Abstract:
INTRODUCTION:The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis. METHODS:The main clinical data of patients treated in centers affiliated to the GUONE (North-Eastern Uro-Oncological Group, Italy) were reviewed. We considered 52 patients (54 tumors, 2 bilateral) whose ages ranged from 13 to 70 years (mean 36). Of the treatments performed, 52 were orchiectomies and 2 were enucleations (unfavorable pathology in only 2 tumors). There were 5 lymphadenectomies (retroperitoneal lymph node dissections): 2 for suspected stage II disease and 1 each for unfavorable pathology, bilateral disease and associated Sertoli tumor (pathology: pN0 in all cases). The length of follow-up ranged from 15 to 249 months (mean 81). RESULTS:There was no relapse in 51 patients and 1 died as a result of metastatic disease (orchiectomy at the age of 70; unremarkable pathology). CONCLUSIONS:Malignant LCT seems to be, in our experience, less frequent than previously reported. Age and pathology are useful prognostic factors, but their predictive value should never be considered absolute. Enucleation seems justified in young patients with favorable pathology. In clinical stage I LCT, retroperitoneal lymph node dissection should be offered to older patients and/or to patients with unfavorable pathology. A prolonged follow-up is mandatory.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Di Tonno F,Tavolini IM,Belmonte P,Bertoldin R,Cossaro E,Curti P,D'Incà G,Fandella A,Guaitoli P,Guazzieri S,Mazzariol C,North-Eastern Uro-Oncological Group, Italy.doi
10.1159/000200790subject
Has Abstractpub_date
2009-01-01 00:00:00pages
152-7issue
2eissn
0042-1138issn
1423-0399pii
000200790journal_volume
82pub_type
杂志文章,多中心研究abstract::Plasma carcinoembryonic antigen (CEA) levels were performed preoperatively by radioimmunoassay in 124 patients with histologically proved bladder carcinoma. The level of CEA was used to determine its prognostic value in patients with bladder cancer. The correlation of CEA levels with the stage of the disease, histolog...
journal_title:Urologia internationalis
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journal_title:Urologia internationalis
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journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章,随机对照试验
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