Abstract:
OBJECTIVE:Laparoscopic nephroureterectomy (LNU) offers a superior morbidity profile compared with open nephroureterectomy (ONU) in treating upper urinary tract urothelial cell carcinoma. Evidence of oncological equivalence between LNU and ONU is limited. We compare operative and oncological outcomes for LNU and ONU using matched-pair analysis. METHODS:Of 159 patients who underwent a nephroureterectomy at a single institution between April 1992 and April 2010, 13 pairs of ONU and LNU patients were matched for gender, age, tumour location, tumour grade and stage. Operative details, post-operative characteristics and recurrences were collated and survival rates analysed using the Kaplan-Meier method. RESULTS:There was no significant difference in mean operation time between LNU (191 min) and ONU (194 min, p=0.92). There was no significant difference in the 5-year survival rate between LNU and ONU (overall survival 59.1% vs. 73.5%, p=0.18; progression-free survival 24.0% vs. 56.0%, p=0.14; cancer-specific survival 60.9% vs. 73.5%, p=0.56; bladder cancer recurrence-free survival 8.7% vs. 0.0%, p=0.09). CONCLUSION:Amidst limited RCT and comparative studies, this study presents further evidence of oncological equivalence between LNU and ONU. There was a trend towards poorer outcomes following LNU though, which merits further study.
journal_name
Urol Intjournal_title
Urologia internationalisauthors
Blackmur JP,Stewart GD,Egong EA,Cutress ML,Tolley DA,Riddick AC,McNeill SAdoi
10.1159/000364833subject
Has Abstractpub_date
2015-01-01 00:00:00pages
156-62issue
2eissn
0042-1138issn
1423-0399pii
000364833journal_volume
94pub_type
杂志文章abstract::Nutrition plays a major role in the pathogenesis of the most widespread forms of nephrolithiasis, i.e. calcium (calcium oxalate and phosphate) and uric acid stone disease. For this reason, dietary measures are the first level of intervention in primary prevention, as well as in secondary prevention of recurrences. An ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000076588
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:The objective of this study is to describe and analyze the experience over a period of 10 years at our center through a retrospective study of a series of diagnosed and treated cases of penile fracture. MATERIAL AND METHODS:From 2005 to 2009 the Urology Department of the Hospital Clínico San Carlos of Madri...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324249
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To assess MRI/Transrectal Ultrasound (TRUS) fusion three-dimensional model-guided targeted biopsy (3D-Tb) versus TRUS-guided systematic biopsy (Sb) in detecting overall and high-Gleason-score (≥7) prostate cancer (PCa). METHODS:Pubmed and Web of science were searched. Studies with men having a suspicious lesio...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000484144
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To report conservative and surgical strategies for treatment of mesh erosion after pelvic organ prolapse (POP) repair. METHODS:Between 1998 and 2008, 179 patients underwent integral pelvic floor reconstruction for advanced POP in our tertiary urogynecological unit. Patients' charts and follow-up data were en...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324243
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Phosphatidylinositol 3-kinase (PI3K)-AKT signaling is a well-characterized pathway involved in the control of cell proliferation, apoptosis and oncogenesis. LY294002 is a commonly used pharmacologic inhibitor which acts at the ATP-binding site of the PI3K enzyme, thus selectively inhibiting the PI3K-AKT nexu...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000322849
更新日期:2011-01-01 00:00:00
abstract::A case of malignant peripheral nerve sheath tumor of the bladder in a 57-year-old man with multiple neurofibromatosis type 1 is presented. The patient had a recent history of a transurethrally resected bladder ganglioneuroma. A probable histogenetic association between these two extremely rare neoplasms is proposed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000065568
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Open radical cystectomy (ORC) is the gold standard of treatment for muscle-invasive bladder cancer. Laparoscopic radical cystectomy (LRC) has emerged to provide an alternative. METHODS:Between 2006 and 2012, 155 patients who underwent LRC or ORC were compared (mean follow-up 53 months). RESULTS:The ORC gro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000350237
更新日期:2013-01-01 00:00:00
abstract::Tumour markers which occur in blood or urine are of value in the management of cancer patients because they allow disease status to be monitored by non-invasive techniques at low cost. An antigen, 'B5', on erythrocytes has been shown to become enhanced when cancer develops, regardless of tumour type, and thus the B5 a...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281951
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:We compared the results of holmium laser and pneumatic intracorporeal lithotripsy for large ureteric calculi in terms of efficacy, safety and complications. METHODS:The study was conducted between April 2009 and October 2010. 80 patients divided into two equally matched groups were included in a prospective ...
journal_title:Urologia internationalis
pub_type: 杂志文章,随机对照试验
doi:10.1159/000336254
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:We reviewed our experiences in performing cytoreductive metastatectomy before initiating systemic immunochemotherapy and tried to investigate potential prognostic factors for such an approach. PATIENTS AND METHODS:A retrospective analysis of 57 patients who received interleukin-2, interferon-alpha, and 5-...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000091630
更新日期:2006-01-01 00:00:00
abstract::We report a rare case of massive bilateral staghorn calculi in a spinal cord injury patient with significant renal compromise. The patient was successfully treated with percutaneous nephrolithotomy to achieve a stone-free status. The various options of treatment are discussed with special attention to the technical as...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000030340
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVES:Endorectal coil MRI (endoMRI) of the prostate is useful to evaluate tumor localization. There is little evidence on patient characteristics affecting its diagnostic performance. We evaluate the influence of clinical and histological parameters on the accuracy of endoMRI. METHODS:Sixty-nine patients with pro...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000324098
更新日期:2011-01-01 00:00:00
abstract:AIM:To examine the hypothesis that the risk of high-grade bladder cancer can be predicted using noninvasively obtained data. PATIENTS AND METHODS:We retrospectively analyzed the database of 431 patients that had transurethral resection of first-time bladder tumors between June 1998 and December 2009. Pre-operative par...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000328635
更新日期:2011-01-01 00:00:00
abstract::Multiple oral doses of alpha-difluoromethyl-ornithine (alpha-DFMO), 18-24 g/day for up to 2 months, were administered to 2 patients with invasive and metastatic carcinoma of the bladder and to 3 patients with metastatic renal cancer in an open study. The moderate antigrowth effect of alpha-DFMO in these patients was c...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000280403
更新日期:1981-01-01 00:00:00
abstract:INTRODUCTION:MicroRNA (miR)371a-3p was suggested to be a sensitive and specific new serum biomarker of germ cell tumours (GCTs); however, its clinical usefulness remains unproven. PATIENTS, METHODS:In 312 consecutive cases with various testicular diseases, serum levels of miR371a-3p were measured. Measurement results ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000477446
更新日期:2017-01-01 00:00:00
abstract::Loin pain haematuria (LPHS) is a rare and difficult-to-diagnose syndrome. Different therapeutic approaches have been used historically with little or no success. We report a case of LPHS in which bilateral renal autotransplantation led to pain relief, cessation of all medication and no recurrence beyond two years of f...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000430503
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate prognostic factors for patients with upper urinary tract urothelial carcinoma (UUT-UC) after nephroureterectomy and to seek a better way of finding more favorable clinical results for these patients. PATIENTS AND METHODS:We retrospectively reviewed the medical rec...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000335274
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:The goal of the study was to define treatment rules for the uncommon, rarely (10%) malignant and chemorefractory Leydig cell tumors (LCT) of the testis. METHODS:The main clinical data of patients treated in centers affiliated to the GUONE (North-Eastern Uro-Oncological Group, Italy) were reviewed. We cons...
journal_title:Urologia internationalis
pub_type: 杂志文章,多中心研究
doi:10.1159/000200790
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Urologists have to master a variety of techniques to be able to offer the most appropriate surgical stone treatment for each individual patient. Therefore, we performed a survey among board-certified Swiss urologists to assess the availability of the different surgical methods, the current practices of sur...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000502806
更新日期:2019-01-01 00:00:00
abstract:AIMS:This study was to identify factors that influence the early increase in the dose of intracavernous vasoactive agents to maintain erection for satisfactory intercourse and to elucidate when the dose increase would begin. METHODS:Seventy-nine patients using intracavernous pharmacotherapy with tri-mix (PGE(1), papav...
journal_title:Urologia internationalis
pub_type: 临床试验,杂志文章
doi:10.1159/000064877
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:The aim of this work was to verify the tolerability and the preliminary clinical results of intensive intravesical instillations of a mitomycin C (MMC) regimen. PATIENTS AND METHODS:From September 2007 to November 2009, 40 consecutive evaluable patients with pathologically confirmed intermediate-risk non-mus...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000315492
更新日期:2010-01-01 00:00:00
abstract::A 25-year-old male with an incisional hernia following suprapubic trocar cystostomy for a failed traumatic perurethral catheterization is presented. This is only the 2nd case reported in the literature. Pathophysiology and management of this rare complication are discussed. ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000068764
更新日期:2003-01-01 00:00:00
abstract::Primary penile carcinoma is one of the rarest male genital tract tumors. We rarely encounter this malignancy in Turkey because circumcision is routinely performed as a part of the Islamic tradition. Despite the medical paradox that the penis is rarely affected by metastases, approximately 300 cases have been reported ...
journal_title:Urologia internationalis
pub_type: 杂志文章,评审
doi:10.1159/000090872
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND/AIMS:Periurethral cysts are a rare entity that may be confused with urethral diverticula. The protocol for diagnosis and management of these lesions is still unclear. We present our experience with six patients presenting with periurethral cysts. METHODS:From 2001 to 2005 we evaluated six patients with a pa...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000098068
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION AND AIM:Surgical vasectomy remains the gold standard for fertility control in men. Endoluminal occlusion of the seminal ducts, thus avoiding an external incision, may become an appealing alternative to this approach. As our group has shown, nontraumatic endoscopic inspection of the seminal ducts is feasibl...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000478790
更新日期:2017-01-01 00:00:00
abstract::Among the number of urological symptoms in women complaining of incontinence more specific symptoms are often overlooked. Frequency, urge, suprapubic pain, nocturia, etc., are typical for bladder wall disorders, but also often misleading as part of the incontinence symptomatology. The final diagnosis of bladder wall d...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000281652
更新日期:1990-01-01 00:00:00
abstract::Here we describe the clinical, radiologic, histopathological and immunohistochemical features of a rare spontaneous rupture of renal angiosarcoma detected in the left kidney of a 55-year-old male. Due to the rarity of this neoplasm (less than 15 cases have been reported), there is no unanimous consensus for therapy fo...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000048419
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Genetic variants of vitamin D receptor (VDR) were implicated in urolithiasis susceptibility in several case-control studies. However, these studies so far have provided conflicting results. In order to investigate the potential relationship, a meta-analysis was conducted. METHODS:Eligible studies were retrie...
journal_title:Urologia internationalis
pub_type: 杂志文章,meta分析,评审
doi:10.1159/000323949
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The best technique of radical prostatectomy--open retropubic versus robot-assisted surgery--is a subject of controversy. PATIENTS AND METHODS:Between January 1st, 2007 and December 31st, 2011, 2,177 men underwent radical prostatectomy at our department. 252 (12%) cases were laparoscopic robot-assisted, the ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000345320
更新日期:2013-01-01 00:00:00
abstract::149 men suffering from erectile failure underwent a standardized combined procedure including intracavernosal pharmacological injection test (P test) artificial erection, pharmacocavernosography and cavernosometry with analysis of intracavernosal erection pressure and pressure drop. Patients with negative P test were ...
journal_title:Urologia internationalis
pub_type: 杂志文章
doi:10.1159/000282163
更新日期:1991-01-01 00:00:00