Abstract:
INTRODUCTION:The role of positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is currently under evaluation in urologic oncology. The aim of the present study was to investigate the use of [18F]FDG positron emission tomography ([18F]FDG-PET) in the detection and treatment control of malignant germ cell tumors compared to computed tomography (CT). MATERIALS AND METHODS:Thirty-two PET studies and CT scans were carried out in 23 patients with histologically proven germ cell tumors (10 seminomas, 12 non-seminomatous germ cell tumors (NSGCT), 1 unclassified serologic recurrent disease) Lugano stage I-III. The scans were done either after initial diagnosis (n = 21) and/or within 3-45 days after chemotherapy was completed (n = 11). PET and CT were validated either by histology (n = 7) or clinical follow-up of 6-11 months after the last PET study has been performed (n = 16). Sensitivity, specificity, accuracy, positive and negative predictive values were determined for PET and CT. Differences between PET and CT for parameters of diagnostic value were evaluated by chi(2) test. RESULTS:Although not statistically significant, the sensitivity, accuracy and negative predictive value were higher for PET than for CT with respect to the detection of metastatic infradiaphragmatic and supradiaphragmatic lesions after initial diagnosis. The specificity and positive predictive value of PET and CT were comparable. After chemotherapy, PET was found to be significantly superior in specificity and accuracy compared to CT with respect to infradiaphragmatic lesions (p < 0.05). False-positive PET findings in supradiaphragmatic lesions after chemotherapy occurred in the case of inflammatory processes and resulted in a loss of specificity and accuracy compared to CT (p < 0.05). CONCLUSIONS:These preliminary results demonstrate [18F]FDG-PET to be a useful diagnostic tool for the initial staging and treatment control in patients with germ cell tumors. Possible advantages compared to CT, however, are as yet not clearly defined. The possibility of false-positive PET findings due to reactive supradiaphragmatic inflammatory processes early after chemotherapy have to be considered.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Tsatalpas P,Beuthien-Baumann B,Kropp J,Manseck A,Tiepolt C,Hakenberg OW,Burchert W,Franke WG,Wirth MPdoi
10.1159/000048442subject
Has Abstractpub_date
2002-01-01 00:00:00pages
157-63issue
3eissn
0042-1138issn
1423-0399pii
48442journal_volume
68pub_type
杂志文章abstract:INTRODUCTION:Appropriate management of renal trauma is controversial. The purpose of this study is to present our 5-year experience in renal trauma and review the literature. MATERIALS AND METHODS:From 1999 to 2003, 28 patients were identified with renal injuries. 25 (89.3%) of the injuries were caused by blunt trauma...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000093899
更新日期:2006-01-01 00:00:00
abstract:INTRODUCTION:Radical prostatectomy (RP) in patients with locally advanced (cT3) prostate cancer (PCa) is considered an optional therapy. AIM:To evaluate outcomes of surgery for cT3 disease and to compare results with those of patients treated for cT1-T2 PCa. PATIENTS AND METHODS:Data of 74 consecutive patients with c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000316944
更新日期:2010-01-01 00:00:00
abstract::Plasma carcinoembryonic antigen (CEA) levels were performed preoperatively by radioimmunoassay in 124 patients with histologically proved bladder carcinoma. The level of CEA was used to determine its prognostic value in patients with bladder cancer. The correlation of CEA levels with the stage of the disease, histolog...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280285
更新日期:1979-01-01 00:00:00
abstract::Transrectal ultrasonography was performed in 46 patients with hemospermia. Abnormal findings in the prostate and seminal vesicles, including prostatic stones, benign prostatic hyperplasia, prostatitis, and dilatation and calculi of the seminal vesicles, were observed in 34 patients (73.9%). However, no malignant lesio...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282655
更新日期:1994-01-01 00:00:00
abstract::Aneurysmectomy and renal angioplasty were performed on a 14-year-old Japanese male and the blood pressure was within normal values 3 years after this surgery. Measurement of renal blood flow was facilitated by using 133Xe washout technique. This incidence is the eighth such case to be reported from Japan. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280073
更新日期:1976-01-01 00:00:00
abstract::Splenic metastases of solid tumors are exceptional. We report the first case of an isolated splenic metastasis from prostate carcinoma, 5 years after radical prostatectomy. The splenic tumor was revealed by a pain and progressive increase in the serum prostate-specific antigen (PSA) level. Histology of the spleen show...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000096942
更新日期:2007-01-01 00:00:00
abstract::Serum-ionized calcium (Ca++) was measured in 65 patients with idiopathic calcium urolithiasis. The patients were then divided into hypercalciuric and normocalciuric groups based on the mean + SD of the control group, with greater than 180 mg/24 h in males and greater than 176 mg/24 h in females defined as hypercalciur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280303
更新日期:1980-01-01 00:00:00
abstract::Clinical and experimental investigations seem to underline the important role of fatty acids in the pathogenesis of hypercalciuria, a well-known risk factor for lithogenesis. To evaluate the relationships between the previously reported increase in plasma phospholipid arachidonic acid level and the factors responsible...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000087161
更新日期:2005-01-01 00:00:00
abstract::An unusual case of a double testicular tumor, with different histology and the same marker chromosome, led to a search of the literature for cases of testicular tumors that were double, bilateral, or familial. The literature on abnormal chromosomes in tumors of the testis is also reviewed. After a discussion of the fa...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000281443
更新日期:1989-01-01 00:00:00
abstract::The functional activity of the sphincter muscle of the urethra is known to be controlled largely by the hypogastric and pudendal nerves. It remains unknown, however, whether innervation of the muscle by these peripheral nerves is ipsi- or bilateral. In an attempt to answer this question urethral closure pressure was d...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281328
更新日期:1988-01-01 00:00:00
abstract::Modern LDR brachytherapy has drastically reduced rectal toxicity and decreased the occurrence of rectourethral fistulas to <0.5% of patients. Therefore, symptoms of late-onset sequelae are often ignored initially. These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the o...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000209374
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:The regulation proteins retinoblastoma protein (pRb) and p16 play an important role in the cell cycle as tumor suppressors. pRb is the main substrate for the function of cyclin-dependent kinases during the cell cycle in the transition from G(1) to S phase. In this study, the immunohistochemical expression ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000320510
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Stricture of the vesicourethral anastomosis remains a well-documented complication after radical retropubic prostatectomy. MATERIALS AND METHODS:We performed a retrospective study of 294 patients with prostate cancer who underwent radical retropubic prostatectomy. Possible correlations between anastomotic st...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000075267
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To assess the usefulness of tumor-centered multiplanar reconstruction (TC-MPR) for predicting intraoperative urinary collecting system (UCS) entry in patients with peripheral renal tumors undergoing partial nephrectomy (PN). METHODS:Dynamic computed tomography images of 50 peripheral cT1 renal tumors treated...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000484254
更新日期:2018-01-01 00:00:00
abstract::A 50-year-old man with hemophilia A presented with recurrent hematuria due to renal stone disease. He was receiving approximately 50,000 units of recombinant factor (rF) VIII concentrate every year due to hematuria. Between 1996 and 2002, his serum creatinine level increased from 0.7 to 1.2 ng/ml. In an effort to reso...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000100846
更新日期:2007-01-01 00:00:00
abstract::Controversies abound in relation to the treatment of every stage of prostate cancer and its natural history. We critically evaluate the controversies and information that exist. An ongoing autopsy project at Wayne State University aims to: define the prevalence of incidental cancer in subjects between 20 and 70 years ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000282860
更新日期:1996-01-01 00:00:00
abstract::An unusual case of metastatic carcinoma of prostate, which presented as a huge abdominal mass and responded extremely well to endocrine therapy, is presented. The literature is reviewed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281205
更新日期:1986-01-01 00:00:00
abstract:INTRODUCTION:The treatment of T1G3 bladder cancer is still a controversial issue. Nowadays, intravesical bacillus Calmette-Guérin (BCG) instillation is considered to be the treatment of choice for patients with high-grade superficial bladder tumour after transurethral resection of all visible tumour. The aim of this re...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000066121
更新日期:2002-01-01 00:00:00
abstract::Amputation of the penis is by no means the quickest and least invasive of the surgical methods of treating penis carcinoma. Radiation therapy has the advantage of preserving the integrity of the penis and does not render a later operation of the penis impossible. Regional lymph node metastases should be removed surgic...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280899
更新日期:1983-01-01 00:00:00
abstract::Two patients with entire urethral stricture were treated with balloon dilatation of the whole urethra using a torpedo-type dilatation balloon with satisfactory results. Postdilatation urethrograms revealed that the lumen of the urethra was of satisfactory width in both cases, and the patients are now voiding normally....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282141
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Phytate as sodium salt has been used at high doses to treat stone-former patients with idiopathic hypercalciuria. The experimental and clinical hypocalciuric effects of dietary fiber have also been assigned to the presence of phytate as calcium-magnesium salt (phytin). As a consequence of the additional inte...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000077123
更新日期:2004-01-01 00:00:00
abstract:INTRODUCTION:The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis. METHODS:The main clinical data of patients treated in centers affiliated to the GUONE (North-Eastern Uro-Oncological Group, Italy) were reviewed. We cons...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000200790
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The best technique of radical prostatectomy--open retropubic versus robot-assisted surgery--is a subject of controversy. PATIENTS AND METHODS:Between January 1st, 2007 and December 31st, 2011, 2,177 men underwent radical prostatectomy at our department. 252 (12%) cases were laparoscopic robot-assisted, the ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345320
更新日期:2013-01-01 00:00:00
abstract:AIM:Papillary renal cell carcinoma type 1 (pRCC1) represents the second most common type of malignant renal epithelial tumour. The origin of its characteristic appearance, its growth mechanism, and the long-term efficiency of its surgical treatment remain uncertain. Our aim was to determine typical characteristics of s...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000448434
更新日期:2017-01-01 00:00:00
abstract::Recordings of local pressure within the membranous urethra were performed in 15 male spinal cord injury patients before and after external sphincterotomy. Transurethral division of the external sphincter reduced the intraurethral pressure by 55% in the upper part of the membranous urethra and by 66% in the lower part....
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000279962
更新日期:1975-01-01 00:00:00
abstract:INTRODUCTION:Mini percutaneous nephrolithotomy (mini-PCNL) and retrograde intrarenal surgery (RIRS) are well-established techniques with little morbidity. The combined use of standard PCNL and the mini-PCNL or the RIRS technique was evaluated and compared to investigate their own role in the management of staghorn calc...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000360708
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:With a median age at diagnosis of 73 years, bladder cancer has the highest median age of all cancers. Age alone seems to be an independent risk factor for developing the disease with peak age advancing into the range of 85 years. As demographic changes will lead to an ever more aging population in western count...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000510137
更新日期:2020-01-01 00:00:00
abstract::From April 1978 to September 1993, the Department of Urology of Giessen Medical School used laser urethrotomy as standard endoscopic treatment in benign urethral strictures. In this period, 900 urethrotomies were performed in 450 patients. The majority of strictures treated were iatrogenic (65%), located in the poster...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282774
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:To assess perioperative complications and 90-day mortality of radical cystectomy (RC) in elderly patients with muscle-invasive bladder cancer (MIBC). MATERIALS AND METHODS:This is a retrospective, multicentre (n = 11) study of a consecutive series of patients ≥75 years who underwent RC for MIBC between 2006 ...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000357127
更新日期:2014-01-01 00:00:00
abstract::We developed a new system to record urethral pressure curves separately for the anterior, posterior, right and left walls of the urethra. It consists of a catheter with four channels running radially along the axis in 90 degree sectors from the bladder to the external urethral orifice and expresses the data stereograp...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280976
更新日期:1984-01-01 00:00:00