of unilateral ureteral ligation in the rat nephron has been morphometrically analysed. The glomeruli show no significant differences compared with the control groups. The lumen of the tubulus rectus I increases significantly, but irregularly, after the 6th day of ureter ligation. The brush border is most...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280329
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:To present our experience and results with the transvesical laparoscopic diverticulectomy, developed by Pansadoro et al. [BJU Int. 2009;103(3):412-24], as treatment of symptomatic bladder diverticula, with a medium-term follow-up. METHODS:Between June 2010 and July 2018, we successfully operated 15 patients...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000510242
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Currently, surgical repair for vesicovaginal fistula (VVF) provides excellent results, but the recurrent VVF is difficult to treat as compared to primary. PATIENTS AND METHODS:Sixty-eight patients (44 primipara and 24 multipara) with recurrent VVF repair from January 2002 to December 2007 were included in...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000331503
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Splenectomy had been previously performed in ABO-incompatible kidney transplantation to reduce the B cell pool. However, studies have shown that patients undergoing splenectomy may have a lifelong susceptibility to infection and mortality. Splenectomy may affect the incidence of cytomegalovirus (CMV) disea...
journal_title:Urologia internationalis
pub_type:
doi:10.1159/000504862
更新日期:2020-01-01 00:00:00
abstract:AIM:The aim of this study was to compare the postoperative analgesic effectiveness of the 2 block types. We also aimed to evaluate the effect of these block types on the postoperative complications and parental satisfaction. MATERIALS AND METHODS:This prospective observational study was conducted between April and Jul...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000509173
更新日期:2020-01-01 00:00:00
abstract::The present study was undertaken to analyze the changes in neuroendocrine cells of the human prostate induced by neoplasms and the effect of hormonal treatment. Samples of human prostate (n = 47) were obtained during surgery or removal of organs for transplantation. The cases analyzed represent normal prostates (n = 4...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000283051
更新日期:1997-01-01 00:00:00
abstract::A buccal mucosa graft from the lower lip was used for meatal reconstruction in 3 patients. The buccal mucosa graft was combined with a bladder mucosa graft for urethral substitution in 1 adult and 1 child, and was anastomosed to a skin tube for creating a glanular urethra in 1 child. The buccal mucosa graft obtained w...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282743
更新日期:1995-01-01 00:00:00